Journal
ONCOLOGY REPORTS
Volume 23, Issue 4, Pages 893-899Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or_00000712
Keywords
Notch signaling; breast cancer; RNA interference: proliferation; apoptosis; chemosensitivity
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Notch signaling plays a critical role in determining cell fate Such as proliferation, differentiation, and apoptosis. Accumulating evidence indicates that aberrant Notch signaling has tumor-promoting function in breast cancer. We hypothesized that Notch signaling may be a potential therapeutic target for human breast cancer. To address this issue, we down-regulated the expression of the Notch-1 receptor by siRNA in human breast cancer cells. We found that the down-regulation of Notch-1 signaling Caused cancer cell,growth inhibition by apoptosis Induction. The effect of the down-regulation of Notch-1 may be through the inactivation of NF-kappa B. In addition, the down-regulation of Notch-1 signaling increased chemosensitivity to doxorubicin and docetaxel. Our results suggested that Notch signaling may be a promising target for breast cancer treatment.
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