Journal
ONCOLOGY REPORTS
Volume 23, Issue 4, Pages 989-995Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or_00000724
Keywords
breast cancer; IGF-IR; IGFBP-3; immunocytochemistry
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Funding
- Kangbuk Samsung Hospital, Seoul, South Korea
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We analyzed insulin-like growth factor receptor I (IGF-IR) and insulin growth factor binding protein-3 (IGFBP-3) expression with respect to overall survival and relapse-free survival (RFS) in 460 patients with primary invasive breast cancer using immunohistochemistry. IGF-IR expression had a significant positive correlation with positive estrogen receptor (ER), positive progesterone receptor (PR) and Bcl-2 expression. Univariate analysis showed significantly C better overall survival (p=0.0001) and RFS (p=0.004), ill the IGF-IR-positive Group. Multivariate analysis showed a significant reduction in relative risk for overall Survival (p=0.019, HR=0.221, 95% CI=0.062-0.780) and RFS (p=0.026, HR=0.462 95% CI=0.234-0.913) in the IGF-IR-positive group. IGF-IR expression in primary breast cancer is an independent favorable prognostic factor. IGFBP-3 expression in breast cancer is associated with Poor outcome.
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