Article
Immunology
Evelin A. Leibinger, Gabor Pauler, Noemi Benedek, Timea Berki, Istvan Jankovics, Richard McNally, Gabor Ottoffy
Summary: The study found that normal CD4+ lymphocyte levels within age-specific ranges are associated with better antibody response to certain influenza strains post-vaccination. Patients with CD3+CD56+ (NKT-like) cells above predicted values based on age also showed significant associations with antibody response against all three influenza strains investigated. Additionally, having an absolute lymphocyte count above 1000/mu l was positively correlated with antibody response to certain strains post-vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Polina Kaidun, Samuel J. Holzmayer, Sarah M. Greiner, Anna Seller, Christian M. Tegeler, Ilona Hagelstein, Jonas Mauermann, Tobias Engler, Andre Koch, Andreas D. Hartkopf, Helmut R. Salih, Melanie Maerklin
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. The development of bispecific fusion proteins (BFPs) targeting NKG2DLs has shown promising results in activating NK and T cells against TNBC cells, leading to efficient eradication of tumors. This approach could be a valuable addition to the current treatment options for TNBC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Ratna S. Wijaya, Scott A. Read, Stephen Schibeci, Shuanglin Han, Mahmoud K. Azardaryany, David van der Poorten, Rita Lin, Lawrence Yuen, Vincent Lam, Mark W. Douglas, Jacob George, Golo Ahlenstiel
Summary: This study investigated the phenotype and function of CD56- NK cells in patients with chronic hepatitis B (CHB). CHB patients had a higher frequency of CD56- NK cells, which exhibited functional impairments and were positively correlated with serum HBV DNA levels.
LIVER INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Ruifeng Shi, Fang Dai, Yong He, Li Sun, Min Xu, Datong Deng, Qiu Zhang
Summary: This study identified 70 DEGs between T1DM patients and healthy controls, screened out 10 hub genes, and constructed a NK cell-specific gene co-expression network. By intersection analysis, 13 overlapping genes were found between two datasets, with 7 hub genes identified. 59 target miRNAs were predicted, and 7 differentially expressed miRNAs were selected from the validation dataset GSE97123.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Xin Zhang, Xiaofan Lu, Allen Ka Loon Cheung, Qiuyue Zhang, Zhiying Liu, Zhen Li, Lin Yuan, Rui Wang, Yan Liu, Bin Tang, Huan Xia, Hao Wu, Tong Zhang, Bin Su
Summary: TIGIT expression on NK cells is associated with dysfunction during chronic HIV infection, but its roles in acute HIV-1 infection are unclear. Our study found that TIGIT-expressing NK cells did not increase significantly until chronic infection, and their numbers were positively correlated with HIV-1 viral load in acute infection. Additionally, the expression of CD96 and CD226 on NK cells changed during different infection stages, with opposite associations with viral load and CD4 T-cell counts. Overall, TIGIT(+)NK cells displayed weaker functionalities compared to TIGIT(-)NK cells, indicating their limited ability to combat HIV-1 replication and maintain CD4 T-cell counts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Huiqiang Huang, Jun Zhu, Ming Yao, Tae Min Kim, Dok Hyun Yoon, Seok-Goo Cho, Hyeon Seok Eom, Soon Thye Lim, Su-peng Yeh, Yuqin Song, Yok Lam Kwong, Jin Seok Kim, Jie Jin, Yuankai Shi, HyeJin Kim, Min Qing, Tianyuan Zhou, Grace Gao, Zongqi Dong, Ming Qi, Won Seog Kim
Summary: In this study, daratumumab monotherapy showed an overall response rate of 25.0% in patients with relapsed or refractory NKTCL. However, no patients achieved complete response, and the duration of response was short. Adverse events were manageable and there were no new safety concerns identified.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Immunology
Shi Qian, Chunbin Xiong, Meiting Wang, Zining Zhang, Yajing Fu, Qinghai Hu, Haibo Ding, Xiaoxu Han, Hong Shang, Yongjun Jiang
Summary: The ectonucleotidases CD38 and CD39 play critical roles in HIV infection by regulating the activity of NK cells and suppressing T cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Balazs Sonkodi, Eva Pallinger, Tamas Radovits, Emese Csulak, Kinga Shenker-Horvath, Bence Kopper, Edit Buzas, Nora Sydo, Bela Merkely
Summary: The purpose of this study was to investigate the immunophenotypical characterization, with a focus on natural killer cells, of junior swimmers from the Hungarian National Swim Team before and after intense exercise. The findings showed an increase in the percentage of CD3(-)/CD56(+) natural killer cells and CD3(-)/CD56(dim+) NK cells, as well as a decrease in the percentage of CD3(+) T cells among lymphocytes after exercise. Additionally, a link between delayed-onset muscle soreness and imbalanced control of CD3(+)/CD56(+) NKT-like cells among lymphocytes was demonstrated for the first time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Madeline P. Lauener, Shima AzadPour, Sayeh Abdossamadi, Vaishnavi Parthasarathy, Bernard Ng, Elena Ostroumov, Geoffrey D. E. Cuvelier, Megan K. Levings, Katherine N. MacDonald, Amina Kariminia, Kirk R. Schultz
Summary: This study found that CD56bright natural killer (NK) cells are strongly associated with a lack of chronic graft-versus-host disease (cGvHD) and may function to suppress cGvHD. Phenotypic and transcriptome analysis revealed the characteristics of regulatory NK (NKreg) cells associated with the suppression of cGvHD. These NKreg cells can suppress allogeneic CD4+ T cells through a non-cytolytic, cell-cell contact dependent mechanism.
Article
Chemistry, Multidisciplinary
Songbo Zhao, Jiazhi Duan, Yalin Lou, Ruyun Gao, Shanshan Yang, Piming Wang, Chunhua Wang, Lin Han, Minghuan Li, Chunhong Ma, Xiaohong Liang, Hong Liu, Yuanhua Sang, Lifen Gao
Summary: A novel immunotherapy approach utilizing NK cells conjugated with magnetic nanoparticles has been developed for treating solid tumors, demonstrating improved tumor targeting and inhibition capabilities through magnetic field guidance.
Article
Oncology
Zi-Hao Wang, Pei Zhang, Wen-Bei Peng, Lin-Lin Ye, Xuan Xiang, Xiao-Shan Wei, Yi-Ran Niu, Si-Yu Zhang, Qian-Qian Xue, Hao-Lei Wang, Qiong Zhou
Summary: In this study, the researchers identified altered phenotypic and metabolic features of FOXP3(+) NKT-like cells in human MPE, providing new insights into the understanding and treatment of malignant pleural effusion.
Article
Immunology
J. C. Andreu-Ballester, M. A. Arribas, M. Rico, C. Garcia-Ballesteros, L. Galindo-Regal, R. Sorando-Serra, L. Albert, A. Navarro, F. Lopez-Chulia, F. Peydro, C. Cuellar
Summary: This study aimed to investigate the relationship between changes in γδT cell count and the progression of sepsis. The results showed that the number of γδT cells decreased with the severity of sepsis, particularly in non-surviving patients, while cell apoptosis increased.
CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Elisaveta Voynova, Nga Hawk, Francis A. Flomerfelt, William G. Telford, Ronald E. Gress, Jennifer A. Kanakry, Damian Kovalovsky
Summary: Chimeric antigen receptors (CAR) can redirect the activity of NK cells to target T-cell malignancies. Recognition of CD5 molecules in malignant T cells by the CAR leads to improved antitumor response compared to targeting CD3. A specific CAR-NK framework has superior activity on NK effector cells. CD3-CAR-T is more active than CD5-CAR-T in vitro, but less efficient in eliminating tumor cells in vivo. The CAR-NK framework greatly improves the efficacy of CARs in NK cells.
Article
Allergy
Robert Ose, Benno Weigmann, Detlef Schuppan, Ari Waisman, Joachim Saloga, Iris Bellinghausen
Summary: CD56(+)CD3(+) iNKT cells promote allergen-specific gut and lung inflammation in PBMC-engrafted humanized mice, opening up new possibilities for therapeutic intervention in allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Hematology
Maissa Mhibik, Erika M. Gaglione, David Eik, Ellen K. Kendall, Amy Blackburn, Keyvan Keyvanfar, Maria Joao Baptista, Inhye E. Ahn, Clare Sun, Junpeng Qi, Christoph Rader, Adrian Wiestner
Summary: BTK inhibitors enhance bsAb-induced cytotoxicity by relieving T cells of immunosuppressive restraints imposed by CLL cells, potentially providing a benefit for combination therapy in clinical trials.
Article
Multidisciplinary Sciences
Beata Kasztelan-Szczerbinska, Katarzyna Adamczyk, Agata Surdacka, Jacek Rolinski, Agata Michalak, Agnieszka Bojarska-Junak, Mariusz Szczerbinski, Halina Cichoz-Lach
Summary: This study found gender-related differences in the frequencies of PD-1/PD-L1 positive T and B cells in patients with ALD. Upregulation of PD-1+/PD-L1+ lymphocytes paralleled both the severity of alcoholic hepatitis and liver dysfunction in ALD females.
Article
Allergy
Malgorzata Bartkowiak-Emeryk, Andrzej Emeryk, Jacek Rolinski, Ewelina Wawryk-Gawda, Ewa Markut-Miotla
Summary: The study showed that PMBL (R) administration for 10 days per month for 3 months changed the panel of T lymphocytes in children with allergic asthma, with some cell counts increasing and others significantly decreasing.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Michal Tomaszewski, Ewelina Grywalska, Weronika Topyla-Putowska, Piotr Blaszczak, Marcin Kurzyna, Jacek Rolinski, Grzegorz Kopec
Summary: PAH can be caused by disorganized endothelial cell proliferation in the pulmonary arterioles, and factors such as genetic susceptibility, hypoxia, inflammation, drug response, and toxins may contribute to its development. The interaction of CD200 and CD200R in immune response modulation plays a crucial role in vascular remodeling associated with PAH. The dysregulation of CD200 and CD200R expression may be involved in the pathogenesis of various immune diseases, making these molecules potential markers for distinguishing different types of PAH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Michal K. Zarobkiewicz, Agnieszka A. Bojarska-Junak
Summary: CLL is the most common leukemia among adults, and currently there is no cure. Despite the dysfunction of gamma delta T cells in CLL patients, they can still be used for immunotherapy.
Article
Biochemistry & Molecular Biology
Wioleta Kowalska, Michal Zarobkiewicz, Waldemar Tomczak, Justyna Wos, Izabela Morawska, Agnieszka Bojarska-Junak
Summary: Monocytes, particularly non-classical subpopulations, may play an important role in chronic lymphocytic leukemia (CLL) pathogenesis. This study assessed monocyte subsets divided based on SLAN and CD16 expression in CLL patients. The findings suggest an increased percentage of non-classical monocytes producing TNF and IL-12, while intermediate monocytes showed a higher percentage of cells synthesizing anti-inflammatory IL-10. The percentage of CD14(dim)CD16(+)SLAN(+) monocytes producing TNF and IL-12 decreased with CLL stage and correlated with prognostic factors. Notably, CLL patients requiring treatment had a lower percentage of CD14(dim)CD16(+)SLAN(+) monocytes producing TNF and IL-12, potentially indicating a beneficial effect of non-classical monocytes on anti-tumor response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ewelina Firlej, Wioleta Kowalska, Karolina Szymaszek, Jacek Rolinski, Joanna Bartosinska
Summary: Acne vulgaris is a common skin disease caused by multiple factors and inflammation. Recent studies have found that skin immune cells play a significant role in the course of the disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Jakub Litak, Wieslawa Grajkowska, Jacek Bogucki, Pawel Kowalczyk, Alicja Petniak, Arkadiusz Podkowinski, Justyna Szumilo, Janusz Kocki, Jacek Rolinski, Mansur Rahnama-Hezavah, Marcin Roszkowski, Cezary Grochowski
Summary: High-grade pediatric glioma is a common malignancy in children. This study found a significant correlation between miR-155 concentration and PD-L1 expression in tumor tissue.
Article
Medicine, General & Internal
Michal K. Zarobkiewicz, Izabela Morawska, Wioleta Kowalska, Pawel Halczuk, Jacek Rolinski, Agnieszka A. Bojarska-Junak
Summary: This study found differential expression of PECAM-1 on γδT cells and a significant downregulation of CD3 expression during relapse in patients with multiple sclerosis, which may indicate overall activation of γδT cells.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Violetta Opoka-Winiarska, Ewelina Grywalska, Izabela Korona-Glowniak, Izabela Morawska, Krzysztof Gosik, Anna Malm, Jacek Rolinski
Summary: This study aimed to evaluate the impact of COVID-19 disease on patients with childhood rheumatic diseases. The study found significantly higher levels of SARS-CoV-2 antibodies in JIA patients compared to the control group, and these levels were correlated with the serological response to SARS-CoV-2. Additionally, serum PD-1 levels were also significantly higher in JIA patients and control volunteers who were seropositive for SARS-CoV-2 antibodies. The findings highlight the need for further observation of these detected abnormalities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Paulina Niedzwiedzka-Rystwej, Adam Majchrzak, Bogusz Aksak-Was, Karol Serwin, Zenon Czajkowski, Ewelina Grywalska, Izabela Korona-Glowniak, Jacek Rolinski, Milosz Parczewski
Summary: Current research shows that immune dysregulation and immune exhaustion are common in COVID-19, and markers of disease severity may include immune checkpoint molecules such as PD-1 and PD-L1. This study evaluated the expression of PD-1/PD-L1 in COVID-19 patients and found that increased PD-1+ and PD-L1+ lymphocytes are associated with disease severity and mortality.
Review
Oncology
Jakub Litak, Wojciech Czyzewski, Michal Szymoniuk, Leon Sakwa, Barbara Pasierb, Joanna Litak, Zofia Hoffman, Piotr Kamieniak, Jacek Rolinski
Summary: Spine metastases are a common and life-threatening complication of advanced-stage malignancies, often with a poor prognosis. Understanding metastatic processes is crucial in order to find targeted therapeutic options. The current literature provides knowledge about molecular pathways and biomarkers involved in spine metastases, as well as current and emerging treatment options.
Article
Biochemistry & Molecular Biology
Sylwia Chocholska, Michal Zarobkiewicz, Agata Szymanska, Natalia Lehman, Justyna Wos, Agnieszka Bojarska-Junak
Summary: The aim of this study was to investigate the expression of miR-17 similar to 92 cluster members in CLL patients. The study provides new evidence regarding the heterogeneity of miR-17 similar to 92 cluster members' expression in CLL patients. High miR-20a expression can be considered an independent favorable prognostic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Agnieszka Bojarska-Junak, Wioleta Kowalska, Sylwia Chocholska, Agata Szymanska, Waldemar Tomczak, Michal Konrad Zarobkiewicz, Jacek Rolinski, Daniela De Totero, Paolo Giannoni
Summary: This study explores the potential role of Galectin-9 (Gal-9) as a novel prognostic biomarker in chronic lymphocytic leukemia (CLL). Through quantification of Gal-9 mRNA expression in purified B-lymphocytes of 100 CLL patients, the study reveals the upregulation of Gal-9 mRNA in malignant B-cells, which is closely associated with unfavorable prognostic markers and a shorter time to treatment. Furthermore, the study suggests that EBV coinfection may worsen prognosis in CLL by inducing upregulation of Gal-9 expression.