LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling

Sphingosine 1-phosphate signalling in cancer

(2012) Nigel J. Pyne et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway

(2012) S Maseki et al.   BRITISH JOURNAL OF CANCER

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Lrig1: a new master regulator of epithelial stem cells

(2012) Paloma Ordóñez-Morán et al.   EMBO JOURNAL

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

EGFR Kinase Promotes Acquisition of Stem Cell-Like Properties: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma Stem Cells

(2012) Eric L. Abhold et al.   PLoS One

Regulation of matrix metalloproteinases activity studied in human endometrium as a paradigm of cyclic tissue breakdown and regeneration

(2011) Héloïse P. Gaide Chevronnay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

Lrig1 Is an Estrogen-Regulated Growth Suppressor and Correlates with Longer Relapse-Free Survival in ER -Positive Breast Cancer

(2011) S. R. Krig et al.   MOLECULAR CANCER RESEARCH

Analysis of EGFR signaling pathway in nasopharyngeal carcinoma cells by quantitative phosphoproteomics

(2011) Lin Ruan et al.   Proteome Science

Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition

(2011) Javier Milara et al.   THORAX

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1

(2010) Wei Yi et al.   EXPERIMENTAL CELL RESEARCH

Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

(2010) Evette S. Radisky et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 Are Genomic Markers for Prognosis of Advanced Nasopharyngeal Carcinoma

(2009) J. J.-C. Sheu et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma

(2009) J. J.-C. Sheu et al.   CANCER RESEARCH

Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

(2009) Kim B. Jensen et al.   Cell Stem Cell

Epidermal stem cell diversity and quiescence

(2009) Fiona M. Watt et al.   EMBO Molecular Medicine

Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity

(2009) Fei Ye et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment

(2008) Sara I. Pai et al.   Annual Review of Pathology-Mechanisms of Disease

A stem cell gene expression profile of human squamous cell carcinomas

(2008) Kim B. Jensen et al.   CANCER LETTERS

Suppression of the Negative Regulator LRIG1 Contributes to ErbB2 Overexpression in Breast Cancer

(2008) J. K. Miller et al.   CANCER RESEARCH

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

Microsatellite instability and loss of heterozygosity in squamous cell carcinoma of the head and neck

(2008) Susanne Koy et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Recurrent chemical reactivations of EBV promotes genome instability and enhances tumor progression of nasopharyngeal carcinoma cells

(2008) Chih-Yeu Fang et al.   INTERNATIONAL JOURNAL OF CANCER

Lrig1 Is an Endogenous Inhibitor of Ret Receptor Tyrosine Kinase Activation, Downstream Signaling, and Biological Responses to GDNF

(2008) F. Ledda et al.   JOURNAL OF NEUROSCIENCE

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

(2008) M A Stutz et al.   ONCOGENE

LRIG1 and squamous epithelial uterine cervical cancer: correlation to prognosis, other tumor markers, sex steroid hormones, and smoking

(2007) A.K. LINDSTRÖM et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER