Article
Multidisciplinary Sciences
Moke Liu, Luna Liu, Honglin Guo, Xiude Fan, Tianbao Liu, Chao Xu, Zhao He, Yongfeng Song, Ling Gao, Shanshan Shao, Jiajun Zhao, Peng Lu
Summary: In this study, a mouse model carrying the HNF1a P291fsinsC mutation was established, and it was found that this mutation led to liver steatosis. Further analysis revealed changes in innate immune response and lipid metabolism pathways. The study also showed that HNF1a inhibited the expression of CFD in hepatocytes, and that CFD regulated hepatocyte lipid deposition.
Article
Biochemistry & Molecular Biology
Alex J. McCann, Jieqiong Lou, Mehdi Moustaqil, Matthew S. Graus, Ailisa Blum, Frank Fontaine, Hui Liu, Winnie Luu, Paulina Rudolffi-Soto, Peter Koopman, Emma Sierecki, Yann Gambin, Frederic A. Meunier, Zhe Liu, Elizabeth Hinde, Mathias Francois
Summary: The study reveals that the mutant SOX18(RaOp) disrupts the system through molecular interferences, impairing the functions of wild-type SOX18 protein, and amplifying the dominant-negative effect by poisoning the interactome of its wild-type counterpart.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Immunology
Zebing Song, Xiaodong Song, Hang Li, Zongbing Cheng, Zengyi Mo, Xuewei Yang
Summary: This study identified and validated a mutant gene, DNAH5, which was negatively correlated with the prognosis of HCC patients and could serve as an independent prognostic factor for HCC. The mutant gene DNAH5 also showed potential as a new immunotherapy target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tong Lin, E. Zhang, Pei-pei Mai, Ying-zhao Zhang, Xiang Chen, Li-sheng Peng
Summary: This study revealed that CXCL2/10/12/14 may predict outcomes of HCC patients and are closely related to the immune microenvironment in HCC. Enhancing effective immunity surveillance through intervening in these CXCLs could be a prospective therapeutic strategy for HCC.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
M. Mazzoni, K. Todoerti, L. Agnelli, E. Minna, S. Pagliardini, T. Di Marco, M. G. Borrello, A. Neri, A. Greco
Summary: This study aimed to further understand the regulatory factors of TIMP3 tumor suppressor function in papillary thyroid cancer (PTC). The analysis of genes related to TIMP3 expression revealed an association between TIMP3 expression levels and the regulation of inflammatory functions and immune cell infiltration composition, providing a broader view on the oncosuppressor role of TIMP3 in PTC.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Eric L. Bolf, Noelle E. Gillis, Cole D. Davidson, Lauren M. Cozzens, Sophie Kogut, Jennifer A. Tomczak, Seth Frietze, Frances E. Carr
Summary: This study found that restoring TR beta expression in breast cancer cells resulted in more epithelial cell characteristics, reduced expression of mesenchymal cytokeratins, and decreased epithelial to mesenchymal transition pathway activity. Additionally, comparison with thyroid cancer cells revealed shared gene regulation by TR beta in pathways such as lipid metabolism and chromatin remodeling.
MOLECULAR CARCINOGENESIS
(2021)
Article
Medicine, General & Internal
Zhen-xing Yu, Cheng Xiang, Sheng-gui Xu, Yang-ping Zhang
Summary: This study evaluated the clinical significance of thyroid hormone-responsive protein (THRSP) in thyroid carcinoma (THCA) and explored its relevant pathways. The findings showed that THRSP gene expression was significantly increased in THCA and high expression was associated with better overall survival. THRSP expression was also related to stage, histological subtype, and methylation in THCA patients. The study further identified metabolic pathways as being positively related to THRSP. These results suggest that THRSP may play a role in inhibiting THCA progression through regulation of metabolic pathways.
Article
Biochemistry & Molecular Biology
Qing Zhu, Yarui Ma, Junbo Liang, Zhewen Wei, Mo Li, Ying Zhang, Mei Liu, Huan He, Chunfeng Qu, Jianqiang Cai, Xiaobing Wang, Yixin Zeng, Yuchen Jiao
Summary: The study found that the aryl hydrocarbon receptor (AHR) plays a crucial role in the toxicity of AFB1-associated HCC, and suggests that anti-PD-L1 therapy may be a therapeutic option for AFB1-related HCC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Lisa Wu, Stephen Xu, Brian Yang, Jenny Yang, Claire Yee, Nicola Cirillo
Summary: The study found evidence of the effects of HPT components on oral cancer cells through literature search. However, there is limited research on the production of HPT axis components by oral tissues. Therefore, the possible role of the local HPT axis equivalent in the oral mucosa remains to be further analyzed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Yingxin Fang, Tingting Liu, Huimin Hou, Zhihong Wang, Zhongyan Shan, Yanli Cao, Xiaochun Teng
Summary: Resistance to thyroid hormone beta (RTHb) is a rare hereditary disorder that is difficult to diagnose. Recent studies have suggested a connection between THRB mutations and human cancers. This study reports two cases of RTHb coexisting with papillary thyroid carcinoma (PTC), and follow-up results show no recurrence of cancer.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Ekaterina V. Borisova, Yuliya A. Evstratova, Andrew G. Newman, Vera P. Kuldaeva, Maria S. Gavrish, Elena V. Kondakova, Victor S. Tarabykin, Alexey A. Babaev, Egor A. Turovsky
Summary: Epilepsy is a common neurological disease that affects both adults and infants. Recent research suggests that genetic and epigenetic factors play an important role in epileptogenesis. This article presents a newly generated mouse model of epilepsy using gene knockout and mutagenesis methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
J. Hadoux, R. Elisei, M. S. Brose, A. O. Hoff, B. G. Robinson, M. Gao, B. Jarzab, P. Isaev, K. Kopeckova, J. Wadsley, D. Fuehrer, B. Keam, S. Bardet, E. J. Sherman, M. Tahara, M. I. Hu, R. Singh, Y. Lin, V Soldatenkova, J. Wright, B. Lin, P. Maeda, J. Capdevila, L. J. Wirth
Summary: This study compared the efficacy of Selpercatinib with cabozantinib or vandetanib as first-line therapy in patients with RET-mutant medullary thyroid cancer. The results showed that Selpercatinib treatment resulted in superior progression-free survival, treatment failure-free survival, and overall response rate.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, Research & Experimental
Chuanrui Xu, Zhong Xu, Yi Zhang, Matthias Evert, Diego F. Calvisi, Xin Chen
Summary: Deregulated Wnt/β-catenin signaling is a major genetic alteration in hepatocellular carcinoma (HCC), and its activation plays an oncogenic role in hepatocarcinogenesis. The activated pathway is associated with specific gene expression patterns and pathological features, and it synergizes with other signaling cascades to promote HCC formation. Therefore, understanding and targeting this pathway has important implications for the diagnosis, classification, and personalized treatment of HCC.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Larissa Valdemarin Bim, Thaise Nayane Ribeiro Carneiro, Vanessa Candiotti Buzatto, Gabriel Avelar Colozza-Gama, Fernanda C. Koyama, Debora Mota Dias Thomaz, Ana Carolina de Jesus Paniza, Eunjung Alice Lee, Pedro Alexandre Favoretto Galante, Janete Maria Cerutti
Summary: Thyroid cancer is the most common endocrine malignancy, but cytological diagnosis of certain malignant thyroid tumors and their benign counterparts poses a challenge for preoperative diagnosis. This study identified novel gene variants through RNA-sequencing of driver-negative samples and described distinct expression signatures in these samples.
Article
Endocrinology & Metabolism
Wenliang Yue, Yong Zhang
Summary: Ct-negative medullary thyroid carcinoma is a rare neuroendocrine tumor with low likelihood of lymph node metastasis. Unilateral lobectomy may provide a beneficial chance of excellent treatment response.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Meeting Abstract
Oncology
Jeffrey R. Infante, Aung Naing, Kyriakos P. Papadopoulos, Karen A. Autio, Patrick A. Ott, Deborah J. Wong, Gerald S. Falchook, Manish Patel, Shubham Pant, Melinda Whiteside, John B. Mumm, Ivan H. Chan, Johanna C. Bendell, Todd M. Bauer, Filip Janku, Milind Javle, Rivka R. Colen, Nizar M. Tannir, Martin Oft
Article
Oncology
Aung Naing, Kyriakos P. Papadopoulos, Karen A. Autio, Patrick A. Ott, Manish R. Patel, Deborah J. Wong, Gerald S. Falchook, Shubham Pant, Melinda Whiteside, Drew R. Rasco, John B. Mumm, Ivan H. Chan, Johanna C. Bendell, Todd M. Bauer, Rivka R. Colen, David S. Hong, Peter Van Vlasselaer, Nizar M. Tannir, Martin Oft, Jeffrey R. Infante
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Meeting Abstract
Oncology
Aung Naing, Jeffrey R. Infante, Kyriakos P. Papadopoulos, Deborah J. Wong, Karen A. Autio, Gerald S. Falchook, Manish Patel, Shubham Pant, Amita Patnaik, Melinda Whiteside, Johanna C. Bendell, John Mumm, Ivan H. Chan, Gail L. Brown, Peter VanVlasselaer, J. R. Hecht, David S. Hong, Nizar M. Tannir, Martin Oft
CANCER IMMUNOLOGY RESEARCH
(2016)
Article
Oncology
Ivan H. Chan, Victoria Wu, Melissa Bilardello, Brett Jorgenson, Harminder Bal, Scott McCauley, Peter Van Vlasselaer, John B. Mumm
Meeting Abstract
Oncology
Ivan H. Chan, Ming-Hong Xie, Andrew Lam, Fumiko T. Axelrod, Jennifer Elechko, Angie I. Park, Austin Gurney
Article
Multidisciplinary Sciences
Ivan H. Chan, Dennis Van Hoof, Marina Abramova, Melissa Bilardello, Elliot Mar, Brett Jorgensen, Scott McCauley, Harminder Bal, Martin Oft, Peter Van Vlasselaer, John B. Mumm
Article
Oncology
Aung Naing, Jeffrey R. Infante, Kyriakos P. Papadopoulos, Ivan H. Chan, Cong Shen, Navneet P. Ratti, Bianca Rojo, Karen A. Autio, Deborah J. Wong, Manish R. Patel, Patrick A. Ott, Gerald S. Falchook, Shubham Pant, Annie Hung, Kara L. Pekarek, Victoria Wu, Matthew Adamow, Scott McCauley, John B. Mumm, Phillip Wong, Peter Van Vlasselaer, Joseph Leveque, Nizar M. Tannir, Martin Oft
Meeting Abstract
Oncology
Chao Guo, Yanying Fan, Alexander Aronov, Qi Zhang, Sombeet Sahu, Mary-Lee Dequeant, Changan Guo, Sushant Karnik, Glenn D. Leary, Chandirasegaran Massilamany, Ivan H. Chan, James B. Trager
Meeting Abstract
Oncology
Chao Guo, Yanying Fan, Alexander Aronov, Qi Zhang, Sombeet Sahu, Mary-Lee Dequeant, Changan Guo, Sushant Karnik, Glenn D. Leary, Chandirasegaran Massilamany, Ivan H. Chan, James B. Trager
Meeting Abstract
Oncology
Chao Guo, Ivan H. Chan, Luxuan Buren, Yanying Fan, Alexander Aronov, James B. Trager
Meeting Abstract
Oncology
Guangnan Li, Xiumin Wu, Ivan H. Chan, James B. Trager
Meeting Abstract
Oncology
Luxuan G. Buren, Chao Guo, Yanying Fan, Alexander Aronov, Xiumin Wu, Daofeng Liu, Ming-Hong Xie, Sasha Lazetic, Ivan H. Chan, James B. Trager
CANCER IMMUNOLOGY RESEARCH
(2020)
Meeting Abstract
Oncology
Martin Oft, Aung Naing, Jeffrey R. Infante, Kyriakos P. Papadopoulos, Ivan H. Chan, Cong Shen, Navneet P. Ratti, Karen A. Autio, Deborah J. Wong, Manish R. Patel, Patrick A. Ott, Gerald S. Falchook, Shubham Pant, Annie Hung, John B. Mumm, Matthew Adamow, Scott McCauley, Rakesh Verma, Phillip Wong, Peter VanVlasselaer, Joseph Leveque, Nizar M. Tannir
CANCER IMMUNOLOGY RESEARCH
(2019)
Meeting Abstract
Oncology
Aung Naing, Kyriakos P. Papadopoulos, Jeffrey R. Infante, Deborah Jean Lee Wong, Karen A. Autio, Patrick Alexander Ott, Gerald Steven Falchook, Manish R. Patel, Shubham Pant, Amita Patnaik, John B. Mumm, Melinda Whiteside, Ivan H. Chan, Johanna C. Bendell, Todd Michael Bauer, Filip Janku, Rivka R. Colen, Nizar M. Tannir, Peter Van Vlasselaer, Martin Oft
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Meeting Abstract
Oncology
Kyriakos P. Papadopoulos, Aung Naing, Jeffrey R. Infante, Karen A. Autio, Patrick Alexander Ott, Deborah Jean Lee Wong, Gerald Steven Falchook, Manish R. Patel, Shubham Pant, Melinda Whiteside, John B. Mumm, Ivan H. Chan, Johanna C. Bendell, Drew W. Rasco, Kent C. Shih, Milind M. Javle, Todd Michael Bauer, Rivka R. Colen, Peter Van Vlasselaer, Martin Oft
JOURNAL OF CLINICAL ONCOLOGY
(2016)