CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity

(2010) Elisabet Ognedal Berge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron

(2010) W. C. Reinhold et al.   CANCER RESEARCH

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

(2010) Hiroyuki Niida et al.   EMBO JOURNAL

Genome-Wide mRNA and microRNA Profiling of the NCI 60 Cell-Line Screen and Comparison of FdUMP[10] with Fluorouracil, Floxuridine, and Topoisomerase 1 Poisons

(2010) W. H. Gmeiner et al.   MOLECULAR CANCER THERAPEUTICS

Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines

(2010) S. L. Holbeck et al.   MOLECULAR CANCER THERAPEUTICS

The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

(2010) Ailine Stolz et al.   NATURE CELL BIOLOGY

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

(2010) J Bartkova et al.   ONCOGENE

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid  -amide]

(2009) A. G. Jobson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features

(2009) Dong Sun Kim et al.   LUNG CANCER

Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

(2009) T. D. Pfister et al.   MOLECULAR CANCER THERAPEUTICS

Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase

(2008) Hong Zhao et al.   CYTOMETRY PART A

Chk2 Oligomerization Studied by Phosphopeptide Ligation

(2008) Jiejin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways

(2008) S. Solier et al.   MOLECULAR AND CELLULAR BIOLOGY

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

(2008) E M Bahassi et al.   ONCOGENE