Article
Biochemistry & Molecular Biology
Min Guo, Kaveh M. Goudarzi, Shiva Abedi, Melanie Pieber, Elin Sjoberg, Jinan Behnan, Xing-Mei Zhang, Robert A. Harris, Jiri Bartek, Mikael S. Lindstrom, Monica Nister, Daniel Hagerstrand
Summary: In this study, SFRP2 was identified as an antagonist of SOX2, capable of inducing a mesenchymal subtype transition in glioma cells. The research confirmed that SFRP2 could decrease tumor sphere formation and stemness, while increasing cell motility; conversely, SOX2 had opposite effects.
Article
Biochemistry & Molecular Biology
Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gassmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder, Sandra Bien-Moeller
Summary: Research has shown that PIM1 kinase plays a significant role in the behavior of glioblastoma stem cells, and its inhibition can lead to the death of these stem-like cells, suggesting a potential approach for glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Oncology
Stephen C. Mack, Kelsey C. Bertrand
Summary: Glioblastoma (GBM) is a brain tumor that occurs throughout infancy to adulthood, and ALK gene fusions have been identified as targetable driver alterations in congenital and infant GBM. Understanding the molecular basis and prevalence of ALK gene rearrangements can help identify GBM patients who may benefit from ALK-targeted therapy.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Ander Saenz-Antonanzas, Veronica Moncho-Amor, Jaione Auzmendi-Iriarte, Alejandro Elua-Pinin, Karine Rizzoti, Robin Lovell-Badge, Ander Matheu
Summary: Deletion of SRR2 halts malignant activity of SOX2 in cancer cells, highlighting the importance of SRR2 enhancer in regulating SOX2 expression.
Article
Oncology
Daisuke Kawauchi, Masamichi Takahashi, Kaishi Satomi, Shun Yamamuro, Tatsuya Kobayashi, Eita Uchida, Mai Honda-Kitahara, Yoshitaka Narita, Yasuo Iwadate, Koichi Ichimura, Arata Tomiyama
Summary: The study found that second-generation ALK inhibitors, alectinib and ceritinib, effectively induced GBM cell death in human GBM cell lines expressing low ALK levels and showed antitumor activity, suggesting that they could serve as potent therapeutic strategies against GBM.
Article
Multidisciplinary Sciences
Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim
Summary: The research reveals that the E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a unique manner, consequently enhancing the tumorigenicity and tumor-forming ability of GSCs.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Juanjuan Xiao, Lu Zhang, Huijun Yi, Ling Zou, Jianmei Mo, Feng Xue, Jinhua Zheng, Yingze Huang, Hui Lu, Hansheng Wu, Peipei Xue, Xin Zhang, Lifei He, Zhaoxin Li, Shigui Pang, Guibin Qiao, Qiuhong Duan, Feng Zhu
Summary: This study reveals the role of T-LAK cell-oriented protein kinase (TOPK) in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). The researchers found that TOPK is highly expressed in ALK-positive NSCLC and identified ALK as an upstream kinase of TOPK. Moreover, they showed that inhibiting TOPK enhances tumor sensitivity to an ALK inhibitor, and the combination of alectinib and a TOPK inhibitor suppresses tumor growth and promotes apoptosis of ALK-positive NSCLC cells.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Summary: Glioblastoma (GBM) shares common signaling pathways involving TIM-3, an immune checkpoint, between tumor and non-tumor cells. The study reveals that TIM-3 in glioma cells not only regulates the malignant behaviors of glioma cells but also induces macrophage migration and transition to an anti-inflammatory/protumorigenic phenotype through the TIM-3/IL6 signal. Blocking this feedback loop may provide a novel therapeutic strategy for GBM.
Article
Oncology
Anne -Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, Jared K. Woods, Shakti Ramkissoon, Lori Ramkissoon, Frank Dubois, Kathleen Schoolcraft, Jessica Tsai, Dayle Wang, Robert Jones, Jayne Vogelzang, Kristine Pelton, Sarah Becker, Fiona Watkinson, Claire Sinai, Elizabeth F. Cohen, Matthew A. Booker, Michael Y. Tolstorukov, Veerle Haemels, Liliana Goumnerova, Karen Wright, Mark Kieran, Katie Fehnel, David Reardon, Arnault Tauziede-Espariat, Rishi Lulla, Benjamin Carcamo, Stanley Chaleff, Alain Charest, Frederik De Smet, Azra H. Ligon, Adrian Dubuc, Melanie Pages, Pascale Varlet, Patrick Y. Wen, Brian M. Alexander, Susan Chi, Sanda Alexandrescu, Ralf Kittler, Robert Bachoo, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon
Summary: This study comprehensively analyzed ALK expression and genomic aberrations in 371 glioblastomas and validated the abnormalities in vitro and in vivo. The findings showed that ALK aberrations were present in 12% of gliomas across a wide age range and ALK fusions were more common in congenital/infant glioblastomas. ALK fusions promoted pathways related to tumor transformation and responded well to ALK inhibitors, supporting their use in clinical trials for glioblastomas in different age groups.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Li Kang, Yujie Liu, Jianzhong He, Yaling Wang, Mengyang Xue, Xin Wu, Zhen Wang, Yunpeng Zhang, Manyu Chu, Jialun Li, Wei Wei, Jiwen Li, Enmin Li, Lujian Liao, Jianru Xiao, Rong Zhang, Liyan Xu, Jiemin Wong
Summary: By screening a small-molecule kinase inhibitor library, GSK3 ss was identified as a critical kinase for promoting the overexpression of SOX2 in ESCC. Inhibition of GSK3 ss selectively impaired the proliferation and stemness of SOX2-positive ESCC cells. Clinical studies also showed a positive correlation between GSK3 ss and SOX2 protein levels in esophageal tumors, indicating the potential of targeting GSK3 ss for the treatment of ESCC.
Article
Oncology
Xueran Chen, Wanxiang Niu, Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Junqi Fan, Xuebiao Yao, Zhiyou Fang
Summary: In this study, it was found that Oct4A can impact the tumorigenic activity of glioblastoma and its stability is maintained through palmitoylation. Oct4A palmitoylation helps to integrate Sox4 and Oct4A in the SOX2 enhancement subregion, thereby maintaining the stem performance of glioma stem cells. The study also designed Oct4A palmitoylation competitive inhibitors that can inhibit the self-renewal ability and tumorigenicity of glioma stem cells.
Article
Biochemistry & Molecular Biology
Brianna Chen, Dylan McCuaig-Walton, Sean Tan, Andrew P. Montgomery, Bryan W. Day, Michael Kassiou, Lenka Munoz, Ariadna Recasens
Summary: The study demonstrates the important role of DYRK1A kinase in regulating the differentiation commitment of glioblastoma stem cells. Inhibiting DYRK1A insulates GSCs from differentiation-inducing signals, promoting differentiation and limiting stemness acquisition through deactivation of CDK5. This novel DYRK1A-CDK5-SOX2 pathway sheds further light on the mechanisms underlying the maintenance of glioblastoma stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yue Pan, Chao Deng, Zhenhua Qiu, Chenghui Cao, Fang Wu
Summary: This review discusses the resistance mechanisms of ALK TKIs in advanced NSCLC, providing a theoretical basis and research ideas for solving the problem of ALK drug resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Peiwen Chen
Summary: TFPI2 has been identified as a crucial molecule in the symbiotic interaction between glioblastoma stem cells and microglia. Blocking this symbiosis not only inhibits tumor growth but also synergizes with an immune checkpoint inhibitor in mouse models of glioblastoma.
Article
Oncology
Zhengqi Wen, Dun Xiong, Shurong Zhang, Jiankun Liu, Bitao Li, Raomei Li, Hushan Zhang
Summary: Gastric cancer treatment options are limited due to insufficient understanding of molecular characteristics. A novel form of ALK fusion was identified in gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hirokazu Takami, Akitake Mukasa, Shunsaku Takayanagi, Tsukasa Koike, Reiko Matsuura, Masako Ikemura, Tetsuo Ushiku, Gakushi Yoshikawa, Junji Shibahara, Shota Tanaka, Nobuhito Saito
Summary: Oligoastrocytoma has been removed from the revised fourth edition of the World Health Organization Classification of Tumours of the Central Nervous System, except in cases where it is specified as not otherwise specified (NOS). However, there have been few reports on the histopathological and genetic backgrounds of cases with dual features of astrocytoma/oligodendroglioma. In this study, a case of a 54-year-old man with a glioma containing two distinct parts, astrocytoma and oligodendroglioma, was encountered. The findings suggest that gliomas with two distinct lineages might mix to produce oligoastrocytoma, and genetic alterations may be acquired during chemo-radiotherapy.
BRAIN TUMOR PATHOLOGY
(2023)
Correction
Oncology
Hirokazu Takami, Akitake Mukasa, Shunsaku Takayanagi, Tsukasa Koike, Reiko Matsuura, Masako Ikemura, Tetsuo Ushiku, Gakushi Yoshikawa, Junji Shibahara, Shota Tanaka, Nobuhito Saito
BRAIN TUMOR PATHOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tatsuya Uchida, Taichi Kin, Katsuya Sato, Tsukasa Koike, Satoshi Kiyofuji, Yasuhiro Takeda, Ryoko Niwa, Toki Saito, Ikumi Takashima, Takuya Kawahara, Satoru Miyawaki, Hiroshi Oyama, Nobuhito Saito
Summary: This study investigates the relationship between image slice thickness and face reproducibility in three-dimensional reconstructed facial models obtained from head CT data. The results show that thinner slice thickness improves the match rate and increases the risk of personally identifiable health information.
CURRENT MEDICAL IMAGING
(2023)
Article
Clinical Neurology
Yudai Hirano, Satoru Miyawaki, Hideaki Imai, Hiroki Hongo, Yu Teranishi, Daiichiro Ishigami, Yu Sakai, Daisuke Shimada, Motoyuki Umekawa, Masafumi Segawa, Satoshi Koizumi, Hideaki Ono, Hirofumi Nakatomi, Nobuhito Saito
Summary: This study aimed to clarify the clinical and genetic characteristics of patients with both ischemic and hemorrhagic cerebrovascular events in moyamoya disease. The majority of patients experienced an ischemic event first, and those who developed ischemia in childhood may have subsequent hemorrhage approximately 20-25 years after bypass surgery. In adults, male sex is a risk factor for a subsequent hemorrhagic event in ischemic moyamoya disease.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Motoyuki Umekawa, Yuki Shinya, Hirotaka Hasegawa, Atsuto Katano, Nobuhito Saito
Summary: Surgical resection of intraventricular meningiomas (IVMs) is challenging due to their deep locations and proximity to vital structures. Stereotactic radiosurgery (SRS) is a safe and effective treatment option for benign brain tumors, but its outcomes for IVMs have been rarely reported. This study evaluates the SRS outcomes for IVMs at their institution, showing that SRS provides safe and excellent tumor control for IVMs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Hirotaka Hasegawa, Yuki Shinya, Minoru Ono, Shu Kikuta, Kenji Kondo, Nobuhito Saito
Summary: Kashime, a novel surgical suture, can effectively repair skull base dural defects in endoscopic transnasal surgery without the need for tying. Preliminary experiments showed that a single dural stitch using Kashime can be completed in approximately 2 minutes, and no postoperative cerebrospinal fluid leakage was observed.
OPERATIVE NEUROSURGERY
(2023)
Article
Clinical Neurology
Satoshi Kiyofuji, Taichi Kin, Toki Saito, Tsukasa Koike, Yasuhiro Takeda, Tatsuya Uchida, Katsuya Sato, Naoyuki Shono, Ryoko Niwa, Yasuyuki Furuta, Nobuhito Saito
Summary: An online interactive neurosurgical simulator was developed to enhance portability and validate a unique psychometric method for providing tactile information. Neurosurgical residents evaluated the simulator along with lectures, slide reviews, and dissection of a 3D printed temporal bone model. Questionnaires were used to gather feedback from the residents.
OPERATIVE NEUROSURGERY
(2023)
Article
Oncology
Yuki Shinya, Hirotaka Hasegawa, Masahiro Shin, Kosuke Kashiwabara, Mariko Kawashima, Shunya Hanakita, Tomoyuki Koga, Satoshi Koizumi, Atsuto Katano, Yuichi Suzuki, Nobuhito Saito
Summary: This study found that age significantly affects post-treatment hemorrhage and nidus obliteration rate in patients with brain arteriovenous malformations (BAVMs) treated with stereotactic radiosurgery. Younger patients are more likely to experience reduced cerebral hemorrhages and achieve earlier nidus obliteration compared to older patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Tatsuya Uchida, Taichi Kin, Toki Saito, Naoyuki Shono, Satoshi Kiyofuji, Tsukasa Koike, Katsuya Sato, Ryoko Niwa, Ikumi Takashima, Hiroshi Oyama, Nobuhito Saito
Summary: A new de-identification technique for head CT images was developed to prevent face identification while maintaining the accuracy of deep-learning models.
Article
Cell Biology
Yasuyuki Shima, Shota Sasagawa, Nakao Ota, Rieko Oyama, Minoru Tanaka, Mie Kubota-Sakashita, Hirochika Kawakami, Mika Kobayashi, Naoko Takubo, Atsuko Nakanishi Ozeki, Xiaoning Sun, Yeon-Jeong Kim, Yoichiro Kamatani, Koichi Matsuda, Kazuhiro Maejima, Masashi Fujita, Kosumo Noda, Hiroyas Kamiyama, Rokuya Tanikawa, Motoo Nagane, Junji Shibahara, Toru Tanaka, Yoshiyuki Rikitake, Nobuko Mataga, Satoru Takahash, Kenjiro Kosaki, Hideyuki Okano, Tomomi Furihata, Ryo Nakaki, Nobuyoshi Akimitsu, Youichiro Wada, Toshihisa Ohtsuka, Hiroki Kurihara, Hiroyuki Kamiguchi, Shigeo Okabe, Masato Nakafuku, Tadafumi Kato, Hidewaki Nakagawa, Nobuhito Saito, Hirofumi Nakatomi
Summary: This study identified somatic mutations in multiple signaling genes related to the NF-κB signaling pathway in both fusiform and saccular intracranial aneurysms (IAs). These mutations were highly prevalent among IA cases and were found to constitutively activate ERK and NF-κB signaling, enhance cell motility, and induce inflammation-related gene expression. Virus-mediated overexpression of a mutant PDGFRB induced arterial dilatation in a mouse model, which could be blocked by a tyrosine kinase inhibitor. This study highlights the importance of NF-κB signaling pathway-related gene mutations in both types of IAs and suggests new avenues for pharmacological interventions.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Satoshi Kuroda, Shusuke Yamamoto, Takeshi Funaki, Miki Fujimura, Hiroharu Kataoka, Tomohito Hishikawa, Jun Takahashi, Hidenori Endo, Tadashi Nariai, Toshiaki Osato, Nobuhito Saito, Norihiro Sato, Emiko M. Hori, Yoichi Ito, Susumu Miyamoto
Summary: This study aimed to investigate the 5-year risk of stroke and its predictors in patients with asymptomatic moyamoya disease. The results showed that the annual risk of stroke in these patients was 1.0%, with the majority of strokes being hemorrhagic. Grade-2 choroidal anastomosis was found to be a predictor for stroke, and microbleeds and Grade-2 choroidal anastomosis were associated with the risk of hemorrhagic stroke.
Article
Medicine, General & Internal
Ryota Kurogi, Akiko Kada, Kuniaki Ogasawara, Kunihiro Nishimura, Takanari Kitazono, Toru Iwama, Yuji Matsumaru, Nobuyuki Sakai, Yoshiaki Shiokawa, Shigeru Miyachi, Satoshi Kuroda, Hiroaki Shimizu, Shinichi Yoshimura, Toshiaki Osato, Nobutaka Horie, Izumi Nagata, Kazuhiko Nozaki, Isao Date, Yoichiro Hashimoto, Haruhiko Hoshino, Hiroyuki Nakase, Hiroharu Kataoka, Tsuyoshi Ohta, Hitoshi Fukuda, Nanako Tamiya, Ai Kurogi, Nice Ren, Ataru Nishimura, Koichi Arimura, Takafumi Shimogawa, Koji Yoshimoto, Daisuke Onozuka, Soshiro Ogata, Akihito Hagihara, Nobuhito Saito, Hajime Arai, Susumu Miyamoto, Teiji Tominaga, Koji Iihara
Summary: This study aimed to examine the 6-year trends in clinical outcomes of SAH patients who underwent clipping or coiling, and the influence of CSC capabilities on patient outcomes. The results showed a decrease in in-hospital mortality and stable proportion of poor functional outcomes. The use of coiling and multidisciplinary care for untreated patients increased. Higher CSC scores were associated with increased use of coiling but not with short-term patient outcomes.
Review
Oncology
Ako Matsuhashi, Shota Tanaka, Hirokazu Takami, Masashi Nomura, Masako Ikemura, Yoshitaka Matsubayashi, Yusuke Shinoda, Keisuke Yamada, Yu Sakai, Yasuaki Karasawa, Shunsaku Takayanagi, Nobuhito Saito
Summary: This article presents a case of vertebral metastasis in a patient with glioblastoma. The study found that younger age at initial presentation, multiple surgical interventions, and long overall survival seem to be risk factors for vertebral metastasis. As the prognosis of glioblastoma improves over time, vertebral metastasis appears to be more common, therefore extradural metastasis should be considered in the treatment of glioblastoma. Further genomic analysis on multiple paired specimens is necessary to elucidate the molecular mechanisms of vertebral metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Shunya Hanakita, Masahiro Shin, Hirotaka Hasegawa, Masaaki Shojima, Kenta Ohara, Yuki Shinya, Mariko Kawashima, Kenji Kondo, Nobuhito Saito
Summary: Surgical resection of tumors invading the cavernous sinus remains challenging. This study shows that endoscopic transsphenoidal surgery (ETS) can achieve sufficient surgical resection in most patients with acceptable neurological complications. ETS may offer the opportunity for improving cranial nerve functions in patients with cranial nerve symptoms.
OPERATIVE NEUROSURGERY
(2023)
Article
Medicine, Research & Experimental
Hiroshi Fukuhara, Yuzuri Tsurumaki Sato, Jiangang Hou, Miwako Iwai, Tomoki Todo
Summary: This study evaluates different methods of expressing IL-12 as an immunostimulatory payload for oncolytic HSV-1 using G47 increment as the backbone. The results show that expressing the two IL-12 subunits as a fusion peptide is more effective than co-expression and leads to improved anti-cancer effects in tumor models.
COMMUNICATIONS MEDICINE
(2023)
