Effect of Sodium Taurocholate on Aggregation Behavior of Amphiphilic Drug Solution

The aggregation behavior of promazine hydrochloride (PMZ) and bile salt (sodium taurocholate (NaTC)) mixtures at various compositions and temperature in pure and mixed states were studied using conductometry technique in aqueous solutions. The values of experimental and ideal critical micelle concentration (cmc and cmc(id)) propose attractive interactions in PMZ-NaTC mixtures. By applying the regular solution theory (RST) various physicochemical parameter such as micellar mole fraction in the mixed (X-1) and ideal (X-1(id)) state, interaction parameters (beta), thermodynamic parameters of micellization as well as other related parameters have been evaluated and discussed in detail. The results show that the synergistic effect between drug and bile salt plays a crucial role in the redtdprefuction of the overall cmc value in aqueous solution at various composition of NaTC. The thermodynamic parameters recommend the discharge of water from the hydrophobic part of the PMZ at higher temperatures.