Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Review
Oncology
J. L. Dickson, C. Horst, A. Nair, S. Tisi, R. Prendecki, S. M. Janes
Summary: Lung cancer is the leading cause of cancer death worldwide, with early detection playing a crucial role in improving survival rates. Studies have shown that low-dose computed tomography can significantly reduce lung cancer-specific mortality. Despite some barriers and concerns, this screening method should still be widely promoted.
ANNALS OF ONCOLOGY
(2022)
Article
Medicine, General & Internal
Lisa Jungblut, Harry Etienne, Caroline Zellweger, Alessandra Matter, Miriam Patella, Thomas Frauenfelder, Isabelle Opitz
Summary: This pilot study in Switzerland assesses the implementation and performance of low-dose CT lung cancer screening and explores its potential impact on reducing mortality rates. The study enrolls participants meeting specific criteria and uses LDCT scans for assessment. Preliminary results suggest the feasibility of LDCT lung cancer screening in Switzerland.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Harriet L. Lancaster, Marjolein A. Heuvelmans, Matthijs Oudkerk
Summary: Lung cancer causes more deaths than breast, cervical, and colorectal cancer combined. Despite the proven benefits of early detection through LDCT lung cancer screening, it is not widely practiced globally. The focus is now on implementation research to successfully introduce standardized, effective, and accessible screening programs.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Respiratory System
Jennifer L. Dickson, Helen Hall, Carolyn Horst, Sophie Tisi, Priyam Verghese, Anne-Marie Mullin, Jonathan Teague, Laura Farrelly, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Tania Anastasiadis, Karen Sennett, John McCabe, Anand Devaraj, Arjun Nair, Neal Navani, Matthew E. J. Callister, Allan Hackshaw, Samantha L. Quaife, Sam M. Janes
Summary: Telephone-based risk assessment is an efficient method to optimize selection for lung cancer screening appointments, but further adjustments are needed to ensure fairness, especially for younger individuals and minority ethnic groups.
Article
Oncology
Eric W. Zhang, Jo-Anne O. Shepard, Anderson Kuo, Wariya Chintanapakdee, Florence Keane, Justin F. Gainor, Mari Mino-Kenudson, Michael Lanuti, Inga T. Lennes, Subba R. Digumarthy
Summary: The study investigated the characteristics and outcomes of screening-detected lung cancers, and found that LCS implementation achieved a higher cancer detection rate, detection of early-stage cancers, and more multifocal lung cancers compared with the NLST, with low complications and mortality.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Kerpel-Fronius, Zsuzsanna Monostori, Gabor Kovacs, Gyula Ostoros, Istvan Horvath, Diana Solymosi, Orsolya Pipek, Ferenc Szatmari, Anita Kovacs, Zsolt Markoczy, Livia Rojko, Ferenc Renyi-Vamos, Konrad Hoetzenecker, Krisztina Bogos, Zsolt Megyesfalvi, Balazs Dome
Summary: Lung cancer is the leading cause of cancer-related deaths in Hungary, highlighting the need for a national screening program. The HUNCHEST pilot program found that LDCT screening may facilitate early diagnosis and curative treatment.
EUROPEAN RADIOLOGY
(2022)
Article
Critical Care Medicine
Paul F. Pinsky, Eric Miller
Summary: This study used the SEER-Medicare database to assess various characteristics of low-dose CT (LDCT) scan lung cancer screening in US clinical practice. The study found that the use of LDCT scans was relatively low but increased over time. Patients with lung cancer who underwent screening had a higher proportion of early-stage cases and higher survival rates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Yeol Kim
Summary: Elevating the diameter threshold for solid nodules from 6 to 9 mm may lead to a substantial reduction in unnecessary follow-up LDCTs with a small proportion of diagnostic delay of lung cancers.
EUROPEAN RADIOLOGY
(2021)
Article
Critical Care Medicine
Lynn T. Tanoue, Polly Sather, Isabel Cortopassi, Demetrius Dicks, Anne Curtis, Gaetane Michaud, Anna Bader, Christopher Gange, Frank Detterbeck, Jonathan Killam
Summary: Standardization of reporting positive findings on low-dose CT scans is crucial for high-quality lung cancer screening. Developing a structured system for standardized reporting can help reduce the risk of variability in reporting and unnecessary evaluations.
Article
Medicine, General & Internal
Elke A. Nekolla, Gunnar Brix, Juergen Griebel
Summary: Recent studies have shown that low-dose computed tomography (LDCT) screening can significantly reduce lung cancer mortality in heavy smokers or ex-smokers. However, LDCT screening is associated with radiation risks, and the benefits and risks need to be carefully considered.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Soon Ho Yoon, Yeol Kim
Summary: Implementing CAD and semi-automated measurement for lung nodules in a nationwide lung cancer screening program resulted in a significant increase in the number of detected nodules and a reduction in variability in positive rates across institutions.
EUROPEAN RADIOLOGY
(2021)
Review
Medicine, General & Internal
Theresa Hunger, Eva Wanka-Pail, Gunnar Brix, Juergen Griebel
Summary: The review found that screening for lung cancer in (former) smokers with low-dose computed tomography (LDCT) can significantly reduce disease-specific mortality. However, the screening may have a high false positive rate and carries the risk of overdiagnosis.
Article
Gastroenterology & Hepatology
Meylin Caballeros Lam, Paula Pujols, Ana Ezponda Casajus, Fernando Guillen Valderrama, Maria Jose Garcia Velloso, Alejandra Wyss, Loreto Garcia del Barrio, Javier Larrache Latasa, Jesus Pueyo Villoslada, Maria Dolores Lozano Escario, Juan P. de-Torres, Ana Belen Alcaide Ocana, Aranzazu Campo Ezquibela, Luis Seijo Maceiras, Luis Montuenga Badia, Javier Zulueta, Mercedes Inarrairaegui Bastarrica, Ignacio Herrero Santos, Gorka Bastarrika Aleman
Summary: In this study, a lung cancer screening program was implemented in liver transplant recipients (LTR) using low-dose CT and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET). The results showed that 9.7% of the LTR were diagnosed with lung cancer, most of which were non-small cell subtype. The majority of lung cancers (82.3%) were diagnosed at stage I, indicating the effectiveness of the screening program in detecting early-stage lung cancer.
LIVER TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Giulia Picozzi, Nicola Sverzellati, Sandra Anglesio, Maurizio Bartolucci, Edoardo Cavigli, Annalisa Deliperi, Massimo Falchini, Fabio Falaschi, Domenico Ghio, Paola Gollini, Anna Rita Larici, Alfonso Marchiano, Stefano Palmucci, Lorenzo Preda, Chiara Romei, Carlo Tessa, Cristiano Rampinelli, Mario Mascalchi
Summary: Smoking is the main risk factor for lung cancer, and low dose computed tomography (LDCT) screening has been proven to reduce lung cancer mortality, especially in women. Several Italian initiatives are currently offering LDCT screening and smoking cessation to high-risk individuals, with the aim of implementing a population-based screening program. This position paper provides recommendations for LDCT scan protocol, nodule classification, and management based on international guidelines.