Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context

RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents

(2011) Kristy R. Stengel et al.   CELL CYCLE

Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

(2009) Awad Shamma et al.   CANCER CELL

The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras

(2009) V M Ho et al.   ONCOGENE

Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

(2008) Sanjeev Shangary et al.   Annual Review of Pharmacology and Toxicology

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage

(2008) Mirentxu Santos et al.   MOLECULAR CARCINOGENESIS

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

(2008) M Kitagawa et al.   ONCOGENE

A role for Myc in facilitating transcription activation by E2F1

(2008) J Y Leung et al.   ONCOGENE

Apoptotic signaling by c-MYC

(2008) B Hoffman et al.   ONCOGENE

p107 acts as a tumor suppressor in pRb-deficient epidermis

(2007) M. Fernanda Lara et al.   MOLECULAR CARCINOGENESIS