Review
Gastroenterology & Hepatology
May San Martinho, Derek J. Nancarrow, Theodore S. Lawrence, David G. Beer, Dipankar Ray
Summary: The incidence of esophageal adenocarcinoma and other gastrointestinal cancers is rising, emphasizing the need to identify oncogenic drivers to develop effective therapies. Targeting molecular chaperones that mediate mutant p53 stability may prove to be an effective strategy in improving cancer outcomes. Targeting the interaction of mutant p53 with E3 ubiquitin ligase isoforms like GRAIL could help mitigate esophageal adenocarcinoma development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel Kalb, Huy D. Vo, Samantha Adikari, Elizabeth Hong-Geller, Brian Munsky, James Werner
Summary: IL-1 beta and TNF-alpha are canonical immune response mediators that play key regulatory roles in various inflammatory responses. Using single-cell mRNA analysis, we found that U0126 and MG132 can successfully block the expression of these genes, indicating the potential for targeted drug interventions in immune responses.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Edgar Uhl, Friederike Wolff, Sriyash Mangal, Henry Dube, Esther Zanin
Summary: The research reveals that the versatile proteasome inhibitor MG132, inactivated with a photolabile protection group, can be restored with blue light irradiation, causing cancer cells to arrest during metaphase of the cell cycle or undergo apoptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Vasudha Tandon, Rita Moreno, Kira Allmeroth, Jean Quinn, Sandra E. Wiley, Lynden G. Nicely, Martin S. Denzel, Joanne Edwards, Laureano de la Vega, Sourav Banerjee
Summary: Preserving proteostasis is a crucial survival mechanism for cancer, and targeting the kinase DYRK2 and its substrate HSF1 can induce apoptosis faster than individual targeting. This study suggests that cotargeting DYRK2 and HSF1 could be a promising strategy in suppressing cancer.
BIOSCIENCE REPORTS
(2023)
Review
Endocrinology & Metabolism
Giuseppe Fanciulli, Roberta Modica, Anna La Salvia, Erika Maria Grossrubatscher, Tullio Florio, Francesco Ferrau, Alessandro Veresani, Flaminia Russo, Annamaria Colao, Antongiulio Faggiano
Summary: This study aims to summarize the role of proteasome inhibitors (PrIn) in medullary thyroid cancer (MTC) based on in vitro and in vivo data. The results revealed a discrepancy between preclinical studies and clinical trials, suggesting the need for more accurate clinical trials to determine the effectiveness of PrIn in MTC treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Waqas Azeem, Jan Roger Olsen, Margrete Reime Hellem, Yaping Hua, Kristo Marvyin, Xisong Ke, Anne Margrete oyan, Karl-Henning Kalland
Summary: This study investigated the role of GATA2 in prostate epithelial cells and found that exogenous GATA2 protein was rapidly degraded and its expression could be rescued by proteasome inhibitors. The inhibition of proteasome also induced the transcription of AR mRNA and luminal marker genes in prostate cells. Different intrinsic mechanisms restricted the expression of GATA2 in these cells. These findings suggest the existence of crucial cofactors for AR mRNA expression and luminal differentiation at the proteolytic level.
Article
Biochemistry & Molecular Biology
Shuji Ueda, Moeka Nishihara, Yuuki Hioka, Ken-ichi Yoshino, Soichiro Yamada, Minoru Yamanoue, Yasuhito Shirai
Summary: Protein homeostasis, including folding, refolding, and degradation, is believed to decline with aging. HSPB5 acts as a molecular chaperone and prevents protein aggregation. In this study, we discovered a new binding protein for HSPB5 called PLK2, which is involved in apoptosis. PLK2 was upregulated in cells treated with MG132 and co-localized with HSPB5 near the ER. Inhibition of PLK2 increased apoptosis and decreased ER stress-induced phosphorylation of HSPB5. These findings suggest the importance of HSPB5 phosphorylation during ER stress and highlight the essential role of the PLK2/HSPB5 pathway in cytoprotection against proteasome inhibition-induced ER stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Dipti Kanabar, Mimansa Goyal, Emma Kane, Tejashri Chavan, Abbas Kabir, Xuechun Wang, Snehal Shukla, Joseph Almasri, Sona Goswami, Gizem Osman, Marino Kokolis, Donald E. Spratt, Vivek Gupta, Aaron Muth
Summary: This study reports the structure-based design of small molecules that can bind to Gankyrin and inhibit its overexpression in breast and lung cancers, showing potential therapeutic value.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Plant Sciences
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He
Summary: As global warming intensifies, the earth's average temperature continues to rise. Plants have developed two main mechanisms, the heat stress response and the thermomorphogenesis response, to cope with elevated temperatures. This review summarizes recent progress in understanding these heat-responsive molecular regulatory pathways in plants and discusses future perspectives in this field.
Review
Plant Sciences
Yeeun Kang, Kwanuk Lee, Ken Hoshikawa, Myeongyong Kang, Seonghoe Jang
Summary: The effects of climate change, such as increased global temperatures and abnormal weather events, are causing concerns for plant vegetation and crop productivity. This review focuses on the molecular processes of plants in response to heat stress, with emphasis on the classification and functions of heat shock proteins. Developing vegetable crops with enhanced thermotolerance using genetic tools is crucial to alleviate the adverse effects of heat stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L. Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Summary: Induction of a heat shock-related stress response mediated by Foldlin reduces the levels of misfolded/aggregated mutant p53 and prevents the formation of stress-induced p53 nuclear inclusion bodies. The proteasome inhibitor Bortezomib has similar cellular effects as Foldlin. Induction of a cellular heat shock response seems to be an effective strategy to deal with pathological protein aggregation.
Review
Pharmacology & Pharmacy
Paula Moyano, Emma Sola, Maria Victoria Naval, Lucia Guerra-Menendez, Maria De la Cabeza Fernandez, Javier del Pino
Summary: The amount and diversity of environmental pollutants (EPs) have increased due to human activities, and several neurodegenerative diseases (NDs) are believed to be related to EPs exposure. EPs induce neurotoxic effects, including the accumulation of misfolded toxic proteins, leading to neuronal dysfunction and cell death. Heat shock proteins (HSPs) and the proteasome system are involved in the elimination of these toxic proteins, but exposure to EPs can disrupt their function. Therapeutic approaches involving recombinant HSPs/proteasome or compounds that increase their expression or activity have been proposed. This article reviews the current literature on NDs related to EP exposure and their relationship with proteasome system and HSPs dysfunction, as well as discusses the toxic effects and contradictory findings. It also covers the therapeutic use of drugs and recombinant proteasome/HSPs to eliminate toxic proteins and prevent/treat EP-induced neurodegeneration.
Review
Biochemistry & Molecular Biology
Ayush Ranawade, Rati Sharma, Erel Levine
Summary: The Heat Shock Response (HSR) is a conserved genetic system that protects the proteome in organisms. Mathematical modeling has been crucial in understanding its regulation, but there are still many unanswered questions that can benefit from quantitative modeling.
Review
Physiology
Sebastian Koetter, Martina Krueger
Summary: This review explores the composition of the sarcomere, the smallest molecular unit of muscle contraction and relaxation, and focuses on the role of the sarcomere protein titin and its relationship with protein quality control. It summarizes the current state of research on titin turnover and discusses the involvement of various intracellular degradation mechanisms. Additionally, it examines how perturbations in protein quality control can affect sarcomeric proteins, particularly titin, in different disease states.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Agronomy
Hsien-Tzu Wang, Yu-Jung Cheng, Jhih-Ting Hsiao, Fuu Sheu, Yen-Chou Kuan
Summary: This study investigated the expression of broccoli HSP and the effect of 17-AAG on broccoli senescence. Through RNA-sequencing, 11 HSP and related genes were identified, with 10 nM 17-AAG treatment significantly alleviating yellowing of broccoli and enhancing stress tolerance. This research highlights the potential of using HSP inducers like 17-AAG to improve shelf life and quality of postharvest crops.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Cell Biology
Floriane Nicol-Benoit, Pascale le Goff, Denis Michel
BIOLOGY OF THE CELL
(2013)
Article
Biophysics
Floriane Nicol-Benoit, Axelle Amon, Colette Vaillant, Pascale le Goff, Yves le Drean, Farzad Pakdel, Gilles Flouriot, Yves Valotaire, Denis Michel
BIOPHYSICAL JOURNAL
(2011)
Review
Biochemistry & Molecular Biology
Floriane Nicol-Benoit, Pascale Le-Goff, Yves Le-Drean, Florence Demay, Farzad Pakdel, Gilles Flouriot, Denis Michel
CELLULAR AND MOLECULAR LIFE SCIENCES
(2012)
Article
Multidisciplinary Sciences
Sylvain Lecomte, Lea Reverdy, Catherine Le Quement, Florent Le Masson, Axelle Amon, Pascale Le Goff, Denis Michel, Elisabeth Christians, Yves Le Drean
Article
Biochemistry & Molecular Biology
Charly Jehanno, Tamara Fernandez-Calero, Denis Habauzit, Stephane Avner, Frederic Percevault, Emmanuelle Jullion, Pascale Le Goff, Marie May Coissieux, Simone Muenst, Monica Marin, Denis Michel, Raphael Metivier, Gilles Flouriot
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2020)
Article
Biochemistry & Molecular Biology
Gilles Flouriot, Charly Jehanno, Yann Le Page, Pascale Le Goff, Benjamin Boutin, Denis Michel
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Lea Clusan, Pascale Le Goff, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer is the most common cancer among women worldwide. While most ER-positive breast cancer cases initially respond to antiestrogen therapies, a high percentage develop resistance over time. Research on mutated forms of ER alpha has led to potential developments in new antiestrogen treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Charly Jehanno, Gilles Flouriot, Pascale Le Goff, Denis Michel
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2017)
Article
Cell Biology
Philippe Nizard, Susanne Tetley, Yves Le Drean, Tanguy Watrin, Pascale Le Goff, Mark R. Wilson, Denis Michel
Article
Biochemistry & Molecular Biology
F Loison, L Debure, P Nizard, P Le Goff, D Michel, Y Le Dréan
BIOCHEMICAL JOURNAL
(2006)
Article
Biotechnology & Applied Microbiology
F Loison, P Nizard, T Sourisseau, P Le Goff, L Debure, Y Le Drean, D Michel
Article
Oncology
P Le Goff, Y Le Dréan, C Le Péron, C Le Jossic-Corcos, A Ainouche, D Michel
EXPERIMENTAL CELL RESEARCH
(2004)
Article
Endocrinology & Metabolism
Y Le Drean, N Mincheneau, P Le Goff, D Michel
Article
Marine & Freshwater Biology
T Madigou, P Le Goff, G Salbert, JP Cravedi, H Segner, F Pakdel, Y Valotaire
AQUATIC TOXICOLOGY
(2001)