Article
Multidisciplinary Sciences
Milena Simes F. Silva, Tiago E. Arantes, Renata Moreto, Justine R. Smith, Joo M. Furtado
Summary: Multiple studies have shown the negative impact of non-infectious uveitis on quality of life. This study investigated the vision-related quality of life in individuals who had recovered from ocular syphilis. The results showed that the overall quality of life was low and was influenced by age and final visual acuity, suggesting that early treatment may improve quality of life after recovery from ocular syphilis.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Sean Teabagy, Emma Wood, Evan Bilsbury, Sean Doherty, Priya Janardhana, Darren J. Lee
Summary: Ocular immune privilege refers to the ability of foreign tissue grafts placed in the eye to survive indefinitely. This privilege is maintained by various mechanisms, including the blood-ocular barrier, lack of lymphatics in the eye, production of immune-suppressing molecules in the ocular microenvironment, and induction of systemic regulatory immunity. Failure of ocular immune privilege can lead to uveitis, which is a group of inflammatory disorders that can cause vision loss. Current treatments for uveitis involve immunosuppressive and anti-inflammatory medications. Research on ocular immune privilege mechanisms and the development of novel uveitis treatments is ongoing.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Article
Medicine, General & Internal
Yosuke Harada, Tomona Hiyama, Yoshiaki Kiuchi
Summary: This single-center retrospective study found that MTX is effective in controlling ocular inflammation for Japanese patients with non-infectious uveitis, but the relatively high incidence of MTX-related adverse effects in the Japanese population emphasizes the need for careful monitoring and dose adjustments for long-term use of this therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Wenjuan Wan, Zhijun Chen, Yan Xun, Kun Yi, Ying Zhu, Yanlin Pu, Guannan Su, Chunjiang Zhou, Yao Wang, Peizeng Yang
Summary: Pediatric uveitis can cause severe impairment of vision in children, affecting their functional visual ability, quality of life, and cognitive development.
Article
Ophthalmology
Katsuya Nagahori, Hiroshi Keino, Makiko Nakayama, Takayo Watanabe, Yoshimasa Ando, Isami Hayashi, Shinya Abe, Annabelle A. Okada
Summary: This study analyzed the clinical features, treatment, complications, and visual outcomes of ocular sarcoidosis in a tertiary center in Tokyo. The majority of patients were women with bilateral disease and panuveitis involvement. Most eyes maintained good visual acuity, although surgical interventions for cataract and epiretinal membrane were common.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biology
Samantha C. Pendleton, Luke T. Slater, Andreas Karwath, Rose M. Gilbert, Nicola Davis, Konrad Pesudovs, Xiaoxuan Liu, Alastair K. Denniston, Georgios Gkoutos, Tasanee Braithwaite
Summary: This study developed an ontology for ocular immune-mediated inflammatory diseases (OcIMIDo) to extract and analyze data from online patient support forum. The ontology includes 661 classes, 1661 relationships and axioms, 2851 annotations, and 187 patient-preferred synonyms. The language sentiment analysis of forum posts showed generally positive sentiment, with first posts having higher odds of expressing negative sentiment compared to replies.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dahlia Palevski, Gil Ben-David, Yehonatan Weinberger, Rabeei Haj Daood, Jose A. Fernandez, Ivan Budnik, Sarina Levy-Mendelovich, Gili Kenet, Yael Nisgav, Dov Weinberger, John H. Griffin, Tami Livnat
Summary: 3K3A-APC has been shown to have anti-inflammatory properties and may be a novel treatment for retinal diseases associated with inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kai On Chu, Kwok Ping Chan, Yolanda Wong Ying Yip, Wai Kit Chu, Chi Chiu Wang, Chi Pui Pang
Summary: The study showed that GTE indirectly induced systemic phosphorylcholine lipids to suppress inflammatory responses, hepatic damage, and respiratory mitochondrial stress in EIU rats induced by LPS. Phospholipids may be a therapeutic target of GTE for anterior chamber inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ji-Young Lee, Jin-Ho Kim, Tae-Yoon La, Jin-A Choi
Summary: The study aims to compare the structure-function characteristics and vision-related quality of life (VR-QoL) between uveitic glaucoma (UG) and open-angle glaucoma (OAG). Results show no significant differences in binocular integrated visual fields (IVF) and mean deviation (MD) between the two groups, but the average retinal nerve fiber layer thickness (RNFLT) is significantly thinner in the OAG group. UG patients exhibit lower composite scores and scores on five subscales of the VFQ-25 compared to OAG patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Benson S. Chen, Patrick Yu-Wai-Man, Mike Horton
Summary: This study aimed to validate the psychometric validity of the Visual Function Index (VF-14) for use by patients with Leber hereditary optic neuropathy (LHON). The VF-14 was found to have limitations, but the revised VF-14R showed improved psychometric validity.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Ophthalmology
Nicole K. Kelly, Aheli Chattopadhyay, S. R. Rathinam, John A. Gonzales, Radhika Thundikandy, Anuradha Kanakath, S. Bala Murugan, R. Vedhanayaki, Dean Cugley, Lyndell L. Lim, Eric B. Suhler, Hassan A. Al-Dhibi, Caleb D. Ebert, Elyse J. Berlinberg, Travis C. Porco, Nisha R. Acharya
Summary: The study evaluated changes in health-related and vision-related quality of life among patients with noninfectious uveitis treated with antimetabolites. The results showed that patients in the treatment group had significant improvements in VRQoL and HRQoL over the course of 1 year, indicating a positive impact on their overall well-being and daily functioning.
Article
Medicine, General & Internal
Florence Chaudot, Pascal Seve, Antoine Rousseau, Alexandre Thibault Jacques Maria, Pierre Fournie, Pierre Lozach, Jeremy Keraen, Marion Servant, Romain Muller, Baptiste Gramont, Sara Touhami, Habeeb Mahmoud, Pierre-Antoine Quintart, Stephane Dalle, Olivier Lambotte, Laurent Kodjikian, Yvan Jamilloux
Summary: This study analyzed ocular immunotherapy-related adverse events (IRAEs) diagnosed in France after the marketing of immune checkpoint inhibitors (ICPIs). The results showed that these events were more common in patients undergoing treatment for metastatic melanoma, and local or systemic corticosteroids were effective in controlling them.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yating Xu, Jingjing Li, Yuxuan Xu, Wei Xia, Xingfan Mo, Mingzhi Feng, Fanghua He, Shanshan Li, Fangzhi Du, Qianqiu Wang, Minzhi Wu
Summary: The clinical features of ocular syphilis include vision loss and ocular symptoms, and it often co-occurs with neurosyphilis. Timely and effective treatment is crucial to prevent vision impairment and other adverse outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Kyung Woo Kim, Sentaro Kusuhara, Hisanori Imai, Noriyuki Sotani, Ryuto Nishisho, Wataru Matsumiya, Makoto Nakamura
Summary: The study showed that 27-gauge PPV surgery can improve BCVA and reduce intraocular inflammation in uveitis-related ocular disorders, making it a promising option for the treatment of such conditions.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Elizabeth J. Chen, Muhammad Amir Bin Ismail, Helen Mi, Su Ling Ho, Wee Kiak Lim, Stephen C. Teoh, Rupesh Agrawal
OCULAR IMMUNOLOGY AND INFLAMMATION
(2018)
Article
Ophthalmology
Leslie Ang, Aera Kee, Tun Hang Yeo, V. G. Dinesh, Su Ling Ho, Stephen C. Teoh, Rupesh Agrawal
INTERNATIONAL OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Philemon K. Huang, Chen Jianping, Daniel Vitor Vasconcelos-Santos, Jacqueline Souza Dutra Arruda, Parthopratim Dutta Majumder, Eliza Anthony, Sudha K. Ganesh, Jyotirmay Biswas, Ho Su Ling, Stephen C. Teoh, Rupesh Agrawal
OCULAR IMMUNOLOGY AND INFLAMMATION
(2018)
Article
Ophthalmology
Joanne H. Lee, Helen Mi, Rachel Lim, Su Ling Ho, Wee Kiak Lim, Stephen C. Teoh, Rupesh Agrawal
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Ophthalmology
Joshua Lane, Ethan Nyugen, Julie Morrison, Lyndell Lime, Richard Stawell, Lauren Hodgson, Muhammad Amir Bin Ismail, Ho Su Ling, Stephen Teoh, Rupesh Agrawal, Padmamalini Mahendradas, Parvathi Hari, Poornachandra B. Gowda, Ankush Kawali, Peter J. McCluskey
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Ophthalmology
Rupesh Agrawal, Dinesh Visva Gunasekeran, Aniruddha Agarwal, Ester Carreno, Kanika Aggarwal, Bhaskar Gupta, Dhananjay Raje, Somasheila I. Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. Gonzalez-Lopez, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Joanne Lord, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, John Kempen, Emmett T. Cunningham, Andres Rousselot, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Ophthalmology
Xiu Ling Tan, Sophia Seen, Parthopratim Dutta Majumder, Sudha K. Ganesh, Mamta Agarwal, Aniruddh Soni, Jyotirmay Biswas, Kanika Aggarwal, Padmamalini Mahendradas, Vishali Gupta, Ho Su Ling, Stephen Teoh, Carlos Pavesio, Rupesh Agrawal
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Ophthalmology
Rebecca Low, Elizabeth J. Chen, Muhammad Amir Bin Ismail, Helen Mi, Ho Su Ling, Wee Kiak Lim, Stephen C. Teoh, Rupesh Agrawal
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Ophthalmology
Ching Wei Lim, Jun Cheng, Elton Lik Tong Tay, Hwei Yee Teo, Elizabeth Poh Ying Wong, Vernon Khet Yau Yong, Boon Ang Lim, Owen Kim Hee, Hon Tym Wong, Leonard Wei Leon Yip
Review
Ophthalmology
Ilaria Testi, Rupesh Agrawal, Sarakshi Mahajan, Aniruddha Agarwal, Dinesh Visva Gunasekeran, Dhananjay Raje, Kanika Aggarwal, Somasheila Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreno, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. Gonzalez-Lopez, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Degli Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Andres Rousselot, Robert Grant, Onn Min Kon, Emmett T. Cunningham, John Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Ophthalmology
Rupesh Agrawal, Aniruddha Agarwal, Douglas A. Jabs, Aera Kee, Ilaria Testi, Sarakshi Mahajan, Peter J. McCluskey, Amod Gupta, Alan Palestine, Alastair Denniston, Alay Banker, Alessandro Invernizzi, Alex Fonollosa, Aman Sharma, Amitabh Kumar, Andre Curi, Annabelle Okada, Ariel Schlaen, Arnd Heiligenhaus, Atul Kumar, Avinash Gurbaxani, Bahram Bodaghi, Bulbul Islam Shah, Careen Lowder, Christoph Tappeiner, Cristina Muccioli, Daniel Vitor Vasconcelos-Santos, Debra Goldstein, Digambar Behra, Dipankar Das, Dorine Makhoul, Edoardo Baglivo, Ekaterina Denisova, Elisabetta Miserocchi, Ester Carreno, Fatma Asyari, Francesco Pichi, H. Nida Sen, Harvey Uy, Heloisa Nascimento, Ilknur Tugal-Tutkun, J. Fernando Arevalo, Janet Davis, Jennifer Thorne, Joyce Hisae Yamamoto, Justine Smith, Justus G. Garweg, Jyotirmay Biswas, Kalpana Babu, Kanika Aggarwal, Luca Cimino, Lucia Kuffova, Mamta Agarwal, Manfred Zierhut, Manisha Agarwal, Marc De Smet, Maria Sofia Tognon, Marie-Helene Errera, Marion Munk, Mark Westcott, Masoud Soheilian, Massimo Accorinti, Moncef Khairallah, Myhanh Nguyen, Onn Minn Kon, Padmamalini Mahendradas, Peizeng Yang, Piergiorgio Neri, Pinar Ozdal, Radgonde Amer, Richard Lee, Rina La Distia Nora, Romi Chhabra, Rubens Belfort, Salil Mehta, Samir Shoughy, Saurabh Luthra, Shelina Oli Mohamed, Soon-Phaik Chee, Soumyava Basu, Stephen Teoh, Sudha Ganesh, Talin Barisani-Asenbauer, Yan Guex-Crosier, Yilmaz Ozyazgan, Yonca Akova, Zohar Habot-Wilner, John Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Ophthalmology
Rupesh Agrawal, Ilaria Testi, Sarakshi Mahajan, Yew Sen Yuen, Aniruddha Agarwal, Onn Min Kon, Talin Barisani-Asenbauer, John H. Kempen, Amod Gupta, Douglas A. Jabs, Justine R. Smith, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
Summary: The international, expert-led consensus initiative developed evidence-based recommendations for the treatment of tubercular choroiditis. Consensus guidelines were established to bridge the gap between clinical need and available medical evidence for managing this eye condition.
Article
Ophthalmology
Rupesh Agrawal, Ilaria Testi, Sarakshi Mahajan, Yew Sen Yuen, Aniruddha Agarwal, Andres Rousselot, Dhananjay Raje, Dinesh Visva Gunasekeran, Onn Min Kon, Talin Barisani-Asenbauer, John H. Kempen, Amod Gupta, Douglas A. Jabs, Justine R. Smith, Bahram Bodaghi, Manfred Zierhut, Marc DeSmet, Peter Mc Cluskey, Mamta Agarwal, Manisha Agarwal, Kanika Aggarwal, Mukesh Agrawal, Hassan Al-Dhibi, Sofia Androudi, Fatma Asyari, Manohar Babu Balasundaram, Kalpana Babu Murthy, Edoardo Baglivo, Alay Banker, Reema Bansal, Soumyava Basu, Digamber Behera, Jyotirmay Biswas, Ester Carreno, Laure Caspers, Soon Phaik Chee, Romi Chhabra, Luca Cimino, Luz Elena Concha del Rio, Emmett T. Cunningham, Andre Luiz Land Curi, Dipankar Das, Ekaterina Denisova, Alastair K. Denniston, Marie-Helene Errera, Alejandro Fonollosa, Amala George, Debra A. Goldstein, Yan Guex Crosier, Avinash Gurbaxani, Alessandro Invernizzi, Hazlita M. Isa, Shah Md Islam, Nicholas Jones, Deeksha Katoch, Moncef Khairallah, Amit Khosla, Michal Kramer, Amitabh Kumar, Atul Kumar, Rina La Distia Nora, Richard Lee, Careen Lowder, Saurabh Luthra, Padmamalini Mahendradas, Dorine Makhoul, Shahana Mazumdar, Salil Mehta, Elisabetta Miserocchi, Manabu Mochizuki, Oli S. Mohamed, Cristina Muccioli, Marion R. Munk, Somasheila Murthy, Shishir Narain, Heloisa Nascimento, Piergiorgio Neri, Myhanh Nguyen, Annabelle A. Okada, Pinar Ozdal, Alan Palestine, Francesco Pichi, S. R. Rathinam, Ariel Schlaen, Shobha Sehgal, H. Nida Sen, Aman Sharma, Kusum Sharma, Samir S. Shoughy, Nirbhai Singh, Ramandeep Singh, Masoud Soheilian, Sudharshan Sridharan, Jennifer E. Thorne, Christoph Tappeiner, Stephen Teoh, Maria Sofia Tognon, Ilknur Tugal-Tutkun, Mudit Tyagi, Harvey Uy, Daniel Vitor Vasconcelos Santos, Natasa Vidovic Valentincic, Mark Westcott, Ryoji Yanai, Bety Yanez Alvarez, Rahman Zahedur, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Ophthalmology
Aniruddha Agarwal, Rupesh Agrawal, Dinesh Visva Gunasekaran, Dhananjay Raje, Bhaskar Gupta, Kanika Aggarwal, Somasheila L. Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreno, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. Gonzalez-Lopez, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett Cunningham, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Ophthalmology
Mohamed K. Soliman, Giampoalo Gini, Ferenc Kuhn, Mariano Iros, Barbara Parolini, Sengul Ozdek, Zofia Michalewska, Silvia Bopp, Ron A. Adelman, Ahmed B. Sallam
OPHTHALMOLOGY RETINA
(2019)
