Journal
ONCOGENE
Volume 33, Issue 21, Pages 2681-2689Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2013.227
Keywords
SWI/SNF; chromatin remodeling; BRG1; MYC; cancer; cell differentiation
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Our rapidly growing knowledge about cancer genetics attests to the widespread occurrence of alterations at genes encoding different components of the SWI/SNF complex. This reveals an important new feature that sustains cancer development: the blockade of chromatin remodeling. Here, we provide an overview of our current knowledge on the gene alterations of chromatin-remodeling factors, and how they relate to cancer and human developmental diseases. We also consider the functional repercussions, particularly how the inactivation of the SWI/SNF complex impairs the appropriate cell response to nuclear receptor signaling, which, in turn, prevents cell differentiation and sustains cell growth independently of the environment.
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