Article
Medical Laboratory Technology
Irene Maria Beune, Stefanie Elisabeth Damhuis, Wessel Ganzevoort, John Ciaran Hutchinson, Teck Yee Khong, Eoghan E. Mooney, Neil James Sebire, Sanne Jehanne Gordijn
Summary: This study established a consensus-based definition for fetal growth restriction in fetal death through a modified online Delphi survey with an international panel of experts. The consensus definition included antenatal clinical diagnosis, birth weight criteria, and contributory variables, aiming to improve management and outcomes of subsequent pregnancies.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Acoustics
Sami R. Chmait, Martha A. Monson, Lisa M. Korst, Arlyn Llanes, Andrew H. Chon
Summary: In a retrospective study of sFGR Type III patients, meeting more stringent parameters of the consensus definition was not associated with disease progression or dual survivorship.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Georgios Moros, Theodora Boutsikou, Charalambos Fotakis, Zoe Iliodromiti, Rozeta Sokou, Theodora Katsila, Theodoros Xanthos, Nicoletta Iacovidou, Panagiotis Zoumpoulakis
Summary: The study found a clear association between altered metabolomic profiles in maternal and cord blood in IUGR pregnancies. Elevated levels of amino acids alanine, leucine, valine, isoleucine, and phenylalanine in IUGR pregnancies suggest a connection with impaired amino acid metabolism and transplacental flux. The increased levels of branched chain amino acids in intrauterine growth restricted pregnancies were linked with increased insulin resistance. Lower glycerol levels were attributed to imbalance between gluconeogenesis and glycolysis pathways, indicating poor glycolysis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Natalia Yeste, Nestor Gomez, Marta Vazquez-Gomez, Consolacion Garcia-Contreras, Marti Pumarola, Antonio Gonzalez-Bulnes, Anna Bassols
Summary: The study showed that under IUGR conditions, LBW fetuses had reduced numbers of mature neurons in the hippocampus and Dentate Gyrus regions, along with an increase in immature neurons and alterations in neuronal morphology. Additionally, LBW fetuses exhibited changes in neurotransmitter profiles, with an increase in the serotonin pathway. Supplementation with HTX was able to reverse these morphological and neurochemical changes in LBW fetuses.
Article
Medicine, Research & Experimental
Elisa C. Cella, Julia Conte, Rafaela C. K. Stolte, Flaviano Lorenzo, Tamires Gregorio, Bruna B. Simas, Alex Rafacho, Fernanda B. Lima
Summary: Administration of dexamethasone (DEX) during late gestation can lead to behavioral changes in dams, impacting offspring survival. Adequate maternal care is crucial for pup's survival, and cross-fostering can improve the survival index of DEX offspring.
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Yennifer Cortes-Araya, F. Xavier Donadeu, Cheryl J. Ashworth
Summary: This study aimed to investigate the temporal changes in testicular gene expression during testes development in fetuses of different size. The results showed that testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at gestational days 60 and 90. Fetal size was not associated with seminiferous tubule area and number, as well as the number of germ or Sertoli cells per tubule. The expression of DMRT1 and SPP1 mRNA was lower in testes associated with the lightest fetuses compared to the closest to mean litter weight fetuses at gestational day 90. These findings provide insights into the expression profiles of genes associated with testicular development and function.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Developmental Biology
A. Arias, J. A. Schander, M. Bariani, F. Correa, A. P. Dominguez Rubio, M. Cella, C. B. Cymeryng, M. L. Wolfson, A. M. Franchi, J. Aisemberg
Summary: Maternal dexamethasone administration during late gestation results in fetal and placental growth restriction, potentially due to altered placental angiogenesis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Acoustics
Wesley Lee, Lauren M. Mack, Roxanna Miremadi, Betul Yilmaz Furtun, Haleh Sangi-Haghpeykar, Greggory R. DeVore
Summary: The objective of this study was to investigate cardiac size, shape, and ventricular contractility in fetuses with estimated fetal weight (EFW) <10th centile at sea level. The results showed that fetuses with EFW <10th centile at sea level often had enlarged and globular-shaped hearts, with increased ventricular contractility. In comparison, fetuses at higher altitude had similar heart shape but a higher proportion with decreased ventricular contractility.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Environmental Sciences
Fei-Xiang Xu, Xu Chen, Heng Zhang, Yi-Jun Fan, Ya-Ping Song, Jin-Wei Lv, Ya-Li Xie, Yichao Huang, Dao-Zhen Chen, Hua Wang, De-Xiang Xu
Summary: Gestational arsenic exposure is associated with intrauterine growth restriction, and this restriction may be related to a reduction in folate content in maternal and umbilical plasma.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Nutrition & Dietetics
Francesca Garofoli, Iolanda Mazzucchelli, Micol Angelini, Catherine Klersy, Virginia Valeria Ferretti, Barbara Gardella, Giulia Vittoria Carletti, Arsenio Spinillo, Chryssoula Tzialla, Stefano Ghirardello
Summary: This study investigated the association between perinatal leptin concentrations and growth trajectories of newborns during their first year. The results showed an inverse correlation between leptin levels and maternal plasma and milk. Premature infants seemed to be most affected by leptin, and low leptin levels appeared to hinder their ability to regain a normal body weight within one year.
Review
Medicine, General & Internal
Steven J. Korzeniewski, Elizabeth Sutton, Carlos Escudero, James M. Roberts
Summary: Preeclampsia is a maternal syndrome characterized by new onset hypertension after 20 weeks of gestation that may have long-term adverse effects on both mothers and their children, including cardiovascular, metabolic, cerebral, and cognitive complications.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Asghar Ali, Frieder Hadlich, Muhammad W. Abbas, Muhammad A. Iqbal, Dawit Tesfaye, Gerrit J. Bouma, Quinton A. Winger, Siriluck Ponsuksili
Summary: Dysregulation of miRNAs in the placenta can affect placental development and function, and potentially serve as diagnostic biomarkers for pregnancy complications. However, the differential expression of miRNAs in maternal circulation may not always reflect placental status, making it challenging to find a reliable biomarker for placental dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ingrid Dudink, Petra S. Huppi, Stephane V. Sizonenko, Margie Castillo-Melendez, Amy E. Sutherland, Beth J. Allison, Suzanne L. Miller
Summary: Fetal growth restriction (FGR) is mainly caused by suboptimal placental function, leading to limited nutrient and oxygen supply to the developing fetus, particularly affecting brain development. FGR results in altered brain morphology, disrupted connectivity, and region-specific brain network disturbances, which are associated with cognitive and behavioral impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Jianzhong Hu, Paula Benny, Michelle Wang, Yula Ma, Luca Lambertini, Inga Peter, Yajuan Xu, Men-Jean Lee
Summary: Although no significant differences in alpha or beta diversity were found, IUGR patients showed higher levels of pathogens such as Neisseriaceae and anaerobic bacteria like Desulfovibrio in their reproductive microbiome. These findings suggest that the composition of the reproductive microbiome may serve as potential biomarkers for fetal health and that Neisseriaceae could be a promising target for IUGR treatment.
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, General & Internal
Jara Pascual-Mancho, Pilar Pintado-Recarte, Carlos Romero-Roman, Jorge C. Morales-Camino, Concepcion Hernandez-Martin, Julia Bujan, Miguel A. Ortega, Juan De Leon-Luis
Summary: This study investigated the variation in Reelin levels in FGR newborns and their association with neurodevelopmental impairment. Results showed a significant association of elevated Reelin levels in FGR fetuses with cerebral blood redistribution compared to the normal weight group and the FGR with abnormal umbilical artery group. Future research should focus on expanding the knowledge of the relationship of Reelin and neurodevelopment impairment in FGR newborns.
