Review
Agriculture, Dairy & Animal Science
Stephen J. LeBlanc
Summary: This paper reviews recent data and concepts on metritis, purulent vaginal discharge, and endometritis in dairy cows and their impact on reproductive performance. It discusses the causes, diagnosis, and treatment of these diseases, as well as the potential for improved management strategies.
Article
Agriculture, Dairy & Animal Science
Nicolas Barbeau-Gregoire, Alexandre Boyer, Marjolaine Rousseau, Marie-Lou Gauthier, Jocelyn Dubuc
Summary: The study aimed to validate the accuracy of on-farm bacteriological culture media (Tri-plate and Petrifilm) from endometrial samples compared to the results from the diagnostic laboratory. Results showed that using >90 and >100 colonies as criteria for Tri-plate and Petrifilm on-farm systems respectively gave optimal results when compared to the standard laboratory. This suggests that Tri-plate media with a threshold of >90 colonies is effective in diagnosing endometritis accurately.
Article
Agriculture, Dairy & Animal Science
Leen Lietaer, Kristel Demeyere, Stijn Heirbaut, Evelyne Meyer, Geert Opsomer, Osvaldo Bogado Pascottini
Summary: This study isolated PMN from the postpartum uterus of dairy cows and found a highly dynamic range of viability and functionality in uterine PMN, with the ability to identify functional PMN capable of phagocytosis. The correlation between peripheral and endometrial PMN functionality was poor, underscoring the need for further research to understand the role of uterine PMN in bovine uterine health.
Article
Agriculture, Dairy & Animal Science
Goncalo Perelra, Yongzhi Guo, Elisabete Silva, Marta Filipa Silva, Claudia Bevilacqua, Gilles Charpigny, Luis Lopes-da-Costa, Patrice Humblot
Summary: This study discovered distinct transcription profiles of endometrial stromal, glandular, and luminal epithelial cells associated with different endometrial health statuses. Recovery or persistence of inflammation was related to gene expression patterns involved in immune function, tissue remodeling, cell adhesion, and uterine receptivity.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
A. R. Guadagnin, L. K. Fehlberg, B. Thomas, Y. Sugimoto, I. Shinzato, F. C. Cardoso
Summary: This study aimed to investigate the effects of feeding rumen-protected lysine (RPL) prepartum and postpartum on reproductive performance, uterine health, and gene expression. The results showed that feeding RPL prepartum improved uterine immune status, but had no effect on days to first ovulation postpartum.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Microbiology
Boris Bogdanow, Quang Vinh Phan, Luder Wiebusch
Summary: Cytomegaloviruses induce significant changes in cell cycle regulation to enable replication of their DNA genomes. They establish a unique cell cycle arrest at the G(1)/S transition, while activating S phase-specific gene expression and nucleotide metabolism. Despite similarities in cell cycle regulation between human and murine CMVs, there are considerable differences in viral cell cycle effectors and mechanisms of action.
Article
Immunology
Mette Ratzer Freytag, Sofie Eg Jorgensen, Michelle Molgaard Thomsen, Ali Al-Mousawi, Alon Schneider Hait, David Olagnier, Jakob T. Bay, Marie Helleberg, Trine H. Mogensen
Summary: This study describes a 19-year-old woman with systemic HSV-1 infection and HLH, as well as a fatal course of neonatal herpesvirus infection postpartum. Investigation showed impaired antiviral responses in the mother's cells, potentially caused by variants in CASP8 or other noncoding regions of the genome.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
J. Dubuc, V Fauteux, M. Villettaz-Robichaud, J-P Roy, M. Rousseau, S. Buczinski
Summary: This study aimed to quantify the efficacy of a second intrauterine cephapirin treatment on postpartum dairy cows affected by PVD or ENDO. Results showed that a second treatment increased the pregnancy risk at first insemination in cows affected by PVD and ENDO. Administering a second intrauterine cephapirin infusion 14 days after the initial treatment did improve subsequent reproductive performance in these cows.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Hiroaki Okawa, Missaka M. P. Wijayagunawardane, Peter L. A. M. Vos, Osamu Yamato, Masayasu Taniguchi, Mitsuhiro Takagi
Summary: Intrauterine infusion of chitosan solution in early postpartum dairy cows can accelerate uterine recovery from endometritis, potentially serving as a replacement for prostaglandin F-2 alpha administration. The treatment has antimicrobial effects on the uterus and does not show adverse effects on fertility.
Article
Biochemistry & Molecular Biology
Sarah M. Kedziora, Kristin Kraker, Lajos Marko, Julia Binder, Meryam Sugulle, Martin Gauster, Dominik N. Muller, Ralf Dechend, Nadine Haase, Florian Herse
Summary: Preeclampsia is associated with renal injuries during pregnancy, but most of these pathologies often recover postpartum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Hayami Kudo, Tomochika Sugiura, Seiya Higashi, Kentaro Oka, Motomichi Takahashi, Shigeru Kamiya, Yutaka Tamura, Masaru Usui
Summary: The study revealed that the early postpartum microbiota changes in primiparous cows have a significant impact on the development of endometritis. Bacteria such as Trueperella, Enterococcus, and Bifidobacterium showed specific abundance changes at different time points in healthy and endometritis-diagnosed cows. Building an environment with an increase in beneficial bacteria, such as Lactobacillus, may help reduce the abundance of pathogenic bacteria like Trueperella and control endometritis.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Lu Cao, Rui Qin, Junbao Liu
Summary: This study investigated the protective effects of FXR on LPS-induced endometritis and the underlying mechanisms. The results showed that FXR agonists alleviated endometritis, while FXR knockout mice had more severe inflammatory responses. Ferroptosis was increased during endometritis, and its inhibition alleviated the condition. Activation of FXR by OCA decreased ferroptosis and inhibited endometritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Obstetrics & Gynecology
Simone Reaves, Vaishali Mehta, Jason K. Baxter, Reneita Ross
Summary: Uterine prolapse during pregnancy is a rare condition that can result in various complications. This article presents a case of uterine prolapse in the third trimester and discusses its management. Furthermore, it highlights the potential complications of postpartum Group A Streptococcus endometritis and emphasizes the importance of prompt recognition and treatment.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Plant Sciences
Yan Chen, Qiwen Xiang, Fu Peng, Song Gao, Lei Yu, Yunli Tang, Zhou Yang, Wei Pu, Xiaofang Xie, Cheng Peng
Summary: This study investigated the material basis and mechanism of action of safflower in the treatment of endometritis induced by incomplete abortion. The results showed that safflower contains 20 active components and can regulate the composition and ratio of gut microbiota by activating the ERα/PI3K/AKT signaling pathway to treat endometritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Veterinary Sciences
Yahia A. Amin, Sahar Gamal Abdelaziz, Alaa H. Said
Summary: Postpartum endometritis significantly affects the health and productivity of cattle, causing significant economic loss. Treatment of postpartum endometritis is challenging due to the high risk of antibiotic treatment failure. Recent research has shown that zinc oxide nanoparticles have broad-spectrum antibacterial efficacy against various bacterial pathogens, including multidrug-resistant strains.
RESEARCH IN VETERINARY SCIENCE
(2023)