Different phenotypic consequences of simultaneous versus stepwise Apc loss

APC +/- alters colonic fibroblast proteome in FAP

(2015) Bhavinkumar B. Patel et al.   Oncotarget

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

Altered Dynamics of Intestinal Cell Maturation in Apc1638N/+ Mice

(2010) D. Wang et al.   CANCER RESEARCH

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue

(2010) Aaron J. Quyn et al.   Cell Stem Cell

Pharmacotherapy for inherited colorectal cancer

(2010) Patrick M Lynch   EXPERT OPINION ON PHARMACOTHERAPY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

A mathematical framework to determine the temporal sequence of somatic genetic events in cancer

(2010) Camille Stephan-Otto Attolini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

(2010) K. E. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

(2010) C. Lopez-Garcia et al.   SCIENCE

Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo

(2010) Michael Buchert et al.   PLoS Genetics

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

(2009) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

One-Hit Effects in Cancer: Altered Proteome of Morphologically Normal Colon Crypts in Familial Adenomatous Polyposis

(2008) A. T. Yeung et al.   CANCER RESEARCH

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Generating somatic mosaicism with a Cre recombinase–microsatellite sequence transgene

(2008) Aytekin Akyol et al.   NATURE METHODS

Tractable Cre-lox system for stochastic alteration of genes in mice

(2008) Ashleigh J Miller et al.   NATURE METHODS