Article
Endocrinology & Metabolism
Likui Lu, Bangbei Wan, Miao Sun
Summary: This study used Mendelian randomization (MR) analysis to assess the causal relationship between age at menarche (AAM) and gestational diabetes mellitus (GDM) risk. The results showed a causal association between early AAM and higher GDM risk, independent of other factors. Additionally, the study found correlations between sex hormone-binding globulin (SHBG) levels and bioavailable testosterone (BioT) levels with GDM risk. However, after controlling for AAM and other factors, there was no direct causal effect of SHBG levels and BioT levels on GDM risk. Furthermore, there was no direct causal association identified between estradiol levels and GDM risk.
DIABETES OBESITY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Wenhua Liu, Zheren Huang, Shanshan Tang, Zhifen Zhang, Qing Yu, Jing He
Summary: The inflammatory response state is related to the pathogenesis of gestational diabetes mellitus. Increased serum levels of Hcy and hs-CRP in pregnant women with GDM, and decreased levels of SHBG, were discovered compared with pregnant women with normal glucose tolerance. Elevated Hcy and hs-CRP levels and decreased SHBG levels during pregnancy were independent predictors of GDM.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Xi Luo, Wang-Yu Cai, Jian-Yuan Song, Cui-Cui Duan, Wei Wu, Yu-Jing Man, Xiao-Ke Wu, Jian Xu
Summary: SHBG shows predictive value for GDM and may improve GDM screening, but heterogeneity among studies requires further research.
BIOMARKERS IN MEDICINE
(2021)
Article
Obstetrics & Gynecology
Khalid Siddiqui, Teena P. George, Salini Scaria Joy, Shaik Sarfaraz Nawaz
Summary: This study demonstrates a strong association between sex hormone binding globulin (SHBG) and gestational age in women with gestational diabetes mellitus (GDM). The findings suggest that parity and gestational age should be considered when analyzing SHBG as a marker for GDM diagnosis.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Rong Huang, Ying Wang, Rengna Yan, Bo Ding, Jianhua Ma
Summary: This study investigated the correlation between sex hormones, sex hormone binding globulin (SHBG), and insulin resistance in male patients with newly diagnosed type 2 diabetes mellitus (T2DM). The results showed that SHBG is an independent predictor for insulin resistance in male patients with newly diagnosed T2DM.
Review
Physiology
Martin Hill, Antonin Parizek, Patrik Simjak, Michal Koucky, Katerina Anderlova, Hana Krejci, Daniela Vejrazkova, Leona Ondrejikova, Andrej Cerny, Radmila Kancheva
Summary: Gestational diabetes mellitus (GDM) is associated with elevated levels of steroids and their crucial role in pregnancy. Factors such as low SHBG levels, placental hormones, and neuroactive steroids play important roles in the pathophysiology of GDM. The complex actions of steroids, including their effects on insulin resistance, hyperinsulinemia, and pituitary functioning, require further studies to determine their predominant effects and predictive values in predisposition to GDM.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao
Summary: This study aims to evaluate the association between sex hormones and sex hormone-binding globulin (SHBG) with bone mineral density (BMD) in adolescents. The results show differences in the association of sex hormones with BMD in boys and girls, where an appropriate increase in serum testosterone levels may be beneficial for skeletal development in girls and keeping estradiol levels below a certain level in boys may be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Chadakarn Phaloprakarn, Siriwan Tangjitgamol
Summary: Suboptimal glycemic control during GDM pregnancy increases the risk of postpartum T2DM and prediabetes.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Biochemistry & Molecular Biology
Justin Harbs, Sabina Rinaldi, Pekka Keski-Rahkonen, Xijia Liu, Richard Palmqvist, Bethany Van Guelpen, Sophia Harlid
Summary: Endogenous sex hormones and DNA methylation have important roles in various diseases, but their interaction is largely unknown. This study investigated the associations between circulating sex hormones, sex hormone binding globulin (SHBG), and DNA methylation in blood samples from 77 men. The findings suggest a relationship between circulating sex hormones and DNA methylation, and several differentially methylated regions were associated with hormone-related genes and diseases.
Article
Public, Environmental & Occupational Health
Shuai Yuan, Lijuan Wang, Jing Sun, Lili Yu, Xuan Zhou, Jie Yang, Yimin Zhu, Dipender Gill, Stephen Burgess, Joshua C. Denny, Susanna C. Larsson, Evropi Theodoratou, Xue Li
Summary: This study used Mendelian randomization to investigate the associations between sex hormone binding globulin (SHBG), testosterone, and estradiol levels and disease outcomes. The results suggest a causal relationship between sex hormones and several health outcomes.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ali Alquraini
Summary: This study evaluated the efficacy of hexaconazole to bind with sex hormone-binding globulin (SHBG) and found that it has a stable molecular interaction with SHBG, leading to significant endocrine disruption during agricultural work.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Michel E. S. Watz, Asa Tivesten, Kristin Ottarsdottir, Ying Li, Margareta I. Hellgren, Ulf Lindblad, Bledar Daka
Summary: The study investigated the association between SHBG levels, blood pressure changes, and development of hypertension. The results showed that higher SHBG levels were associated with a lower risk of developing hypertension and a decrease in blood pressure levels.
JOURNAL OF HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Pei Xu, Rong Zeng, Qiyou Wan, Yan Xie, Xingyan Liu, Songlin An, Jing Jiang, Jing Yang, Yuanzhong Zhou, Xubo Shen
Summary: This study investigated the association between serum sex hormone-binding globulin (SHBG) levels and synthesis-related factors in men of different age groups. The findings revealed that SHBG levels increased with age while the levels of hepatic nuclear factor 4α (HNF-4α) and peroxisome proliferator-activated receptor γ (PPAR-γ) decreased. Similar results were observed in rats, suggesting that the aging-related increase in SHBG levels is associated with increased SHBG synthesis.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Yutang Wang
Summary: This study established criteria for low SHBG among US adults and found the estimated national prevalence to be 3.3% in men and 2.7% in women. Risk factors for this condition include higher BMI, diabetes, ethnicity, COPD, coronary heart disease, and smoking.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Yutang Wang
Summary: Consumption of tree nuts is positively associated with circulating levels of SHBG in women in a general population, particularly in premenopausal women. Adjustment for all tested confounders showed that tree nut consumption is positively associated with SHBG levels, but not with testosterone and estradiol.
NUTRITION RESEARCH
(2021)
