Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Xiaomei Yu, Li He
Summary: The study suggests that heparin and aspirin treatment show significant improvements in live birth rate, birth weight, and delivery outcomes compared to other treatment options for recurrent spontaneous abortion in women with antiphospholipid syndrome.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Daniel E. Pleguezuelo, Oscar Cabrera-Marante, Magdalena Abad, Edgard Alfonso Rodriguez-Frias, Laura Naranjo, Alicia Vazquez, Olga Villar, Francisco Javier Gil-Etayo, Manuel Serrano, Alfredo Perez-Rivilla, Laura de la Fuente-bitaine, Antonio Serrano
Summary: This study showed that criteria aPL were absent in the majority of patients with recurrent early miscarriage, fetal loss, and extra-criteria recurrent pregnancy loss. However, aPS/PT antibodies were positive in a significant portion of these patients. The presence of aPS/PT antibodies posed a higher risk for recurrent pregnancy loss, but successful live births were achieved in patients who received appropriate treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Shuhai Lan, Shengwen Dong, Shuwen Tang
Summary: Unexplained recurrent spontaneous abortion (URSA) is a challenging issue in obstetrics that may be related to prethrombotic state and placental vascular thrombosis, leading to embryonic dysplasia or abortion. Anticoagulant therapy has been of interest in the obstetrics community, but research findings are inconsistent.
JOURNAL OF REPRODUCTIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Long Zhao, Shuqin Bi, Jinhua Fu, Lijuan Qi, Lin Li, Yinghui Fu
Summary: The study showed that there was no significant difference in pregnancy outcomes between fondaparinux and LMWH in the treatment of recurrent spontaneous abortion caused by PTS. However, fondaparinux had a lower occurrence rate of adverse reactions and higher safety compared to LMWH.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Zhilan Liu, Si Sun, Haijing Xu, Xiaoxin Zhang, Chao Chen, Ruojin Fu, Congcong Li, Feng Guo, Aimin Zhao
Summary: Antibody typing and treatment can improve live birth rate in Chinese patients with APS-related RSA. The combination of anticoagulant and anti-inflammatory treatment leads to a higher live birth rate in the treatment of APS-related RSA.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Marie Carbonnel, Paul Pirtea, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Both congenital and acquired uterine anomalies are associated with recurrent pregnancy loss. Initial evaluation of uterine anatomy is crucial for women with RPL. Surgical management of certain uterine anomalies, such as uterine septa, endometrial polyps, intrauterine adhesions, and submucosal myomas, may improve subsequent pregnancy outcomes in specific circumstances.
FERTILITY AND STERILITY
(2021)
Review
Endocrinology & Metabolism
Rosa Wartena, Mushi Matjila
Summary: The relationship between polycystic ovarian syndrome (PCOS) and recurrent pregnancy loss (RPL) is still poorly understood and requires further research. Factors that should be further investigated include the contribution of PCOS phenotypes, BMI, obesity, insulin resistance, hyperandrogenemia, SHBG, hs-CRP, CTRP6, adiponectin, plasma leptin, homocysteine, AMH, and thrombophilia to the risk of miscarriage. Other factors that need to be explored in relation to the risk of miscarriage in PCOS patients with RPL include sOB-R, PAI-Fx, and Factor-V-Leiden mutations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Meilan Liu, Dongyan Wang, Liqiong Zhu, Jianlan Yin, Xiaohui Ji, Yilei Zhong, Yuan Gao, Jianping Zhang, Yukun Liu, Rui Zhang, Hui Chen
Summary: Thyroid peroxidase antibodies are associated with the first trimester miscarriage rate in euthyroid women with unexplained recurrent spontaneous abortion.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Tianqing Deng, Xiaoyang Liao, Shaomi Zhu
Summary: The treatment of RSA is challenging due to its heterogeneous etiology and lack of specific clinical manifestations. Available treatments target hypothetical risk factors, but their effectiveness is controversial.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Article
Public, Environmental & Occupational Health
Amelia K. Wesselink, Lauren A. Wise, Elizabeth E. Hatch, Ellen M. Mikkelsen, David A. Savitz, Kipruto Kirwa, Kenneth J. Rothman
Summary: The study found that environmental or lifestyle factors more prevalent in late summer may be associated with an increased risk of early spontaneous abortion. This conclusion was based on the analysis of data from the Pregnancy Study Online, a preconception cohort study of pregnancy planners from the United States and Canada, who reported the month and gestational week of their pregnancies.
Article
Public, Environmental & Occupational Health
Jennifer J. Yland, Holly M. Crowe, Elizabeth E. Hatch, Sydney K. Willis, Tanran R. Wang, Ellen M. Mikkelsen, David A. Savitz, Allan J. Walkey, Kenneth J. Rothman, Lauren A. Wise
Summary: The study found that there was no significant association between a history of asthma and the incidence of spontaneous abortion (SAB), but severe asthma (based on medication use) was associated with a higher risk of SAB.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Obstetrics & Gynecology
Alexandra C. Sundermann, Digna R. Velez Edwards, James C. Slaughter, Pingsheng Wu, Sarah H. Jones, Eric S. Torstenson, Katherine E. Hartmann
Summary: The study found that each additional week of alcohol exposure during the first trimester increases the risk of spontaneous abortion, even at low levels of consumption and when excluding binge drinking. Alcohol use during weeks 5 through 10 from last menstrual period was associated with increased spontaneous abortion risk, with risk peaking for use in week 9.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Developmental Biology
Yongmei Han, Ying Wang, Chenyu Zhang, Yanru Li, Jing Guo, Chao Tian
Summary: This study reveals that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) regulates methyl-CpG-binding domain protein 4 (MBD4) expression in antiphospholipid antibody-positive recurrent spontaneous abortion (RSA) by recruiting CREB binding protein (CREBBP), leading to a decrease in the occurrence of RSA in mice.
