Review
Obstetrics & Gynecology
Yoshio Yoshida, Daisuke Inoue
Summary: There is a lack of established guidelines for the treatment of gynecological cancer in elderly patients, and more research is needed to address the issues faced by elderly patients undergoing chemotherapy. Assessment of vulnerabilities should be included in the treatment of elderly gynecological cancer patients to better understand their needs and potential risks.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Oncology
Haryani, Yu-Yun Hsu, Shan-Tair Wang
Summary: This study aimed to explore symptom clusters at different time points among gynecological cancer patients undergoing chemotherapy. Six symptom clusters were identified, including pain-related, nutritional, emotional, hormonal-related, fatigue-related, and body-image symptom clusters. Nutrition and emotion symptoms consistently occurred during chemotherapy, while fatigue-related symptoms appeared after chemotherapy and body-image symptoms emerged later in the treatment.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Article
Pharmacology & Pharmacy
Yuwei Hua, Yuling Zou, Mei Guan, Hsiang-Yu Yuan, Yanping Zhou, Fengshuo Liu
Summary: The purpose of this study was to develop a tool to identify elderly patients vulnerable to chemotherapy toxicity. Factors such as cancer type, physical status, chemotherapy regimen, and laboratory test results were found to be associated with severe chemotherapy-related toxicity. A predictive model was constructed to help clinicians identify vulnerable population and adjust treatment regimens accordingly.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Byung Soo Kwan, Ok Jae Lee, Hyun Jin Kim, Kwang Min Kim, Sang Goon Shim, Dae Hyeon Cho, Sung Min Kong, Jun Young Kim, Jun Ho Ji
Summary: This study compared the efficacy and safety of chemotherapy in elderly patients with unresectable pancreatic cancer. The results showed that chemotherapy improved median overall survival among elderly patients, but some patients discontinued treatment due to adverse events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Xin Chen, Junhao Tu, Xiaolan Xu, Wen Gu, Lei Qin, Haixin Qian, Zhenyu Jia, Chuntao Ma, Yinkai Xu
Summary: This study found that adjuvant chemotherapy in elderly patients with stage III colon cancer can reduce cancer-specific mortality rate, but the benefit of chemotherapy in stage II colon cancer patients is suboptimal.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lana Khalil, Xingyu Gao, Jeffrey M. Switchenko, Olatunji B. Alese, Mehmet Akce, Christina Wu, Maria Diab, Bassel F. El-Rayes, Walid L. Shaib
Summary: This age group-based study examines the impact of adjuvant therapy in patients older than 70 with colon cancer. The study suggests that multi-agent chemotherapy may have better survival outcomes compared to single-agent chemotherapy in this age group.
Article
Oncology
Jianping Guo, Zhizhong Xiong, Shi Yin, Yue'e Wen, Longyang Jin, Caiqin Wang, Huaxian Chen, Dandong Luo, Zijian Deng, Dayin Huang, Xianzhe Li, Biying Yi, Chaobin Mao, Lei Lian
Summary: This study identified 75 years old as the optimal age cutoff for defining EGC, and found that EGC patients had significantly worse overall survival and cancer-specific survival compared to non-EGC group. Adjuvant chemotherapy was proved to be unbeneficial for stage II EGC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Chui-ying Chan, Hui Li, Miao-fang Wu, Chang-hao Liu, Huai-wu Lu, Zhong-qiu Lin, Jing Li
Summary: The study aimed to identify the maximum tolerated dose of cisplatin for gynecological cancer patients receiving hyperthermic intraperitoneal chemotherapy at 43 degrees Celsius, concluding that 85 mg/m² was the MTD with observed dose-limiting toxicities in the 85 mg/m² dose group.
FRONTIERS IN ONCOLOGY
(2021)
Article
Integrative & Complementary Medicine
Ulku Ozdemir, Sultan Tasci
Summary: The aim of this study was to investigate the effect of acupressure on the severity and level of cancer-related fatigue in elderly patients with cancer. The results showed that there was a significant reduction in the severity and level of fatigue in the acupressure group compared to the control group. Therefore, acupressure can be recommended as a treatment for cancer-related fatigue in elderly patients.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Oncology
Bogdan Badic, Anne-Marie Bouvier, Veronique Bouvier, Marie Morvan, Valerie Jooste, Arnaud Alves, Jean-Baptiste Nousbaum, Noemi Reboux
Summary: In elderly patients with metastatic colon cancer, low comorbidity burden, curative surgery, and chemotherapy have a significant advantage in terms of overall survival. The location of metastasis, but not of the primary tumor, impacts survival outcomes.
Article
Oncology
Kazuaki Okamoto, Hiroaki Nozawa, Shigenobu Emoto, Koji Murono, Kazuhito Sasaki, Soichiro Ishihara
Summary: This study aimed to investigate the tolerability and efficacy of adjuvant CAPOX therapy in elderly patients compared to young patients. The results showed that adjuvant CAPOX therapy was well-tolerated in elderly Japanese patients, and the prognosis of elderly patients with stage III CRC was similar to that of their younger counterparts. Therefore, advanced age may not be a contraindication for adjuvant chemotherapy in CRC.
Review
Biochemistry & Molecular Biology
Marta Wozniak, Rafal Krajewski, Sebastian Makuch, Siddarth Agrawal
Summary: This review summarizes the current knowledge on phytochemicals with proven antitumor activity in gynecological cancer, emphasizing their effectiveness and mechanism of action in preventing cervical, endometrial, and ovarian cancer. Experimental and epidemiological studies have investigated associations between a plant-based diet and cancer risk, highlighting the chemopreventive and therapeutic potential of plant-derived substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Nan Zhang, Chang Liu, Wen Di
Summary: Gynecological cancer is a serious threat to women's health, and chemotherapy is crucial for its treatment. Renal function is important for completing the full course of systemic treatment and achieving an ideal prognosis. Chronic kidney disease can restrict systematic treatment by affecting drug metabolism, increasing toxicity, and the risk of adverse reactions. Unfortunately, women on renal replacement therapy have a higher risk of developing gynecological cancers. This article summarizes the current knowledge on systemic treatment drugs for gynecological cancer patients undergoing dialysis.
ONCOTARGETS AND THERAPY
(2023)
Article
Surgery
Jueun Park, HyungJoo Baik, Sang Hyun Kang, Sang Hyuk Seo, Kwang Hee Kim, Min Kyung Oh, Hong Sub Lee, Sang Heon Lee, Ki Hyang Kim, Min Sung An
Summary: This study compared the efficacy of oxaliplatin-added chemotherapy and capecitabine monotherapy in high-risk stage II/III elderly colon cancer patients, finding no significant difference in CSS and OS between the two groups. Although the oxaliplatin-added group had more stage III patients, subgroup analysis also showed no significant difference.
ASIAN JOURNAL OF SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Takafumi Watanabe, Shu Soeda, Yuta Endo, Chikako Okabe, Tetsu Sato, Norihito Kamo, Makiko Ueda, Manabu Kojima, Shigenori Furukawa, Hidekazu Nishigori, Toshifumi Takahashi, Keiya Fujimori
Summary: Hereditary cancer syndromes, characterized by onset at an early age and an increased risk of developing certain tumors, are caused by germline pathogenic variants in tumor suppressor genes and inherited in an autosomal dominant manner. Molecular genetic discoveries have changed cancer diagnosis and management, shedding light on important molecular regulatory pathways in tumor development and treatment. Understanding the association between genotypes and phenotypes in one disease provides insights into the etiology of seemingly different diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marianna Buttarelli, Alessandra Ciucci, Fernando Palluzzi, Giuseppina Raspaglio, Claudia Marchetti, Emanuele Perrone, Angelo Minucci, Luciano Giaco, Anna Fagotti, Giovanni Scambia, Daniela Gallo
Summary: Predicting the response of BRCAwt HGSOC patients to first-line chemotherapy using a gene signature is a challenging yet meaningful task.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Obstetrics & Gynecology
Giorgio Bogani, Violante Di Donato, Ludovico Muzii, Jvan Casarin, Fabio Ghezzi, Mario Malzoni, Stefano Greggi, Fabio Landoni, Luca Bazzurini, Vanna Zanagnolo, Francesco Multinu, Roberto Angioli, Francesco Plotti, Giuseppe Caruso, Margherita Fischetti, Gabriella Ferrandina, Innocenza Palaia, Pierluigi Benedetti Panici, Giovanni Scambia, Francesco Raspagliesi
Summary: This article evaluates the adoption of minimally invasive surgery in the treatment of cervical cancer and discusses some unresolved issues.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Giorgio Bogani, Innocenza Palaia, Giorgia Perniola, Alice Fracassi, Ilaria Cuccu, Tullio Golia D'Auge, Assunta Casorelli, Giusi Santangelo, Margherita Fischetti, Ludovico Muzii, Pierluigi Benedetti Panici, Violante Di Donato
Summary: The role of retroperitoneal staging in endometrial cancer is still unclear. Although lymphadenectomy has prognostic value, there is no therapeutic value of nodal dissection. Sentinel node mapping allows for more accurate detection of low-volume diseases, and adjuvant therapy may be effective for these cases. However, the presence of isolated tumor cells alone does not impact outcomes. Molecular and genomic profiling should be used to guide surgical and adjuvant treatments, reducing the need for retroperitoneal staging.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Giorgio Bogani, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Antonella Giancotti, Daniele Di Mascio, Giuseppe Capalbo, Ludovico Muzii, Pierluigi Benedetti Panici, Violante Di Donato
Summary: There is limited consensus on pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer. Chemotherapy and immune checkpoint inhibitors may be promising treatment options.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Letter
Oncology
Giuseppe Capalbo, Violante Di Donato, Andrea Giannini, Giorgio Bogani
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2023)
Review
Pharmacology & Pharmacy
Margherita Fischetti, Violante Di Donato, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Chiara Perrone, Antonella Giancotti, Daniele Di Mascio, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici, Giorgio Bogani
Summary: New small molecules have emerged as an effective approach for the management of ovarian cancer patients, especially in the maintenance setting. Tyrosine kinase inhibitors (TKIs) and poly(ADP-ribose) polymerase (PARP) inhibitors are the most intriguing medications in this setting, with PARP inhibitors being the new standard of care for ovarian cancer patients harboring either a BRCA mutation or with homologous recombination deficiency (HRD).
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Oncology
Camilla Di Dio, Giorgio Bogani, Violante Di Donato, Ilaria Cuccu, Ludovico Muzii, Lucia Musacchio, Giovanni Scambia, Domenica Lorusso
Summary: Endometrial cancer is a heterogeneous disease with specific genomic, molecular, and biological features. Immune checkpoint inhibitors and tyrosine kinase inhibitors have shown promising results in the treatment of advanced or recurrent endometrial cancer. The combination of pembrolizumab and lenvatinib has become the new standard second-line treatment, regardless of the MMR status. Further studies are exploring the use of immune checkpoint inhibitors and PARP inhibitors in combination therapy.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Giorgio Bogani, Isabelle Ray-Coquard, Nicole Concin, Natalie Yan Li Ngoi, Philippe Morice, Giuseppe Caruso, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Domenica Lorusso, Robert Coleman, Michelle M. Vaughan, Masashi Takano, Diane Michele Provencher, Satoru Sagae, Pauline Wimberger, Robert Poka, Yakir Segev, Se Ik Kim, Jae-Weon Kim, Francisco Jose Candido dos Reis, Pedro T. Ramirez, Andrea Mariani, Mario Leitao, Vicky Makker, Nadeem R. Abu-Rustum, Ignace Vergote, Gianfranco Zannoni, David Tan, Mary McCormack, Biagio Paolini, Marta Bini, Francesco Raspagliesi, Pierluigi Benedetti Panici, Violante Di Donato, Ludovico Muzii, Nicoletta Colombo, Sandro Pignata, Giovanni Scambia, Bradley J. Monk
Summary: Endometrial carcinosarcoma is a rare and aggressive type of cancer, with clinical presentation and diagnostic methods similar to the more common endometrioid carcinoma. It is characterized by the presence of both carcinomatous and sarcomatous elements, and the majority of cases have p53 abnormalities. Treatment involves a multimodal approach for non-metastatic disease and palliative chemotherapy for metastatic or recurrent disease.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Giorgio Bogani, Violante Di Donato, Andrea Papadia, Alessandro Buda, Jvan Casarin, Francesco Multinu, Francesco Plotti, Maria Luisa Gasparri, Ciro Pinelli, Anna Myriam Perrone, Simone Ferrero, Flavia Sorbi, Fabio Landoni, Innocenza Palaia, Giorgia Perniola, Pierandrea De Iaco, Stefano Cianci, Salvatore Gueli Alletti, Marco Petrillo, Giuseppe Vizzielli, Francesco Fanfani, Roberto Angioli, Ludovico Muzii, Fabio Ghezzi, Enrico Vizza, Michael D. Mueller, Giovanni Scambia, Pierluigi Benedetti Panici, Francesco Raspagliesi
Summary: This retrospective study compared outcomes in endometrial cancer patients who underwent hysterectomy with or without sentinel node mapping (SNM). Data from 398 patients who had hysterectomy and 174 patients who had hysterectomy plus SNM were collected. The SNM group had a longer operative time, but length of hospital stay, estimated blood loss, and severe complication rates were similar between groups. Hysterectomy, with or without SNM, was found to be a safe and effective method for managing EC patients.
Article
Obstetrics & Gynecology
Innocenza Palaia, Giuseppe Caruso, Giorgia Perniola, Violante Di Donato, Roberto Brunelli, Annarita Vestri, Maria Scudo, Gabriella Gentile, Angela Musella, Pierluigi Benedetti Panici, Ludovico Muzii
Summary: This study evaluated the efficacy of preoperative low-residue diet in reducing postoperative ileus and pain in women undergoing elective cesarean section. It suggests that implementing a low-residue diet before surgery can be beneficial for obstetrical practices. However, further large-scale studies are needed before these research findings can be translated into routine clinical practice.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Violante Di Donato, Andrea Giannini, Giorgio Bogani
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Tullio Golia D'Auge, Ilaria Cuccu, Giusi Santangelo, Ludovico Muzii, Andrea Giannini, Giorgio Bogani, Violante Di Donato
Review
Health Care Sciences & Services
Ilaria Cuccu, Ottavia D'Oria, Ludovica Sgamba, Emanuele De Angelis, Tullio Golia D'Auge, Camilla Turetta, Camilla Di Dio, Maria Scudo, Giorgio Bogani, Violante Di Donato, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Ludovico Muzii, Andrea Giannini
Summary: Endometrial cancer (EC) is a common gynecological malignancy, and molecular and genomic profiling have shown promise in predicting recurrence risk. However, there is limited data on therapeutic value. Ongoing studies are focused on identifying appropriate adjuvant strategies, especially for patients with positive nodes and low volume disease. Molecular classification has the potential to improve risk stratification and management in EC patients. This review aims to explore the evolution of molecular classification and its impact on research and clinical management.
Review
Medicine, General & Internal
Ludovico Muzii, Giulia Galati, Giulia Mattei, Alessandra Chine, Giorgia Perniola, Violante Di Donato, Chiara Di Tucci, Innocenza Palaia
Summary: Management options for ovarian endometriomas include expectant management, medical treatment, surgical treatment, in vitro fertilization (IVF), or a combination of the above. The choice of management depends on clinical parameters, with pain being typically treated with medical therapy and infertility being typically treated with IVF. Both symptoms usually require surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
