Journal
OCULAR IMMUNOLOGY AND INFLAMMATION
Volume 19, Issue 3, Pages 192-201Publisher
INFORMA HEALTHCARE
DOI: 10.3109/09273948.2010.538798
Keywords
immunogenetics; KIR; NK cell; uveitis
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Funding
- MacDonald Foundation, Los Angeles, CA
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Purpose: to review the function and genetics of killer immunoglobulin-like receptors (KIRs) and studies of KIR genetic associations with uveitis. Methods: Review of published studies. Results: KIRs are receptors on NK and some T cells. They may inhibit or activate cellular function, such as cytotoxicity and cytokine production. Studies have been published examining KIR gene associations with birdshot chorioretinopathy (BCR), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated acute anterior uveitis (AAU) and axial spondyloarthropathy. Evidence for increased activating and/or less inhibitory KIR and HLA gene combinations was found for BCR and VKH disease. In HLA-B27-associated disease, a trend toward decreased activation and stronger inhibition was found, except for the weakly inhibitory 3DL1 and Bw4
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