The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling

Oncogenic ERBB3 Mutations in Human Cancers

(2013) Bijay S. Jaiswal et al.   CANCER CELL

Beyond trastuzumab: novel therapeutic strategies in HER2-positive metastatic breast cancer

(2012) R Y Tsang et al.   BRITISH JOURNAL OF CANCER

HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways

(2012) Byung-Kwon Choi et al.   Protein & Cell

ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells

(2012) Byung-Kwon Choi et al.   Cancer Medicine

A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies

(2011) Gabriele Schaefer et al.   CANCER CELL

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

(2011) Avinash Persaud et al.   EMBO JOURNAL

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

(2011) Elena Maspero et al.   EMBO REPORTS

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

(2011) J. T. Garrett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of HER2-overexpressing breast cancer

(2010) J. Baselga   ANNALS OF ONCOLOGY

An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation

(2010) B. Schoeberl et al.   CANCER RESEARCH

Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4

(2010) Qingqiu Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ubiquitin ligases in ErbB receptor quantity control

(2010) Kermit L. Carraway   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells

(2009) Fenghua Zeng et al.   FASEB JOURNAL

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

(2009) Avinash Persaud et al.   Molecular Systems Biology

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis

(2009) B. Schoeberl et al.   Science Signaling

The ERBB3 receptor in cancer and cancer gene therapy

(2008) G Sithanandam et al.   CANCER GENE THERAPY

The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

(2008) S.-M. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY