Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease

(2009) S. Inoue et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction

(2009) Tsutomu Chiba et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

(2009) Nidhi Bhutani et al.   NATURE

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers

(2008) Yoko Endo et al.   GASTROENTEROLOGY

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

(2008) Simon J. Leedham et al.   GASTROENTEROLOGY

Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma

(2008) Junji Komori et al.   HEPATOLOGY

Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression

(2008) Toshiyuki Morisawa et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

(2008) A Takai et al.   ONCOGENE