Article
Nutrition & Dietetics
Bright Opoku Ahinkorah, Iddrisu Amadu, Abdul-Aziz Seidu, Joshua Okyere, Eric Duku, John Elvis Hagan, Eugene Budu, Anita Gracious Archer, Sanni Yaya
Summary: This study examined the prevalence and factors associated with the triple burden of malnutrition (TBM) in sub-Saharan Africa. It found that factors such as child age, size at birth, maternal education, ANC attendance, and use of clean cooking fuel influenced the likelihood of a child experiencing TBM. Regional-specific interventions are recommended to address the regional variations in TBM prevalence and risk.
Article
Biochemistry & Molecular Biology
Ji-Yeon Kim, Sabin Park, Eun Yoon Cho, Jeong Eon Lee, Hae Hyun Jung, Byung Joo Chae, Seok Won Kim, Seok Jin Nam, Soo Youn Cho, Yeon Hee Park, Jin Seok Ahn, Semin Lee, Young-Hyuck Im
Summary: This study compared the genetic characteristics of apocrine carcinoma, a rare subtype of breast cancer, with triple negative breast cancer (TNBC) with low Ki-67 expression (LK-TNBC). The most frequently mutated driver gene in apocrine carcinoma was TP53, followed by PIK3CA, ZNF717, and PIK3R1. Apocrine carcinoma exhibited defective DNA mismatch repair and APOBEC activity-associated mutational signatures, and had better five-year disease-free survival and overall survival rates compared to LK-TNBC.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Shengnan Sha, Luyi Si, Xinrui Wu, Yuanbiao Chen, Hui Xiong, Ying Xu, Wangrui Liu, Haijun Mei, Tao Wang, Mei Li
Summary: This study investigates the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of triple-negative breast cancer (TNBC). The results show that CRGs are closely associated with tumor immunity in TNBC and can be used to evaluate tumor immune cell infiltration, clinical features, and prognosis. This research provides new directions for the development of novel drugs in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yang Liu, Yueting Hu, Jinqi Xue, Jingying Li, Jiang Yi, Jiawen Bu, Zhenyong Zhang, Peng Qiu, Xi Gu
Summary: Immunotherapy has emerged as a promising strategy for treating triple-negative breast cancer (TNBC), which stimulates the immune system to kill tumor cells and offers new hope for patients. Breakthroughs in immune checkpoint inhibitors (ICIs) have led to individualized immunotherapy schedules and the combination with other treatment methods to overcome drug resistance.
Article
Medicine, General & Internal
Karishma Sharma, Shahin Sayed, Mansoor Saleh
Summary: Promoting best practice in cancer patient management relies on the application of new knowledge derived from various sources. Collaboration between oncologists and pathologists is crucial, with the characteristics of the tumor and microenvironment playing a defining role in disease progression and outcome.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Huicheng Liu, Lili Bai, Liu Huang, Na Ning, Lin Li, Yijia Li, Xuejiao Dong, Qiuyang Du, Minghui Xia, Yufei Chen, Likun Zhao, Yanhu Li, Qingwu Meng, Jing Wang, Yaqi Duan, Jie Ming, Andy Qingan Yuan, Xiang-Ping Yang
Summary: The study developed a bispecific antibody F7AK3 targeting TROP2 and CD3 antigens for TNBC, showing potential antitumor activity in vitro and in vivo by activating T cells against TNBC cells. Further preclinical and clinical evaluation of F7AK3 is warranted for advanced or metastatic TNBC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Genetics & Heredity
Sotiris Loizides, Anastasia Constantinidou
Summary: Triple negative breast cancer is a biologically diverse subtype of breast cancer with aggressive clinical behavior and poor prognosis. Recent studies have focused on understanding the complex genomic and biological profile of TNBC in order to develop personalized treatment strategies. The immune driven landscape associated with TNBC includes high immunogenicity, specific immune activation signatures, increased expression of immunosuppressive genes, and higher levels of stromal Tumor Infiltrating Lymphocytes. The unprecedented response of TNBC to immunotherapy has significantly changed the standard of care, but the relationship between immune infiltration and mutational signatures in TNBC is still not fully understood.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, Research & Experimental
Linxiao Shang, Yuting Zhong, Yan Yao, Cun Liu, Lu Wang, Wenfeng Zhang, Jingyang Liu, Xue Wang, Changgang Sun
Summary: Tumor-associated macrophages (TAMs) are crucial in innate immunity and are the most abundant immune cells found in tumors. They have diverse functions including clearing apoptotic bodies, regulating inflammation, and promoting tissue repair. In triple-negative breast cancer (TNBC), TAMs change from promoting tumor growth to suppressing the immune response, playing a significant role in cancer development. This article explores how TAMs in the TNBC ecosystem drive cancer evolution and discusses their potential as targets for TNBC therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Jie Li, Dejiao He, Sicheng Li, Jun Xiao, Zhanyong Zhu
Summary: This review discusses the role of ferroptosis in TNBC and explores its potential value in the progression, diagnosis, and treatment of TNBC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yiwen Zheng, Shujin Li, Hongchao Tang, Xuli Meng, Qinghui Zheng
Summary: The emergence of immunotherapy has revolutionized the treatment of triple-negative breast cancer (TNBC). However, the heterogeneity of TNBC leads to varying efficacy of immunotherapy, with only certain patients benefiting from it. This article focuses on the mechanisms of immune response and summarizes the immune evasion mechanisms in TNBC, including loss of tumor-specific antigen, antigen presentation deficiency, and failure to initiate an immune response. Moreover, the aberrant activation of immune-critical signaling pathways contributes to an immunosuppressive tumor microenvironment. The review aims to elucidate the molecular mechanisms of drug resistance in TNBC, identify potential targets to reverse drug resistance, and lay a foundation for biomarker research to predict immune efficacy and select breast cancer populations for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyuan Ji, Daoxia Guo, Jia Ma, Min Yin, Yun Yu, Chang Liu, Yanfeng Zhou, Jinli Sun, Qian Li, Nan Chen, Chunhai Fan, Haiyun Song
Summary: The hydrogel patch designed to modulate the plasticity of T-ICs in TNBC shows promising results in improving chemosensitivity, enhancing tumor immunogenicity, and increasing T-cell infiltration. Additionally, the patch efficiently suppresses tumor growth, postsurgical relapse, and metastasis with a single dose, demonstrating superior efficacy against multidrug resistance.
ADVANCED MATERIALS
(2021)
Article
Medicine, Research & Experimental
Cuiyu Zhong, Jie Li, Suiping Liu, Weirong Li, Qiang Zhang, Junpeng Zhao, Menghua Xiong, Yan Bao, Yandan Yao
Summary: Researchers developed a nanoblock-mediated strategy to selectively induce anticancer activity of broad-spectrum oncolytic peptides (Olps) for the treatment of triple-negative breast cancer (TNBC). The results showed that the strategy significantly reduced the toxicity of Olps and demonstrated high antitumor efficacy in TNBC cells.
Article
Immunology
Angela Quintana, Enrique Javier Arenas, Cristina Bernado, Jose Fernandez Navarro, Jonatan Gonzalez, Anna Esteve-Codina, Teresa Moline, Merce Marti, Giuseppe Curigliano, Peter Schmid, Vicente Peg, Joaquin Arribas, Javier Cortes
Summary: The heterogeneity of immune infiltration in breast cancer is an important research area. This study found that the heterogeneity of TILs is related to the presence of immune infiltration, rather than patient characteristics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Nataliia Petruk, Arafat Siddiqui, Sina Tadayon, Jorma Maatta, Pieta K. Mattila, Arja Jukkola, Jouko Sandholm, Katri S. Selander
Summary: Bisphosphonates (BPs) are bone-protecting osteoclast inhibitors commonly used in the treatment of osteoporosis and skeletal complications of malignancies. In early breast cancer, adjuvant nitrogen-containing BPs have shown potential benefits, but there is a lack of biomarkers to predict response. This study investigates the mechanisms by which BPs exert their effects and identifies potential factors influencing their efficacy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Yaelle Elfassy, Alice Bongrani, Pierre Levy, Frantz Foissac, Soraya Fellahi, Celine Faure, Chloe McAvoy, Jacqueline Capeau, Joelle Dupont, Bruno Feve, Rachel Levy, Jean-Philippe Bastard, Nathalie Sermondade, Florence Eustache, Myriam Benarroch, Charlotte Dupont, Isabelle Cedrin, Vanina De Larouziere, Emmanuelle Mathieu D'Argent, Angela Sutton, Jerome Guechot, Sebastien Czernichow
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Medicine, General & Internal
Quentin Gibiot, Isabelle Monnet, Pierre Levy, Anne-Laure Brun, Martine Antoine, Christos Chouaid, Jacques Cadranel, Jean-Marc Naccache
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Maxime Lacroix, Frederique Frouin, Anne-Sophie Dirand, Christophe Nioche, Fanny Orlhac, Jean-Francois Bernaudin, Pierre-Yves Brillet, Irene Buvat
FRONTIERS IN ONCOLOGY
(2020)
Article
Respiratory System
Jerome Le Pavec, Dominique Valeyre, Pierre Gazengel, Are M. Holm, Hans Henrik Schultz, Michael Perch, Aurelie Le Borgne, Martine Reynaud-Gaubert, Christiane Knoop, Laurent Godinas, Sandrine Hirschi, Vincent Bunel, Rosalia Laporta, Sergio Harari, Elodie Blanchard, Jesper M. Magnusson, Adrien Tissot, Clement Picard, Laurent Savale, Jean-Francois Bernaudin, Pierre-Yves Brillet, Hilario Nunes, Marc Humbert, Elie Fadel, Jens Gottlieb
Summary: This study retrospectively reviewed data from 112 patients with pulmonary sarcoidosis who underwent lung or heart-lung transplantation, finding that post-transplant survival rates were similar to those with other indications for lung transplantation. Older age and extensive pre-operative lung fibrosis were the main factors associated with worse survival.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Medicine, Research & Experimental
Dominique Valeyre, Florence Jeny, Cecile Rotenberg, Diane Bouvry, Yurdagul Uzunhan, Pascal Seve, Hilario Nunes, Jean-Francois Bernaudin
Summary: Extrapulmonary sarcoidosis can affect various organs and presents with diverse symptoms, requiring individualized treatment considering specific organ functions.
ADVANCES IN THERAPY
(2021)
Letter
Critical Care Medicine
Helene Salvator, Colas Tcherakian, Natacha Maillard, Serge Milin, Anne Bergeron, Louise Bondeelle, Veronique Meignin, Stephanie Nguyen, Laetitia Souchet, Sarah Guenounou, Solene M. Evrard, Marie-Therese Rubio, Marie Robin, Simona Sestili, Eolia Brissot, Anne Fajac, Emilie Catherinot, Claire Givel, Alexandre Chabrol, Celine Goyard, Elisabeth Longchampt, Marie-Laure Chabi-Charvillat, Jean-Francois Bernaudin, Louis-Jean Couderc
Article
Cardiac & Cardiovascular Systems
Lucile Sese, Julien Caliez, Isabella Annesi-Maesano, Vincent Cottin, Giancarlo Pesce, Morgane Didier, Zohra Carton, Dominique Israel-Biet, Bruno Crestani, Stephanie Guillot Dudoret, Jacques Cadranel, Benoit Wallaert, Abdellatif Tazi, Bernard Maitre, Gregoire Prevot, Sylvain Marchand-Adam, Sandrine Hirschi, Sandra Dury, Violaine Giraud, Anne Gondouin, Philippe Bonniaud, Julie Traclet, Karine Juvin, Raphael Borie, Jean Francois Bernaudin, Dominique Valeyre, Catherine Cavalin, Hilario Nunes
Summary: The study identified a negative association between low income and survival and progression-free survival in patients with idiopathic pulmonary fibrosis (IPF), suggesting that low-income IPF patients may be more exposed to occupational exposures.
RESPIRATORY MEDICINE
(2021)
Article
Immunology
Florence Jeny, Jean-Francois Bernaudin, Dominique Valeyre, Marianne Kambouchner, Marina Pretolani, Hilario Nunes, Carole Planes, Valerie Besnard
Summary: Hypoxia has a significant impact on MD-macrophages from sarcoidosis patients, inducing proinflammatory and profibrotic responses while reducing antigen presentation, potentially leading to deficient T cell response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Liasmine Haine, Juliette Bravais, Celine-Hivda Yegen, Jean-Francois Bernaudin, Dominique Marchant, Carole Planes, Nicolas Voituron, Emilie Boncoeur
Summary: The study found that intermittent hypoxia exacerbates lung fibrosis, especially when exposure to hypoxia precedes the induction of lung fibrosis. The enhancement of ER stress markers may be involved in the underlying mechanisms.
Letter
Physiology
Thomas Gille, Lucile Sese, Eric Aubourg, Jean-Francois Bernaudin, Jean-Paul Richalet, Carole Planes
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Letter
Critical Care Medicine
Patrick Brochard, Hugues Begueret, Matthieu Thumerel, Rachida Bakhiyi, Isabelle Leclerc, Carine Audoin, Francois Laurent, Lucile Sese, Jean-Francois Bernaudin
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biophysics
Cecile Patte, Pierre-Yves Brillet, Catalin Fetita, Jean-Francois Bernaudin, Thomas Gille, Hilario Nunes, Dominique Chapelle, Martin Genet
Summary: Pulmonary function is closely related to lung mechanical behavior, and idiopathic pulmonary fibrosis (IPF) affects lung mechanics, thus altering lung function. Currently, the mechanical impact of IPF is only assessed through pressure-volume curves which provide global information. We have developed a personalized poromechanical model of the lung that can diagnose IPF based on clinical data.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Clinical Neurology
Yann Nadjar, Pierre Levy, Vi-Huong Nguyen-Michel, Charles-Edouard Luyt, Louis Puybasset, Vincent Navarro
Summary: This study aimed to identify the features that may predict the outcome of patients with post anoxic coma (PAC) by analyzing electroencephalographic (EEG) patterns. The presence of EEG paroxysms (EP) and their regularity features were strongly associated with poor outcome in PAC patients. A global regularity score derived from visual EEG inspection could be a reliable prognostic tool.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hester Colboc, Philippe Moguelet, Emmanuel Letavernier, Vincent Frochot, Jean-Francois Bernaudin, Raphael Weil, Stephan Rouziere, Patricia Senet, Claude Bachmeyer, Naomi Laporte, Ivan Lucas, Vincent Descamps, Reyhan Amode, Florence Brunet-Possenti, Nicolas Kluger, Lydia Deschamps, Arnaud Dubois, Solenn Reguer, Andrea Somogyi, Kadda Medjoubi, Matthieu Refregiers, Michel Daudon, Dominique Bazin
Summary: Characterization of skin deposits associated with various skin diseases using different physico-chemical techniques provides an opportunity to improve diagnosis, understand pathogenesis, and explore therapeutic interventions.
COMPTES RENDUS CHIMIE
(2022)
Proceedings Paper
Engineering, Biomedical
Catalin Fetita, Mathilde Maury, Aurelien Justet, Juliette Dindart, Jean Richeux, Lucile Sese, Nicolas Aide, Thomas Gille, Hilario Nunes, Jean-Francois Bernaudin, Pierre-Yves Brillet
Summary: The study investigates the existence of residual vascular alteration in post-acute sequelae of COVID-19 (PASC) by analyzing associations between vascular remodeling biomarkers extracted from CT and functional, radiological, and morphological parameters. The results suggest moderate to strong correlations between the biomarkers and the persistence of vascular alterations in PASC, highlighting a promising direction for future research in understanding the development of fibrotic patterns.
MEDICAL IMAGING 2022: COMPUTER-AIDED DIAGNOSIS
(2022)
