Article
Chemistry, Physical
Hao Liu, You-Feng Han, Zhong-Hua Gao, Chun-Lin Zhang, Congyang Wang, Song Ye
Summary: The cooperative N-heterocyclic carbene/nickel-catalyzed redox-neutral hydroacylation of 1,3-dienes with aldehydes in water was successfully achieved, providing synthetically useful compounds with high atom economy. This study demonstrated the compatibility of NHC catalysis with nickel catalysis and utilized water as the sole solvent, which is rarely reported in cooperative metal/organic catalytic systems.
Article
Chemistry, Physical
Hongyu Wang, Chen-Fei Liu, Tong-De Tan, Kyna Ru Bin Khoo, Ming Joo Koh
Summary: The study demonstrates a new method for the highly efficient and site-selective 1,2-diarylation of aliphatic-1,3-dienes using N-heterocyclic carbene (NHC)-Ni(0) catalyst, allowing for the synthesis of products containing tertiary or quaternary centers.
Article
Chemistry, Organic
Killari Satyam, Jakkula Ramarao, Surisetti Suresh
Summary: The NHC-catalyzed intramolecular benzoin condensation-oxidation allows for the expedient synthesis of diverse cyclic 1,2-diketones incorporated in dibenzo-fused seven-membered heterocycles in good to excellent yields under ambient conditions. The transformation appears to proceed through the benzoin intermediate followed by aerobic oxidation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ludwig Zapf, Udo Radius, Maik Finze
Summary: The paper describes the synthesis of 1,3-bis(tricyanoborane)imidazolate anion and its derivatives, including a novel dianionic N-heterocyclic carbene. These compounds exhibit unique electronic and steric properties, making them promising ligands and building blocks for coordination chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Tingting Li, Zhichao Jin, Yonggui Robin Chi
Summary: This review discusses N-heterocyclic carbene-catalyzed reactions for the formation of aromatic compounds, categorizing them into 4 types based on activation modes. The achievements, challenges, and future research directions in NHC-catalyzed arene construction processes are summarized. The outlook is based on the authors' opinions and knowledge on the trends of NHC organocatalysis development.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Physical
Ricardo J. Alves, Laize Zaramello, Elvis N. Nishida, Frank H. Quina, Bruno S. Souza
Summary: In this study, we investigated the transient formation of N-heterocyclic carbenes (NHCs) in zwitterionic imidazolium sulfonate surfactants in a water environment. The formation of NHCs was accelerated above the critical micelle concentration, due to increased local concentration of hydroxide or deuteroxide ions. The rate of NHC formation could be controlled by the anions of added salts, which also affected the selectivity of anion binding to the micelle surface. The NHCs generated at the micelle surface promoted the selective oxidation of 4-nitrobenzaldehyde, demonstrating the importance of micellar microenvironment in controlling reactivity and selectivity in aqueous media.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Organic
Dai Chunbo, Xia Siqi, Chen Xiaoyu, Yang Limin
Summary: A highly efficient N-heterocyclic carbene (NHC) catalyzed formal [3+4] cycloaddition reaction has been developed, producing 4-aminobenzoheptenolactone derivatives in good yields. A theoretical study using density functional theory revealed that the deformation force was the main factor influencing the site selectivity.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Rajendra S. Ghadwal
Summary: This review article aims to highlight recent advances in accessing stable iMICs, quantifying their properties, and exploring their applications in synthesis and catalysis. The synthetic viability and use of vicinal C4,C5-anionic dicarbenes (ADCs) based on a 1,3-imidazole framework are also presented. iMICs and ADCs have the potential to push the limit of classical NHCs by enabling access to conceptually new main-group heterocycles, radicals, molecular catalysts, ligand sets, and more.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Ashmita Singh, A. K. Narula
Summary: A facile method for the amidation of aldehydes by a cascade approach has been developed using NHC as the catalyst and NHS as the mediator. The method utilizes TBHP as the oxidant. Various substituted aldehydes reacted smoothly with NHS to form active esters, which were easily converted into amides. The drug moclobemide was successfully synthesized using this methodology to demonstrate its practical utility.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Keita Tanaka, Martin-Louis Y. Riu, Brian Valladares, Christopher C. Cummins
Summary: In this study, a new class of Azophosphines and N-heterocyclic iminophosphoranes (NHIPs) were successfully synthesized. The NHIPs exhibited tunability of steric demands and good basicity. The facile and scalable synthesis of NHIPs suggests their potential applications in synthetic chemistry.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Keita Tanaka, Martin-Louis Y. Riu, Brian Valladares, Christopher C. Cummins
Summary: This study presents the preparation and cycloaddition reactions of Azophosphines. The results show that these compounds have good adaptability to phosphorus atom substituents and can generate structures similar to cyclic (alkyl)(amino)carbenes. The NHIPs exhibit strong sigma-donor strengths and basicity, and display unique reactivity in certain reactions. The tunability of steric demands and scalability of these compounds suggest that they may have a wide range of applications in synthetic chemistry.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yunquan Man, Xiaojun Zeng, Bo Xu
Summary: We have developed an efficient N-heterocyclic carbene (NHC)-catalyzed thioesterification of aldehydes using N-thiosuccinimides as the thiolation reagent. This method allows easy access to highly functionalized thioesters and demonstrates good chemical yields and functional group tolerance.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Applied
Lakshmikanta Maity, Sahadev Barik, Raju Biswas, Ramalingam Natarajan, Joydev Dinda
Summary: In this study, the synthesis, structures, luminescent properties, and electrochemistry of gold(III)-N-heterocyclic carbene (NHC) complexes with 2,2'-bipyridine (bpy) or 1,10'-phenanthroline (phen) were investigated. The presence of NHC significantly enhanced the emission properties of the complexes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Organic
Mohammed Sharique, Uttam K. Tambar
Summary: Aromatic compounds are commonly used in pharmaceuticals and functional materials, leading to a focus on synthetic methods for constructing highly functionalized aromatic frameworks from acyclic precursors. Transition metal catalysis and base-promoted benzannulation reactions are widely utilized for this purpose. Recently, organocatalytic approaches such as N-heterocyclic carbene catalysis have emerged as efficient tools for the formation of complexly substituted aryl rings under mild reaction conditions.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yulin Han, Anni Qin, Qian Zhang, Xue Zhang, Hui Qian, Shengming Ma
Summary: The Rh-catalyzed reaction allows for the efficient synthesis of cis-fused bicyclic products with excellent selectivity and tolerance towards synthetically useful functional groups. The proposed mechanism involves the rapid racemization of the allene moiety in the starting materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Rahab W. Kamau, Veronica M. Masila, Jacob O. Midiwo, Quintino A. Mgani, Mallika Kumarihamy, Mei Wang, Jianping Zhao, Ilias Muhammad
Summary: A new flavanone-flavonol dimer and 10 known compounds were isolated from the roots of Gnidia apiculata. Four of the known compounds were reported for the first time from the Thymelaeceae plant family. The structures of the isolated compounds were determined using spectroscopic analysis and comparison with literature data. The isolated compounds showed antimicrobial and antiplasmodial activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Balkisu Abdulrahman, Fadime Aydogan, Fazila Zulfiqar, Jianping Zhao, Zulfiqar Ali, Ikhlas A. Khan, Bala Muntari, Bello Oluwasesan
Summary: A targeted investigation of the ethanolic extract of black turtle bean seeds led to the isolation and characterization of five compounds, including a previously undescribed cyclohexane carboxylic acid derivative.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Mechanics
Jinling Zhao, Hongli Ji, Jinhao Qiu, Jianping Zhao, Xiaojuan Xu
Summary: This article evaluates the elastic properties of composites by inverting guided wave velocities and analyzes the sensitivity of ultrasonic waves to stiffness. By developing novel sensitivity kernels, the authors achieve accurate and efficient sensitivity analysis, and further validate the method by identifying elastic properties.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2023)
Article
Chemistry, Multidisciplinary
Yiwen Yuan, Jianping Zhao, Jianfeng Li
Summary: Several five-coordinate high-spin p-toluenethiolate Manganese(II) complexes were successfully synthesized using different ligands, and were characterized in detail by various spectroscopic techniques. The crystal structures exhibited flexible ligands and interactions between the ligands and porphyrin planes. The high-spin states of these complexes were confirmed by EPR, and temperature-dependent EPR and measurement comparisons with different ligand equivalents were conducted.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2023)
Article
Medical Laboratory Technology
Yanjiao Lu, Kum Tang, Shanshan Wang, Zhen Tian, Yan Fan, Boyu Li, Meijia Wang, Jianping Zhao, Jungang Xie
Summary: This study demonstrates that low expression of Dachshund homolog 1 (Dach1) in type II alveolar epithelial cells (AECII) contributes to the progression of pulmonary fibrosis (PF). Dach1 deficiency exacerbates PF in mice, while overexpression of Dach1 alleviates lung damage and fibrosis. Mechanistically, Dach1 represses epithelial apoptosis by binding to the promoter of B-cell lymphoma 2 interacting mediators of cell death (Bim), thus preventing PF development.
TRANSLATIONAL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Hua-Dong Dong, Jian-Ping Zhao, Ming-Xing Peng, Yong -Hui Zhang, Pei -Yuan Xu
Summary: In this study, fusiform ZnO sensitive material was synthesized and its H2 sensing performance was enhanced by loading Au nanoparticles. The material showed good selectivity and long-term stability for H2.
Article
Chemistry, Physical
Jianwei Xi, Elvis Wang Hei Ng, Chun-Yu Ho
Summary: The effects of N-aryl substituents on the configuration and noncovalent interactions of chiral C1 NHCs were studied through Cu-catalyzed borylation. It was found that an inconspicuous N-aryl ortho-H could act as a nonclassical hydrogen bonding site to enhance chiral induction ability. Additionally, a 2,6-unsymmetric substituted N-aryl resulted in improved chiral induction ability and higher reactivity.
Article
Chemistry, Physical
Haiyan Duan, Xu Chen, Yi-Nan Yang, Jianping Zhao, Xiao-Chun Lin, Wen-Jing Tang, Qiang Gao, Guo-Hong Ning, Dan Li
Summary: Despite many efforts in tuning catalytic performance of metal-organic frameworks (MOFs) through modification of MOF nodes, steric tuning of MOF nodes via ligand modification remains challenging. In this study, two two-dimensional Cu(I) cyclic trinuclear unit (Cu-CTU)-based MOFs with similar structures, named JNM-1 and JNM-5, were successfully synthesized. JNM-5 exhibited higher crystallinity, porosity and chemical stability, but lower catalytic activity for hydroboration reactions compared to JNM-1. However, JNM-5 showed higher substrate selectivity and chemo-selectivity for hydroboration of olefins.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Review
Chemistry, Multidisciplinary
Zhifeng Zhang, Yang Chen, Xiao Gu, Chun-Yu Ho
Summary: Well-controlled olefin insertion is crucial for achieving efficient and selective bulk and fine-chemical synthesis. Nickel catalysts, particularly those based on N-heterocyclic carbene (NHC) ligands, have shown great potential in meeting the diverse demands of olefin codimerization and hydrovinylation. These catalysts offer a high level of control and have the ability to unite previously unreactive substrate pairs, leading to the synthesis of complex and structurally diverse compounds.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Construction & Building Technology
Shuxiao Wang, Jianping Zhao, Lixiong Wang, Wenye Hu, Fanfang Yan
Summary: This paper presents a new experimental protocol using a large hemisphere LED screen to study the impact of lighting conditions on circadian behaviors in architectural spaces. Results show that both intrinsic and extrinsic signals regulate pupil size under continuous lighting conditions.
Article
Chemistry, Physical
Tsung-Hsuan Yang, Erik S. Cheng, Samuel M. Johnson, Toshihiko Iwao, Jianping Zhao, John G. Ekerdt, Peter L. G. Ventzek, Gyeong S. Hwang
Summary: Plasma-enhanced atomic layer deposition (PEALD) is a promising technique for controlled growth of silicon nitride (SiNx) thin films. The presence of amines, especially primary amines, plays a key role in dichlorosilane (DCS) decomposition, generating H and Cl atoms as by-products. The by-products can strongly bind to the surface, affecting the SiNx ALD process and decreasing the growth rate.
APPLIED SURFACE SCIENCE
(2023)
Article
Construction & Building Technology
Cailong Ma, Sixuan Wang, Jianping Zhao, Xufeng Xiao, Chenxi Xie, Xinlong Feng
Summary: The purpose of this paper is to develop a data and mechanism co-driven model for predicting the shear strength of reinforced concrete (RC) deep beams. A total of 457 RC deep beams with or without web reinforcements are included in the experimental database, and 9 key input features are determined based on the shear mechanism. Six machine-learning models and five mechanism models are compared, and the XGBoost model outperforms others in terms of prediction accuracy and generalization ability. The interpretability of the XGBoost model is enhanced by combining the Shapley additive explanation (SHAP) approach and the proposed interpretable approach based on the shear mechanism. The proposed interpretable approach is validated qualitatively and quantitatively against other mechanism models, demonstrating its recommendation for similar shear issues of RC members.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Chemistry, Medicinal
Vijayasankar Raman, Yan-Hong Wang, Seethapathy G. G. Saroja, Jianping Zhao, Jane Manfron, Bharathi Avula, Amar G. G. Chittiboyina, Ikhlas A. A. Khan
Summary: This study provides an orthogonal approach to differentiate the dream herb from non-bitter calea using three independent methodologies. Detailed morpho-anatomical and histochemical characterizations of the two species were established, along with the identification of chemical compounds present. The study results would aid in authentication of botanical raw materials and quality control of Calea ternifolia-based products.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Gastroenterology & Hepatology
Yuan-Xiang Lu, Jian-Ping Zhao, Guan-Dou Yuan, Ming-Gen Hu, Chuan-Dong Sun, Kun-Lun Chen, Yao Chen, Yong-Yi Zeng, Zhi-Ying Yang, Wan-Guang Zhang
Summary: This study aimed to investigate the prevalence, patterns, risk factors, and outcomes of peritoneal metastases (PM) in hepatocellular carcinoma (HCC) patients after curative laparoscopic hepatectomy (LH). The results showed that LH was not associated with increased incidence of PM in HCC patients for experienced surgeons, and surgical re-excision of PM was associated with prolonged survival.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Letter
Medicine, General & Internal
Zhenan Deng, Meiling Jin, Changxing Ou, Wei Jiang, Jianping Zhao, Xiaoxia Liu, Shenghua Sun, Huaping Tang, Bei He, Shaoxi Cai, Ping Chen, Penghui Wu, Yujing Liu, Jian Kang, Yunhui Zhang, Mao Huang, Jinfu Xu, Kewu Huang, Qiang Li, Xiangyan Zhang, Xiuhua Fu, Changzheng Wang, Huahao Shen, Lei Zhu, Guochao Shi, Zhongmin Qiu, Zhongguang Wen, Xiaoyang Wei, Wei Gu, Chunhua Wei, Guangfa Wang, Lixin Xie, Jiangtao Lin, Yuling Tang, Zhihai Han, Kian Fan Chung, Qingling Zhang, Nanshan Zhong
CHINESE MEDICAL JOURNAL
(2023)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
