Article
Cardiac & Cardiovascular Systems
Qian Zhang, Fang Zhu, Guocheng Shi, Chen Hu, Weituo Zhang, Puzhen Huang, Chunfeng Zhu, Hong Gu, Dong Yang, Qiangqiang Li, Yonghua Niu, Hao Chen, Ruixiang Ma, Ziyi Pan, Huixian Miao, Xin Zhang, Genxia Li, Yabing Tang, Guyuan Qiao, Yichen Yan, Zhongqun Zhu, Hao Zhang, Fengzhen Han, Yanna Li, Jianhua Lin, Huiwen Chen
Summary: This study evaluated the pregnancy outcomes in women with congenital heart disease (CHD) with and without pulmonary hypertension (PH). The results showed that women with CHD-associated mild PH had better pregnancy outcomes compared to those with moderate-to-severe PH, with similar outcomes to women with CHD and no PH.
Review
Cardiac & Cardiovascular Systems
Isabel Hardee, Lydia Wright, Courtney McCracken, Emily Lawson, Matthew E. Oster
Summary: This study evaluated maternal and neonatal outcomes of pregnancies among women with congenital heart disease (CHD) in the modern era, finding that pregnancy in women with CHD typically has a successful outcome in both mother and child. However, as maternal CHD severity increases, the risk of numerous morbidities and neonatal mortality also increases. These findings may be helpful in counseling women with CHD, especially those with severe lesions, who plan to become pregnant.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Acoustics
Gabriele Saccone, Cihat Sen, Daniele Di Mascio, Alberto Galindo, Amos Grunebaum, Jun Yoshimatsu, Milan Stanojevic, Asim Kurjak, Frank Chervenak, Maria Jose Rodriguez Suarez, Zita Maria Gambacorti-Passerini, Maria de los Angeles Anaya Baz, Esther Vanessa Aguilar Galan, Yolanda Cunarro Lopez, Juan Antonio De Leon Luis, Ignacio Cueto Hernandez, Ignacio Herraiz, Cecilia Villalain, Roberta Venturella, Giuseppe Rizzo, Ilenia Mappa, Giovanni Gerosolima, Lars Hellmeyer, Josefine Koenigbauer, Giada Ameli, Tiziana Frusca, Nicola Volpe, Giovanni Battista Luca Schera, Stefania Fieni, Eutalia Esposito, Giuliana Simonazzi, Gaetana Di Donna, Aly Youssef, Anna Nunzia Della Gatta, Mariano Catello Di Donna, Vito Chiantera, Natalina Buono, Giulio Sozzi, Pantaleo Greco, Danila Morano, Beatrice Bianchi, Maria Giulia Lombana Marino, Federica Laraud, Arianna Ramone, Angelo Cagnacci, Fabio Barra, Claudio Gustavino, Simone Ferrero, Fabio Ghezzi, Antonella Cromi, Antonio Simone Lagana, Valentina Laurita Longo, Francesca Stollagli, Angelo Sirico, Antonio Lanzone, Lorenza Driul, Fabiana Cecchini, Serena Xodo, Brian Rodriguez, Felipe Mercado-Olivares, Deena Elkafrawi, Giovanni Sisti, Rosanna Esposito, Antonio Coviello, Marco Cerbone, Maddalena Morlando, Antonio Schiattarella, Nicola Colacurci, Pasquale De Franciscis, Ilaria Cataneo, Marinella Lenzi, Fabrizio Sandri, Riccardo Buscemi, Giorgia Gattei, Francesca della Sala, Eleonora Valori, Maria Cristina Rovellotti, Elisa Done, Gilles Faron, Leonardo Gucciardo, Valentina Esposito, Flaminia Vena, Antonella Giancotti, Roberto Brunelli, Ludovico Muzii, Luigi Nappi, Felice Sorrentino, Marco Liberati, Danilo Buca, Martina Leombroni, Francesca Di Sebastiano, Massimo Franchi, Quintino Cesare Ianniciello, Simone Garzon, Giuliano Petriglia, Leonardo Borrello, Albaro Jose Nieto-Calvache, Juan Manuel Burgos-Luna, Caroline Kadji, Andrew Carlin, Elisa Bevilacqua, Marina Moucho, Pedro Viana Pinto, Rita Figueiredo, Jose Morales Rosello, Gabriela Loscalzo, Alicia Martinez-Varea, Vincente Diago, Jesus S. Jimenez Lopez, Yeliz Aykanat, Stefano Cosma, Andrea Carosso, Chiara Benedetto, Amanda Bermejo, Otto Henrique May Feuerschuette, Ozlem Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha Atak, Reyhan Gunduz, Esra Tustas Haberal, Bernd Froessler, Anupam Parange, Peter Palm, Igor Samardjiski, Chiara Taccaliti, Erhan Okuyan, George Daskalakis, Renato Augusto Moreira de Sa, Alejandro Pittaro, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Serife Ozlem Genc, Blanka Zlatohlavkova, Anna Luengo Piqueras, Dolores Esteban Oliva, Aylin Pelin Cil, Olus Api, Panos Antsaklis, Liana Ples, Ioannis Kyvernitakis, Holger Maul, Marcel Malan, Albert Lila, Roberta Granese, Alfredo Ercoli, Giuseppe Zoccali, Andrea Villasco, Nicoletta Biglia, Ciuhodaru Madalina, Elena Costa, Caroline Daelemans, Axelle Pintiaux, Elisa Cueto, Eran Hadar, Sarah Dollinger, Noa A. Brzezinski-Sinai, Erasmo Huertas, Pedro Arango, Amadeo Sanchez, Javier Alfonso Schvartzman, Liviu Cojocaru, Sifa Turan, Ozhan Turan, Maria Carmela Di Dedda, Rebeca Garrote Molpeceres, Snezana Zdjelar, Tanja Premru-Srsen, Lilijana Kornhauser-Cerar, Miriam Druskovic, Valentina De Robertis, Vedran Stefanovic, Irmeli Nupponen, Kaisa Nelskyla, Zulfiya Khodjaeva, Ksenia A. Gorina, Gennady T. Sukhikh, Giuseppe Maria Maruotti, Silvia Visentin, Erich Cosmi, Jacopo Ferrari, Alessandra Gatti, Daniela Luvero, Roberto Angioli, Ludovica Puri, Marco Palumbo, Giusella D'Urso, Francesco Colaleo, Agnese Maria Chiara Rapisarda, Ilma Floriana Carbone, Lamberto Manzoli, Maria Elena Flacco, Giovanni Nazzaro, Mariavittoria Locci, Maurizio Guida, Attilio Di Spiezio Sardo, Pierluigi Benedetti Panici, Asma Khalil, Vincenzo Berghella, Giuseppe Bifulco, Giovanni Scambia, Fulvio Zullo, Francesco D'Antonio
Summary: This study evaluated the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection, finding a higher risk of ICU admission for infected mothers but a negligible risk of vertical transmission.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Gastroenterology & Hepatology
Annsa C. Huang, Joshua Grab, Jennifer A. Flemming, Jennifer L. Dodge, Roxanna A. Irani, Monika Sarkar
Summary: The incidence of cirrhosis in pregnancies from outside the United States is rising. This study found that pregnancies with cirrhosis more than doubled over the past decade in the United States. Cirrhosis in pregnancies was associated with an increased risk of adverse events, although maternal and perinatal mortality was low.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Obstetrics & Gynecology
Juan M. M. Gonzalez, Ian Harris, Norma Jimenez Ramirez, Dana Myers, Molly Killion, Mari-Paule Thiet, Katherine Bianco
Summary: The number of women with cardiac disease in the U.S. is increasing, leading to poor obstetrical and neonatal outcomes. A multidisciplinary approach is necessary for optimal care of this high-risk obstetrics population.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Junita Indarti, Seprializa Ria, Fita Maulina, Biancha Andardi, Jessica Octavianti, Victor Prana Andika Santawi
Summary: The study revealed a high rate of preterm birth and cesarean section in pregnancies affected by maternal cardiovascular disease, with a high ICU admission rate. Additionally, the maternal mortality rate was 7.1% and the neonatal asphyxia rate was 11.4%.
JOURNAL OF REPRODUCTIVE MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Rommy H. Novoa, Willy Quintana, Pedro Llancari, Katherine Urbina-Quispe, Enrique Guevara-Rios, Walter Ventura
Summary: Among 322 pregnant women with COVID-19, the most common maternal comorbidity was obesity (24.2%), with 28.4% being asymptomatic at admission. Fever and cough were the most prevalent symptoms, with premature birth being the main adverse obstetric outcome.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Obstetrics & Gynecology
Maeva Landry, Mickael Allouche, Christophe Vayssiere, Paul Guerby, Marion Groussolles
Summary: This study describes the outcomes of pregnancies after 42 years and compares the maternal and fetal morbidities between spontaneous pregnancies and those resulting from assisted reproductive technology (ART). The results show that there are more complications in pregnancies obtained through ART compared to spontaneous pregnancies.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Pediatrics
Mark L. Hudak, Dustin D. Flannery, Kimberly Barnette, Trace Getzlaff, Shiva Gautam, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer, Sascha R. Ellington, Romeo R. Galang, Margaret C. Snead, Kate R. Woodworth, Lauren B. Zapata, Karen M. Puopolo
Summary: The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study found that early in the pandemic, newborns acquired SARS-CoV-2 infection at variable rates and without apparent short-term effects. Additionally, higher than expected numbers of preterm births and maternal in-hospital deaths were observed.
Article
Nutrition & Dietetics
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Su-Fan Lin, Chien-Ning Hsu
Summary: Emerging evidence suggests that disturbances in early-life gut microbiota can influence adult disease. In this study, the researchers found that maternal chronic kidney disease (CKD) can lead to offspring hypertension, but perinatal supplementation of propionate can prevent this and reverse established hypertension. This protective effect is associated with increased propionate-generating bacteria, elevated plasma propionate levels, higher expression of the SCFA receptor GPR41, improved gut microbiota diversity, and shifts in composition.
Article
Obstetrics & Gynecology
Lanbo Yang, Alexander M. Friedman, Nicole M. Krenitsky, Timothy Wen, Mary E. D'Alton, Jason D. Wright, Whitney Booker, Yongmei Huang
Summary: This study aimed to determine whether longitudinal health data of patients with chronic hypertension would contribute to organ injury or death. The analysis of 64,799 deliveries to 61,854 women found that the utilization of healthcare services before pregnancy was associated with adverse maternal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
Elizabeth J. Eggleton, Kate J. McMurrugh, Catherine E. Aiken
Summary: This study systematically assessed the impact of cardiomyopathy on maternal pregnancy outcomes. The results showed that pregnant women with cardiomyopathy have higher risks for adverse maternal outcomes, including cesarean delivery, severe maternal adverse cardiovascular events, and in-hospital mortality, compared to women with no heart disease and women with noncardiomyopathy heart disease. Preconception risk assessments and management by expert teams are crucial for pregnancies affected by cardiomyopathy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Sadia Solaiman, Omaema Omar Al-Baghdadi, Thin Thin Hla, Shabana Abdulmajid Kapadia, Hassan M. Elbiss
Summary: Obesity in women is a global issue, and bariatric surgery is widely used for its management. Guidelines recommend avoiding pregnancy for a certain period after surgery due to risks. This study investigated the relation between surgery-to-conception time and pregnancy outcomes, considering gestational weight gain. The results showed that shorter surgery-to-conception interval was associated with inadequate gestational weight gain and lower birth weight. Conception should be delayed after bariatric surgery to improve pregnancy outcomes.
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study reveals a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal and neonatal morbidity/mortality were significantly increased in women with adult congenital heart disease (ACHD) and their offspring compared to non-ACHD controls, highlighting the importance of specialized care and pre-pregnancy counseling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study revealed a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal morbidity and neonatal morbidity/mortality were significantly increased in women with ACHD and their offspring compared to non-ACHD controls, highlighting the need for specialized care and pre-pregnancy counselling.
EUROPEAN HEART JOURNAL
(2021)
Article
Oncology
Craig Erker, Adam Lane, Brooklyn Chaney, Sarah Leary, Jane E. Minturn, Ute Bartels, Roger J. Packer, Kathleen Dorris, Nicholas G. Gottardo, Katherine E. Warren, Alberto Broniscer, Mark W. Kieran, Xiaoting Zhu, Peter White, Phillip J. Dexheimer, Katie Black, Anthony Asher, Mariko DeWire, Jordan R. Hansford, Sridharan Gururangan, Javad Nazarian, David S. Ziegler, Eric Sandler, Allison Bartlett, Stewart Goldman, Chie-Schin Shih, Tim Hassall, Hetal Dholaria, Pratiti Bandopadhayay, Yvan Samson, Michelle Monje, Paul G. Fisher, Andrew Dodgshun, Sarah Parkin, Murali Chintagumpala, Karen Tsui, David Gass, Valerie Larouche, Emmett Broxson, Mercedes Garcia Lombardi, Stacie Shiqi Wang, Jie Ma, Cynthia Hawkins, Dima Hamideh, Lars Wagner, Carl Koschmann, Christine Fuller, Rachid Drissi, Blaise Jones, James Leach, Maryam Fouladi
Summary: In patients with DIPG aged 10 years and older, long-term survivors are typically older with longer symptom duration, and have higher rates of ATRX mutations.
Article
Cardiac & Cardiovascular Systems
Cecilia Berardi, David A. Bluemke, Brian A. Houston, Todd M. Kolb, Joao A. Lima, Theo Pezel, Ryan J. Tedford, Samuel G. Rayner, Richard K. Cheng, Peter J. Leary
Summary: The study revealed that sFlt-1 levels are associated with incident heart failure and cardiovascular mortality. There is also an association between sFlt-1 levels and cardiac mass.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Oncology
Sarah E. S. Leary, Kilburn Lindsay, J. Russell Geyer, Kocak Mehmet, Jie Huang, Kyle S. Smith, Jennifer Hadley, Ralph Ermoian, Tobey J. MacDonald, Stewart Goldman, Peter Phillips, Tina Young Poussaint, James M. Olson, David W. Ellison, Ira J. Dunkel, Maryam Fouladi, Arzu Onar-Thomas, Paul A. Northcott
Summary: This study evaluated the feasibility and safety of incorporating vorinostat and isotretinoin into an intensive chemotherapy regimen for embryonal tumors of the CNS. The results showed that this combination therapy is safe and feasible, and further study is needed to determine its efficacy in high-risk patients.
Article
Cardiac & Cardiovascular Systems
Sophia R. Larson, Alexi L. Vasbinder, Kerryn W. Reding, Peter J. Leary, Kelley R. Branch, Aladdin H. Shadyab, Karen C. Johnson, Bernhard Haring, Robert Wallace, JoAnn E. Manson, Garnet Anderson, Richard K. Cheng
Summary: The study found that there was no association between H2RA use and incident HF among postmenopausal women in the large-scale WHI study. Further studies are needed to explore potential factors that may modify the relationship between H2RA exposure and HF risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Veterinary Sciences
Stephen M. Schwartz, Silvan R. Urfer, Michelle White, Kate Megquier, Sandi Shrager, Audrey Ruple
Summary: The prevalence of cancer in companion dogs is influenced by age and dog size, with malignant tumors being more common than benign tumors. There is no significant difference in tumor prevalence between mixed breed and purebred dogs.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Hongyang Pi, Selma D. Carlson, Lia M. Barros, Laurie Hogl, James N. Kirkpatrick, Stephanie Nolley, David D. Ralph, Samuel G. Rayner, Peter J. Leary
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Respiratory System
Hongyang Pi, Samuel G. Rayner, David D. Ralph, Stephanie Nolley, Lia M. Barros, Zachary L. Steinberg, Peter J. Leary
Summary: This observational study examined the association between thyroid-stimulating hormone (TSH) and mortality in individuals with pulmonary arterial hypertension (PAH). The results showed a strong association between TSH and mortality, regardless of adjustment. However, there was no consistent association between TSH and other markers of disease severity in the PAH cohort.
BMJ OPEN RESPIRATORY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Hongyang Pi, Lu Xia, David D. Ralph, Samuel G. Rayner, Ali Shojaie, Peter J. Leary, Sina A. Gharib
Summary: In this study, metabolic profiling was used to identify the association between plasma metabolomic profiles and right ventricular dilation, mortality, and measures of disease severity in patients with pulmonary arterial hypertension (PAH). The polyamine, histidine, and sphingomyelin metabolic pathways were found to be associated with RV dilation, mortality, and disease severity.
CIRCULATION RESEARCH
(2023)
Editorial Material
Critical Care Medicine
Despina Michailidou, Delphine L. Chen, Bridget F. Collins, Marjorie P. George, David Montani, Samuel G. Rayner, Chanprasert Sirisak, Peter J. Leary
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren N. Carlozzi, Josh Lee, Lia M. Barros, Yonatan Buber, Delphine L. Chen, Michael Mulligan, Karen Ordovas, David D. Ralph, Samuel G. Rayner, Peter J. Leary, Zachary L. Steinberg
Summary: This report presents an early experience with BPA at a single US center. The study found that BPA can improve non-invasive and invasive metrics in patients with chronic thromboembolic pulmonary hypertension, without adding significant morbidity to a high-risk patient population.
RESPIRATORY MEDICINE
(2023)
Letter
Respiratory System
Crystal E. Brown, Jill M. Steiner, Matthew Modes, Ylinne Lynch, Peter J. Leary, J. Randall Curtis, Ruth A. Engelberg
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Connor Fling, Teresa De Marco, Noah A. Kime, Matthew R. Lammi, Laura J. Oppegard, John J. Ryan, Corey E. Ventetuolo, R. James White, Roham T. Zamanian, Peter J. Leary
Summary: This study found significant regional variation in the characteristics and outcomes of pulmonary arterial hypertension (PAH) patients in the United States. The study analyzed participants in the Pulmonary Hypertension Association Registry (PHAR) and identified differences in age, race, marital status, employment, insurance, smoking, alcohol use, etiology, and treatment characteristics among different census regions. The study also found lower mortality in PHAR participants in the West region. This study highlights the need for further research and improvement in providing equitable care for PAH patients in the United States.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Lindsay B. Kilburn, Dong-Anh Khuong-Quang, Jordan R. Hansford, Daniel Landi, Jasper van der Lugt, Sarah E. S. Leary, Pablo Hernaiz Driever, Simon Bailey, Sebastien Perreault, Geoffrey Mccowage, Angela J. Waanders, David S. Ziegler, Olaf Witt, Patricia A. Baxter, Hyoung Jin Kang, Timothy E. Hassall, Jung Woo Han, Darren Hargrave, Andrea T. Franson, Michal Yalon Oren, Helen Toledano, Valerie Larouche, Cassie Kline, Mohamed S. Abdelbaki, Nada Jabado, Nicholas G. Gottardo, Nicolas U. Gerber, Nicholas S. Whipple, Devorah Segal, Susan N. Chi, Liat Oren, Enrica E. K. Tan, Sabine Mueller, Izzy Cornelio, Lisa Mcleod, Xin Zhao, Ashley Walter, Daniel Da Costa, Peter Manley, Samuel C. Blackman, Roger J. Packer, Karsten Nysom
Summary: In a phase 2 trial, the oral type II RAF inhibitor tovorafenib exhibited an overall response rate of 67% in patients with BRAF-altered relapsed/refractory pediatric low-grade glioma.
Article
Cardiac & Cardiovascular Systems
Laura J. Oppegard, Lia M. Barros, Hongyang Pi, James Kornfield, Catherine L. Hough, Samuel G. Rayner, Jeffrey C. Robinson, Peter J. Leary
Summary: The relationship between obesity and outcomes in pulmonary arterial hypertension (PAH) is complex. Previous studies suggested that obesity, in conjunction with PAH, may be associated with improved survival. However, our research indicates that obesity prior to the development of PAH is actually associated with worse survival, introducing a novel temporal element to the obesity-paradox.
PULMONARY CIRCULATION
(2023)
Letter
Respiratory System
Brandon S. Peplinski, Jonathan Buber, Sina A. Gharib, Hongyang Pi, Daniel Raftery, Peter J. Leary
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
