Article
Pharmacology & Pharmacy
Yisa Han, Tongtong Lan, Xuezhen Ma, Ning Yang, Chuhui Wang, Zhen Xu, Zhao Chen, Meng Tao, Hui Li, Haitao Wang, Yang Song
Summary: By upregulating claudin 7 and E-cadherin, and downregulating N-cadherin in colon cancer cell lines, the combination of inositol hexaphosphate (IP6) and inositol (INS) effectively inhibits the epithelial-mesenchymal transition (EMT) and metastasis of colorectal cancer (CRC), with a stronger effect than either agent alone. The silencing of claudin 7 gene diminishes the anti-metastatic effects of IP6 and INS.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Medicine, Research & Experimental
Keiji Hasebe, Kimitoshi Yamazaki, Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Kazushi Miyata, Masahide Fukaya, Masato Nagino, Tomoki Ebata
Summary: TFF1 has been shown to act as a tumor suppressor in gastric, pancreatic, and hepatocellular carcinogenesis, but its role in esophageal adenocarcinoma (EAC) development is not well understood. This study reveals the role of TFF1 in EAC development and uncovers the underlying mechanisms.
LABORATORY INVESTIGATION
(2022)
Correction
Biochemistry & Molecular Biology
P. Ozenne, D. Dayde, E. Brambilla, B. Eymin, S. Gazzeri
Summary: A correction for this paper has been published.
Article
Biochemistry & Molecular Biology
Collins Waguia Kontchou, Ian E. Gentle, Arnim Weber, Axel Schoeniger, Frank Edlich, Georg Haecker
Summary: During infection of human cells, Chlamydia trachomatis inhibits apoptosis by blocking the activation of the effectors Bak and Bax, upregulating the anti-apoptotic protein Mcl-1, reducing Bax oligomerization and association with the outer mitochondrial membrane, and inhibiting conformational changes of Bak. The protective effect of Chlamydia infection on mitochondria is lost upon protease digestion, and it is dependent on the regulator VDAC2. The outer membrane protein OmpA of Chlamydia can associate with mitochondria and mimic the anti-apoptotic effect of infection.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Oncology
Ewelina Flis, Gillian Barber, Ciara Nulty, Brian Keogh, Peter McGuirk, Akanksha Anand, Jacintha O'Sullivan, Michael Quante, Emma M. Creagh
Summary: The activation of TLR2 in Barrett's organoids and esophageal cancer cells can amplify inflammation and promote cancer development. Neutralizing TLR2 efficiently blocks its inflammatory effects, suggesting TLR2 targeting as a potential therapeutic approach to limit esophageal disease and cancer progression.
Article
Oncology
Linyue Pan, Lu Hu, Mengjie Chen, Yuanlin Song, Zhihong Chen, Yutong Gu, Chun Li, Zhilong Jiang
Summary: In this study, a novel CD47-blocking peptide VK17 was identified and a pro-apoptotic VK30 peptide was obtained. VK30 specifically bound to CD47 on lung cancer cells and induced apoptosis, while improving phagocytic activity of macrophages against lung cancer cells. Combinational treatment with anti-CD47 antibody and VK30 enhanced the binding and increased apoptosis and phagocytosis. Intraperitoneal administration of VK30 effectively suppressed lung cancer cell growth in mice, associated with increased tumor cell apoptosis, macrophage activation, and phagocytosis.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Irina Smirnova, George Draghici, Oxana Kazakova, Lavinia Vlaia, Stefana Avram, Alexandra Mioc, Marius Mioc, Ioana Macasoi, Cristina Dehelean, Adrian Voicu, Codruta Soica
Summary: The use of natural compounds as starting points for semisynthetic derivatives has shown to be a valuable source of active anticancer agents. Hollongdione, obtained from dammarane type triterpenoid dipterocarpol, was modified and a series of derivatives were obtained. These derivatives displayed strong anticancer activity, with 2,21-Bis-[3-pyridinyl]-methylidenohollongdione 9 being the most active one. It showed apoptotic and antiangiogenic activities, and also inhibited mitochondrial respiration. Further analysis at the gene level confirmed its pro-survival/proapoptotic activity. Hollongdione derivatives have potential as therapeutic options for melanoma and breast cancer.
BIOORGANIC CHEMISTRY
(2022)
Article
Food Science & Technology
Yinshen Wee, Chieh-Hsiang Yang, Shau-Kwaun Chen, Yu-Chun Yen, Ching-Shuen Wang
Summary: The study found that IP6 can polarize bone marrow-derived macrophages into an M2a-like subtype, reduce lipopolysaccharide-induced apoptosis and pro-inflammatory responses, and increase the expression levels of genes related to anti-inflammatory responses. These results demonstrate the significant modulatory effects of IP6 on macrophages, suggesting potential therapeutic benefits for inflammatory diseases.
FOOD SCIENCE & NUTRITION
(2021)
Article
Food Science & Technology
Martin Samuel Hernandez-Zazueta, Joel Said Garcia-Romo, Ivan Luzardo-Ocampo, Angel Antonio Carbonell-Barrachina, Pablo Taboada-Antelo, Ema Carina Rosas-Burgos, Josafat Marina Ezquerra-Brauer, Juan Manuel Martinez-Soto, Maria del Carmen Candia-Plata, Hisila del Carmen Santacruz-Ortega, Armando Burgos-Hernandez
Summary: This research synthesized ozopromide (OPC) and confirmed its structure using analysis techniques. OPC showed antiproliferative activity against various cancerous cells and induced apoptosis in A549 cells. It also exhibited anti-inflammatory effects by inhibiting IL-6 and IL-8. This study highlights the potential of OPC as a therapeutic agent for cancer and inflammation.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Nam-Sook Park, Yu-Kyung Park, Anil Kumar Yadav, Young-Min Shin, David Bishop-Bailey, Jong-Soon Choi, Jong Wook Park, Byeong-Churl Jang
Summary: The study showed that dasatinib has strong anti-growth, anti-angiogenic, and pro-apoptotic effects on human oral cancer cells, mediated through the regulation of multiple targets including Src, EGFR, STAT-3, STAT-5, PKB, ERK-1/2, and others.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sher Zaman Safi, Laiba Saeed, Humaira Shah, Zahina Latif, Abid Ali, Muhammad Imran, Nawshad Muhammad, Talha Bin Emran, Vetriselvan Subramaniyan, Ikram Shah Bin Ismail
Summary: This study investigated the stimulatory effect of beta-adrenergic receptors (beta-ARs) on brain-derived neurotropic factor (BDNF) and cAMP response element binding protein (CREB) in Muller cells. The results showed that beta-AR agonists reduced apoptosis, increased BDNF expression, and decreased reactive oxygen species (ROS) production. These findings suggest that beta-ARs play a protective role in Muller cells under high glucose conditions.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Darja Koutova, Radim Havelek, Eva Peterova, Darina Muthna, Karel Kralovec, Katerina Breiterova, Lucie Cahlikova, Martina Rezacova
Summary: Pancracine, a potent compound among natural isoquinolines, exhibited strong antiproliferative activity on A549 cells and induced apoptotic cell death in MOLT-4 cells. The mechanistic understanding of pancracine activity in vitro revealed perturbation of the cell cycle and induction of apoptotic cell death as key mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Mehdi Dadashpour, Meysam Ganjibakhsh, Hanieh Mousazadeh, Kazem Nejati
Summary: This study aimed to investigate the efficiency of Polycaprolactone-Polyethylene Glycol (PCL-PEG) as a nano-carrier for Simvastatin (SIM) to enhance its anti-cancer properties. Results showed that loading SIM on PCL-PEG NPs increased cytotoxicity and promoted apoptosis. Thus, the PCL-PEG NPs system may be a promising new approach for the treatment of breast cancer.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Immunology
Manmohan Kumar, Asha Shelly, Priyanka Dahiya, Atish Ray, Shibnath Mazumder
Summary: This study investigates the molecular mechanisms of Aerornonas hydrophila-induced pathogenesis in fish. The findings suggest that the infection leads to ER stress and mitochondrial dysfunction, resulting in the production of mtROS and translocation of mtDNA into the cytosol, which ultimately triggers cell apoptosis.
Article
Food Science & Technology
Sandra S. Arango-Varela, Ivan Luzardo-Ocampo, Maria E. Maldonado-Celis
Summary: This research evaluated the effects of Aspirin, Andean berry juice (ABJ), and their combination on colorectal cancer. The mixture showed the strongest antiproliferative effect on SW480 cells and inhibited cell growth by regulating apoptotic pathways. In animal experiments, the mixture of Aspirin and ABJ protected the colon and liver. Further research is needed to fully understand the proapoptotic, anti-proliferative, and chemopreventive/chemoprotective effects of ABJ.
FOOD RESEARCH INTERNATIONAL
(2022)
