The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase

Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response

(2012) E. A. Mittendorf et al.   CANCER RESEARCH

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion

(2012) Huan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

(2012) J.-P. Motta et al.   Science Translational Medicine

Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury

(2012) Aoife Kerrin et al.   THORAX

Epigenetic regulation of the transcription factor Foxa2 directs differential elafin expression in melanocytes and melanoma cells

(2011) Kyung Sook Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E

(2011) S. Akli et al.   CANCER RESEARCH

Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)

(2011) Rithwik Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals

(2011) Yaara Zwang et al.   MOLECULAR CELL

The Neutrophil Elastase Inhibitor Elafin Triggers Rb-Mediated Growth Arrest and Caspase-Dependent Apoptosis in Breast Cancer

(2010) J. A. Caruso et al.   CANCER RESEARCH

Pharmacology and therapeutics: Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model

(2010) Xichuan Yang et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

Plasma Neutrophil Elastase and Elafin Imbalance Is Associated with Acute Respiratory Distress Syndrome (ARDS) Development

(2009) Zhaoxi Wang et al.   PLoS One

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE