PML-mediated signaling and its role in cancer stem cells

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

(2012) K. Wolyniec et al.   BLOOD

The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA

(2012) A. Rabellino et al.   CANCER RESEARCH

Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

(2012) Pier Paolo Scaglioni et al.   EMBO Molecular Medicine

Interleukin 6 Signaling Regulates Promyelocytic Leukemia Protein Gene Expression in Human Normal and Cancer Cells

(2012) Sona Hubackova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of the C-terminal Regions of Promyelocytic Leukemia Protein (PML) Isoforms II and V to PML Nuclear Body Formation

(2012) Yunyun Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1

(2012) Joseph K. Hsu et al.   JOURNAL OF CELL BIOLOGY

PML promotes MHC class II gene expression by stabilizing the class II transactivator

(2012) Tobias Ulbricht et al.   JOURNAL OF CELL BIOLOGY

A metabolic prosurvival role for PML in breast cancer

(2012) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

(2012) D Guan et al.   ONCOGENE

BMK1 is involved in the regulation of p53 through disrupting the PML–MDM2 interaction

(2012) Q Yang et al.   ONCOGENE

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs

(2011) L Y Peche et al.   CELL DEATH AND DIFFERENTIATION

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence

(2011) Nadine Martin et al.   EMBO JOURNAL

Regulation of E2Fs and senescence by PML nuclear bodies

(2011) M. Vernier et al.   GENES & DEVELOPMENT

Mitogen-activated Protein Kinase Extracellular Signal-regulated Kinase 2 Phosphorylates and Promotes Pin1 Protein-dependent Promyelocytic Leukemia Protein Turnover

(2011) Jun Hee Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Functions of Histone-LysineN-Methyltransferase Setdb1 Protein at Promyelocytic Leukemia-Nuclear Body (PML-NB)

(2011) Sunwha Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation

(2011) I. Chung et al.   JOURNAL OF CELL SCIENCE

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice

(2011) John S. Welch et al.   JOURNAL OF CLINICAL INVESTIGATION

The alternative lengthening of telomeres pathway may operate in non-neoplastic human cells

(2011) Tania L Slatter et al.   JOURNAL OF PATHOLOGY

Promyelocytic Leukemia Protein in Retinoic Acid-Induced Chromatin Remodeling of Oct4 Gene Promoter

(2011) Ya-Shan Chuang et al.   STEM CELLS

Alternative Lengthening of Telomeres in Human Glioma Stem Cells

(2011) David C. Silvestre et al.   STEM CELLS

Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies

(2010) Marie-Claude Geoffroy et al.   MOLECULAR BIOLOGY OF THE CELL

SUMOylation-Dependent Localization of IKKɛ in PML Nuclear Bodies Is Essential for Protection against DNA-Damage-Triggered Cell Death

(2010) Florian Renner et al.   MOLECULAR CELL

AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation

(2010) Q Li et al.   ONCOGENE

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

(2009) S. Haupt et al.   CANCER RESEARCH

IFN- -Induced Apoptosis in Hepatocellular Carcinoma Involves Promyelocytic Leukemia Protein and TRAIL Independently of p53

(2009) K. Herzer et al.   CANCER RESEARCH

E6AP promotes the degradation of the PML tumor suppressor

(2009) I Louria-Hayon et al.   CELL DEATH AND DIFFERENTIATION

Role of SUMO in RNF4-mediated Promyelocytic Leukemia Protein (PML) Degradation

(2009) Yann Percherancier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells

(2009) John T. Butler et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Telomeric DNA Mediates De Novo PML Body Formation

(2009) Anneke K. Brouwer et al.   MOLECULAR BIOLOGY OF THE CELL

The tumor suppressor Pml regulates cell fate in the developing neocortex

(2009) Tarik Regad et al.   NATURE NEUROSCIENCE

PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool

(2009) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination

(2009) I. Draskovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells

(2008) Peisu Zhang et al.   CURRENT BIOLOGY

Acetylation of PML Is Involved in Histone Deacetylase Inhibitor-mediated Apoptosis

(2008) Fumihiko Hayakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The eIF4E RNA regulon promotes the Akt signaling pathway

(2008) Biljana Culjkovic et al.   JOURNAL OF CELL BIOLOGY

PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation

(2008) Y. Shima et al.   MOLECULAR AND CELLULAR BIOLOGY

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

(2008) Jiancong Liang et al.   NATURE CELL BIOLOGY

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE

Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression

(2008) P. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA