Article
Medicine, Research & Experimental
Jianli Ma, Wenhui Zhao, Han Zhang, Zhong Chu, Huili Liu, Xue Fang, Dabei Tang
Summary: This study found that the expression of ANRIL was significantly upregulated in TNBC patients and cell lines. Knockdown of ANRIL overcame drug resistance in TNBC by inhibiting glycolysis and increasing the cytotoxic effect of ADT. ANRIL may function through the miR-125a/ENO1 pathway.
Article
Biochemistry & Molecular Biology
Adam M. Lee, Asmaa Ferdjallah, Elise Moore, Daniel C. Kim, Aritro Nath, Emily Greengard, R. Stephanie Huang
Summary: Osteosarcoma has a poor prognosis due to chemo-resistance and/or metastases. Increasing evidence shows that long non-coding RNAs (lncRNAs) can play an important role in drug sensitivity and cancer metastasis. ANRIL may serve as a potential biomarker for chemosensitivity and prognosis in osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Zhijiang Jin, Hongfeng Shen, Wei Cha, Haijiang Xia, Longbin Liu
Summary: This study investigated the possible association between plasma long non-coding RNA (lncRNA) levels and in-stent restenosis (ISR) following coronary stent implantation. The results showed that the lncRNA RNA antisense non-coding RNA at the INK4 locus (ANRIL) was upregulated and the lncRNA homeobox A11 antisense (HOXA11-AS) was downregulated in the plasma of patients with ISR. Logistic regression and receiver operating characteristic analysis revealed that ANRIL was an independent risk factor for ISR, while HOXA11-AS was an independent protective factor. Furthermore, the combination of ANRIL and HOXA11-AS levels in plasma was more effective at predicting ISR compared to evaluating either ANRIL or HOXA11-AS alone.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Retraction
Biochemistry & Molecular Biology
Hong Zhang, Xiuli Wang, Xinxin Chen
Summary: The study on the potential role of long non-coding RNA ANRIL in pediatric medulloblastoma was retracted due to inconsistencies between the presented results and described experimental methods.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Sergey V. Razin, Alexey A. Gavrilov
Summary: This review discusses the role of architectural RNAs in the construction of the cell nucleus and maintenance of the three-dimensional organization of the genome, highlighting the important support function of non-coding RNAs within cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Yeyu Zhang, Yuxing Zhu, Mengqing Xiao, Yaxin Cheng, Dong He, Jianye Liu, Liang Xiang, Lian Gong, Zhanwang Wang, Liping Deng, Ke Cao
Summary: The study reveals that TMPO-AS1 is upregulated in bladder cancer and promotes cell proliferation, migration, invasion, and inhibits apoptosis. Mechanistically, TMPO-AS1 interacts with E2F1, leading to E2F1 stabilization and ultimately promoting malignant behaviors in bladder cancer. Additionally, rescue experiments demonstrate that TMPO-AS1 promotes bladder cancer growth in an E2F1-dependent manner.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Aymeric Sanchez, Julien Lhuillier, Guillaume Grosjean, Lilia Ayadi, Sylvain Maenner
Summary: ANRIL, a long non-coding RNA encoded in the human chromosome 9p21 region, interacts with multiple proteins and miRNAs to regulate gene expression. It plays important roles in cellular processes like cell cycle control and proliferation. Dysregulation of ANRIL has been associated with diseases like cancers and cardiovascular diseases. Understanding its oncogenic role and potential as a biomarker in cancer is crucial.
Article
Biochemistry & Molecular Biology
Shantanu Gupta, Ronaldo F. Hashimoto
Summary: This study investigated the role of long non-coding RNAs in non-small cell lung cancer (NSCLC). Using a Boolean model, the authors identified ANRIL and UFC1 as important gene regulators in NSCLC and confirmed the significance of the miR-34a/Myc pathway in lung cancer cells.
Review
Biochemistry & Molecular Biology
Anshika Goenka, Deanna Marie Tiek, Xiao Song, Rebeca Piatniczka Iglesia, Minghui Lu, Bo Hu, Shi-Yuan Cheng
Summary: Research in cancer biology has predominantly focused on protein-coding genes, but the discovery of non-coding RNAs (ncRNAs) has shed light on their crucial role in various biological processes and human diseases including cancer. Dysregulated ncRNA expression affects cancer initiation, progression, and therapy resistance. This review emphasizes the recent developments and advances in ncRNA biology relevant to glioma tumorigenesis and therapy response, highlighting the potential of ncRNAs as biomarkers and therapeutic agents in glioma.
Article
Oncology
Shudan Mao, Jieping Jin, Zhe Li, Wenqi Yang
Summary: The knockdown of ANRIL inhibits cell proliferation and promotes apoptosis in Burkitt lymphoma by regulating the TGF-beta 1 signaling pathway, providing a potential novel target for its treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Endocrinology & Metabolism
Guanqing Zhou, Mimi Zhang, Jingzhi Zhang, Yaofeng Feng, Zhishen Xie, Siyi Liu, Detu Zhu, Yumei Luo
Summary: Non-coding RNAs play important roles in cell differentiation, proliferation, apoptosis, and the pathogenesis of various diseases. Especially in non-obstructive azoospermia, the expression of non-coding RNAs is associated with pathological conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Virology
Zeynab Rahni, Seyed Masoud Hosseini, Shabnam Shahrokh, Mahsa Saeedi Niasar, Shahrzad Shoraka, Hamed Mirjalali, Ehsan Nazemalhosseini-Mojarad, Mohammad Rostami-Nejad, Habib Malekpour, Mohammad Reza Zali, Seyed Reza Mohebbi
Summary: This study assessed the circulating levels of lncRNAs ANRIL, THRIL, NEAT1, and MALAT1 in COVID-19 patients' blood and found that the expression levels of ANRIL and THRIL were correlated with disease severity and could serve as circulating biomarkers for disease progression.
Review
Cell Biology
Chaohua Si, Chen Chen, Yaxin Guo, Qiaozhen Kang, Zhenqiang Sun
Summary: This review discusses the significant role of m6A RNA modifications in the tumor microenvironment, highlighting their potential as biomarkers and therapeutic targets for cancer therapy. Understanding the relationship between TME and m6A RNA modifications may lead to new approaches for future cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Zhenqing Tan, Kaibo Zhu, Yafei Yin, Zimian Luo
Summary: This study revealed that lncRNA ANRIL is significantly increased in AML patients and associated with clinical features and prognosis. High expression of lncRNA ANRIL is correlated with low CR rate and shorter EFS and OS in AML patients.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: Heart failure is a complex clinical syndrome with increasing prevalence, and finding new molecular biomarkers is an interesting tool to improve its prevention, diagnosis, treatment, and prognosis. This review emphasizes the relevance of microRNAs, long non-coding RNAs, and circular RNAs as potential biomarkers in heart failure. Further studies in this field are crucial to support their widespread clinical use.
Article
Nutrition & Dietetics
Kim-Oanh Pham, Akinori Hara, Hiromasa Tsujiguchi, Keita Suzuki, Fumihiko Suzuki, Sakae Miyagi, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Hirohito Tsuboi, Thao Thi Thu Nguyen, Yukari Shimizu, Yasuhiro Kambayashi, Masaharu Nakamura, Chie Takazawa, Haruki Nakamura, Toshio Hamagishi, Aki Shibata, Tadashi Konoshita, Atsushi Tajima, Hiroyuki Nakamura
Summary: This study aimed to investigate the interaction between dietary vitamin intake and the rs883484 genotype in the development of CKD. The results showed that higher intake of niacin, alpha-tocopherol, and vitamin C were independently associated with a lower tendency of CKD in individuals with the minor homozygotes of the rs883484 gene variant. This suggests the importance of dietary vitamin intake in preventing CKD in middle-aged to older-aged Japanese individuals with this specific gene variant.
Article
Clinical Neurology
Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Oanh Kim Pham, Sakae Miyagi, Thao Thi Thu Nguyen, Haruki Nakamura, Fumihiko Suzuki, Tomoko Kasahara, Yukari Shimizu, Yohei Yamada, Yasuhiro Kambayashi, Hirohito Tsuboi, Takehiro Sato, Takayuki Kannon, Kazuyoshi Hosomichi, Atsushi Tajima, Toshinari Takamura, Hiroyuki Nakamura
Summary: This study investigated the association between chronic pain, serum 25-hydroxyvitamin D concentrations, and single nucleotide polymorphisms. The results suggest that lower serum 25-hydroxyvitamin D concentrations are associated with chronic pain in individuals with a specific polymorphism.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yohei Shinmyo, Kengo Saito, Toshihide Hamabe-Horiike, Narufumi Kameya, Akitaka Ando, Kanji Kawasaki, Tung Anh Dinh Duong, Masataka Sakashita, Jureepon Roboon, Tsuyoshi Hattori, Takayuki Kannon, Kazuyoshi Hosomichi, Michal Slezak, Matthew G. Holt, Atsushi Tajima, Osamu Hori, Hiroshi Kawasaki
Summary: This study reveals the important role of localized astrogenesis in gyrus formation in the mammalian brain. The findings suggest that the positive feedback loop of FGF signaling is a crucial mechanism underlying cortical folding.
Article
Genetics & Heredity
Zannatun Nayema, Takehiro Sato, Takayuki Kannon, Hiromasa Tsujiguchi, Kazuyoshi Hosomichi, Hiroyuki Nakamura, Atsushi Tajima
Summary: Amylase activity and levels are heritable quantitative traits. A genome-wide association study (GWAS) in 814 Japanese individuals identified significant single-nucleotide variants (SNVs) near the AMY cluster on chromosome 1 that are associated with serum amylase levels (SAL). The study also found that the diploid copy number of AMY1 is significantly associated with SAL, while no significant associations were found for AMY2A or AMY2B. The AMY1 CNV appears to be the major genetic factor influencing SAL in the Japanese population.
JOURNAL OF HUMAN GENETICS
(2023)
Article
Psychology, Multidisciplinary
Shinobu Fukushima, Fumihiko Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Takayuki Kannon, Keita Suzuki, Yukari Shimizu, Thao Thi Thu Nguyen, Toru Yanagisawa, Fumika Oku, Kuniko Sato, Masaharu Nakamura, Koichiro Hayashi, Aki Shibata, Tadashi Konoshita, Yasuhiro Kambayashi, Hirohito Tsuboi, Atsushi Tajima, Hiroyuki Nakamura
Summary: This study investigated the relationships among depression, body mass index (BMI), and chronic pain (CP). The results showed a positive correlation between depression and lumbar/knee pain in the BMI < 25 group, but not in the BMI >= 25 group. Additionally, a higher BMI was associated with lumbar/knee pain.
BEHAVIORAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, Tetsuo Nishikawa, Hiroshi Furusho, Takekatsu Saito, Hiroaki Hirase, Kunio Ohta, Manabu Fujimoto, Yuki Horita, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Soichiro Usui, Kenji Sakata, Noboru Fujino, Atsushi Tajima, Masakazu Yamagishi, Masayuki Takamura
Summary: Genetic testing is crucial for identifying disease-causing variants and distinguishing between pathogenic and benign variants. In this study, a zebrafish model was used to investigate the clinical significance of KCNQ1 variants. The results showed that KCNQ1 variants could affect action potential duration and should be reevaluated physiologically.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Aya Ogawa, Hiromasa Tsujiguchi, Masaharu Nakamura, Koichi Hayashi, Akinori Hara, Keita Suzuki, Sakae Miyagi, Takayuki Kannon, Chie Takazawa, Jiaye Zhao, Yasuhiro Kambayashi, Yukari Shimizu, Aki Shibata, Tadashi Konoshita, Fumihiko Suzuki, Hirohito Tsuboi, Atsushi Tajima, Hiroyuki Nakamura
Summary: This study investigated the interrelationships among nutrient intake, alcohol consumption, and the incidence of diabetes. It found that vegetable protein intake was negatively associated with the incidence of diabetes in males, while animal fat intake was positively associated with the incidence of diabetes. Therefore, considering vegetable protein and animal fat intake, along with drinking habits, is important for the prevention of diabetes.
Article
Nutrition & Dietetics
Reina Yamamoto, Yumie Takeshita, Hiromasa Tsujiguchi, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Keita Suzuki, Yuki Kita, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Tatsuya Yamashita, Shuichi Kaneko, Atsushi Tajima, Hiroyuki Nakamura, Toshinari Takamura
Summary: Recent studies have shown that nonalcoholic fatty liver disease (NAFLD) is correlated with genetic polymorphisms. However, the effects of genetic variation on nutritional metabolism and NAFLD are complex and further studies are needed.
CURRENT DEVELOPMENTS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Tsuyoshi Hattori, Stanislav M. Cherepanov, Ryo Sakaga, Jureepon Roboon, Dinh Thi Nguyen, Hiroshi Ishii, Mika Takarada-Iemata, Takumi Nishiuchi, Takayuki Kannon, Kazuyoshi Hosomichi, Atsushi Tajima, Yasuhiko Yamamoto, Hiroshi Okamoto, Akira Sugawara, Haruhiro Higashida, Osamu Hori
Summary: This study reveals that astrocytes, specifically the CD38 protein expressed in them, play a crucial role in social behavior by regulating oxytocin release and synapse formation. Deletion of CD38 in postnatal astrocytes impairs social memory and inhibits synaptogenesis, highlighting the importance of astrocytes in neural circuit formation.
Article
Nutrition & Dietetics
Akinori Hara, Hiromasa Tsujiguchi, Keita Suzuki, Masaharu Nakamura, Masaru Okada, Jiaye Zhao, Chie Takazawa, Fumihiko Suzuki, Tomoko Kasahara, Yukari Shimizu, Hirohito Tsuboi, Takayuki Kannon, Atsushi Tajima, Toshinari Takamura, Hiroyuki Nakamura
Summary: The study explored the relationship between dietary intake of fatty acids and chronic kidney disease (CKD) in Japanese people. It found that low intake of omega-3 and high omega-6-to-omega-3 ratio were associated with CKD in participants with diabetes, but not in those without diabetes.
Article
Multidisciplinary Sciences
Tadashi Toyama, Miho Shimizu, Taihei Yamaguchi, Hidekazu Kurita, Tetsurou Morita, Megumi Oshima, Shinji Kitajima, Akinori Hara, Norihiko Sakai, Atsushi Hashiba, Takuzo Takayama, Atsushi Tajima, Kengo Furuichi, Takashi Wada, Yasunori Iwata
Summary: Association rule, a transparent machine learning method, was used to evaluate the risk for kidney disease in diabetic patients. The study found significant relationships between glycemic control, anemia, obesity, and hypertension with kidney function. Stratified risk assessment using association rules revealed the importance of the presence or absence of risk factors.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Satoko Okuwaki, Kazuyoshi Hosomichi, Atsushi Tajima, Tetsutaro Yamaguchi
Summary: In this study, continuous professional mechanical tooth cleaning (PMTC) for orthodontic patients wearing multi-bracket appliances was found to significantly reduce plaque in the oral cavity without causing changes in the oral or gut microbiota or an increase in pathogenic bacteria. This suggests that continuous PMTC can inhibit the growth of pathogenic bacteria by maintaining a clean oral environment and avoiding dysbiosis in both the oral and gut microbiota. Furthermore, differences in food intake and choices at each treatment stage may affect the gut microbiota.
APPLIED SCIENCES-BASEL
(2023)
Article
Health Care Sciences & Services
Shingo Nakai, Fumihiko Suzuki, Shigefumi Okamoto, Sakae Miyagi, Hiromasa Tsujiguchi, Akinori Hara, Thao Thi Thu Nguyen, Yukari Shimizu, Koichiro Hayashi, Keita Suzuki, Tomoko Kasahara, Masaharu Nakamura, Chie Takazawa, Takayuki Kannon, Atsushi Tajima, Hirohito Tsuboi, Noriyoshi Ogino, Tadashi Konoshita, Toshinari Takamura, Hiroyuki Nakamura
Summary: This study aimed to investigate the association between oral frailty and decreased bone mineral density (BMD) and renal function. The results showed that lower BMD was significantly associated with lower renal function in individuals with an estimated glomerular filtration rate (eGFR) of < 60 and oral frailty. Further longitudinal studies are needed to confirm these findings.
Article
Genetics & Heredity
Regina Gamirova, Elena Shagimardanova, Takehiro Sato, Takayuki Kannon, Rimma Gamirova, Atsushi Tajima
Summary: This study aimed to explore the genetics of idiopathic generalized epilepsy (IGE) and identify candidate gene variants associated with IGE. Through whole-exome sequencing analysis, the study found that IGE shows high heterogeneity and identified several novel candidate variants. The results suggest that the current Genes4Epilepsy panel is incomplete for the clinical diagnosis of IGE.
JOURNAL OF HUMAN GENETICS
(2023)
Letter
Oncology
Hiroki Mizumaki, Dung Cao Tran, Kohei Hosokawa, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Rena Yamazaki, Hiroshi Fujiwara, Atsushi Tajima, Shinji Nakao
BLOOD CANCER JOURNAL
(2023)