Article
Cell Biology
Jorian J. Sepers, Joao J. Ramalho, Jason R. Kroll, Ruben Schmidt, Mike Boxem
Summary: The interaction between ERM-1 and NRFL-1 plays a role in intestinal lumen formation in C. elegans. The localization of NRFL-1 depends on its interaction with ERM-1. Loss of NRFL-1 does not affect the localization or activity of ERM-1, but specific mutations in ERM-1 that interact with NRFL-1 have severe effects on intestinal lumen formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Kevin Leguay, Barbara Decelle, Yu Yan He, Anthony Pagniez, Mireille Hogue, Hiroyuki Kobayashi, Christian Le Gouill, Michel Bouvier, Sebastien Carreno
Summary: ERM proteins, including ezrin, radixin, and moesin, play a crucial role in cell signaling and morphogenesis. Understanding the regulation of these proteins is vital for studying cell shape control mechanisms and developing innovative cancer therapies.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Takuro Kobori, Yui Ito, Yuka Sawada, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: CD47 is overexpressed on the surface of pancreatic cancer cells and is correlated with worse clinical outcomes. In KP-2 cells, ezrin/radixin family members contribute to the cellular membrane localization of CD47. Specifically, radixin interacts with CD47 and regulates its surface expression in KP-2 cells.
Article
Chemistry, Physical
Jinyuan Liu, Lin Kang, Ishara Ratnayake, Phil Ahrenkiel, Steve Smith, Congzhou Wang
Summary: Targeting CD146 with low-dose gold nanorods and mild hyperthermia can effectively stop cancer cell migration by disrupting the actin cytoskeleton. This approach alters cell morphology and inhibits cell migration by depleting membrane CD146 and interfering with ezrin-radixin-moesin phosphorylation. The findings suggest a versatile and safe strategy for preventing cancer metastasis.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Orthopedics
L. Xiao, J. Matharoo, J. Chi, J. Ma, M. Chen, B. Manley, P. Xu, W. Shi, R. A. Felder, S. -S. J. Sung, L. Jin, X. Li
Summary: Macrophages are abundantly detected at sites of disc herniation, however, their function in the disease progression is unclear. We aim to investigate the functions of macrophages in acute disc herniation using a macrophage Fas-induced apoptosis (MaFIA) transgenic mouse strain.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Latoya McGlorthan, Ana Paucarmayta, Yovanni Casablanca, G. Larry Maxwell, Viqar Syed
Summary: The study demonstrates that progesterone and calcitriol induce apoptosis in cancer cells through activation of different caspase enzymes, inhibiting their proliferation.
Review
Immunology
Byeong-Oh Hwang, Se-Young Park, Eunae Sandra Cho, Xianglan Zhang, Sun Kyoung Lee, Hyung-Joon Ahn, Kyung-Soo Chun, Won-Yoon Chung, Na-Young Song
Summary: Cancer tissues form complex and heterogeneous tumor microenvironments, where platelets play a crucial role in promoting cancer progression. In oral squamous cell carcinoma, high platelet counts and low tumor-stromal ratio are associated with increased metastasis and poor prognosis, suggesting that targeting the interaction between platelets and cancer cells could be a promising therapeutic strategy to inhibit cancer invasion and metastasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Riasat Zaman, Andrew Lombardo, Cecile Sauvanet, Raghuvir Viswanatha, Valerie Awad, Locke Ezra-Ros Bonomo, David McDermitt, Anthony Bretscher
Summary: The study reveals that LOK/SLK play a central role in activating ERMs, and their knockout results in significant changes in apical structures. Active ERMs act as negative regulators of RhoA-GTP, forming a novel local feedback loop.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Medicine, General & Internal
Chihiro Tanaka, Takuro Kobori, Rie Okada, Rina Doukuni, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Nobumasa Takagaki, Tokio Obata
Summary: This study reveals the mechanism of PD-L1 localization on endometrial cancer cell surfaces. The ERM protein family, with Ezrin as a key scaffold protein, contributes to the cell surface localization of PD-L1.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Laura Abrego Fuentes, Amarilla B. Mandola, Bo Ngan
Summary: X-linked moesin-associated immunodeficiency (X-MAID) is a rare immunodeficiency disorder characterized by severe leukopenia and multi-organ involvement. This study reports a case of a young boy with X-MAID who required double lung transplant, providing detailed description of his clinical presentation, immune evaluation, and lung histopathology findings.
LYMPHOSIGN JOURNAL-THE JOURNAL OF INHERITED IMMUNE DISORDERS
(2023)
Article
Medicine, General & Internal
Mayuka Tameishi, Honami Ishikawa, Chihiro Tanaka, Takuro Kobori, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: Programmed death ligand-1 (PD-L1) is a molecule on the plasma membrane of cancer cells that negatively regulates immune surveillance. This study suggests that ezrin may be responsible for the plasma membrane expression of PD-L1 in ovarian cancer cells, making it a potential therapeutic target for improving immune checkpoint inhibitor treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Nader Rahimi, Rachel X. Y. Ho, Kevin Brown Chandler, Kyle Oliver Corcino De la Cena, Razie Amraei, Ashley J. Mitchel, Nels Engblom, Catherine E. Costello
Summary: TMIGD1 interacts with ERM family proteins moesin and ezrin, regulating their cellular localization and impacting cell morphology, migration, and mitotic spindle organization. The findings provide a molecular framework for understanding the complex functional interplay between TMIGD1 and ERM family proteins in the regulation of cell adhesion and mitotic spindle assembly, with implications in physiological and pathological processes such as cancer progression.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chihiro Tanaka, Takuro Kobori, Mayuka Tameishi, Yoko Urashima, Takuya Ito, Tokio Obata
Summary: The ERM family scaffold proteins play a role in PD-L1 expression in HeLa cells, with ezrin potentially acting as a scaffold protein for PD-L1 and regulating its protein expression. This finding suggests ezrin could be a therapeutic target for cervical cancer, improving immune checkpoint blockade therapy.
Article
Biochemistry & Molecular Biology
Olga Simo-Servat, Hugo Ramos, Patricia Bogdanov, Marta Garcia-Ramirez, Jordi Huerta, Cristina Hernandez, Rafael Simo
Summary: This study found that the overexpression of ERM proteins in diabetic mice may be one of the mechanisms leading to vascular leakage in diabetic retinopathy. Moreover, the upregulation of the ERM complex by diabetes is induced by inflammatory mediators rather than high glucose itself.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yosuke Senju, Emi Hibino
Summary: Neurofibromatosis type 2 (NF2), caused by the mutated merlin gene, belongs to the FERM domain-containing 4.1 superfamily. Merlin, a tumor suppressor, shares sequence homology with ERM proteins and plays important roles in cell-cell adhesions. This article provides insights into the molecular functions of merlin and its interactions with PI(4,5)P2, shedding light on its fundamental roles in cells and tissues.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Immunology
Yu-Jung Wu, Yung-Hsuan Wu, Shu-Ting Mo, Huey-Wen Hsiao, You-Wen He, Ming-Zong Lai
JOURNAL OF IMMUNOLOGY
(2015)
Article
Medicine, Research & Experimental
Ya-Ting Wang, Jocelyn Chen, Chou-Wei Chang, Jayu Jen, Tzu-Yu Huang, Chun-Ming Chen, Roger Shen, Suh-Yuen Liang, I-Cheng Cheng, Shuenn-Chen Yang, Wu-Wei Lai, Kuang-Hung Cheng, Tao-Shih Hsieh, Ming-Zong Lai, Hung-Chi Cheng, Yi-Ching Wang, Ruey-Hwa Chen
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Cell Biology
Tzu-Sheng Hsu, Shu-Ting Mo, Ping-Ning Hsu, Ming-Zong Lai
CELL DEATH & DISEASE
(2018)
Article
Multidisciplinary Sciences
Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang, Ming-Zong Lai
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Ming-Zong Lai, Ruey-Hwa Chen
Article
Hematology
Yu-Hsun Lo, Yu-Wen Huang, Yung-Hsuan Wu, Chi-Shan Tsai, Yu-Chuan Lin, Shu-Ting Mo, Wen-Chih Kuo, Ya-Ting Chuang, Si-Tse Jiang, Hsiu-Ming Shih, Ming-Zong Lai
Article
Hematology
Wan-Chen Hsieh, Ya-Ting Chuang, I-Hsuan Chiang, Shu-Ching Hsu, Shi-Chuen Miaw, Ming-Zong Lai
Article
Biochemistry & Molecular Biology
Y-H Wu, W-C Kuo, Y-J Wu, K-T Yang, S-T Chen, S-T Jiang, C. Gordy, Y-W He, M-Z Lai
CELL DEATH AND DIFFERENTIATION
(2014)
Article
Immunology
Yu-Chi Lee, An-Yun Chang, Ming-Hsien Lin-Feng, Wen-I Tsou, I-Hsuan Chiang, Ming-Zong Lai
EUROPEAN JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
Yung-Hsuan Wu, Chen-Ying Yang, Wen-Li Chien, Kuo-I Lin, Ming-Zong Lai
JOURNAL OF IMMUNOLOGY
(2012)
Article
Rheumatology
Chuen-Miin Leu, Tzu-Sheng Hsu, Yu-Ping Kuo, Ming-Zong Lai, Po-Chun Liu, Ming-Huang Chen, Deh-Ming Chang, Chang-Youh Tsai, Ming-Han Chen
Article
Cell Biology
Yung-Hsuan Wu, Ting-Fang Chou, Leslie Young, Fu-Yi Hsieh, Hsuan-Yin Pan, Shu-Ting Mo, Shani Bialik Brown, Ruey-Hwa Chen, Adi Kimchi, Ming-Zong Lai
CELL DEATH & DISEASE
(2020)
Review
Biochemistry & Molecular Biology
Cheng-Lung Ku, I-Ting Chen, Ming-Zong Lai
Summary: Inborn errors of immunity (IEIs) are genetically defined disorders that may lead to defective immunity. Some IEIs are linked to mutations of immune receptors or signaling molecules. In cases of COVID-19, IEIs have been associated with increased inflammation in some patients, and targeting inflammation may be a potential therapeutic approach for these diseases.
Article
Biochemistry & Molecular Biology
I-Ting Chen, Hsiao-Chi Chen, Yu-Hsun Lo, Peng-Yeh Lai, Fu-Yi Hsieh, Yung-Hsuan Wu, Hsiu-Ming Shih, Ming-Zong Lai
Summary: PML not only promotes apoptosis but also necroptosis. PML deficiency leads to reduced necroptosis and increased resistance to TNF-induced systemic inflammatory response. PML promotes necroptosis and apoptosis by targeting MK2 activation and autocrine TNF production.
Article
Multidisciplinary Sciences
Yung-Hsuan Wu, Shu-Ting Mo, I. -Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai
Summary: Inhibition of Caspase-8 leads to inflammasome assembly and production of IL-10 and IL-18 in Toll-like receptor (TLR)-primed myeloid cells. Autophagy and cathepsin-B play important roles in the activation of inflammasomes when apoptosis and necroptosis are blocked and Caspase-8 is inhibited.