Article
Biochemistry & Molecular Biology
May Wathone Oo, Hotaka Kawai, Htoo Shwe Eain, Yamin Soe, Kiyofumi Takabatake, Sho Sanou, Qiusheng Shan, Yasunori Inada, Masae Fujii, Yoko Fukuhara, Ziyi Wang, Shintaro Sukegawa, Mitsuaki Ono, Keisuke Nakano, Hitoshi Nagatsuka
Summary: Tumor angiogenesis is an important process in solid tumor development. This study investigates the impact of oral squamous cell carcinoma (OSCC) stromal cells on tumor vascularization and finds that the expression of extracellular superoxide dismutase (SOD3) in stromal cells may potentially regulate the tumor vascularization mechanism in OSCC.
Article
Biochemistry & Molecular Biology
Russell Moser, Kay E. Gurley, Olga Nikolova, Guangrong Qin, Rashmi Joshi, Eduardo Mendez, Ilya Shmulevich, Amanda Ashley, Carla Grandori, Christopher J. Kemp
Summary: The study identified targetable dependencies in cancers carrying mutations in Ras and p53, and revealed differences in functional kinome profiles between Ras mutant cell lines, indicating rewiring of survival pathways caused by co-mutations.
Review
Immunology
Vahide Saeidi, Nicole Doudican, John A. Carucci
Summary: Primary cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with a rising incidence of about 1.8 million in the United States annually. Surgery is usually curative, but in some cases, cSCC can metastasize and result in death. The introduction of checkpoint inhibitor immunotherapy has significantly improved treatment outcomes for advanced or metastatic cSCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Manuela Santarosa, Roberta Maestro
Summary: The loss of epithelial integrity and the role of autophagy in cancer progression, particularly in the context of dysregulation of cell adhesion molecules like E-cadherin, are crucial factors. Cell adhesion and EMT play significant roles in the transition process of cancer, while autophagy may have dual effects on tumor progression, acting as both a suppressor and a promoter through mechanisms like EMT and drug resistance.
Article
Oncology
Zhenning Li, Lixia Zhang, Fa-yu Liu, Peng Li, Jing He, Cameron L. Kirkwood, Jiho Sohn, Jon M. Chan, William J. Magner, Keith L. Kirkwood
Summary: The study showed that the expression of MKP-1 in oral squamous cell carcinoma is inversely related to oral cancer burden and nodal involvement, and the role of MKP-1 signaling in tumor associated macrophages (TAMs) was assessed in murine models of OSCC. The results indicated that myeloid-based Dusp1 deficiency increases OSCC burden and metastasis through alteration in TAM recruitment, gene profile, and polarity.
Article
Chemistry, Medicinal
Guya Diletta Marconi, Ylenia Della Rocca, Luigia Fonticoli, Francesco Melfi, Thangavelu Soundara Rajan, Simone Carradori, Jacopo Pizzicannella, Oriana Trubiani, Francesca Diomede
Summary: The study aims to evaluate the role of c-Myc in the pathogenesis of oral squamous cell carcinoma (OSCC). The results show the vital role of c-Myc in tumor growth and cell survival/proliferation, along with the inhibitory effect of Doxorubicin (Doxo) on c-Myc signaling pathway.
Article
Pathology
Yanru Yang, Saijie Zuo, Wenqing Li, Man Di, Jin Liu, Jia Chai, Jingjing Wang, Yuan Yuan, Mingyang Li, Qingge Jia
Summary: TRIM21 is highly expressed in cervical squamous cell carcinoma (CESC) tissues compared with paracancerous tissues. The overexpression of TRIM21 promotes cell proliferation, migration, invasion, and stemness, while knockdown of TRIM21 inhibits tumor cell activities in CESC. Furthermore, TRIM21 expression levels are associated with individual prognostic factors and may serve as a poor predictor of prognosis for CESC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Chengzhi Xu, Yunbin Zhang, Yupeng Shen, Yong Shi, Ming Zhang, Liang Zhou
Summary: This study identified ENDOU as a biomarker with prognostic significance in HNSCC progression. Overexpression of ENDOU inhibited proliferation and migration of FaDu and Cal-27 cells, indicating its tumor-suppressing role in HNSCC progression. GSEA analysis revealed ENDOU downstream pathways such as DNA replication, mismatch repair, cell cycle, and IL-17 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Samer George Hakim, Clara Taubitz, Steffen Hoppe, Daniel Steller, Dirk Rades, Julika Ribbat-Idel, Ubai Alsharif, Mohamed Falougy
Summary: The epithelial-mesenchymal transition (EMT) is a biological mechanism that plays a crucial role in multiple pathophysiological diseases. The cadherin switch, characterized by the de novo development of N-cadherin (N-CAD) and loss of E-cadherin (E-CAD) expression, is a hallmark of EMT and has been studied in various cancer entities. The loss of E-CAD expression in re-OSCC is an independent risk factor for poor survival and may be used to stratify therapy and de/escalate the multimodal treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Bin Zhao, Cong Huang, Jie Pan, Hao Hu, Xiaojuan Liu, Kaoyuan Zhang, Fenli Zhou, Xin Shi, Jun Wu, Bo Yu, Xiaofan Chen, Wei Zhang
Summary: Recent evidence shows that circRNAs, particularly circPLIN2, play important regulatory roles in the development and progression of clear cell renal cell carcinoma (ccRCC) by increasing mRNA stability and competitively binding specific miRNA.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jingpeng Liu, Xiao Jiang, Ailing Zou, Zhaoyi Mai, Zhijie Huang, Liying Sun, Jianjiang Zhao
Summary: The study identified a unique circRNA, circIGHG, which is significantly upregulated in oral squamous cell carcinoma (OSCC) and associated with poor prognosis. It promotes OSCC invasion and metastasis by interacting with miR-142-5p and IGF2BP3, with epithelial-mesenchymal transition being the main mechanism. These findings suggest that circIGHG could serve as a biomarker and therapeutic target for early diagnosis and treatment of OSCC.
Article
Medicine, Research & Experimental
Shohei Yoshimoto, Hiromitsu Morita, Miho Matsuda, Yoshinori Katakura, Masato Hirata, Shuichi Hashimoto
Summary: This study reveals the molecular mechanism of hyperosmolarity's effect on the development of oral squamous cell carcinoma, with NFAT5 transcription factor and DPAGT1 enzyme playing crucial roles in oral cancer cell proliferation.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Brihget Sicairos, Shorna Alam, Yuchun Du
Summary: Contrary to previous beliefs, the CDH1 gene and E-cadherin protein are not downregulated during tumor progression and metastasis. Instead, their levels are often upregulated or remain unchanged in most carcinoma cells. The upregulation of CDH1 mRNA in the early stages of tumor development may serve as a reliable biomarker for the diagnosis of certain cancers.
Review
Oncology
Fabian Acker, Jan Stratmann, Lukas Aspacher, Ngoc Thien Thu Nguyen, Sebastian Wagner, Hubert Serve, Peter J. Wild, Martin Sebastian
Summary: KRAS is a commonly mutated oncogene, with a specific inhibitor targeting the p.G12C mutation recently approved for use in adenocarcinomas of the lung and other solid tumors. The prevalence and significance of KRAS mutations in squamous cell carcinoma of the lung remain poorly understood.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fen Ma, Seiji Arai, Keshan Wang, Carla Calagua, Amanda R. Yuan, Larysa Poluben, Zhongkai Gu, Joshua W. Russo, David J. Einstein, Huihui Ye, Meng Xiao He, Yu Liu, Eliezer Van Allen, Adam G. Sowalsky, Manoj K. Bhasin, Xin Yuan, Steven P. Balk
Summary: This study reveals the importance of Wnt/beta-catenin signaling in prostate cancer, showing its role in stem cell maintenance and invasion. It identifies new effectors and drivers of this pathway in prostate cancer, such as ROR1 and APC genomic loss. The findings suggest that targeting Wnt/beta-catenin signaling may be a potential therapeutic strategy for prostate cancer.
Article
Oncology
Xin Dong, Hui Xue, Fan Mo, Yen-Yi Lin, Dong Lin, Nelson K. Y. Wong, Yingqiang Sun, Scott Wilkinson, Anson T. Ku, Jun Hao, Xinpei Ci, Rebecca Wu, Anne Haegert, Rebecca Silver, Mary-Ellen Taplin, Steven P. Balk, Joshi J. Alumkal, Adam G. Sowalsky, Martin Gleave, Colin Collins, Yuzhuo Wang
Summary: This study aimed to develop clinically relevant models for studying ADT-induced prostate cancer dormancy. The researchers established 11 ADT-induced dormant prostate cancer models that closely mimicked the clinical courses of ADT-treated prostate cancer and identified two ADT-induced dormancy subtypes that differed in morphology, gene expression, and relapse rates. They also discovered transcriptomic differences in precastration PDXs that predisposed the dormancy response to ADT and developed a dormancy subtype-based, predisposed gene signature that was significantly associated with ADT response in hormonal naive prostate cancer and clinical outcome in castration-resistant prostate cancer treated with ADT or androgen-receptor pathway inhibitors.
MOLECULAR CANCER RESEARCH
(2022)
Article
Urology & Nephrology
John R. Bright, Rosina T. Lis, Anson T. Ku, Nicholas T. Terrigino, Nichelle C. Whitlock, Shana Y. Trostel, Nicole Carrabba, Stephanie A. Harmon, Baris Turkbey, Scott Wilkinson, Adam G. Sowalsky
Summary: The study evaluated the ability of antibodies against PSMA to specifically detect residual tumor in patients treated with iADT and enzalutamide. The results showed that PSMA reacted positively with tumor in all cases and had high sensitivity but low specificity for benign regions. PSMA could also identify highly dedifferentiated prostate carcinomas, indicating its potential as a valuable marker.
JOURNAL OF UROLOGY
(2022)
Editorial Material
Oncology
Scott Wilkinson, Adam G. Sowalsky
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Adam G. Sowalsky, Ines Figueiredo, Rosina T. Lis, Ilsa Coleman, Bora Gurel, Denisa Bogdan, Wei Yuan, Joshua W. Russo, John R. Bright, Nichelle C. Whitlock, Shana Y. Trostel, Anson T. Ku, Radhika A. Patel, Lawrence D. True, Jonathan Welti, Juan M. Jimenez-Vacas, Daniel Nava Rodrigues, Ruth Riisnaes, Antje Neeb, Cynthia T. Sprenger, Amanda Swain, Scott Wilkinson, Fatima Karzai, William L. Dahut, Steven P. Balk, Eva Corey, Peter S. Nelson, Michael C. Haffner, Stephen R. Plymate, Johann S. de Bono, Adam Sharp
Summary: This study demonstrates that further analytical validation and clinical qualification are required before AR-V7 can be considered for clinical use in CSPC as a predictive biomarker.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Jennifer Wilkinson Carlisle, Caroline S. Jansen, Maria Andrea Cardenas, Ewelina Sobierajska, Adriana Moon Reyes, Rachel Greenwald, Luke Del Balzo, Nataliya Prokhnevska, Omer Kucuk, Bradley C. Carthon, Patrick Connor Mullane, Adeboye Osunkoya, Deborah Baumgarten, Fares Hosseinzadeh, Scott Wilkinson, Ross Lake, Adam G. Sowalsky, Yuan Liu, Viraj A. Master, Mehmet A. Bilen, Haydn Kissick
Summary: This study identifies potential immunological biomarkers that can predict therapeutic response in patients with advanced renal cell carcinoma (RCC). Assessing changes in T cells in the peripheral blood and tumor microenvironment, the researchers found that patients with the highest increase in specific activated T cells had the best antitumor immune response and clinical benefit.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Editorial Material
Oncology
David Y. Takeda, Adam G. Sowalsky
Summary: A recent report in Nature demonstrates that whole-genome sequencing of circulating tumor DNA from patients with metastatic PCa can inform on the subclonal composition of metastatic disease and infer patterns of gene expression.
Letter
Urology & Nephrology
Adam G. Sowalsky, Stephen R. Plymate, Michael C. Haffner, Johann S. de Bono, Adam Sharp
Article
Biology
Alexandre A. Germanos, Sonali Arora, Ye Zheng, Erica T. Goddard, Ilsa M. Coleman, Anson T. Ku, Scott Wilkinson, Hanbing Song, Nicholas J. Brady, Robert A. Amezquita, Michael Zager, Annalysa Long, Yu Chi Yang, Jason H. Bielas, Raphael Gottardo, David S. Rickman, Franklin W. Huang, Cyrus M. Ghajar, Peter S. Nelson, Adam G. Sowalsky, Manu Setty, Andrew C. Hsieh
Summary: In this study, we found that the expansion of castration-resistant intermediate luminal cells is associated with treatment resistance and poor prognosis in prostate cancer. The transformed epithelial cells and associated fibroblasts create a microenvironment that promotes pro-tumorigenic immune infiltration, which is influenced by androgen levels. Androgen-independent prostate cancer leads to significant diversification of intermediate luminal cell populations with varying androgen signaling activities, which are inversely correlated with proliferation and mRNA translation. The findings suggest that targeting translation inhibition could potentially lead to epithelial cell death, loss of pro-tumorigenic signaling, and decreased tumor heterogeneity.
Editorial Material
Oncology
Scott Wilkinson, Adam G. Sowalsky
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Meeting Abstract
Oncology
Caroline Jansen, Prasanthi Chappa, Nataliya Prokhnevska, Maria Cardenas, Roshan Prabhu, Jim Zhong, Kimberly Hoang, Subir Goyal, Suzanna Logan, Jeffrey Olson, Edjah Nduom, Luke del Balzo, Kirtesh Patel, Stuart Burri, Anthony Asher, Scott Wilkinson, Ross Lake, Kristin Higgins, Pretesh Patel, Vishal Dhere, Mylin Torres, Adam Sowalsky, Mohammad Khan, Haydn Kissick, Zachary Buchwald
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Nichelle C. Whitlock, Margaret E. White, Brian J. Capaldo, Anson T. Ku, Supreet Agarwal, Lei Fang, Scott Wilkinson, Shana Y. Trostel, Zhen-Dan Shi, Falguni Basuli, Karen Wong, Elaine M. Jagoda, Kathleen Kelly, Peter L. Choyke, Adam G. Sowalsky
Summary: Our study reveals that the epigenetic activity of transcription factor oncogenes undergoes a shift during prostate cancer progression, leading to distinctive effects on metabolism. These epigenetically-driven changes in lipid metabolism may serve as novel targets for the development of imaging agents and therapeutics.
Meeting Abstract
Oncology
Rahim Hirani, Subhiksha Nandakumar, Teja Kalidindi, Deborah Fidele, Harisha Rajanala, Ying Mazzu, Yuki Yoshikawa, Lina Jehane, Gwo-Shu Mary Lee, Elisa de Stanchina, Adam Sowalsky, Michael J. Morris, Heiko Schoder, Naga Vara Kishore Pillarsetty, Lorelei A. Mucci, Daniel Danila, Goutam Chakraborty, Philip W. Kantoff
Meeting Abstract
Oncology
Caroline S. Jansen, Luke del Balzo, Roshan Prabhu, Suzanna Logan, Prasanthi Chappa, Kirtesh Patel, Scott Wilkinson, Ross Lake, Hui-Kuo G. Shu, Jim Zhong, Vishal Dhere, Jeffrey Olson, Adam G. Sowalsky, Mohammad K. Khan, Haydn T. Kissick, Zachary S. Buchwald
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Katherine L. Morel, Anjali Sheahan, Deborah L. Burkhart, Sylvan C. Baca, Nadia Boufaied, Yin Liu, Xintao Qiu, Israel Canadas, Kevin Roehle, Max Heckler, Carla Calagua, Huihui Ye, Constantia Pantelidou, Phillip Galbo, Sukanya Panja, Antonina Mitrofanova, Scott Wilkinson, Nichelle C. Whitlock, Shana Y. Trostel, Anis A. Hamid, Adam S. Kibel, David A. Barbie, Atish D. Choudhury, Mark M. Pomerantz, Christopher J. Sweeney, Henry W. Long, David J. Einstein, Geoffrey Shapiro, Stephanie K. Dougan, Adam G. Sowalsky, Housheng Hansen He, Matthew L. Freedman, Steven P. Balk, Massimo Loda, David P. Labbe, Brian M. Olson, Leigh Ellis
Summary: Combination of EZH2 inhibition and anti-PD-1 has been shown to enhance antitumor immune responses in prostate cancer by activating the dsRNA-STING-ISG stress response signaling; EZH2 inhibition upregulates genes involved in antigen presentation and interferon response, suggesting it as a therapeutic direction to enhance prostate cancer response to PD-1 CPI.