Article
Psychology, Multidisciplinary
Bente Sommerfeldt, Finn Skarderud, Ingela Lundin Kvalem, Kjersti S. S. Gulliksen, Arne Holte
Summary: There is a higher prevalence of eating disorders among women seeking in vitro fertilization (IVF). Women with a history of eating disorders may be particularly vulnerable to eating disorder relapse during IVF, pregnancy, and early motherhood. The experience of these women during this process has hardly been studied scientifically, despite its high clinical relevance. Therefore, healthcare workers providing services to women undergoing IVF should be attentive and intervene when they suspect a history of eating disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Health Care Sciences & Services
Corinna Jacobi, Bianka Vollert, Kristian Huetter, Paula von Bloh, Nadine Eiterich, Dennis Goerlich, C. Barr Taylor
Summary: This study aimed to assess the efficacy of a web-based prevention program for women at risk for anorexia nervosa (AN). The results showed promising reductions in risk factors and symptoms of AN, suggesting the potential for preventing the onset of full-syndrome AN.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Obstetrics & Gynecology
Ido Feferkorn, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan
Summary: This population-based study investigated the implications of anorexia nervosa on pregnancy outcomes in a US population. The data from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample were used to create a dataset of deliveries between 2004 and 2014. Women with anorexia nervosa were compared to those without, and associations between anorexia nervosa and delivery and neonatal outcomes were explored. The results showed that women with anorexia nervosa had higher rates of preterm delivery, placental abruption, and small for gestational age neonates compared to the control group. Healthcare providers, especially fertility specialists, need to be aware of these adverse outcomes in women with anorexia nervosa.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Psychology, Clinical
Jeremy Ryan Pan, Tina Yutong Li, Danny Tucker, Kai Yang Chen
Summary: It is a common misconception that women with active anorexia nervosa (AN) are less likely to conceive. Pregnancies in women with AN are considered high risk, with various complications reported. However, with the help of obstetricians and psychiatrists, the risks can be reduced and appropriate management and follow-up can be provided during pregnancy and postpartum.
JOURNAL OF EATING DISORDERS
(2022)
Article
Nutrition & Dietetics
Youl-Ri Kim, Zhen An, Kyung-Hee Kim, Da-Mee Kim, Bo-In Hwang, Mirihae Kim
Summary: This study found that overweight was associated with overeating, while underweight was associated with less frequent overeating and longer sleep duration. Individuals with anorexia nervosa consumed less alcohol, while those with bulimia nervosa had a larger discrepancy between ideal and current body shape. Both overweight status and bulimia nervosa were associated with more obsessive-compulsive symptoms.
Article
Nutrition & Dietetics
Shubhangi Tuli, Vibha Singhal, Meghan Slattery, Nupur Gupta, Kathryn S. Brigham, Jennifer Rosenblum, Seda Ebrahimi, Kamryn T. Eddy, Karen K. Miller, Madhusmita Misra
Summary: The bone outcomes of adolescent and young adult women with atypical anorexia nervosa (AAN) are characterized as intermediate between typical AN and normal-weight healthy controls (HC), indicating that AAN patients have a moderate level of bone impairment compared to AN patients and HC individuals.
Article
Medicine, General & Internal
Angla Mantel, Anne K. Ortqvist, Angelica Linden Hirschberg, Olof Stephansson
Summary: This study aimed to evaluate the association between maternal eating disorders before or during pregnancy and the risk of neuropsychiatric diseases in offspring. The findings suggest that children born to mothers with eating disorders, particularly those with active disorders during pregnancy, are at increased risk of developing ADHD and ASD.
Article
Nutrition & Dietetics
Katarzyna Jowik, Monika Dmitrzak-Weglarz, Natalia Pytlinska, Anna Jasinska-Mikolajczyk, Agnieszka Slopien, Marta Tyszkiewicz-Nwafor
Summary: This study evaluated the plasma levels of APE-13 and ASP, as well as related metabolic and psychometric parameters, in patients with anorexia nervosa. The findings suggest that APE-13 and ASP may serve as biomarkers for anorexia nervosa, and their levels are associated with eating behavior, emotional behavior, and the severity of psychopathological symptoms of eating disorders.
Article
Psychology, Multidisciplinary
Bente Sommerfeldt, Finn Skarderud, Ingela Lundin Kvalem, Kjersti S. Gulliksen, Arne Holte
Summary: Pregnancy is a vulnerable period for women with a history of eating disorders. Our study found that almost all participants experienced worsening or relapse of their disorder during pregnancy.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Nutrition & Dietetics
Sebastien Grigioni, Najate Achamrah, Philippe Chan, Charlene Guerin, Christine Bole-Feysot, Julie Delay, Guillaume Colange, Muriel Quillard, Aude Coquard, Michael Bubenheim, Pierre Jesus, Marie-Pierre Tavolacci, Pierre Dechelotte, Moise Coeffier
Summary: Anorexia nervosa (AN) patients may have increased intestinal permeability, but it does not seem to affect appetite-regulating peptides and their reactive immunoglobulins.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Vibha Singhal, Supritha Nimmala, Meghan Slattery, Kamryn T. Eddy, Karen K. Miller, Anne Klibanski, Madhusmita Misra
Summary: Physiologic estrogen replacement has similar effects on bone density and structure in young women with AN as in normal-weight healthy controls, with additional benefits for radial cortical tissue mineral density, cortical vBMD, and failure load.
Article
Psychiatry
Philipp Traut, Georg Halbeisen, Karsten Braks, Thomas J. Huber, Georgios Paslakis
Summary: Eating disorders are highly severe mental disorders in both women and men, often leading to significant limitations in daily functioning, comorbidities, chronic illness, and even mortality rates. However, the differences between men and women with eating disorders have not been well explored.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychology, Multidisciplinary
Octavian Vasiliu
Summary: The importance of detecting and treating eating disorders during pregnancy is crucial due to the significant negative impact on both maternal and fetal health. However, there are limitations in understanding the diagnostic criteria, risk factors, and mechanisms, necessitating further research for specific diagnostic criteria and treatment approaches.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Felicitas Weineck, Dana Schultchen, Freya Dunker, Gernot Hauke, Karin Lachenmeir, Andreas Schnebel, Matislava Karacic, Adrian Meule, Ulrich Voderholzer, Olga Pollatos
Summary: The study found that women with anorexia nervosa have lower explicit feelings of power compared to non-AN participants, but similar implicit power motives. Discrepancies between explicit feelings of power and implicit power motives were positively correlated with trait anxiety in AN patients.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Giammarco Cascino, Antonietta Canna, Andrea Gerardo Russo, Francesco Monaco, Alessio Maria Monteleone, Rossella Ceres, Marco Carfagno, Francesco Di Salle, Palmiero Monteleone
Summary: Childhood maltreatment is associated with distinct clinical and biological characteristics in people with eating disorders. The measurement of local gyrification index (lGI) may help to characterize the impact of childhood maltreatment on cortical structure. The present study investigated the association of childhood maltreatment with lGI in women with anorexia nervosa and bulimia nervosa. The results showed that maltreated individuals with eating disorders had lower lGI in the left middle temporal gyrus compared to non-maltreated individuals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
William M. Spalding, Monica L. Bertoia, Cynthia M. Bulik, John D. Seeger
Summary: This study aimed to characterize real-world treatment patterns among adult patients diagnosed with binge-eating disorder (BED). The results showed that pharmacotherapy was more frequently prescribed than psychotherapy, indicating a discrepancy between real-world treatment patterns and evidence-based recommendations.
POSTGRADUATE MEDICINE
(2023)
Article
Psychology, Clinical
Benjamin Mac Donald, Cynthia M. Bulik, Janne T. Larsen, Anders H. Carlsen, Loa Clausen, Liselotte Petersen
Summary: This study explored the utilization patterns of involuntary treatment (IT) events in patients with anorexia nervosa (AN), and identified factors associated with subsequent IT utilization and restraint. The study found that IT utilization peaked in the initial few years following the index admission, and a small percentage of patients accounted for a majority of the IT events. Factors such as female sex, lower age, and previous admissions with psychiatric disorders were associated with increased IT rates and restraint. It is important to explore alternative approaches to treatment that can reduce the need for IT in these patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Katrin E. Giel, Cynthia M. Bulik, Fernando Fernandez-Aranda, Phillipa Hay, Anna Keski-Rahkonen, Kathrin Schag, Ulrike Schmidt, Stephan Zipfel
Summary: Binge eating disorder (BED) is a complex eating disorder characterized by loss of control over eating behavior and consuming large amounts of food. It is commonly associated with obesity and various somatic and mental health issues. The etiology of BED involves genetic, environmental, neuroendocrinological, and neurobiological factors. Psychotherapy is the recommended treatment, but further research and efforts are needed for prevention and improved treatment outcomes.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Health Care Sciences & Services
Robyn E. Kilshaw, Colin Adamo, Jonathan E. Butner, Pascal R. Deboeck, Qinxin Shi, Cynthia M. Bulik, Rachael E. Flatt, Laura M. Thornton, Stuart Argue, Jenna Tregarthen, Brian R. W. Baucom
Summary: This article focuses on utilizing personal digital device data to capture dynamic patterns of risk for binge eating disorder (BED) and bulimia nervosa (BN). The methods used to collect and prepare the data for analysis are described, and the potential for developing personalized models of eating disorder pathologies and just-in-time interventions is discussed.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Psychology, Clinical
Ruyue Zhang, Andreas Birgegard, Bengt Fundin, Mikael Landen, Laura M. Thornton, Cynthia M. Bulik, Lisa Dinkler
Summary: Among individuals with eating disorders, those with co-occurring autism are often considered to have more severe presentations and poorer prognosis. A study on a large cohort of individuals with anorexia nervosa found that individuals with confirmed autism diagnosis had significantly more severe eating disorder symptoms. Adapting eating disorder treatment to the needs of individuals with co-occurring autism is an important research direction to improve treatment outcome in this group.
EUROPEAN EATING DISORDERS REVIEW
(2022)
Article
Psychology, Clinical
Nhung T. H. Trinh, Birgitte Dige Semark, Trine Munk-Olsen, Xiaoqin Liu, Oyvind Ro, Cynthia M. Bulik, Leila Torgersen, Angela Lupattelli, Liselotte Vogdrup Petersen
Summary: This study found no association between continued antidepressant use during pregnancy and postpartum psychiatric visits for eating disorders or mood/anxiety disorders in women with preexisting eating disorders. However, continuation of antidepressant treatment into the early postpartum was associated with a reduced likelihood of postpartum visits for eating disorders.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Daria Igudesman, Jamie Crandell, Karen D. Corbin, Dessi P. Zaharieva, Ananta Addala, Joan M. Thomas, Cynthia M. Bulik, Brian W. Pence, Richard E. Pratley, Michael R. Kosorok, David M. Maahs, Ian M. Carroll, Elizabeth J. Mayer-Davis
Summary: This study aimed to evaluate the association between disordered eating and gut microbiota-derived short chain fatty acids (SCFA) in individuals with type 1 diabetes. The results showed that disordered eating and insulin restriction were associated with a reduced abundance of gut microbes that produce SCFA.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Psychology, Clinical
Hannah Chatwin, Katrine Holde, Zeynep Yilmaz, Janne Tidselbak Larsen, Clara Albinana, Bjarni Johann Vilhjalmsson, Preben Bo Mortensen, Laura M. Thornton, Cynthia M. Bulik, Liselotte Vogdrup Petersen
Summary: This study aimed to examine sex differences in risk factors for anorexia nervosa (AN). The results showed that the effects of early life exposures and genetic risk scores on AN risk were comparable between females and males, with no significant sex differences. However, there were sex-specific effects of parental psychiatric history and body mass index genetic risk scores, although these effects did not survive corrections for multiple comparisons. Therefore, collaboration between countries is needed to further investigate sex-specific risk factors for AN and improve early identification of the disorder.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Editorial Material
Psychology, Clinical
Cynthia M. M. Bulik
Summary: Levine and Sadeh-Sharvit (2023) propose a logical and evidence-based targeted prevention strategy, adapted from the field of depression, which aims to reduce the risk of intergenerational transmission of eating disorders. The approach provides support for parents dealing with their own eating disorders and disordered eating, while also addressing the potential environmental exposures that could amplify genetic risk in children of affected parents.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Psychology, Clinical
Benjamin Mac Donald, Sanna A. Gustafsson, Cynthia M. Bulik, Loa Clausen
Summary: This study explored the experiences and perspectives of patients with multiple involuntary treatment events in order to understand involuntary treatment and potentially inform treatment. The results showed that patients with anorexia nervosa and multiple involuntary treatment events experience a life of coercion, both internally from the illness itself and externally from involuntary treatment. Involuntary treatment can aid in the internal battle against anorexia nervosa and perspectives on involuntary treatment can change over time. However, it can also have negative effects on patients, such as feelings of being hunted or assaulted. Clinicians should be aware of these potential negative effects and only use involuntary treatment in life-threatening situations.
JOURNAL OF EATING DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Christopher Hubel, Mohamed Abdulkadir, Moritz Herle, Alish B. Palmos, Ruth J. F. Loos, Gerome Breen, Nadia Micali, Cynthia M. Bulik
Summary: Thinness and anorexia nervosa are characterized by persistent low weight, but they differ in terms of distorted perceptions of body and weight-loss behaviors. Genetic correlations suggest that thinness is negatively associated with psychiatric disorders, distinguishing it from anorexia nervosa.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Monika A. Waszczuk, Katherine G. Jonas, Marina Bornovalova, Gerome Breen, Cynthia M. Bulik, Anna R. Docherty, Thalia C. Eley, John M. Hettema, Roman Kotov, Robert F. Krueger, Todd Lencz, James J. Li, Evangelos Vassos, Irwin D. Waldman
Summary: Genome-wide association studies (GWAS) have the potential to provide biological insights into disease mechanisms and offer clinically useful biomarkers. This review examines the use of quantitative and transdiagnostic phenotypes in GWAS for major psychiatric disorders. The authors discuss themes and recommendations, including issues of sample size, phenotypic reliability, sources of phenotypic information, and the use of biological and behavioral markers. The review also highlights the importance of multi-trait methods and the potential of dimensional and transdiagnostic phenotypes for gene discovery in psychiatric conditions.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Clara Albinana, Zhihong Zhu, Andrew J. Schork, Andres Ingason, Hugues Aschard, Isabell Brikell, Cynthia M. Bulik, Liselotte V. Petersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, David M. Hougaard, Thomas Werge, Anders D. Borglum, Preben Bo Mortensen, John J. McGrath, Benjamin M. Neale, Florian Prive, Bjarni J. Vilhjalmsson
Summary: The authors have developed a multi-polygenic score framework that increases prediction accuracy for complex diseases and traits. This framework leverages a large library of polygenic scores and is well-suited for emerging biobank data. By utilizing genetically correlated phenotypes, the sample size can be effectively increased without the need for costly and time-consuming collection of additional samples.
NATURE COMMUNICATIONS
(2023)
Article
Psychology, Clinical
Natalie M. Papini, Cynthia M. Bulik, Samuel J. R. A. Chawner, Nadia Micali
Summary: This study examines the prevalence and correlates of pica behaviors during childhood using data from the ALSPAC study. The findings suggest that pica is uncommon in childhood, but children with developmental delay or autism may be more likely to exhibit pica behaviors between the ages of 36 and 115 months. Additionally, eating difficulties and body mass index may be related to pica behaviors in children.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Psychiatry
Ruyue Zhang, Ralf Kuja-Halkola, Stina Borg, Virpi Leppae, Laura M. Thornton, Andreas Birgegard, Cynthia M. Bulik, Sarah E. Bergen
Summary: The associations between eating disorders (EDs) and schizophrenia have been recognized, and familial liability to schizophrenia in individuals with anorexia nervosa (AN) reveals distinct patterns of clinical outcomes. This study investigates the influence of schizophrenia genetic liability among individuals with EDs, finding that higher schizophrenia polygenic risk scores (PRS) are significantly associated with increased risk of major depressive disorder (MDD) and substance abuse disorder (SUD). Additionally, higher schizophrenia PRS is related to earlier age at first ED symptom, higher ED symptom scores, and increased risk of MDD and SUD.
TRANSLATIONAL PSYCHIATRY
(2023)
