Article
Oncology
Kaja Rahu, Mati Rahu, Anssi Auvinen, Hajo Zeeb, John D. Boice Jr
Summary: From 1986 to 1991, 4831 men from Estonia were sent to clean up radioactively contaminated areas near Chernobyl. The study compared their cancer incidence rates to that of the male population of Estonia. It was found that there was an excess of radiation-related cancers combined, but not when smoking- and alcohol-related cancers were excluded. Less educated workers had a higher risk of all cancers and smoking-related cancers. An elevated risk of alcohol-related cancers was evident 15 to 24 years after return from the Chernobyl area.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Buse Sarigul, Ahmet Ogrenci, Mesut Yilmaz, Orkun Koban, Mazhar Mammadov, Sedat Dalbayrak
Summary: Sacral insufficiency fracture (SIF) should be considered in elderly and osteoporotic patients with back and pelvic pain. MRI with coronal STIR imaging is recommended for diagnosing SIF. Sacroplasty provides better and faster pain relief compared to conservative management.
EUROPEAN SPINE JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Ruben Lopez-Bueno, Lars Louis Andersen, Joaquin Calatayud, Jose Casana, Begona Martinez-Jarreta, Jose Francisco Lopez-Gil, Borja del Pozo Cruz
Summary: Recent research from Nordic countries identified occupational physical activity (OPA) as a risk factor for disability pension, but further research in novel populations is needed. This study aimed to assess the association between OPA and disability pension using administrative data. The results showed that participants exposed to higher levels of OPA had a higher risk for disability pension in an exposure-response fashion, highlighting the need for preventative measures for workers with high physical work demands.
PREVENTIVE MEDICINE
(2023)
Article
Orthopedics
Francesco Smeraglia, Morena Anna Basso, Giulia Famiglietti, Andrea Cozzolino, Giovanni Balato, Alessio Bernasconi
Summary: This study aimed to evaluate the clinical and radiographic outcomes of Pyrocardan (R) arthroplasty for treating trapeziometacarpal joint osteoarthritis. The results showed significant improvements in clinical scores and X-ray findings after surgery, with stable results during the follow-up period. The incidence of complications was low, and the implant had a high survival rate.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Medicine, General & Internal
Sanae Abe, Takeshi Iwase
Summary: This case report describes a 65-year-old female patient with patchy chorioretinal atrophy (PCA) progressing to macular intrachoroidal cavitation (ICC) over a 4-year follow-up. The lesion gradually expanded, leading to decreased visual acuity. OCT images revealed thinning of the sensory retina and disappearance of the RPE-Bruch's membrane complex.
Article
Environmental Sciences
Beatrice Bocca, Beatrice Battistini, Veruscka Leso, Luca Fontana, Stefano Caimi, Mauro Fedele, Ivo Iavicoli
Summary: This study developed a methodology for human biomonitoring, based on SP-ICP-MS, to assess the exposure of workers involved in nanomaterial activities. The results showed the presence of ENPs in both workers and controls, suggesting that extra-professional exposure is a potential source of ENPs.
Article
Biochemistry & Molecular Biology
Chen-Jung Wu, A-Chuan Ho, Shih-Ya Chen, Chih-Hong Pan, Hsiao-Chi Chuang, Ching-Huang Lai
Summary: It was found that workers exposed to metal fumes had an increased risk of metabolic syndrome, which was correlated with decreased serum adiponectin levels. Therefore, the study aimed to investigate the impact of heavy metal exposure on adiponectin levels.
Article
Public, Environmental & Occupational Health
Guillaume Saint-Lorant, Michele Vasseur, Delphine Allorge, Nicolas Beauval, Nicolas Simon, Pascal Odou
Summary: This study aimed to monitor contamination by antineoplastic drugs on work surfaces in a compounding unit for 4 years. By analyzing the contamination rate, critical incidents, and safety measures, it was found that the overall contamination rate decreased after the unit's opening and the implementation of corrective actions.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Environmental Sciences
Jiehui Li, Charles B. Hall, Janette Yung, Rebecca D. Kehm, Rachel Zeig-Owens, Ankura Singh, James E. Cone, Robert M. Brackbill, Mark R. Farfel, Baozhen Qiao, Maria J. Schymura, Moshe Z. Shapiro, Christopher R. Dasaro, Andrew C. Todd, David J. Prezant, Paolo Boffetta
Summary: In this study of World Trade Center rescue/recovery workers, overall mortality rates were lower than expected. However, significantly increased mortality risks were observed in certain sub-groups with high exposure, highlighting the need for further investigation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
Ya-Li Wang, Jun-Ru Wang, Bai-Ling Huang, Xu-Huan Yang, Hui-Rong Guo, Yu-Ming Ren
Summary: This study followed up with patients with obsessive-compulsive disorder (OCD) for 4 years to examine changes in efficacy outcomes, defense style questionnaire (DSQ) scores, and clinical features. The study also analyzed the relationship between efficacy levels and changes in patients' psychological defense mechanisms. The findings suggest that abnormal psychological defense mechanisms play a significant role in OCD, and the use of mature defense mechanisms is associated with treatment efficacy.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biotechnology & Applied Microbiology
Kumaran Deiva, Jerome Ausseil, Stephanie De Bournonville, Michel Zerah, Beatrice Husson, Marie-Lise Gougeon, Beatrice Poirier-Beaudouin, Dimitrios Zafeiriou, Giancarlo Parenti, Jean-Michel Heard, Marc Tardieu
Summary: This study reports the safety and efficacy of a novel intracerebral gene therapy in children with Sanfilippo B over a 5.5-year follow-up. While the treatment showed a good safety profile, adverse events were reported and enzyme activity remained detectable in the cerebrospinal fluid, suggesting a lack of acquired tolerance. Patients showed varying levels of neurocognitive evolution, with the youngest patient showing milder disease progression and better cognitive outcomes.
HUMAN GENE THERAPY
(2021)
Article
Multidisciplinary Sciences
Manxue Zhang, Xiao Hu, Jian Jiao, Danfeng Yuan, Sixun Li, Tingting Luo, Meiwen Wang, Mingjing Situ, Xueli Sun, Yi Huang
Summary: Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder, with only a small proportion of people obtaining optimal outcomes. This study revealed abnormalities in the white matter microstructure of children with ASD and identified a predictor of optimal outcome.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
M. Locquet, D. Sanchez-Rodriguez, O. Bruyere, A. Geerinck, L. Lengele, J-Y Reginster, C. Beaudart
Summary: The concept of intrinsic capacity, specifically in the domains of mobility and psychological well-being, is crucial for assessing the health and well-being of older adults. Satisfactory levels of intrinsic capacity in these domains are associated with reduced mortality risk. Integration of the concept of intrinsic capacity into clinical practice is recommended for improving the care of older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Medicine, General & Internal
Gregg W. Stone, William T. Abraham, JoAnn Lindenfeld, Saibal Kar, Paul A. Grayburn, D. Scott Lim, Jacob M. Mishell, Brian Whisenant, Michael Rinaldi, Samir R. Kapadia, Vivek Rajagopal, Ian J. Sarembock, Andreas Brieke, Steven O. Marx, David J. Cohen, Federico M. Asch, Michael J. Mack, COAPT Investigators
Summary: Data from a 5-year follow-up of outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation in patients with heart failure demonstrate that this procedure, in addition to medical therapy, leads to lower rates of hospitalization for heart failure and all-cause mortality compared to medical therapy alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Clinical Neurology
Sonja Holm-Yildiz, Thomas Krag, Nanna Witting, Britt Staevnsbo Pedersen, Tina Dysgaard, Louise Sloth, Jonas Pedersen, Rebecca Kjaer, Linda Kannuberg, Julia Dahlqvist, Josefine de Stricker Borch, Tuva Solheim, Freja Fornander, Anne-Sofie Eisum, John Vissing
Summary: This study found that HypoPP can be a progressive myopathy in both patients with and without attacks of paralysis. The study also found that fat replacement of muscles increased in these patients.
JOURNAL OF NEUROLOGY
(2023)
