Article
Infectious Diseases
Haein Kim, Hyeonji Seo, Sunghee Park, Hyemin Chung, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Yong Pil Chong
Summary: The clinical significance of Clostridium tertium bacteremia remains uncertain. This study evaluated the incidence, clinical characteristics, and outcomes of C. tertium bacteremia in neutropenic and non-neutropenic patients. It was found that 10% of patients with Clostridium species bacteremia had C. tertium bacteremia, with a higher prevalence in patients with recent chemotherapy and neutropenia or hematologic malignancy.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Review
Nutrition & Dietetics
Marie-France Vaillant, Maud Alligier, Nadine Baclet, Julie Capelle, Marie-Paule Dousseaux, Evelyne Eyraud, Philippe Fayemendy, Nicolas Flori, Esther Guex, Veronique Hennequin, Florence Lavandier, Caroline Martineau, Marie-Christine Morin, Fady Mokaddem, Isabelle Parmentier, Florence Rossi-Pacini, Gaelle Soriano, Elisabeth Verdier, Gilbert Zeanandin, Didier Quilliot
Summary: This study developed guidelines for hospital food and diets using the Delphi method, aiming to provide nutritionally rich and tailored diet options for patients. Twenty-three recommendations were validated by a panel of 50 experts to standardize hospital food and therapeutic food prescriptions, emphasizing the importance of providing tasty meals for patients in the hospital setting.
Article
Critical Care Medicine
Soo Jin Na, Dong Kyu Oh, Sunghoon Park, Yeon Joo Lee, Sang-Bum Hong, Mi-Hyun Park, Ryoung-Eun Ko, Chae-Man Lim, Kyeongman Jeon
Summary: Neutropenic sepsis is associated with distinct clinical characteristics and outcomes compared to non-neutropenic sepsis. Patients with neutropenia have higher-grade organ dysfunction at the time of sepsis diagnosis and a higher mortality rate.
Article
Medicine, Research & Experimental
Anna Maria Peri, Felicity Edwards, Andrea Henden, Patrick N. A. Harris, Mark D. Chatfield, David L. Paterson, Kevin B. Laupland
Summary: Knowledge of the epidemiology of bloodstream infection in haematology patients is crucial for patient management. This study investigates the epidemiology of bloodstream infection in haematological malignancy patients in Queensland over the last two decades, revealing a high prevalence of neutropenic patients and gram-negative pathogens as the main causative agents, with increasing antimicrobial resistance.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Michael G. White, Ryan B. Morgan, Michael W. Drazer, Oliver S. Eng
Summary: Surgeons are increasingly encountering neutropenic patients, who present with challenging infectious complications. Managing these patients requires a comprehensive understanding of the medical or oncologic disease course and often involves coordinating multiple specialty consultants.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Oncology
Pelin Gueneri, Joel B. Epstein, Gaye Bolukbasi, Ricardo T. Spielberger
Summary: Neutropenic ulcerations are mucosal ulcerations that occur in the presence of neutropenia, and can be caused by various factors such as neutropenia, trauma, microbial factors, and cytotoxicity. Early oral ulcers in cancer patients are primarily caused by oral mucositis, while later ulcers may result from intraoral trauma. The host's response plays a crucial role in the progression and repair process of these ulcers.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Infectious Diseases
Maria Aquino, Maria Tinoco, Joana Bicker, Amilcar Falcao, Marilia Rocha, Ana Fortuna
Summary: Amikacin is the preferred antibiotic for treating Gram-negative infections in neutropenic oncology patients. However, there is a lack of population pharmacokinetic studies on amikacin in this patient population. This large-scale retrospective study investigated the effects of tumor diseases, chemotherapy, lag time, age, and renal function on amikacin pharmacokinetics in neutropenic cancer patients. The results showed that oncology patients received higher daily doses of amikacin and had increased drug clearance. Chemotherapy influenced amikacin pharmacokinetics and drug clearance decreased with longer lag time. The impact of aging on amikacin doses was stronger than chemotherapy. This research suggests that cancer patients may require higher initial doses of amikacin, especially within 30 days of starting chemotherapy.
Article
Microbiology
Thomas De Bock, Liesbeth Jacxsens, Femke Maes, Svenya Van Meerhaeghe, Marina Reygaerts, Mieke Uyttendaele
Summary: For people with severe immunodeficiency, a neutropenic or low-microbial diet is prescribed to avoid high-risk foods that may contain pathogens. This study evaluates the current guidelines used by Ghent University Hospital based on food processing and preservation technologies and scientific evidence on microbiological quality and safety. Three important criteria were identified for evaluating the suitability of foodstuffs for a low-microbial diet: microbial contamination level and composition, presence of foodborne pathogens, and vigilance for a specific pathogen. However, the variability in microbial contamination due to processing differences makes it challenging to determine the suitability of certain foodstuffs without prior knowledge of ingredients and manufacturing processes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Li Zhang, Jinzhou Xiao, Mingwei Du, Wenzhi Lei, Weiwei Yang, Xiaochun Xue
Summary: Neutropenia is a common complication in the treatment of hematological diseases and the most common predisposing factor for invasion by fungi, such as Candida krusei. Recent studies have shown that C. krusei, a life-threatening pathogen, has developed resistance to amphotericin B (AMB). However, the mechanisms that led to the rapid emergence of this AMB-resistant phenotype are unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Vidmantas Petraitis, Ruta Petraitiene, Povilas Kavaliauskas, Ethan Naing, Andrew Garcia, Naoki Ishibashi, Benjamin Georgiades, Roger Echols, Robert A. Bonomo, Yoshinori Yamano, Michael J. Satlin, Thomas J. Walsha
Summary: Cefiderocol demonstrates high efficacy in the treatment of S. maltophilia pneumonia, leading to improved survival rate, reduced bacterial burden, and lung injury in a rabbit model.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Nutrition & Dietetics
Ana-Catarina Pinho-Gomes, Asha Kaur, Peter Scarborough, Mike Rayner
Summary: The study found good agreement between the 2005 and 2018 versions of the NPM and the EWG in assessing the healthiness of diets in the UK population.
Article
Multidisciplinary Sciences
Ziqi Chen, Bo Peng, Vassilis N. Ioannidis, Mufei Li, George Karypis, Xia Ning
Summary: Effective and successful clinical trials are crucial for developing new drugs and advancing treatments. However, the high costs and low success rates of clinical trials have prompted research on extracting knowledge from existing trials. In this manuscript, we introduce the construction of the first publicly available Clinical Trials Knowledge Graph (CTKG), which includes medical entities in trials and their relationships. Our analysis shows the potential utilities of CTKG in applications like drug repurposing and similarity search.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Ella. L. L. Bracci, Courtney. R. R. Davis, Karen. J. J. Murphy
Summary: Australian healthy food baskets are often based on Government Guidelines for healthy eating, but they haven't been updated recently and there's no Mediterranean Diet basket available for the Australian population. However, research suggests that following a Mediterranean Diet is beneficial for health. This study compared the nutrition and cost of different food baskets and found that the Mediterranean Diet basket was generally cheaper than the Australian Guide to Healthy Eating (AGHE) and Western Diet baskets.
Review
Hematology
Natacha Kapandji, Elie Azoulay, Lara Zafrani
Summary: This review provides insights into the clinical entity, diagnostic and therapeutic management of neutropenic enterocolitis (NE), and hypotheses on pathophysiology for further research.
Review
Clinical Neurology
Lina Palaiodimou, Amrou Sarraj, Apostolos Safouris, Georgios Magoufis, Robin Lemmens, Else Charlotte Sandset, Guillaume Turc, Marios Psychogios, Georgios Tsivgoulis
Summary: This study conducted a systematic review and meta-analysis, finding that endovascular treatment (EVT) can significantly reduce disability, improve independent ambulation, and lead to good functional outcomes for large-core acute ischaemic stroke (AIS). However, it has no significant impact on excellent functional outcomes and carries a risk of intracranial hemorrhage. Overall, EVT is effective and safe for large-core AIS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)