Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma
Authors
Keywords
-
Journal
ONCOGENE
Volume 33, Issue 15, Pages 1877-1889
Publisher
Springer Nature
Online
2013-05-13
DOI
10.1038/onc.2013.129
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1
- (2015) Julie S. Barber-Rotenberg et al. Oncotarget
- Targeting developmental pathways in children with cancer: what price success?
- (2013) Lia Gore et al. LANCET ONCOLOGY
- Anaplastic lymphoma kinase status in rhabdomyosarcomas
- (2013) Akihiko Yoshida et al. MODERN PATHOLOGY
- An adaptive Src–PDGFRA–Raf axis in rhabdomyosarcoma
- (2012) Jinu Abraham et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Proteasome inhibitors in multiple myeloma: 10 years later
- (2012) P. Moreau et al. BLOOD
- In Vivo Imaging of Tumor-Propagating Cells, Regional Tumor Heterogeneity, and Dynamic Cell Movements in Embryonal Rhabdomyosarcoma
- (2012) Myron S. Ignatius et al. CANCER CELL
- Identification of FoxM1/Bub1b Signaling Pathway as a Required Component for Growth and Survival of Rhabdomyosarcoma
- (2012) X. Wan et al. CANCER RESEARCH
- PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation
- (2012) Elizabeth Charytonowicz et al. Clinical & Translational Oncology
- Rare Cancer Trial Design: Lessons from FDA Approvals
- (2012) H. Gaddipati et al. CLINICAL CANCER RESEARCH
- Targeting the fetal acetylcholine receptor in rhabdomyosarcoma
- (2012) Katja Simon-Keller et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors
- (2012) Gayathri Chadalapaka et al. INTERNATIONAL JOURNAL OF CANCER
- The FDA Safety and Innovation Act
- (2012) Robert Steinbrook et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- PAX3/FOXO1Fusion Gene Status Is the Key Prognostic Molecular Marker in Rhabdomyosarcoma and Significantly Improves Current Risk Stratification
- (2012) Edoardo Missiaglia et al. JOURNAL OF CLINICAL ONCOLOGY
- Drug Approvals 2011: Focus on Companion Diagnostics
- (2012) M. Goozner JNCI-Journal of the National Cancer Institute
- Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
- (2012) L Chen et al. LEUKEMIA
- User Fees and Beyond — The FDA Safety and Innovation Act of 2012
- (2012) Daniel B. Kramer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma
- (2012) K Kikuchi et al. ONCOGENE
- Initial testing of the MDM2 inhibitor RG7112 by the pediatric preclinical testing program
- (2012) Hernan Carol et al. PEDIATRIC BLOOD & CANCER
- 18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models
- (2012) Anuradha Soundararajan et al. PEDIATRIC BLOOD & CANCER
- Overcoming autopsy barriers in pediatric cancer research
- (2012) Jennifer L. Alabran et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of the phosphatidylinositol 3′ kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program
- (2012) C. Patrick Reynolds et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program
- (2012) Richard Gorlick et al. PEDIATRIC BLOOD & CANCER
- Rhabdomyosarcoma: Review of the Children's Oncology Group (COG) soft-tissue Sarcoma committee experience and rationale for current COG studies
- (2012) Suman Malempati et al. PEDIATRIC BLOOD & CANCER
- Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant
- (2012) Ulrica Tostar et al. PLoS One
- Systemic Analysis of Gene Expression Profiles Identifies ErbB3 as a Potential Drug Target in Pediatric Alveolar Rhabdomyosarcoma
- (2012) Janne Nordberg et al. PLoS One
- Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma
- (2012) Vishnu Hosur et al. Cancer Genetics
- Differential PAX3 functions in normal skin melanocytes and melanoma cells
- (2011) Sandra Medic et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The clinical, research, and social value of autopsy after any cancer death
- (2011) Sheri L. Spunt et al. CANCER
- Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma
- (2011) Brian P. Rubin et al. CANCER CELL
- Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer
- (2011) Hernan Carol et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
- (2011) M.-H. Lee et al. CANCER RESEARCH
- Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells
- (2011) Aiguo Liu et al. CANCER SCIENCE
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
- (2011) Philip J. Stephens et al. CELL
- Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo
- (2011) L Raimondi et al. CELL DEATH AND DIFFERENTIATION
- Inhibition of the Notch-Hey1 Axis Blocks Embryonal Rhabdomyosarcoma Tumorigenesis
- (2011) B. C. Belyea et al. CLINICAL CANCER RESEARCH
- IL-4R Drives Dedifferentiation, Mitogenesis, and Metastasis in Rhabdomyosarcoma
- (2011) T. Hosoyama et al. CLINICAL CANCER RESEARCH
- Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways
- (2011) N. Shukla et al. CLINICAL CANCER RESEARCH
- High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis
- (2011) Vera Paulson et al. GENES CHROMOSOMES & CANCER
- Characteristics of Clinical Trials to Support Approval of Orphan vs Nonorphan Drugs for Cancer
- (2011) Aaron S. Kesselheim JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Caveolins in rhabdomyosarcoma
- (2011) Stefania Rossi et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative, Locally Recurrent or Metastatic Breast Cancer
- (2011) Nicholas J. Robert et al. JOURNAL OF CLINICAL ONCOLOGY
- Induction of a regenerative microenvironment in skeletal muscle is sufficient to induce embryonal rhabdomyosarcoma in p53-deficient mice
- (2011) Marybeth Camboni et al. JOURNAL OF PATHOLOGY
- Rhabdomyosarcoma in Children: A SEER Population Based Study
- (2011) Eduardo A. Perez et al. JOURNAL OF SURGICAL RESEARCH
- Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
- (2011) Jinxuan Hou et al. Journal of Translational Medicine
- Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma
- (2011) J. Abraham et al. MOLECULAR CANCER THERAPEUTICS
- PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma
- (2011) Amy D. Marshall et al. MOLECULAR CARCINOGENESIS
- Seattle Genetics rare cancer drug sails through accelerated approval
- (2011) Laura DeFrancesco NATURE BIOTECHNOLOGY
- Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice
- (2011) F Nitzki et al. ONCOGENE
- Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program
- (2011) Peter J. Houghton et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of LCL161, a SMAC mimetic, by the pediatric preclinical testing program
- (2011) Peter J. Houghton et al. PEDIATRIC BLOOD & CANCER
- The long road to immunotherapy for childhood rhabdomyosarcoma
- (2011) Elaine Huang et al. PEDIATRIC BLOOD & CANCER
- Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program
- (2011) Richard B. Lock et al. PEDIATRIC BLOOD & CANCER
- Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group
- (2011) Joseph G. Pressey et al. PEDIATRIC BLOOD & CANCER
- Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells
- (2011) S. Hettmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis
- (2011) Idriss M Bennani-Baiti Epigenomics
- Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma
- (2010) M Eichenmüller et al. BRITISH JOURNAL OF CANCER
- MDM2 displays differential activities dependent upon the activation status of NFκB
- (2010) Misty D. Cheney et al. CANCER BIOLOGY & THERAPY
- Targeting Wild-Type and Mutant p53 with Small Molecule CP-31398 Blocks the Growth of Rhabdomyosarcoma by Inducing Reactive Oxygen Species-Dependent Apoptosis
- (2010) J. Xu et al. CANCER RESEARCH
- Silencing of SPRY1 Triggers Complete Regression of Rhabdomyosarcoma Tumors Carrying a Mutated RAS Gene
- (2010) G. Schaaf et al. CANCER RESEARCH
- Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer
- (2010) L. Cao et al. CANCER RESEARCH
- MicroRNA miR-183 Functions as an Oncogene by Targeting the Transcription Factor EGR1 and Promoting Tumor Cell Migration
- (2010) A. L. Sarver et al. CANCER RESEARCH
- TGF-β1 signal pathway may contribute to rhabdomyosarcoma development by inhibiting differentiation
- (2010) Shouli Wang et al. CANCER SCIENCE
- Folotyn (Pralatrexate Injection) for the Treatment of Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma: U.S. Food and Drug Administration Drug Approval Summary
- (2010) S. M. Malik et al. CLINICAL CANCER RESEARCH
- Notch Pathway Inhibition Significantly Reduces Rhabdomyosarcoma Invasiveness and Mobility In Vitro
- (2010) J. Roma et al. CLINICAL CANCER RESEARCH
- Intercohort Gene Expression Co-Analysis Reveals Chemokine Receptors as Prognostic Indicators in Ewing's Sarcoma
- (2010) I. M. Bennani-Baiti et al. CLINICAL CANCER RESEARCH
- Caveolin 1 is a marker of poor differentiation in Rhabdomyosarcoma
- (2010) Stefania Rossi et al. EUROPEAN JOURNAL OF CANCER
- Educational paper
- (2010) Terzah M. Horton et al. EUROPEAN JOURNAL OF PEDIATRICS
- Inhibition of rhabdomyosarcoma's metastatic behavior through downregulation of MET receptor signaling.
- (2010) Ewa Lukasiewicz et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- Role of I-TAC-binding receptors CXCR3 and CXCR7 in proliferation, activation of intracellular signaling pathways and migration of various tumor cell lines.
- (2010) Katarzyna Miekus et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- Overlapping and distinct role of CXCR7-SDF-1/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomas
- (2010) Katarzyna Grymula et al. INTERNATIONAL JOURNAL OF CANCER
- Randomized Phase II Window Trial of Two Schedules of Irinotecan With Vincristine in Patients With First Relapse or Progression of Rhabdomyosarcoma: A Report From the Children's Oncology Group
- (2010) Leo Mascarenhas et al. JOURNAL OF CLINICAL ONCOLOGY
- Canakinumab
- (2010) Eugen Dhimolea mAbs
- Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD
- (2010) T. Shalaby et al. MOLECULAR CANCER THERAPEUTICS
- Immune Competency of aHairlessMouse Strain for Improved Preclinical Studies in Genetically Engineered Mice
- (2010) Beverly S. Schaffer et al. MOLECULAR CANCER THERAPEUTICS
- Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-xL
- (2010) L H Mayeenuddin et al. ONCOGENE
- Initial testing (stage 1) of AZD6244 (ARRY-142886) by the pediatric preclinical testing program
- (2010) E. Anders Kolb et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program
- (2010) Hernan Carol et al. PEDIATRIC BLOOD & CANCER
- FDA approves pralatrexate for treatment of rare lymphoma
- (2009) Cheryl A. Thompson AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- Molecular Classification of Rhabdomyosarcoma—Genotypic and Phenotypic Determinants of Diagnosis
- (2009) Elai Davicioni et al. AMERICAN JOURNAL OF PATHOLOGY
- Mice Lacking Dystrophin or α Sarcoglycan Spontaneously Develop Embryonal Rhabdomyosarcoma with Cancer-Associated p53 Mutations and Alternatively Spliced or Mutant Mdm2 Transcripts
- (2009) Karen Fernandez et al. AMERICAN JOURNAL OF PATHOLOGY
- Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells
- (2009) M Hirotsu et al. BRITISH JOURNAL OF CANCER
- MI-63: A novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53
- (2009) J A Canner et al. BRITISH JOURNAL OF CANCER
- Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005
- (2009) Simona Ognjanovic et al. CANCER
- Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma
- (2009) K. Nishijo et al. CANCER RESEARCH
- Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)- Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors
- (2009) U. McDermott et al. CANCER RESEARCH
- Reversal of P-glycoprotein-Mediated Multidrug Resistance by the Murine Double Minute 2 Antagonist Nutlin-3
- (2009) M. Michaelis et al. CANCER RESEARCH
- Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma
- (2009) Y. Hoshida et al. CANCER RESEARCH
- Restoration of p53 Pathway by Nutlin-3 Induces Cell Cycle Arrest and Apoptosis in Human Rhabdomyosarcoma Cells
- (2009) M. Miyachi et al. CLINICAL CANCER RESEARCH
- RAS signaling dysregulation in human embryonal Rhabdomyosarcoma
- (2009) Simone Martinelli et al. GENES CHROMOSOMES & CANCER
- Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: An approach to identify candidate genes involved in tumor development
- (2009) Edoardo Missiaglia et al. GENES CHROMOSOMES & CANCER
- Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2β as biomarkers for rhabdomyosarcoma diagnostics
- (2009) Beate Grass et al. HISTOPATHOLOGY
- MicroRNA-1/206 Targets c-Metand Inhibits Rhabdomyosarcoma Development
- (2009) Dongsheng Yan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4
- (2009) P. Nanni et al. MOLECULAR CANCER THERAPEUTICS
- MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma
- (2009) F. Marampon et al. MOLECULAR CANCER THERAPEUTICS
- BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
- (2009) J. M. Carboni et al. MOLECULAR CANCER THERAPEUTICS
- T (brachyury) gene duplication confers major susceptibility to familial chordoma
- (2009) Xiaohong R Yang et al. NATURE GENETICS
- Beta-Catenin Mutation Does Not Seem to Have an Effect on the Tumorigenesis of Pediatric Rhabdomyosarcomas
- (2009) Dorothée Bouron-Dal Soglio et al. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
- Initial testing (stage 1) of lapatinib by the pediatric preclinical testing program
- (2009) Richard Gorlick et al. PEDIATRIC BLOOD & CANCER
- Molecular Staging of Pathologically Negative Sentinel Lymph Nodes from Melanoma Patients Using Multimarker, Quantitative Real-Time RT-PCR
- (2008) Josep M. Hilari et al. ANNALS OF SURGICAL ONCOLOGY
- Addiction to Elevated Insulin-like Growth Factor I Receptor and Initial Modulation of the AKT Pathway Define the Responsiveness of Rhabdomyosarcoma to the Targeting Antibody
- (2008) L. Cao et al. CANCER RESEARCH
- The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors
- (2008) F. Huang et al. CANCER RESEARCH
- Clinical Significance of CXC Chemokine Receptor-4 and c-Met in Childhood Rhabdomyosarcoma
- (2008) F. Diomedi-Camassei et al. CLINICAL CANCER RESEARCH
- Molecular Characterization of the Pediatric Preclinical Testing Panel
- (2008) G. Neale et al. CLINICAL CANCER RESEARCH
- Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells
- (2008) C. Santoriello et al. Disease Models & Mechanisms
- Incidence and time trends of soft tissue sarcomas in German children 1985–2004 – A report from the population-based German Childhood Cancer Registry
- (2008) Thomas Weihkopf et al. EUROPEAN JOURNAL OF CANCER
- Different telomere maintenance mechanisms in alveolar and embryonal rhabdomyosarcoma
- (2008) Anat Ohali et al. GENES CHROMOSOMES & CANCER
- PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma
- (2008) E Taniguchi et al. ONCOGENE
- Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish
- (2008) D M Langenau et al. ONCOGENE
- Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
- (2008) L Liu et al. ONCOGENE
- ALK Expression in Rhabdomyosarcomas: Correlation with Histologic Subtype and Fusion Status
- (2008) Diana A. Corao et al. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
- Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
- (2008) E. Anders Kolb et al. PEDIATRIC BLOOD & CANCER
- Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program
- (2008) Malcolm A. Smith et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
- (2007) Peter J. Houghton et al. PEDIATRIC BLOOD & CANCER
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More