Article
Multidisciplinary Sciences
Yue-Mei Hu, Zhao-Feng Bi, Ya Zheng, Li Zhang, Feng-Zhu Zheng, Kai Chu, Ya-Fei Li, Qi Chen, Jia-Li Quan, Xiao-Wen Hu, Xing-Cheng Huang, Kong-Xin Zhu, Ya-Hui Wang-Jiang, Han -Min Jiang, Xia Zang, Dong-Lin Liu, Chang -Lin Yang, Hong-Xing Pan, Qiu-Fen Zhang, Ying-Ying Su, Shou-Jie Huang, Guang Sun, Wei-Jin Huang, Yue Huang, Ting Wu, Jun Zhang, Ning-Shao Xia
Summary: This study evaluated the immunogenicity and safety of the Escherichia coli-produced second-generation nonavalent HPV vaccine (Cecolin 9). The results showed that Cecolin 9 had good immunogenicity against all nine HPV types and was well tolerated.
Article
Oncology
Shreya P. P. Ramkumar, Matthew C. C. Simpson, Eric Adjei Boakye, Aleksandr R. R. Bukatko, Jastin L. L. Antisdel, Sean T. T. Massa, Nosayaba Osazuwa-Peters
Summary: This study aimed to assess the independent prognostic role of human papillomavirus (HPV) status in sinonasal cancer. The results showed that HPV16/18-positive sinonasal cancer had a higher survival rate compared to HPV-negative cases, while other high-risk and low-risk HPV subtypes had similar survival rates to HPV-negative disease. Therefore, HPV status may be an important independent prognostic factor in sinonasal cancer.
Article
Immunology
Yajun Shu, Yebin Yu, Ying Ji, Li Zhang, Yuan Li, Haiyang Qin, Zhuhang Huang, Zhiqiang Ou, Meilian Huang, Qiong Shen, Zehong Li, Meng Hu, Chunyun Li, Gaoxia Zhang, Jikai Zhang
Summary: This study demonstrates that the novel 4- and 9-valent HPV vaccines are non-inferior to Gardasil 4 in terms of immunogenicity and safety. The vaccines are highly immunogenic and well tolerated.
Article
Immunology
Adolfo Pedroza-Saavedra, Angelica Nallelhy Rodriguez-Ocampo, Azucena Salazar-Pina, Aislinn Citlali Perez-Morales, Lilia Chihu-Amparan, Minerva Maldonado-Gama, Aurelio Cruz-Valdez, Fernando Esquivel-Guadarrama, Lourdes Gutierrez-Xicotencatl
Summary: Antibodies against VLPs-16/18 are effective in detecting HPV-vaccinated women, while antibodies against L1-16 are better at differentiating the CIN3/CC group. Larger population studies are needed to validate these results.
Article
Immunology
Kavita Panwar, Anna Godi, Clementina E. Cocuzza, Nick Andrews, Jo Southern, Paul Turner, Elizabeth Miller, Simon Beddows
Summary: The study evaluated the antibody response of HPV vaccines against different types of human papillomavirus. The findings showed that the vaccines provided long-lasting protection against vaccine types and maintained high antibody levels against related non-vaccine types. This contributes to the evidence base supporting public health intervention.
Review
Pharmacology & Pharmacy
Xiaoli Yan, Hongyu Li, Bin Song, Ge Huang, Qing Chang, Dan Wang, Ping Yan
Summary: This study aimed to evaluate whether periconceptional or pregnancy exposure to human papillomavirus (HPV) vaccination would increase the risk of adverse pregnancy outcomes. The meta-analysis included four randomized controlled trials and eight cohort studies. The results showed that HPV vaccine exposure in the periconceptional period or during pregnancy did not increase the risks of adverse pregnancy outcomes, such as spontaneous abortion, birth defects, stillbirth, preterm birth, and ectopic pregnancy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Kai Chu, Zhao-Feng Bi, Wei-Jin Huang, Ya-Fei Li, Li Zhang, Chang-Lin Yang, Han -Min Jiang, Xia Zang, Qi Chen, Dong-Lin Liu, Hong-Xing Pan, Yue Huang, Feng-Zhu Zheng, Qiu-Fen Zhang, Guang Sun, Ying-Ying Su, Shou-Jie Huang, Hui-Rong Pan, Ting Wu, Yue-Mei Hu, Jun Zhang, Feng-Cai Zhu, Ning-Shao Xia
Summary: This phase 1 clinical trial evaluated the safety and immunogenicity of a second-generation nonavalent HPV vaccine and showed that it was well tolerated and immunogenic, providing encouragement for further studies in larger cohorts and a wider age range.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Virology
Laura Sichero, Silvaneide Ferreira, Rossana V. M. Lopez, Barbara P. Mello, Victor Costa, Vivian N. R. El-Achkar, Roman Carlos, Alfredo Ribeiro-Silva, Shirley Pignatari, Estela Kaminagakura, Luisa L. Villa
Summary: The study revealed variations in the distribution of HPV 6 and 11 variants in juvenile onset and adult onset laryngeal papillomas, however, there was no association found between any specific HPV 6 or 11 variant and clinicopathological features.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Shang-Ying Hu, Sabrina H. Tsang, Feng Chen, Qin-Jing Pan, Wen-Hua Zhang, Ying Hong, Joshua N. Sampson, Allan Hildesheim, Fang-Hui Zhao, Aimee R. Kreimer
Summary: The study found that vaginal infections are associated with incident non-HPV16/18 infections in the cervix, but do not impact the persistence of non-HPV16/18 infections after 6 months among women vaccinated with HPV16/18.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Anna P. Staniczenko, Timothy Wen, Ana G. Cepin, Jean Guglielminotti, Teresa C. Logue, Nicole Krenitsky, Youngmei Huang, Mary D'Alton, Alexander M. Friedman
Summary: The number of delivery hospitalizations among adolescents has decreased, but the risk of comorbidities and adverse outcomes has increased.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alexandru Tirziu, Speranta Avram, Leonard Mada, Mihaela Crisan-Vida, Casiana Popovici, Dan Popovici, Cosmin Faur, Corina Duda-Seiman, Virgil Paunescu, Corina Vernic
Summary: Human papillomavirus types 16 and 18 are major causes of cervical cancers worldwide. While prophylactic vaccines based on virus-like particles (VLP) of the major capsid protein (L1) are available, they cannot eliminate existing infections. This study proposes a synthetic long peptide (SLP)-based vaccine as an alternative for infected individuals, including those with precancerous lesions. The SLP vaccine is designed to stimulate both CD8+ and CD4+ T cells, providing a strong and long-lasting immune response.
Article
Virology
Taro Ikegami, Norimoto Kise, Hidetoshi Kinjyo, Shunsuke Kondo, Mikio Suzuki, Narutoshi Tsukahara, Akikazu Murakami, Asanori Kiyuna, Shinya Agena, Katsunori Tanaka, Narumi Hasegawa, Junko Kawakami, Akira Ganaha, Hiroyuki Maeda, Hitoshi Hirakawa
Summary: This study investigated the viral gene expression of HPV-11 and evaluated antibodies against HPV-6 and HPV-11 E4 protein in laryngeal papilloma (LP). The results showed potential clinical applications for these E4-specific antibodies in functional studies and targeted molecular therapies for patients with HPV-6 and HPV-11 infection.
Article
Acoustics
Dong Wook Kwak, Jeong In Yang, Kwan Heup Song, Hyun Mee Ryu, You Jung Han, Moon Young Kim, Jin Hoon Chung
Summary: Fetal crown-rump length (CRL) measured between 11 to 13 weeks of gestation can predict the risk of large for gestational age (LGA), small for gestational age, or preterm delivery. A small CRL is associated with an increased risk of smaller-than-gestational-age neonates and preterm delivery, while a large CRL is associated with an increased risk of LGA neonates and a decreased risk of gestational diabetes.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Immunology
Joske Hoes, Petra J. Woestenberg, Johannes A. Bogaards, Audrey J. King, Hester E. de Melker, Johannes Berkhof, Christian J. P. A. Hoebe, Marianne A. B. van der Sande, Birgit H. B. van Benthem
Summary: This study assessed trends in HPV prevalence over 8 years postvaccination among men and women in the Netherlands. Significant declines were observed in vaccine types HPV-16/18 among women, heterosexual men, and unvaccinated women, while increases were observed for certain HPV types in women and unvaccinated women. The results provide evidence of herd effects against HPV-16/18 among heterosexual men and cross-protective types, as well as herd effects against vaccine types among unvaccinated women.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Oncology
Fausto Petrelli, Gabriella De Santi, Valentina Rampulla, Antonio Ghidini, Paola Mercurio, Marco Mariani, Michele Manara, Emanuele Rausa, Veronica Lonati, Matteo Viti, Andrea Luciani, Andrea Celotti
Summary: The study found that HPV-16/18 can be detected in approximately 1 in 5 cases of ESCC, with varying prevalences worldwide. HPV infection is moderately but significantly associated with a diagnosis of ESCC. Further epidemiological studies are needed to confirm and expand the current knowledge on this topic.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
