Article
Oncology
Shigemasa Takamizawa, Yoshitaka Honma, Naoya Murakami, Taisuke Mori, Hiroki Oka, Shun Yamamoto, Tairo Kashihara, Kimiteru Ito, Yuko Kubo, Atsuo Ikeda, Fumihiko Matsumoto, Go Omura, Kenya Kobayashi, Jun Itami, Ken Kato, Seiichi Yoshimoto
Summary: This study aimed to evaluate the short-term outcomes of locally advanced nasopharyngeal carcinoma patients treated with induction chemotherapy (IC) using TPF followed by chemoradiotherapy (CRT) with cisplatin. The results showed promising short-term effectiveness of IC-TPF followed by CRT, but also highlighted the high rates of hematological toxicity. Long-term follow-up is needed to further assess the clinical outcomes and late-phase toxicity of this therapeutic approach.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Oncology
Zhiyuan Xu, Li Yang, Wai-Tong Ng, Aya El Helali, Victor Ho-Fun Lee, Lingyu Ma, Qin Liu, Jishi Li, Lin Shen, Jijie Huang, Jiandong Zha, Cheng Zhou, Anne W. M. Lee, Longhua Chen
Summary: This study evaluated the efficacy of reduced cumulative doses of induction and concurrent cisplatin in treating nasopharyngeal carcinoma. The results showed that the treatment scheme achieved similar favorable outcomes to the NPC-0501 trial with excellent tolerability.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Ruijuan Chen, Yongkai Lu, Yuemei Zhang, Ruixin He, Fengwen Tang, Wei Yuan, Yi Li, Xiaowei Zhang
Summary: The TPF+CCRT regimen is superior to CCRT alone for the treatment of LA-NPC, showing improved overall survival and reduced risks of progression and distant metastasis, but also increasing the incidences of severe acute hematological toxicity and some non-hematological toxicities.
Article
Oncology
Li Xiang, Yun Zheng, PeiRong Ren, Sheng Lin, JianWen Zhang, QingLian Wen, LiJia He, ChangLing Shang, JingBo Wu
Summary: Continuous infusion of 5-fluorouracil combined with cisplatin via the superficial temporal artery showed promising survival benefits and few toxicities in patients with advanced T-stage nasopharyngeal carcinoma (NPC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenwen Hao, Lisha Wu, Linhui Cao, Jinxiu Yu, Li Ning, Jingshu Wang, Xiaoping Lin, Yanfeng Chen
Summary: Cisplatin resistance in nasopharyngeal carcinoma is correlated with radioresistance, with upregulation of SLC1A6 gene leading to reduced sensitivity to cisplatin, suggesting a potential novel therapeutic target for resistant patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shi-Wei He, Yuan Zhang, Lei Chen, Wei-Jie Luo, Xiao-Min Li, Yang Chen, Sheng-Yan Huang, Qing-Mei He, Xiao-Jing Yang, Ying-Qin Li, Na Liu, Yin Zhao, Jun Ma
Summary: The combination of gemcitabine and cisplatin significantly inhibits NPC cell proliferation and tumor growth by inducing cell cycle arrest, cell apoptosis, and DNA damage response, revealing the mechanisms of improving locoregionally advanced NPC with combined GEM and DDP induction chemotherapy.
Article
Biochemistry & Molecular Biology
Jiawei Lv, Yuan Wei, Jian-Hua Yin, Yu-Pei Chen, Guan-Qun Zhou, Chen Wei, Xiao-Yu Liang, Yuan Zhang, Cui-Juan Zhang, Shi-Wei He, Qing-Mei He, Zhuo-Li Huang, Jia-Li Guan, Jia-Yi Shen, Xiao-Min Li, Jun-Yan Li, Wen-Fei Li, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Rui Sun, Yu-Hui Zheng, Wen-Wen Zhou, Ke-Xu Xiong, Si-Qi Wang, Xin Jin, Na Liu, Gui-Bo Li, Dong-Ming Kuang, Ying Sun, Jun Ma
Summary: By using single-cell RNA sequencing and T cell and B cell receptor sequencing, this study reveals that Gemcitabine plus cisplatin (GP) chemotherapy activates an innate-like B cell (ILB)-dominant antitumor immune response, which enhances cytotoxic T cells and improves the treatment outcome for patients with nasopharyngeal carcinoma (NPC). ILB frequency serves as a potential biomarker for predicting favorable outcomes in patients receiving GP-based treatment and immunotherapy combined treatment.
Article
Medicine, General & Internal
Yan Wang, Chengtao Wang, Shasha He, Li Bai, Fei Kong, Siyang Wang, Lei Cui, Qiang Qin, Yunying Yang, Wei Xiao, Meiyan Zhu, Zeyu Zhang, Yulin Lai, Wenjing Bao, Zhenwei Peng, Yong Chen
Summary: This study aimed to evaluate the noninferiority of docetaxel plus cisplatin (TP) induction chemotherapy regimen compared to docetaxel plus cisplatin plus fluorouracil (TPF) regimen in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). The study showed that TP induction chemotherapy regimen was noninferior to TPF regimen in terms of failure-free survival, with fewer side effects.
Article
Oncology
Donghyun Kim, Jiho Nam, Wontaek Kim, Dahl Park, Jihyeon Joo, Hosang Jeon, Yongkan Ki
Summary: The study investigated risk factors for radiation-associated facial lymphedema in nasopharyngeal carcinoma patients after concurrent chemoradiation therapy. Results showed that mean dose to the level IV and level I-VII neck nodes were significantly correlated with the development of moderate/severe lymphedema. Keeping the mean dose below 58.7 Gy for level IV and 58.6 Gy for level I-VII neck nodes may reduce the likelihood of severe lymphedema after CCRT for NPC.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Tian Xia, Hui Tian, Kaiwen Zhang, Siyu Zhang, Wenhui Chen, Si Shi, Yiwen You
Summary: This study demonstrated that ERp44 plays a crucial role in strengthening cisplatin resistance in nasopharyngeal carcinoma (NPC) by influencing cell apoptosis and pyroptosis, and NPC cells under endoplasmic reticulum stress can release exosomes containing ERp44 to transfer to adjacent cells, enhancing chemoresistance. These findings suggest that exosomal ERp44 derived from ER-stressed NPC cells could serve as a potential treatment target for overcoming chemoresistance.
Article
Multidisciplinary Sciences
Shiliang Liu, Liling Luo, Lei Zhao, Yujia Zhu, Hui Liu, Qiaoqiao Li, Ling Cai, Yonghong Hu, Bo Qiu, Li Zhang, Jingxian Shen, Yadi Yang, Mengzhong Liu, Mian Xi
Summary: "The results of this study show that the addition of induction chemotherapy to definitive chemoradiotherapy does not improve the response rate or survival of patients with unresectable esophageal squamous cell carcinoma."
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Qian Chen, Shan Li
Summary: This study compares the reduction in tumor volume after induction chemotherapy with gemcitabine plus cisplatin and docetaxel plus cisplatin in locoregionally advanced nasopharyngeal carcinoma. It was found that gemcitabine plus cisplatin achieved a greater reduction in gross tumor volume of the nasopharynx and had advantages in subsequent chemoradiotherapy dose planning parameters.
Article
Multidisciplinary Sciences
Zhongwei Chen, Zhen Zeng, Shanshan Zhu, Ying Zeng, Qihuang Lin, Lianzhong Luo, Xuan Hong
Summary: This study evaluated the effects of different combination regimens of cisplatin, metformin, and quercetin on the growth of nasopharyngeal carcinoma cell line Sune-1 and subcutaneous xenograft in nude mice. The simultaneous combination of the three drugs showed the most significant inhibitory effects.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Wei Cen Wang, Beatrice Preti, Nancy Read, Paul Gibson, Keith Kwan, Eric Winquist
Summary: This case illustrates the potential benefit of immunotherapy for improving survival and quality of life in selected patients with metastatic EBV-positive cisplatin-refractory NPC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiao-Min Li, Xiao-Min Zhang, Jun-Yan Li, Ning Jiang, Lei Chen, Ling-Long Tang, Yan-Ping Mao, Wen-Fei Li, Guan-Qun Zhou, Ying-Qin Li, Na Liu, Yuan Zhang, Jun Ma
Summary: The study found that in nasopharyngeal carcinoma patients undergoing gemcitabine and cisplatin (GP) induction chemotherapy, immunosuppressive cells decreased significantly while T cells, B cells, and pro-inflammatory cytokines increased significantly. The cytotoxic activity and proliferative capacity of T cells were not weakened by GP chemotherapy. These results provide a solid basis for combining GP with immunotherapy in the treatment of nasopharyngeal carcinoma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvia Tresoldi, Nicola Flor, Andrea Luciani, Maria Antonietta Lombardi, Bernardo Colombo, Gianpaolo Cornalba
EUROPEAN RADIOLOGY
(2015)
Article
Oncology
Andrea Luciani, Laura Biganzoli, Giuseppe Colloca, Cristina Falci, Bruno Castagneto, Irene Floriani, Nicolo Battisti, Lorenzo Dottorini, Daris Ferrari, Pasquale Fiduccia, Elena Zafarana, Francesca Del Monte, Francesca Galli, Silvio Monfardini, Paolo Foa
JOURNAL OF GERIATRIC ONCOLOGY
(2015)
Article
Oncology
Daris Ferrari, Carla Codeca, Barbara Bocci, Francesca Crepaldi, Martina Violati, Giulia Viale, Carmela Careri, Sarah Caldiera, Veronica Bordin, Andrea Luciani, Sabrina Zonato, Gabriela Cassinelli, Paolo Foa
Article
Oncology
Elisa Latorre, Stephana Carelli, Ivan Raimondi, Vito D'Agostino, Ilaria Castiglioni, Chiara Zucal, Giacomina Moro, Andrea Luciani, Giorgio Ghilardi, Eleonora Monti, Alberto Inga, Anna Maria Di Giulio, Alfredo Gorio, Alessandro Provenzani
Article
Geriatrics & Gerontology
Laura Biganzoli, Anna Rachelle Mislang, Samantha Di Donato, Dimitri Becheri, Chiara Biagioni, Stefania Vitale, Giuseppina Sanna, Elena Zafarana, Stefano Gabellini, Francesca Del Monte, Elena Mori, Daniele Pozzessere, Antonella Brunello, Andrea Luciani, Letizia Laera, Luca Boni, Angelo Di Leo, Giuseppe Mottino
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Oncology
Giulio Metro, Antonio Passaro, Giuseppe Lo Russo, Laura Bonanno, Raffaele Giusti, Vanesa Gregorc, Enrica Capelletto, Olga Martelli, Fabiana L. Cecere, Diana Giannarelli, Andrea Luciani, Alessandra Bearz, Alessandro Tuzi, Vieri Scotti, Giuseppe Tonini, Domenico Galetta, Annamaria Carta, Hector Soto Parra, Alberto Rebonato, Alessandro Morabito, Rita Chiari
Article
Oncology
Cesare Gridelli, Alessandro Morabito, Luigi Cavanna, Andrea Luciani, Paolo Maione, Laura Bonanno, Virginio Filipazzi, Silvana Leo, Saverio Cinieri, Fortunato Ciardiello, Marco Angelo Burgio, Domenico Bilancia, Diego Cortinovis, Francesco Rosetti, Roberto Bianco, Vittorio Gebbia, Fabrizio Artioli, Roberto Bordonaro, Vittorio Fregoni, Manlio Mencoboni, Fabrizio Nelli, Ferdinando Riccardi, Giuditta di Isernia, Raffaele Costanzo, Gaetano Rocco, Gennaro Daniele, Simona Signoriello, Maria Carmela Piccirillo, Ciro Gallo, Francesco Perrone
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Review
Oncology
L. Decoster, K. Van Puyvelde, S. Mohile, U. Wedding, U. Basso, G. Colloca, S. Rostoft, J. Overcash, H. Wildiers, C. Steer, G. Kimmick, R. Kanesvaran, A. Luciani, C. Terret, A. Hurria, C. Kenis, R. Audisio, M. Extermann
ANNALS OF ONCOLOGY
(2015)
Letter
Oncology
Karla V. Ballman, Murielle Mauer, Ulrich Wedding, Supriya G. Mohile, Hyman Muss, Martine Extermann, Andrea Luciani, Harvey Jay Cohen, Arti Hurria, Stuart M. Lichtman, Giuseppe Curigliano, Hans Wildiers
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Oncology
Cesare Gridelli, Silvia Novello, Nicoletta Zilembo, Andrea Luciani, Adolfo Gino Favaretto, Filippo De Marinis, Giovenzio Genestreti, Lucio Crino, Francesco Grossi, Orazio Caffo, Francesco Ferrau, Giorgio Cruciani, Alba Ariela Brandes, Domenico Galetta, Sandro Barni, Gianpiero Fasola, Giulio Cerea, Silvia Ferrari, Claudio Iannacone, Fortunato Ciardiello
JOURNAL OF THORACIC ONCOLOGY
(2014)
Article
Oncology
Daris Ferrari, Carla Codeca, Nicolo Battisti, Francesca Broggio, Francesca Crepaldi, Martina Violati, Cecilia Bertuzzi, Lorenzo Dottorini, Sarah Caldiera, Andrea Luciani, Laura Moneghini, Federico Biglioli, Gabriela Cassinelli, Alberto Morabito, Paolo Foa
Review
Radiology, Nuclear Medicine & Medical Imaging
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna Maria Ierardi, Gianpaolo Carrafiello
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)
Review
Radiology, Nuclear Medicine & Medical Imaging
Luca Tagliabue, Stefano Vassallo, Simona Malaspina, Andrea Luciani
CLINICAL AND TRANSLATIONAL IMAGING
(2018)
Article
Oncology
Filippo De Marinis, Paolo Bidoli, Andrea Luciani, Domenico Amoroso, Giuseppe Tonini, Alessandro Bertolini, Alba A. Brandes, Maria Rita Migliorino, Adolfo Favaretto, Cesare Gridelli
ANTICANCER RESEARCH
(2017)
Review
Radiology, Nuclear Medicine & Medical Imaging
Luca Tagliabue, Giulia Manfrinato, Andrea Luciani
INDIAN JOURNAL OF NUCLEAR MEDICINE
(2017)