Article
Endocrinology & Metabolism
Amani A. Mahbub, Akhmed Aslam, Mohamed E. Elzubier, Mohamed El-Boshy, Abdelghany H. Abdelghany, Jawwad Ahmad, Shakir Idris, Riyad Almaimani, Aiman Alsaegh, Mahmoud Zaki El-Readi, Mohammed A. Baghdadi, Bassem Refaat
Summary: The study found that the individual use of E2 and P4 can inhibit the development of colorectal cancer, showing good anti-tumor effects in male mice and cell experiments. The combination of the two shows a stronger anti-cancer effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Santa Rocca, Giovanni Minervini, Cinzia Vinanzi, Alberto Bottacin, Federica Lia, Carlo Foresta, Maria Pennuto, Alberto Ferlin
Summary: This study evaluated the frequency and type of androgen receptor (AR) gene variants in a large cohort of infertile males. The study found that patients with AR gene variants had lower sperm count, higher testosterone concentration, and higher androgen sensitivity index compared to patients without variants. Two novel potentially pathogenic AR variants were identified. Based on these findings, AR sequencing is suggested as a routine genetic test in cases of idiopathic oligozoospermia with high testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Urology & Nephrology
Samuel Tremblay, Lily Summers-Trasiewicz, Frederic Pouliot, Juanita M. Crook, Keyue Ding, Laurence Klotz, Paul Toren
Summary: This study aimed to evaluate the relationship between testosterone levels and PSA levels during ADT and its impact on clinical outcomes. The results showed that testosterone levels had a smaller prognostic effect compared to PSA levels on outcomes. Specifically, there was no significant association between the cumulative testosterone exposure and outcomes.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyo-Jung Kim, Bo-Ram Jin, Hyo-Jin An
Summary: Umbelliferone, derived from coumarin, has been found to exert anti-proliferative effects in BPH-1 cells by modulating the STAT3/E2F1 axis and demonstrating an anti-BPH effect in TP-induced rats by reducing prostate size and inhibiting cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Yi Zhao, Xue-Nan Li, Hao Zhang, Jia-Gen Cui, Jia-Xin Wang, Ming-Shan Chen, Jin-Long Li
Summary: Male infertility is a significant concern due to the decline in sperm quality worldwide. Phthalates, particularly DEHP or its metabolite MEHP, have negative effects on male reproductive development and function, leading to reduced fertility. Lycopene, a natural antioxidant, has the potential to be used as a therapeutic option for male infertility. This research demonstrates that DEHP reduces testosterone production in Leydig cells and impairs secretory function in Sertoli cells, resulting in impaired spermatogenesis. Additionally, MEHP causes mitochondrial and oxidative damage, posing a serious threat to spermatogenesis. However, LYC supplementation reverses these changes. Mechanistically, DEHP disrupts the T/AR signaling pathway, contributing to male infertility. Overall, this study highlights the critical role of the T/AR signal transduction in male fertility and provides promising insights into the protective role of LYC in phthalate-induced male reproductive disorders.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Di Zhang, Jingjing Fan, Hui Liu, Guobin Qiu, Sheng Cui
Summary: The study reveals that testosterone enhances taurine synthesis by interacting with androgen receptor and binding to cysteine sulfinate decarboxylase (CSAD) promoter zone. Estrogen has no significant effects on liver CSAD expression or taurine synthesis in male mice, indicating gender differences in the effects of sex steroids on taurine synthesis in the liver.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Oncology
Cristina Aguirre-Portoles, Riley Payne, Aspen Trautz, J. Kevin Foskett, Christopher A. Natale, John T. Seykora, Todd W. Ridky
Summary: Testosterone signaling through ZIP9 mediates some of the sex differences in melanoma, and drugs that target AR can be repurposed to block ZIP9 and inhibit melanoma in males.
Article
Endocrinology & Metabolism
Takashi Yazawa, Hiroyuki Inaba, Yoshitaka Imamichi, Toshio Sekiguchi, Junsuke Uwada, Mohammad Sayful Islam, Makoto Orisaka, Daisuke Mikami, Takanori Ida, Takahiro Sato, Yoshimichi Miyashiro, Satoru Takahashi, Md. Rafiqul Islam Khan, Nobuo Suzuki, Akihiro Umezawa, Takeshi Kitano
Summary: This study compared the presence and production of DHT and 11KDHT in Japanese eels and humans. The results suggest that in teleosts, DHT and 11KDHT may be important 5 alpha-reduced androgens produced in the gonads, while in healthy humans, DHT is the only major 5 alpha-reduced androgens.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Kajal Khodamoradi, Alexandra Dullea, Katherine Campbell, Christian Ramsoomair, Roei Golan, Ranjith Ramasamy
Summary: This study aimed to measure androgen receptor (AR) signaling levels in corpus cavernosal tissue of males with different serum testosterone (T) levels. The results showed no significant difference in VEGF expression above a serum T level of 200 ng/dl. Therefore, there may be a saturation level of approximately 200 ng/dl that fully saturates tissue androgen receptors and results in optimal male function.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Pharmacology & Pharmacy
Xueni Wang, Junjie Zhu, Huimin Yan, Mengyao Shi, Qiaoqi Zheng, Yu Wang, Yan Zhu, Lin Miao, Xiumei Gao
Summary: Kaempferol has been identified as a natural compound that inhibits tumor development in androgenic related prostate cancer and suppresses testosterone-induced benign prostatic hyperplasia (BPH) via modulation of the androgen receptor function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Biology
Alessandra Buonacquisto, Anna Chiara Conflitti, Francesco Pallotti, Antonella Anzuini, Serena Bianchini, Luisa Caponecchia, Anna Carraro, Maria Rosa Ciardi, Fabiana Faja, Cristina Fiori, Daniele Gianfrilli, Andrea Lenzi, Miriam Lichtner, Claudio Maria Mastroianni, Patrizia Pasculli, Flavio Rizzo, Pietro Salacone, Annalisa Sebastianelli, Francesco Lombardo, Donatella Paoli
Summary: Male patients are more prone to develop severe forms of COVID-19. Genetic predisposition, including CAG repeat polymorphism, low testosterone levels, and reduced androgen receptor activity, may play a role in this susceptibility. Disease severity is associated with an increase in CAG repeat number and lower testosterone levels.
Review
Cell Biology
Irshad Ahmad, Annie E. Newell-Fugate
Summary: This review focuses on the effects of androgens on mitochondrial structure and function, including biogenesis, fusion/fission, mitophagy, bioenergetics, and reactive oxygen species production. Although there have been numerous studies on the effects of androgens in these areas of mitochondrial function, the precise mechanisms by which androgens cause these effects remain unclear. Future research should focus on the direct effects of androgens on mitochondrial function.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An
Summary: Purple corn extract (PCE) has ameliorative effects on benign prostatic hyperplasia (BPH) by reducing androgen receptor (AR) expression and inhibiting the PI3K/AKT signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Christopher McNair, Kexin Xu, Amy C. Mandigo, Matteo Benelli, Benjamin Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Mateus Crespo, Bram De laere, Luc Dirix, Tapio Visakorpi, Fugen Li, Felix Y. Feng, Johann de Bono, Francesca Demichelis, Mark A. Rubin, Myles Brown, Karen E. Knudsen
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Oncology
Edward J. Hartsough, Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison Goldberg, Michael A. Davies, Matthew J. Schiewer, Karen E. Knudsen, Gideon Bollag, Andrew E. Aplin
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Medicine, Research & Experimental
Matthew J. Schiewer, Karen E. Knudsen
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2019)
Article
Oncology
Margaret M. Centenera, Theresa E. Hickey, Shalini Jindal, Natalie K. Ryan, Preethi Ravindranathan, Hisham Mohammed, Jessica L. Robinson, Matthew J. Schiewer, Shihong Ma, Payal Kapur, Peter D. Sutherland, Clive E. Hoffmann, Claus G. Roehrborn, Leonard G. Gomella, Jason S. Carroll, Stephen N. Birrell, Karen E. Knudsen, Ganesh V. Raj, Lisa M. Butler, Wayne D. Tilley
MOLECULAR ONCOLOGY
(2018)
Article
Oncology
Emanuela Dylgjeri, Christopher McNair, Jonathan F. Goodwin, Heather K. Raymon, Peter A. Mccue, Ayesha A. Shafi, Benjamin E. Leiby, Renee de Leeuw, Vishal Kothari, Jennifer J. McCann, Amy C. Mandigo, Saswati N. Chand, Matthew J. Schiewer, Lucas J. Brand, Irina Vasilevskaya, Nicolas Gordon, Talya S. Laufer, Leonard G. Gomella, Costas D. Lallas, Edouard J. Trabulsi, Felix Y. Feng, Ellen H. Filvaroff, Kristin Hege, Dana Rathkopf, Karen E. Knudsen
CLINICAL CANCER RESEARCH
(2019)
Article
Multidisciplinary Sciences
Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renee de Leeuw, Karen E. Knudsen, J. Alan Diehl
Article
Oncology
Jennifer J. McCann, Irina A. Vasilevskaya, Neermala Poudel Neupane, Ayesha A. Shafi, Christopher McNair, Emanuela Dylgjeri, Amy C. Mandigo, Matthew Schiewer, Randy S. Schrecengost, Peter Gallagher, Timothy J. Stanek, Steven B. Mcmahon, Lisa D. Berman-Booty, William F. Ostrander, Karen E. Knudsen
Article
Oncology
Corinne N. Haines, Hope D. Klingensmith, Makanko Komara, Craig J. Burd
Article
Multidisciplinary Sciences
Ayesha A. Shafi, Chris M. McNair, Jennifer J. McCann, Mohammed Alshalalfa, Anton Shostak, Tesa M. Severson, Yanyun Zhu, Andre Bergman, Nicolas Gordon, Amy C. Mandigo, Saswati N. Chand, Peter Gallagher, Emanuela Dylgjeri, Talya S. Laufer, Irina A. Vasilevskaya, Matthew J. Schiewer, Michael Brunner, Felix Y. Feng, Wilbert Zwart, Karen E. Knudsen
Summary: CRY1, a transcriptional coregulator associated with the circadian clock, is identified as a tumor specific regulator of DNA repair. It is androgen-responsive, stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation. These findings nominate CRY1 as a new therapeutic target for cancer treatment.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Jonathan Welti, Adam Sharp, Nigel Brooks, Wei Yuan, Christopher McNair, Saswati N. Chand, Abhijit Pal, Ines Figueiredo, Ruth Riisnaes, Bora Gurel, Jan Rekowski, Denisa Bogdan, William West, Barbara Young, Meera Raja, Amy Prosser, Jordan Lane, Stuart Thomson, Jenny Worthington, Stuart Onions, Jonathan Shannon, Silvia Paoletta, Richard Brown, Don Smyth, Gareth W. Harbottle, Veronica S. Gil, Susana Miranda, Mateus Crespo, Ana Ferreira, Rita Pereira, Nina Tunariu, Suzanne Carreira, Antje J. Neeb, Jian Ning, Amanda Swain, David Taddei, Matthew J. Schiewer, Karen E. Knudsen, Neil Pegg, Johann S. de Bono
Summary: The resistance to AR blockade in CRPC is associated with sustained AR signaling through alternative splicing of AR (AR-SV). Inhibitors of transcriptional coactivators like p300/CBP are attractive therapeutic targets for lethal prostate cancer. CCS1477, a novel small-molecule inhibitor of p300/CBP, shows promise in inhibiting cell proliferation in prostate cancer cell lines and regulating AR and C-MYC signaling.
Article
Biochemistry & Molecular Biology
Timothy J. Stanek, Victoria J. Gennaro, Mason A. Tracewell, Daniela Di Marcantonio, Kristen L. Pauley, Sabrina Butt, Christopher McNair, Feng Wang, Andrew Kossenkov, Karen E. Knudsen, Tauseef Butt, Stephen M. Sykes, Steven B. McMahon
Summary: The SAGA coactivator complex is crucial for eukaryotic transcription, with USP22 in humans playing a role in the early stages of stimulus-responsive transcription by maintaining enhancer-promoter contacts, controlling transcription factor loading, and potentially acting on specific substrates.
Article
Oncology
Zachary Quinn, Benjamin Leiby, Guru Sonpavde, Atish D. Choudhury, Christopher Sweeney, David Einstein, Russell Szmulewitz, Oliver Sartor, Karen Knudsen, Eddy Shih-Hsin Yang, Wm. Kevin Kelly
Summary: The purpose of this study was to evaluate the safety of combining Radium-223 with the PARP inhibitor niraparib for the treatment of metastatic castrate-resistant prostate cancer (mCRPC) in patients without known BRCA mutations. The results showed that the combination of niraparib and Radium-223 was safe in patients.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Daniel Nava Rodrigues, Nicola Casiraghi, Alessandro Romanel, Mateus Crespo, Susana Miranda, Pasquale Rescigno, Ines Figueiredo, Ruth Riisnaes, Suzanne Carreira, Semini Sumanasuriya, Paola Gasperini, Adam Sharp, Joaquin S. Mateo, Alan Makay, Christopher McNair, Matthew Schiewer, Karen Knudsen, Gunther Boysen, Francesca Demichelis, Johann S. de Bono
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Ayesha A. Shafi, Matthew J. Schiewer, Renee de Leeuw, Emanuela Dylgjeri, Peter A. McCue, Neelima Shah, Leonard G. Gomella, Costas D. Lallas, Edouard J. Trabulsi, Margaret M. Centenera, Theresa E. Hickey, Lisa M. Butler, Ganesh Raj, Wayne D. Tilley, Edna Cukierman, Karen E. Knudsen
EUROPEAN UROLOGY ONCOLOGY
(2018)