Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy

Long-term study of indolent adult T-cell leukemia-lymphoma

(2010) Y. Takasaki et al.   BLOOD

Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells

(2010) A. Y. Swaims et al.   BLOOD

Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma

(2010) T. Ishii et al.   CLINICAL CANCER RESEARCH

Identification of Small Molecules That Suppress MicroRNA Function and Reverse Tumorigenesis

(2010) Koichi Watashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

(2010) S. Mehdi Belgnaoui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes

(2010) Ali Bazarbachi et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma

(2010) Kazuhito Yamamoto et al.   JOURNAL OF CLINICAL ONCOLOGY

Human T-Lymphotropic Virus Type 1-Induced CC Chemokine Ligand 22 Maintains a High Frequency of Functional FoxP3+ Regulatory T Cells

(2010) F. Toulza et al.   JOURNAL OF IMMUNOLOGY

Induction of Reactive Oxygen Species by Human T-Cell Leukemia Virus Type 1 Tax Correlates with DNA Damage and Expression of Cellular Senescence Marker

(2010) T. Kinjo et al.   JOURNAL OF VIROLOGY

Compromised Spindle Assembly Checkpoint due to Altered Expression of Ubch10 and Cdc20 in Human Papillomavirus Type 16 E6- and E7-Expressing Keratinocytes

(2010) D. Patel et al.   JOURNAL OF VIROLOGY

Role of microRNAs in HTLV-1 infection and transformation

(2010) Katia Ruggero et al.   MOLECULAR ASPECTS OF MEDICINE

Heterochromatin silencing of p53 target genes by a small viral protein

(2010) Conrado Soria et al.   NATURE

Hematopoietic stem cells and retroviral infection

(2010) Prabal Banerjee et al.   Retrovirology

Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo

(2010) Linda Zane et al.   Retrovirology

Quantitative Comparison of HTLV-1 and HIV-1 Cell-to-Cell Infection with New Replication Dependent Vectors

(2010) Dmitriy Mazurov et al.   PLoS Pathogens

The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation

(2009) Soo-Jin Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia

(2009) M. Bellon et al.   BLOOD

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse

(2009) M. Nejmeddine et al.   BLOOD

HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165

(2009) S. Lambert et al.   BLOOD

Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability

(2009) Shih-Hsuan Pan et al.   CARCINOGENESIS

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression

(2009) Arne Lindqvist et al.   EMBO JOURNAL

Viral transformation and aneuploidy

(2009) Junichiro Yasunaga et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF- B

(2009) J.-M. Peloponese et al.   JOURNAL OF VIROLOGY

Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses

(2009) Ana-Monica Pais-Correia et al.   NATURE MEDICINE

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species

(2009) B. Gruhne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

(2009) Mineki Saito et al.   Retrovirology

The HBZ gene, a key player in HTLV-1 pathogenesis

(2009) Masao Matsuoka et al.   Retrovirology

Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2

(2009) Toshiyuki Shoji et al.   Retrovirology

T-cell activation promotes tumorigenesis in inflammation-associated cancer

(2009) Dan Rauch et al.   Retrovirology

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis

(2009) Masaya Higuchi et al.   Retrovirology

Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-κB pathway

(2009) Julie Lodewick et al.   VIROLOGY

Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma: Impact of Antithymocyte Globulin on Clinical Outcome

(2008) Ryuji Tanosaki et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation

(2008) J. Arnold et al.   BLOOD

Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF- B

(2008) T. Zhao et al.   BLOOD

Roles for MicroRNAs, miR-93 and miR-130b, and Tumor Protein 53–Induced Nuclear Protein 1 Tumor Suppressor in Cell Growth Dysregulation by Human T-Cell Lymphotrophic Virus 1

(2008) Man Lung Yeung et al.   CANCER RESEARCH

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation

(2008) Hidekatsu Iha et al.   EMBO JOURNAL

HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase

(2008) Sarah S. Durkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding

(2008) J. Hein et al.   JOURNAL OF VIROLOGY

Transcriptional Control of Spliced and Unspliced Human T-Cell Leukemia Virus Type 1 bZIP Factor (HBZ) Gene

(2008) M. Yoshida et al.   JOURNAL OF VIROLOGY

Human T-Cell Leukemia Virus Type 1 Tax Attenuates the ATM-Mediated Cellular DNA Damage Response

(2008) C. Chandhasin et al.   JOURNAL OF VIROLOGY

Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells

(2008) Kathryn S Jones et al.   NATURE MEDICINE

Human T-Lymphotropic Virus-1 Visualized at the Virological Synapse by Electron Tomography

(2008) Endre Majorovits et al.   PLoS One

How HTLV-1 may subvert miRNAs for persistence and transformation

(2008) Amel B Bouzar et al.   Retrovirology

MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes

(2008) Klemens Pichler et al.   Retrovirology

Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome

(2008) Emad Ramadan et al.   Retrovirology

The HTLV-1 Tax interactome

(2008) Mathieu Boxus et al.   Retrovirology

Human T-Cell Lymphotropic Virus Type 1 Infection of CD34+Hematopoietic Progenitor Cells Induces Cell Cycle Arrest by Modulation of p21cip1/waf1and Survivin

(2008) Prabal Banerjee et al.   STEM CELLS

High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response

(2007) F. Toulza et al.   BLOOD

PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells

(2007) Soo-Jin Jeong et al.   VIROLOGY