Review
Acoustics
K. Hessami, A. A. Nassr, N. Sananes, J. Castillo, H. A. Castillo, M. Sanz Cortes, J. Espinoza, R. V. Donepudi, R. C. Sun, E. Krispin, M. A. Belfort, A. A. Shamshirsaz
Summary: The incidence of NDI in TTTS survivors is 14.0%, and is associated with later gestational age at the time of FLP, earlier gestational age at delivery, and lower birth weight. Preterm birth before 32 weeks is linked to a higher risk of NDI.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Filomena Giulia Sileo, Francesco D'antonio, Can Benlioglu, Amar Bhide, Asma Khalil
Summary: This systematic review and meta-analysis evaluated the outcomes of monochorionic-diamniotic twin pregnancies affected by late TTTS with different management options. The results indicated a need for further high-quality research to determine the optimal management of these pregnancies, as evidence on perinatal mortality and morbidity was of very low quality.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Acoustics
F. D'Antonio, D. Marinceu, S. Prasad, N. Eltaweel, A. Khalil
Summary: This systematic review examines the outcomes of laser surgery for twin-twin transfusion syndrome (TTTS) in monochorionic diamniotic (MCDA) twin pregnancies complicated by selective fetal growth restriction (sFGR). The study finds that MCDA twin pregnancies with TTTS and sFGR have a higher risk of fetal loss after laser surgery, as well as a higher risk of neurological morbidity in the donor twin.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Genetics & Heredity
Ahmed A. Nassr, Kamran Hessami, Sherif A. Shazly, Jimmy Espinoza, Roopali Donepudi, Magdalena Sanz Cortes, Michael A. Belfort, Alireza A. Shamshirsaz
Summary: Incidental septostomy (IS) following laser photocoagulation for TTTS is associated with increased risk of preterm delivery, PPROM, but does not seem to affect neonatal survival rate.
PRENATAL DIAGNOSIS
(2021)
Article
Pediatrics
Angel Chimenea, Lutgardo Garcia-Diaz, Guillermo Antinolo
Summary: This study aimed to evaluate the risk of neurodevelopmental impairment in monochorionic diamniotic twins undergoing fetoscopic laser surgery for twin-twin transfusion syndrome (TTTS) compared to uncomplicated MCDA twin pregnancies. The results showed that the outcome in MCDA twins who underwent surgery for TTTS was comparable to uncomplicated MCDA twins. These findings underscore the importance of long-term neurodevelopmental follow-up in children from monochorionic twin pregnancies.
Review
Acoustics
F. G. Sileo, J. Curado, F. D'Antonio, C. Benlioglu, A. Khalil
Summary: This study evaluated the incidence of antenatally diagnosed brain abnormality in twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and quantified the perinatal mortality, morbidity, and long-term neurodevelopmental outcome of these fetuses. The results showed that the overall incidence of antenatally diagnosed fetal brain abnormality in twin pregnancies complicated by TTTS treated with laser surgery is around 2%, mainly ischemic in nature. More than half of the cases chose termination of pregnancy.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Nazila Mesbah, Vajiheh Marsousi, Laleh Eslamian, Hadi Montazerlotfelahi, Alireza A. Shamshirsaz, Kamran Hessami, Ashraf Jamal, Maryam Noorzadeh, Mahsa Naemi, Marjan Ghaemi
Summary: This study evaluated the neurodevelopmental outcomes at 12 months of age among infants with TTTS undergoing FLP. The results showed that 10.2% of the infants had minor or major neurodevelopmental impairment. This information is useful for counseling couples before undergoing the procedure.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Obstetrics & Gynecology
Shuhan Yan, Yuan Wang, Zhifang Chen, Feng Zhang
Summary: Through a systematic review and meta-analyses, this study found that monochorionic twins are associated with an increased risk of neurodevelopment impairment compared to dichorionic twins. Twin-twin transfusion syndrome is an important factor contributing to the increased risk of neurodevelopmental impairment and cerebral palsy, and fetoscopic laser surgery is an effective treatment modality.
JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Hiba J. Mustafa, Ali Javinani, Katherine Goetzinger, Faezeh Aghajani, Christopher Harman, Alireza A. Shamshirsaz, Magdalena Sanz Cortes, Roopali Donepudi, Eyal Krispin, Ahmed A. Nassr, Jimmy Espinoza, Michael A. Belfort, Ozhan M. Turan
Summary: This study identified several preoperative and operative factors associated with fetal demise in twin-to-twin transfusion syndrome, including selective fetal growth restriction, abnormal umbilical artery blood flow, and abnormal ductus venosus waveforms.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Medicine, General & Internal
Charles Reighard, Shaqif Junaid, William M. Jackson, Ayesha Arif, Hannah Waddington, Andrew J. O. Whitehouse, Caleb Ing
Summary: This study found that exposure to anesthesia in children can lead to adverse effects in neurodevelopmental domains such as behavioral problems, cognitive difficulties, and decreased executive function.
Article
Obstetrics & Gynecology
Angela Guzys, Susan M. Reid, Christie Bolch, Dinah S. Reddihough, Mark Teoh, Ricardo Palma-Dias, Alison Fung, Stephen Cole, Ryan Hodges, Michael Fahey, Susan P. Walker
Summary: This study aimed to investigate the presence of neurodevelopmental disabilities in child survivors of monochorionic pregnancies managed by placental laser photocoagulation in Victoria, Australia. The study found that approximately 31% of the survivors had neurodevelopmental impairment, with speech/language disorders, attention deficit (hyperactivity) disorders, and fine motor impairment being the most common. Neonatal length of stay was identified as the highest risk factor for impairment.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Behavioral Sciences
Dan Wu, Yicheng Li, Lingyan Chen, Marieke Klein, Barbara Franke, Jinjin Chen, Jan Buitelaar
Summary: There is a global association between abnormal gestational weight gain and neurodevelopmental outcomes in offspring, although the results are inconsistent.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Acoustics
H. J. Mustafa, A. Javinani, E. Krispin, H. Tadbiri, A. A. Shamshirsaz, J. Espinoza, A. A. Nassr, R. Donepudi, M. A. Belfort, M. Sanz Cortes, C. Harman, O. M. Turan
Summary: This study investigated the perinatal outcome of triplet pregnancies with twin-twin transfusion syndrome (TTTS) treated with fetoscopic laser photocoagulation (FLP) and conducted a systematic review. The results showed that triplet pregnancies with TTTS are at high risk for adverse perinatal outcome and preterm birth, regardless of chorionicity. The survival rate after FLP in monochorionic triamniotic (MCTA) triplets was higher in this study compared to previous studies and currently comparable to dichorionic triamniotic (DCTA) triplets.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Li-Chun Chiu, Yao-Lung Chang, An-Shine Chao, Shuenn-Dyh Chang, Po-Jen Cheng, Yi-Chiao Liao
Summary: The aim of this study was to evaluate the effect of gestational age (GA) at the time of fetoscopic laser photocoagulation (FLP) for severe twin-twin transfusion syndrome (TTTS) on perinatal outcomes in a single center in Taiwan. The study found that performing FLP at an earlier GA was associated with deeper maximum vertical pocket in the recipient twin, higher rate of PPROM development, and lower rates of twin survival. GA at the time of FLP, cervical length before FLP, and stage III TTTS were associated with the survival of both twins after FLP. Delaying FLP for stage I TTTS cases diagnosed at an early GA without risk factors may be considered, but further trials are needed to determine the optimal delay time and its impact on surgical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Fengming Tu, Aimei Fei
Summary: This study examines the impact of gestational diabetes mellitus (GDM) on maternal and neonatal outcomes in singleton and twin pregnancies. The results showed that singleton pregnancies with GDM had a lower risk of cesarean section, small-for-gestational age neonates, preterm delivery, respiratory morbidity, neonatal hyperbilirubinemia, and NICU admission compared to twin pregnancies with GDM. Therefore, interventions should be focused on twin pregnancies with GDM.