Journal
OCULAR IMMUNOLOGY AND INFLAMMATION
Volume 17, Issue 3, Pages 133-141Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/09273940903108544
Keywords
intraocular lymphoma; diagnosis; cytology; cytokines; immunohistochemistry
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Funding
- Intramural NIH HHS [Z99 EY999999] Funding Source: Medline
- NATIONAL EYE INSTITUTE [ZIEEY000482, ZIAEY000375] Funding Source: NIH RePORTER
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Diagnosis of PIOL can be challenging. It requires a high degree of clinical suspicion and differential diagnosis includes infectious and non-infectious etiologies particularly the common masquaraders sarcoidosis, tuberculosis, viral retinitis and syphilis. The definitive diagnosis depends on demonstration of malignant lymphoma cells in ocular specimens or CSF. Ocular specimen could include vitreous, aqueous or chorioretinal biopsy. Ocular pathologist should be consulted prior to the diagnostic procedure to help handle and process the specimen appropriately. In addition to cytology, flow cytometry, immunohistochemistry, molecular analysis and cytokines may be used as adjuncts in facilitating the diagnosis.
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