Article
Oncology
Vincent Quoc-Huy Trinh, Joseph Thomas Roland, Jahg Wong, Frank Revetta, Krutika Patel, Chanjuan Shi, Kathleen E. DelGiorno, Bruce D. Carter, Marcus Chuan Beng Tan
Summary: The study found that nerve density increases from low-grade to high-grade dysplasia in IPMN, but does not further increase once invasive IPMN is present. The expression of nerve growth factor (NGF) correlates with higher nerve density. The presence of neural precursor cells reaches peak density in high-grade dysplasia, indicating the importance of nerve-tumor interactions in IPMN progression.
JOURNAL OF PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Devarshi R. Ardeshna, Shiva Rangwani, Troy Cao, Timothy M. Pawlik, Peter P. Stanich, Somashekar G. Krishna
Summary: Hereditary pancreatic cancer accounts for about 10% of pancreatic cancer diagnoses. Early detection of pre-cancerous pancreatic cysts, such as intraductal papillary mucinous cystic neoplasms (IPMNs), has become an important focus to reduce pancreatic cancer incidence and mortality. This review explores the prevalence of IPMNs in patients with hereditary pancreatic cancer and their relatives, and discusses the need for surveillance changes in high-risk individuals.
Article
Gastroenterology & Hepatology
Carlo Alberto Pacilio, Davide Cavaliere, Giorgio Ercolani
Summary: This article describes a case of a 74-year-old woman with a branch-duct intraductal papillary mucinous neoplasm located more than 1 cm from the main pancreatic duct. A robotic enucleation through an inframesocolic approach was performed successfully. The final pathological diagnosis revealed a low-grade dysplasia branch-duct intraductal papillary mucinous neoplasm. The inframesocolic approach can provide a safe limited resection for selected cases.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Tingting Lin, Xin Chen, Jingjing Liu, Yingying Cao, Wenjing Cui, Zhongqiu Wang, Cheng Wang, Xiao Chen
Summary: Imaging-based pancreatic atrophy is significantly associated with malignant IPMNs or invasive carcinoma, serving as an independent factor. In MPD-involved IPMNs, pancreatic atrophy performs better in identifying invasive carcinoma compared to mural nodules.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Hye yeon Yang, Incheon Kang, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang
Summary: This study compared the efficacy and potential oncologic impact of intraoperative pancreatoscopy (IOP) with frozen section biopsy (FSB) in pancreaticoduodenectomy (PD) for main pancreatic duct (MPD)-involved intraductal papillary mucinous neoplasms (IPMNs). It was found that IOP could be safely performed and the initial surgical plan could be changed based on its findings, but there was no significant difference in overall disease-free survival rate between the two groups.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Mihyeon Park, Jisun Lee, Yook Kim, Kyung Sik Yi, Bum Sang Cho, Chi-Hoon Choi, Kil Sun Park
Summary: This article describes two cases in which patients were initially diagnosed with SCNs, but were misdiagnosed as IPMN due to radiologic imaging showing apparent connection between the pancreatic duct and cystic lesion, leading to unnecessary surgery. Particular attention should be paid to the interpretation of clinicoradiologic findings of pancreatic cystic lesions, especially in the decision of surgical intervention. Additionally, awareness of the atypical radiologic features of SCN may expand the knowledge base of radiologists.
Article
Oncology
Hao Zhou, Xin Chen, Cheng Wang, Tingting Lin, Xiaoshuang Li, Wenjing Cui, Jianhua Wang, Yu Wang, Xiao Chen
Summary: Diabetes mellitus is associated with a higher risk of malignant intraductal papillary mucinous neoplasms, especially in patients with main pancreatic duct involvement.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Charikleia Triantopoulou, Sofia Gourtsoyianni, Dimitrios Karakaxas, Spiros Delis
Summary: Intraductal papillary mucinous neoplasm of the pancreas (IPMN) is a mucin-producing tumor that originates from the ductal epithelium and can progress from mild dysplasia to invasive carcinoma. Different types of IPMN exist, including the branch duct variant, main duct variant (with higher malignancy prevalence), and mixed-type variant. Cross-sectional imaging plays a crucial role in the detection and characterization of IPMNs, and identifying worrisome features for malignancy is important. This review discusses recent imaging advances, management guidelines, complications, and prognostic biomarkers for IPMNs.
Article
Medicine, General & Internal
Dana Zelnik Yovel, Erwin Santo, Majd Khader, Roie Tzadok, Nir Bar, Asaf Aizic, Oren Shibolet, Dana Ben-Ami Shor
Summary: This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs. The results showed that IPMN patients have a significantly higher incidence of gastric cancer compared to the general population. However, the incidence of esophagogastroduodenal findings, including gastric and esophageal cancer, is similar between IPMN patients and those who undergo an EGD for similar clinical indications. Further research is needed to determine optimal surveillance strategies for IPMN patients regarding their risk of developing gastric cancer.
Article
Surgery
Naziheh Assarzadegan, Elizabeth Thompson, Kevan Salimian, Matthias M. Gaida, Lodewijk A. A. Brosens, Laura Wood, Syed Z. Ali, Ralph H. Hruban
Summary: Informed clinical decisions in the treatment of Intraductal Papillary Mucinous Neoplasms (IPMNs) are based on a deep understanding of the pathology of these lesions, with a focus on balancing the risk of over treatment with the patient's best interests.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Oncology
Fan Xu, Yingying Liang, Wei Guo, Zhiping Liang, Liqi Li, Yuchao Xiong, Guoxi Ye, Xuwen Zeng
Summary: DWI is effective in predicting the malignant potential in patients with IPMNs, with a high sensitivity and specificity. The slice thickness of DWI and DWI parameter are significant factors influencing diagnostic specificity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Charlotte Vestrup Rift, Linea Cecilie Melchior, David Scheie, Carsten Palnaes Hansen, Eva Lobner Lund, Jane Preuss Hasselby
Summary: The study aimed to investigate the impact of molecular heterogeneity of the luminal cyst wall on tissue sampling strategies for intraductal papillary mucinous neoplasms (IPMNs). NGS and immunohistochemical phenotyping on 18 IPMNs revealed various degrees of dysplasia and concomitant carcinoma. The results showed that small biopsies from the cyst wall are sufficient to provide a molecular diagnosis.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheng Wang, Tingting Lin, Xinru Wang, Zhicheng Yu, Xiaoling Zhuge, Wenjing Cui, Miaomiao Wang, Zhongqiu Wang, Chuangen Guo, Xiao Chen
Summary: Low HDL-c levels are associated with malignant IPMNs, serving as a potential biomarker for identifying malignant IPMNs and improving the predictive ability of malignancy in BD-IPMNs.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Oncology
Xiaoling Zhuge, Hao Zhou, Liming Chen, Hui Chen, Xiao Chen, Chuangen Guo
Summary: This study demonstrated that elevated serum ferritin levels are associated with malignant IPMNs, and may serve as a useful marker for identifying malignancy in IPMNs. Serum ferritin outperformed CEA and CA19-9 in identifying malignant IPMNs.
Article
Gastroenterology & Hepatology
Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Shuichi Tange, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Hirofumi Kogure, Suguru Mizuno, Kei Saito, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Mariko Tanaka, Keisuke Tateishi, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro
Summary: This study investigated the long-term effects of dilation of the main pancreatic duct (MPD) on intraductal papillary mucinous neoplasms (IPMNs) and found that MPD dilation was associated with higher incidence and prevalence of pancreatic carcinoma.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Se Woo Park, Kyong Joo Lee, Moon Jae Chung, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seung Woo Park, Si Young Song, Huapyong Kang, Eui Joo Kim, Yeon Suk Kim, Jae Hee Cho, Seungmin Bang
Summary: This study compared the clinical outcomes of UCDBS and PCDBS for distal MBO. The results showed that PCDBS had a longer stent patency, but there were no significant differences between the two groups in overall survival and stent dysfunction.
GASTROINTESTINAL ENDOSCOPY
(2023)
Editorial Material
Oncology
Seung Soo Hong, Dai Hoon Han, Kyung Sik Kim, Jin Sub Choi, Gi Hong Choi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ho Soo Chun, Minjong Lee, Hye Ah Lee, Sejin Lee, Soyeon Kim, Ye Jun Jung, Chaewon Lee, Hyoeun Kim, Han Ah Lee, Hwi Young Kim, Kwon Yoo, Tae Hun Kim, Sang Hoon Ahn, Seung Up Kim
Summary: This study aimed to determine the relationship between sarcopenic obesity (SO) and the risk of significant liver fibrosis or cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD). Through a multicenter retrospective study, it was found that high-risk subjects with SO had a higher risk of liver fibrosis and CVD development. The results demonstrated that high-risk subjects with SO had significantly increased risks of liver fibrosis and CVD development.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuna Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Myung Ji Goh, Wonseok Kang, Seung Up Kim
Summary: This study compared the outcomes of sorafenib and nivolumab as second-line agents after failed lenvatinib treatment in patients with advanced HCC. The results showed that lenvatinib-sorafenib sequential treatment resulted in significantly better survival than lenvatinib-nivolumab sequential treatment.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Han Ah Lee, Seung Up Kim, Jihwan Lim, Moon Young Kim, Sang Gyune Kim, Ki Tae Suk, Jae Young Jang, Hyonggin An, Hyung Joon Yim, Yeon Seok Seo
Summary: This study investigated the factors related to spleen length and the diagnostic accuracy of a model using spleen length corrected by related factors for predicting varices needing treatment. The study found that spleen length is influenced by age, sex, and body mass index in the Asian population. The LSRPS model using the measured/estimated spleen ratio showed higher diagnostic accuracy than the LSPS model in predicting VNT in patients with compensated advanced chronic liver disease.
Article
Endocrinology & Metabolism
Hee Seung Lee, Wonjeong Chae, Min Je Sung, Jiyoung Keum, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eun-Cheol Park, Chung Mo Nam, Sung-In Jang, Seungmin Bang
Summary: This study aimed to investigate the differences in incidence of pancreatic cancer between new-onset diabetes mellitus (NODM) and long-standing DM (LSDM). The results showed that the risk of pancreatic cancer was higher in the group with diabetes compared to the non-diabetes group, and the risk was higher in the NODM group than in the LSDM group, especially in men and patients in their 50s.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Han Ah Lee, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Hyung Joon Yim, Jong Eun Yeon, Yeon Seok Seo, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim
Summary: This study aimed to investigate whether antiviral therapy improves outcomes in patients with HBV-related decompensated cirrhosis and undetectable HBV-DNA. The results showed that antiviral therapy did not reduce the risk of death or hepatocellular carcinoma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Huapyong Kang, Bora Lee, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Joonhyung Park, Hajin Shim, Jung Hyun Lee, Eunho Yang, Eun Hwa Kim, Kwang Joon Kim, Min-Soo Kim, Moon Jae Chung
Summary: A GBM ensemble model and LR model were developed and showed good potential for predicting and preventing hypoxaemia during ERCP under MAC.
YONSEI MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Hee Seung Lee, Dai Hoon Han, Kyungjoo Cho, Soo Been Park, Chanyang Kim, Galam Leem, Dawoon E. Jung, Soon Sung Kwon, Chul Hoon Kim, Jung Hyun Jo, Hye Won Lee, Si Young Song, Jun Yong Park
Summary: The study developed organoids for two ICC subtypes, which revealed distinct transcriptional profiles and potential therapeutic targets.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Hye Yeon Chon, Han Ah Lee, Soo Young Park, Yeon Seok Seo, Sang Gyune Kim, Chang Hun Lee, Tae Hee Lee, Sang Hoon Ahn, Vincent Wai-Sun Wong, Terry Cheuk-Fung Yip, Lilian Yan Liang, In Hee Kim, Grace Lai-Hung Wong, Seung Up Kim
Summary: This study compared the predictive accuracy of three risk prediction models for hepatocellular carcinoma (HCC) development after 5 years of antiviral therapy in patients with chronic hepatitis B. The results showed that the SAGE-B and CAGE-B models might be better than the PAGE-B model in predicting HCC development after 5 years of treatment.
JOURNAL OF DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
David Sooik Kim, Beom Kyung Kim, Jae Seung Lee, Hye Won Lee, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Nikolaos Pyrsopoulos, Seung Up Kim
Summary: This study validated the predictive performance of the CHESS-ALARM model in patients with HBV-related liver cirrhosis and compared it with other TE-based models. The results showed that CHESS-ALARM had similar predictive performance as LSPS, PH, varices risk scores, ALBI, and ALBI-FIB-4.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Eugene Han, Ho Soo Chun, Yong-ho Lee, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Sang Hoon Ahn, Seung Up Kim
Summary: The risks of sarcopenia and cardiovascular disease (CVD) are significantly higher in metabolic dysfunction-associated fatty liver disease (MAFLD) group compared to non-metabolic risk (MR) non-alcoholic fatty liver disease (NAFLD) group. However, the risk does not differ according to fibrotic burden in non-MR NAFLD group. The MAFLD criteria might be better for identifying high-risk fatty liver disease than the NAFLD criteria.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Woo-Hyoung Kang, Shin Hwang, Masaki Kaibori, Jong Man Kim, Kyung Sik Kim, Tsuyoshi Kobayashi, Hiroto Kayashima, Yang Seok Koh, Keiichi Kubota, Akira Mori, Yutaka Takeda, Sung Su Yun, Kousuke Matsui, Kan Toriguchi, Hiroaki Nagano, Myung Hee Yoon, Yuji Soejima, Shunichi Ariizumi, Bum-Soo Kim, Yohan Park, Hee Chul Yu, Bong Wan Kim, Jung Bok Lee, Sang-Jae Park, Jin-Young Jang, Hiroki Yamaue, Masafumi Nakamura, Masakazu Yamamoto, Itaru Endo
Summary: The ADV score, calculated from the concentrations of AFP, DCP, and TV, has been shown to be prognostic of HCC recurrence following HR or liver transplantation. This international validation study demonstrated that ADV score is an integrated surrogate biomarker for post-resection prognosis of HCC.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Health Care Sciences & Services
Jung Hyun Jo, Zhan Gao, Inkyung Jung, Si Young Song, Geert Ridder, Hyungsik Roger Moon
Summary: This article discusses a survival function estimation method for clinical trials of poor prognosis cancer treatments, specifically pancreatic cancer. The copula-graphic estimation is used to handle dependent censoring, and a novel method for choosing the copula parameter is proposed. The method is applied to a clinical trial of GV1001 as a treatment for pancreatic cancer, and the results show statistically significant differences in median survival times between the treatment and control groups.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wonjeong Chae, Hee Seung Lee, Jung Hyun Jo, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Sung-In Jang, Jeong Youp Park
Summary: Gallbladder stones (GS) are associated with an increased risk of cardiovascular disease, but the relationship between cholecystectomy for GS and acute coronary syndrome (ACS) is unclear. In this study, the ACS risk in patients with GS and its association with cholecystectomy were investigated. The risk of ACS was higher in the GS group compared to the control group, and individuals without cholecystectomy in the GS group had a higher risk of ACS development. Cholecystectomy was associated with increased ACS risk in the gallstone group, especially in patients without metabolic disorders.
SCIENTIFIC REPORTS
(2023)
