Article
Cell Biology
Aibin Liu, Yanyan Li, Lin Shen, Liangfang Shen, Zhanzhan Li
Summary: This meta-analysis evaluated the utility of AFP-L3 for diagnosing hepatocellular carcinoma (HCC). The results showed that AFP-L3 has high sensitivity and specificity for diagnosing HCC, especially among Asian populations. AFP-L3 can serve as a useful tool for high-volume screening, helping optimize diagnostic workflows, reduce workload, and improve detection sensitivity. Combining multiple biomarkers may offer even more accurate diagnostic tools for HCC in the future.
Article
Pharmacology & Pharmacy
Ruoyu Liu, Yi Li, Anqi Wu, Mingzhu Kong, Weijia Ding, Zeyang Hu, Lin Chen, Weihua Cai, Feng Wang
Summary: Plasma circular RNA hsa_circ_0005397 is upregulated in HCC patients and closely correlated with tumor size and TNM staging. Its combination with other biomarkers can improve diagnostic sensitivity for HCC, predict recurrence or metastasis, and is associated with shorter overall survival in HCC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Siyu Liu, Liyang Sun, Lanqing Yao, Hong Zhu, Yongkang Diao, Mingda Wang, Hao Xing, Wan Yee Lau, Mingcheng Guan, Timothy M. Pawlik, Feng Shen, Min Xu, Xiangmin Tong, Tian Yang
Summary: This study compared the diagnostic performance of different serum biomarkers alone or in combination for HCV-associated HCC. PIVKA-II showed the best predictive performance, and the combination of PIVKA-II + AFP also had good predictive performance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jian-Ming Zhou, Ting Wang, Kun-He Zhang
Summary: AFP-L3% has high specificity but low sensitivity for diagnosing early HCC, making it more suitable for excluding HCC in cases with elevated AFP levels. A hypersensitive detection method can improve the diagnostic accuracy of AFP-L3% for early HCC.
Article
Nanoscience & Nanotechnology
Yingyan Zhao, Qi Liu, Yujia Qin, Yue Cao, Jing Zhao, Kai Zhang, Ya Cao
Summary: In this work, an electrochemical aptasensor was designed for the high-accuracy assay of AFP-L3 ratio. The aptasensor demonstrated the ability to accurately measure the AFP-L3 ratio in a linear range of 0.0008-40 ng mL-1, with satisfactory specificity and good recoveries in complex serum samples. This aptasensor may serve as a valuable tool for the measurement of AFP-L3 ratio and have great potential for early warning of hepatocellular carcinoma in clinical application.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Gastroenterology & Hepatology
Han Ah Lee, Yoo Ra Lee, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Yoon Tae Jeen, Jong Eun Yeon, Kwan Soo Byun, Yeon Seok Seo
Summary: This study evaluated the diagnostic accuracy of AFP, AFP-L3, and PIVKA-II and their combination for HCC diagnosis. A novel diagnostic model, the ALPs score, calculated using serum levels of these markers, showed improved accuracy in diagnosing HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Kelley G. Nunez, Tyler Sandow, Daniel Fort, Jai Patel, Mina Hibino, Ian Carmody, Ari J. Cohen, Paul Thevenot
Summary: The biomarkers AFP, AFP-L3, and DCP have implications in HCC surveillance, prognosis, and post-surgical recurrence risk. Accumulation of these biomarkers increases HCC progression risk, but patients with triple negative status for these biomarkers have a higher first-line objective response rate.
Review
Gastroenterology & Hepatology
Hira Hanif, Mukarram Jamat Ali, Ammu T. Susheela, Iman Waheed Khan, Maria Alejandra Luna-Cuadros, Muzammil Muhammad Khan, Daryl Tan-Yeung Lau
Summary: Alpha-fetoprotein (AFP) is a tumor marker for hepatocellular carcinoma (HCC), but its utility is limited. However, combining AFP with other novel biomarkers can improve its accuracy. Additionally, increased AFP levels may be associated with liver diseases and other non-hepatic disorders.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Tianying Ren, Xu Hou, Xin Zhang, Dongliang Chen, Juan Li, Yingnan Zhu, Zhiheng Liu, Dawei Yang
Summary: In this study, we developed the AALP model to differentiate between HCC and CLD patients based on serum biomarkers. The AALP model showed good sensitivity and specificity for HCC detection, and also performed well in the subgroup of CLD patients. Furthermore, we demonstrated the consistency between AFP-L3 and PIVKA II levels and imaging results.
Article
Biochemistry & Molecular Biology
Chanida Puangpila, Nattakritta Anukulkich, Siraphatsorn Chiapleam, Benyarat Intajan, Jaroon Jakmunee, Somkid Pencharee
Summary: A rapid and sensitive lateral flow assay using lectin Lens culinaris agglutinin (LCA) was developed for the detection of fucosylated alpha-fetoprotein (AFP-L3). The assay achieved quantitative detection of AFP-L3 within 10 minutes, with a low detection limit and good recovery for spiked human serum.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Dirk Andreas Ridder, Arndt Weinmann, Mario Schindeldecker, Lana Louisa Urbansky, Kristina Berndt, Tiemo Sven Gerber, Hauke Lang, Johannes Lotz, Karl J. Lackner, Wilfried Roth, Beate Katharina Straub
Summary: AFP is a commonly used biomarker for HCC, with its serum concentration moderately correlated to in situ expression. High AFP levels in serum and tissue are associated with poor prognosis, vascular invasion, higher tumor grade, and specific tumor subtype. Serum AFP concentration is a stronger prognostic predictor independent of tissue AFP immunostaining.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemical Research Methods
Jihyeon Lee, Injoon Yeo, Yoseop Kim, Dongyoon Shin, Jaenyeon Kim, Yeongshin Kim, Young-Suk Lim, Youngsoo Kim
Summary: Glycoproteins play important roles in biological functions, and aberrant glycosylation is related to cancers such as liver cancer. AFP-L3, a fucosylated glycan-containing biomarker, has been identified as a potential better marker for hepatocellular carcinoma (HCC) due to its high affinity for LCA lectin. This study compares the effectiveness of different lectins in capturing AFP-L3 and suggests the use of LTL lectin to improve the diagnostic sensitivity in HCC patients.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Oncology
Andrew X. Zhu, Richard S. Finn, Yoon-Koo Kang, Chia-Jui Yen, Peter R. Galle, Josep M. Llovet, Eric Assenat, Giovanni Brandi, Kenta Motomura, Izumi Ohno, Bruno Daniele, Arndt Vogel, Tatsuya Yamashita, Chih-Hung Hsu, Guido Gerken, John Bilbruck, Yanzhi Hsu, Kun Liang, Ryan C. Widau, Chunxiao Wang, Paolo Abada, Masatoshi Kudo
Summary: Baseline AFP is an important prognostic factor and predictive biomarker for the survival benefit of ramucirumab, with AFP response showing a significant association with longer patient survival.
BRITISH JOURNAL OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Yifei Tan, Jianhui Zhu, Cristian D. Gutierrez Reyes, Yu Lin, Zhijing Tan, Zuowei Wu, Jie Zhang, Alva Cano, Sara Verschleisser, Yehia Mechref, Amit G. Singal, Neehar D. Parikh, David M. Lubman
Summary: Aberrant changes in site-specific core fucosylation (CF) of serum proteins can serve as potential diagnostic markers of tumors. A study employed an optimized data-dependent acquisition (DDA) workflow to identify CF of serum proteins in patients with nonalcoholic steatohepatitis-related cirrhosis and hepatocellular carcinoma. The study found significant changes in CF peptides between cirrhosis and HCC, with one peptide showing the best diagnostic performance in discriminating HCC from cirrhosis.
Review
Medicine, General & Internal
Pierluigi Toniutto, Elisa Fumolo, Ezio Fornasiere, Davide Bitetto
Summary: This review discusses the current data on pretransplant criteria for liver transplantation in HCC patients exceeding the Milan Criteria, based on tumor morphological and histological characteristics validated in clinical practice. It also evaluates the role of HCC biological markers and tumor response to downstaging procedures as new tools for selecting patients with a tumor burden outside of the Milan Criteria for liver transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)