Article
Cardiac & Cardiovascular Systems
Fariba Ahmadizar, Negin Soroush, M. Arfan Ikram, Jan A. Kors, Maryam Kavousi, Bruno H. Stricker
Summary: This study aimed to investigate the effects of hydroxychloroquine and chloroquine on electrocardiographic measures and sudden cardiac death. The results showed that current use of these drugs was associated with an increased QTc-interval duration and a higher risk of sudden cardiac death. Therefore, cardiotoxicity is a strong argument against using these drugs to treat COVID-19 infections, in addition to the controversial efficacy against the virus.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Victor Nauffal, Valerie N. Morrill, Sean J. Jurgens, Seung Hoan Choi, Amelia W. Hall, Lu-Chen Weng, Jennifer L. Halford, Christina Austin-Tse, Christopher M. Haggerty, Stephanie L. Harris, Eugene K. Wong, Alvaro Alonso, Dan E. Arking, Emelia J. Benjamin, Eric Boerwinkle, Yuan- Min, Adolfo Correa, Brandon K. Fornwalt, Susan R. Heckbert, Charles Kooperberg, Henry J. Lin, Ruth J.f. Loos, Kenneth M. Rice, Namrata Gupta, Thomas W. Blackwell, Braxton D. Mitchell, Alanna C. Morrison, Bruce M. Psaty, Wendy S. Post, Susan Redline, Heidi L. Rehm, Stephen S. Rich, Jerome I. Rotter, Elsayed Z. Soliman, Nona Sotoodehnia, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz
Summary: Using data from large-scale biorepositories, this study found 54 independent loci associated with cardiac repolarization, including 21 novel loci. The findings suggest that both rare variants in genes underlying cardiac repolarization and polygenic risk play a role in determining the duration of QT interval in the population.
Article
Physiology
Songwen Chen, Guannan Meng, Anisiia Doytchinova, Johnson Wong, Susan Straka, Julie Lacy, Xiaochun Li, Peng-Sheng Chen, Thomas H. Everett
Summary: The study found that compared to healthy volunteers, patients with heart disease had a greater increase in QTc interval and STVQT during SKNA bursts. SKNA bursts were associated with an increase in STVQT, suggesting a potential relationship with arrhythmias.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Benjamin Neumann, A. Suzanne Vink, Ben J. M. Hermans, Krystien V. V. Lieve, Didem Comert, Britt-Maria Beckmann, Sally-Ann B. Clur, Nico A. Blom, Tammo Delhaas, Arthur A. M. Wilde, Stefan Kaeaeb, Pieter G. Postema, Moritz F. Sinner
Summary: Pairwise comparisons between automatic and manual measurements of QT intervals and QTc revealed significant discrepancies, especially in patients with aberrant QTc values. Novel automatic algorithms may be able to improve the agreement between these measurements.
Article
Cardiac & Cardiovascular Systems
Shusuke Mori, Atsushi Hori, Isik Turker, Motoki Inaji, Erika Bello-Pardo, Takashi Miida, Yasuhiro Otomo, Tomohiko Ai
Summary: Abnormal cardiac repolarization can be associated with structural brain abnormalities in patients with seizures or epilepsy, leading to prolonged corrected QT intervals. However, no fatal arrhythmias were observed in the study.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Min Ye, Jing-Wei Zhang, Jia Liu, Ming Zhang, Feng-Juan Yao, Yun-Jiu Cheng
Summary: The dynamic change of QTc interval is associated with increased mortality risk in the general population, with higher or lower Delta QTcF values being linked to various mortality endpoints. Monitoring QTc interval dynamically may provide additional prognostic information.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Psychiatry
Rebekah P. Nash, Lily Wang, Bradley N. Gaynes, Jennifer E. Flythe
Summary: This study investigated the use of oral atypical antipsychotics and compared the cardiac safety between those with FDA warnings for QT prolongation and those without among outpatients receiving hemodialysis. The results showed that quetiapine, which carried an FDA warning for QT prolongation, did not increase the cardiac risk compared to atypical antipsychotics without warnings among hemodialysis outpatients.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Marco Vecchiato, Giulia Quinto, Daniel Neunhaeuserer, Francesca Battista, Silvia Bettini, Andrea Gasperetti, Roberto Vettor, Luca Busetto, Andrea Ermolao
Summary: Obesity is associated with a higher risk of cardiac arrhythmias. Sleeve gastrectomy (SG) may increase the risk of exercise-induced arrhythmias in the early post-surgical phase, but it does not seem to increase the occurrence of arrhythmias in the long-term.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Cardiac & Cardiovascular Systems
Ilan Goldenberg, J. Martijn Bos, Ayhan Yoruk, Anita Y. Chen, Coeli Lopes, David T. Huang, Valentina Kutyifa, Arwa Younis, Mehmet K. Aktas, Spencer Z. Rosero, Scott McNitt, Nona Sotoodehnia, Peter J. Kudenchuk, Thomas D. Rea, Dan E. Arking, Christopher G. Scott, Kaylie A. Briske, Katrina Sorensen, Michael J. Ackerman, Wojciech Zareba
Summary: This study developed a risk prediction model to provide personalized risk estimates for cardiac events and life-threatening events in women with type 1 or type 2 long QT syndrome based on genotype-phenotype data. The model showed 10-year projected rates of CEs and life-threatening events, with C statistics indicating the model's predictive accuracy. External validation in a separate cohort also showed promising results for the model's predictive ability.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Babken Asatryan, Lauren Yee, Yael Ben-Haim, Stephan Dobner, Helge Servatius, Laurent Roten, Hildegard Tanner, Lia Crotti, Jonathan R. Skinner, Carol Ann Remme, Philippe Chevalier, Argelia Medeiros-Domingo, Elijah R. Behr, Tobias Reichlin, Katja E. Odening, Andrew D. Krahn
Summary: Sex-related differences in cardiac channelopathies are increasingly recognized, with varying risks and clinical features between men and women in different conditions, mainly influenced by age and sex hormones. While sex-specific predictors have been identified, gaps in the mechanistic understanding of these differences remain, highlighting the need for further research to address these disparities and improve patient outcomes.
Article
Cardiac & Cardiovascular Systems
Peter J. Schwartz, Cristina Moreno, Maria-Christina Kotta, Matteo Pedrazzini, Lia Crotti, Federica Dagradi, Silvia Castelletti, Kristina H. Haugaa, Isabelle Denjoy, Maria A. Shkolnikova, Paul A. Brink, Marshall J. Heradien, Sandrine R. M. Seyen, Roel L. H. M. G. Spatjens, Carla Spazzolini, Paul G. A. Volders
Summary: Mutations surrounding the A341V mutation in the KCNE1 gene increase the risk of arrhythmias, and the specific loss of PKA-dependent I-Ks enhancement in A341V correlates with its phenotypic severity.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Raquel Neves, Sahej Bains, J. Martijn Bos, Ciorsti J. Macintyre, John R. Giudicessi, Michael J. Ackerman
Summary: Recently, the impact of electronic gaming on cardiac arrhythmias in susceptible individuals has been reported. However, the prevalence of electronic gaming-related cardiac events in genetic heart diseases (GHDs) has not been established. This study aimed to determine the incidence of cardiac events associated with electronic gaming in patients with GHDs. A retrospective review of patient records identified a small number of individuals with a history of playing electronic games at the time of their cardiac event. The results showed that electronic gaming-related cardiac events are extremely rare occurrences in GHD patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Engineering, Biomedical
Alba Martin-Yebra, Leif Sornmo, Pablo Laguna
Summary: This study aims to investigate new techniques for QT adaptation estimation in permanent AF. A multilead strategy based on periodic component analysis provides more accurate QT delineation and improved time lag estimation in AF. Prolonged QT adaptation time lag is associated with a high risk of sudden cardiac death (SCD).
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Gherardo Finocchiaro, Davide Radaelli, Stefano D'Errico, Michael Papadakis, Elijah R. Behr, Sanjay Sharma, Joseph Westaby, Mary N. Sheppard
Summary: This study investigated the causes of sudden cardiac death (SCD) in adolescents and found that the most common autopsy finding was structurally normal heart, indicative of sudden arrhythmic death syndrome. Among young athletes, arrhythmogenic cardiomyopathy, coronary artery anomalies, and commotio cordis were more common causes of SCD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Joanna Fishbein, Kristie M. Coleman, Amarbir Bhullar, Nikhil Sharma, Stefanos Zafeiropoulos, Umair Ansari, Tia Bimal, Yan Liu, Stavros E. Mountantonakis
Summary: This study retrospectively analyzed COVID-19 patients and identified independent factors associated with in-hospital mortality, which were incorporated into a risk score for prediction.
Letter
Endocrinology & Metabolism
Jean-Daniel Lalau, Youssef Bennis, Abdallah Al-Salameh, Anne-Sophie Hurtel-Lemaire, Salha Fendri
DIABETES OBESITY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Nicolas Wiernsperger, Abdallah Al-Salameh, Bertrand Cariou, Jean-Daniel Lalau
Summary: Since the outbreak of Covid-19, studies have shown a favorable association between metformin and Covid-19 outcomes in patients with type 2 diabetes mellitus. Metformin can alleviate cytokine storm, reduce virus entry into cells, protect microvessels, and prevent secondary fibrosis. The findings suggest that metformin is a unique drug with multiple mechanisms of action against Covid-19.
DIABETES & METABOLISM
(2022)
Letter
Endocrinology & Metabolism
Abdallah Al-Salameh, Nicolas Wiernsperger, Bertrand Cariou, Jean-Daniel Lalau
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Damien Basille, Marine Timmerman, Aurelie Basille-Fantinato, Abdallah Al-Salameh, Salha Fendri, Jean-Daniel Lalau
Summary: This study aimed to investigate the prevalence of sleep-disordered breathing (SDB) in type 1 diabetes (T1DM) patients. The results showed that SDB was highly prevalent in these patients and was associated with obesity. However, there was no association between sleep disorders and high glucose variability or low glucose levels.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Bertrand Cariou, Matthieu Wargny, Anne-Sophie Boureau, Sarra Smati, Blandine Tramunt, Rachel Desailloud, Maylis Lebeault, Coralie Amadou, Deborah Ancelle, Beverley Balkau, Lyse Bordier, Sophie Borot, Muriel Bourgeon, Olivier Bourron, Emmanuel Cosson, Martin Eisinger, Celine Gonfroy-Leymarie, Jean-Baptiste Julla, Lucien Marchand, Laurent Meyer, Dominique Seret-Begue, Dominique Simon, Ariane Sultan, Charles Thivolet, Anne Vambergue, Camille Vatier, Patrice Winiszewski, Pierre-Jean Saulnier, Bernard Bauduceau, Pierre Gourdy, Samy Hadjadj
Summary: This study aims to investigate whether diabetes is a risk factor for COVID-19, independent of age and comorbidities.
Review
Endocrinology & Metabolism
Abdallah Al-Salameh, Nacera El Bouzegaoui, Marie Saraval-Gross
Summary: Male sex is a significant cardiovascular risk factor, and men have a higher prevalence of cardiovascular disease than women. Diabetes affects cardiovascular risk differently between men and women, with women having a greater relative risk of cardiovascular events. The impact of anti-hyperglycemic drugs on cardiovascular outcomes according to sex is not well known. Cardiovascular outcomes trials provide an opportunity to study the effects of novel anti-hyperglycemic drugs on cardiovascular outcomes in men and women with type-2 diabetes.
ANNALES D ENDOCRINOLOGIE
(2023)
Article
Endocrinology & Metabolism
Vincent Durlach, Bruno Verges, Abdallah Al-Salameh, Thibault Bahougne, Farid Benzerouk, Ivan Berlin, Carole Clair, Jacques Mansourati, Alexia Rouland, Daniel Thomas, Philippe Thuillier, Blandine Tramunt, Anne-Laurence Le Faou
Summary: Evidence shows that smoking increases the risk of pre-diabetes and diabetes in the general population and aggravates chronic diabetic complications and glycemic control in individuals with diabetes. A joint position statement by the French-Speaking Society on Tobacco and the French-Speaking Society of Diabetes summarizes the data on the association between smoking and diabetes, as well as the impact of smoking and smoking cessation on individuals with type 1, type 2, and gestational diabetes mellitus. It also provides evidence-based information on pharmacological and behavioral strategies for smoking cessation in these patients.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Joe Balmain, Meshal Jarebi, Abdallah Al-Salameh, Patrick Toussaint, Marine Timmerman, Louis Chenin, Jean-Marc Constans, Rachel Desailloud
Summary: This case series provides support for the association between SARS-CoV-2 infection and pituitary apoplexy. The findings emphasize the importance of being aware of potential pituitary diseases caused by the virus.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Letter
Endocrinology & Metabolism
Abdallah Al-Salameh, Joe Balmain, Rachel Desailloud
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Narimane Djekkoun, Flore Depeint, Marion Guibourdenche, Hiba El Khayat Et Sabbouri, Aurelie Corona, Larbi Rhazi, Jerome Gay-Queheillard, Leila Rouabah, Maurice Biendo, Abdallah Al-Salameh, Jean-Daniel Lalau, Veronique Bach, Hafida Khorsi-Cauet
Summary: This study evaluated the effects of perigestational exposure to a high-fat diet and chlorpyrifos on glycemia, lipid profiles, and microbial populations in rats and their offspring, and tested the preventive strategy of inulin supplementation. The results demonstrated that exposure to a high-fat diet and co-exposure to a high-fat diet and chlorpyrifos induced dysmetabolism and an imbalance in the gut flora, which could be mitigated by inulin supplementation.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biology
Abdallah Al-Salameh, Noemie Scherman, Imane Adda, Juliette Andre, Yoann Zerbib, Julien Maizel, Jean-Daniel Lalau, Etienne Brochot, Claire Andrejak, Rachel Desailloud
Summary: This study compared TSH levels in hospitalized COVID-19 patients with critical and non-critical conditions, and described the status of TSH levels three months after hospitalization. The findings suggest that COVID-19 is associated with transient suppression of TSH in some patients, and higher TSH levels three months after COVID-19 may indicate recovery from non-thyroidal illness syndrome.
Article
Environmental Sciences
Sylvain Chamot, Abdallah Al-Salameh, Pascal Petit, Vincent Bonneterre, Christophe Cance, Guillaume Decocq, Agnes Boullier, Karine Braun, Rachel Desailloud
Summary: Systematic screening for congenital hypothyroidism in Picardy, France revealed unexpected heterogeneity in the geographic distribution of newborn thyroid-stimulating hormone concentrations, potentially related to environmental pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)