Review
Endocrinology & Metabolism
Marie-Eve Piche, Isabelle Tardif, Audrey Auclair, Paul Poirier
Summary: The atherogenic dyslipidemia commonly seen in severe obesity includes high triglyceride levels, low HDL cholesterol concentrations, and an increased proportion of small and dense LDL particles. Bariatric surgery has been shown to be effective in improving lipid-lipoprotein profile in severe obesity, with mechanisms possibly involving adipose tissue distribution/function, insulin sensitivity, liver fat content/function and lipid-lipoprotein metabolism.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Medicine, Research & Experimental
Qingqing Hou, Shiming Zhang, Yuan Li, Huanjun Wang, Dan Zhang, Dongmei Qi, Yunlun Li, Haiqiang Jiang
Summary: This study aimed to investigate the association of lipid metabolites, circadian genes, and lipid metabolism associated genes in spontaneously hypertensive rats. Through lipidomics and gene expression analysis, it was found that SHR exhibited significant differences in lipid metabolites levels compared to WKY, as well as disturbances in circadian and lipid metabolism associated gene expressions. Moreover, a strong association between the levels of lipid metabolites and circadian genes and lipid metabolism associated genes was identified.
Article
Biochemistry & Molecular Biology
Claudia Manca, Sebastien Lacroix, Francine Perusse, Nicolas Flamand, Yvon Chagnon, Vicky Drapeau, Angelo Tremblay, Vincenzo Di Marzo, Cristoforo Silvestri
Summary: This study demonstrates the potential effects of capsaicinoids in preventing obesity and promoting beneficial eCBome mediators through drug intervention and biological sample analysis. The key alterations in fecal microbiota induced by capsaicinoids provide insights into the relationship between eCBome and the gut microbiome in obesity.
Article
Chemistry, Medicinal
Xialin Zhu, Qingqing Hou, Ling Zhang, Danyang Wang, Zhenhua Tian, Yuecheng Liu, Yu Wang, Yunlun Li, Haiqiang Jiang
Summary: Hypertension is a progressive metabolic disease characterized by circadian regulation of lipid metabolism disorder. This study found that isorhynchophylline (IRP) can improve lipid metabolism rhythm disorder by regulating specific genes, providing a potential treatment strategy for hypertension.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemical Research Methods
Zerin Alimajstorovic, Susan P. Mollan, Olivia Grech, James L. Mitchell, Andreas Yiangou, Mark Thaller, Hannah Lyons, Matilde Sassani, Senali Seneviratne, Thomas Hancox, Andris Jankevics, Lukas Najdekr, Warwick Dunn, Alexandra J. Sinclair
Summary: This study utilized metabolomic analysis to compare the cerebrospinal fluid and serum of patients with idiopathic intracranial hypertension (IIH) with control subjects. The results revealed differential metabolic pathways in IIH patients, which normalized after treatment. These pathways were associated with clinical measures and provide initial insights into the pathogenesis of IIH.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Geriatrics & Gerontology
Shin Murakami, Patricia Lacayo
Summary: This study provides systematic updates on the genetic and disease hallmarks defined by Alzheimer's disease (AD) genes. The analysis identifies 11 biological hallmarks and shows that AD genes are associated with various neurological diseases, age-related diseases, and other health conditions. The study highlights the heterogeneity of Alzheimer's disease and its shared biological mechanisms with age-related comorbidities.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Obstetrics & Gynecology
K. Johansson, A-k Wikstrom, J. Soderling, I Naslund, J. Ottosson, M. Neovius, O. Stephansson
Summary: A nationwide matched cohort study in Sweden involving over 843,000 singleton pregnancies found that gastric bypass surgery before pregnancy is associated with a reduced risk of pre-eclampsia, with the largest absolute risk reduction observed in nulliparous women.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Chemistry, Medicinal
Parisa Shoaei-Hagh, Farzaneh Kamelan Kafi, Sara Najafi, Mansoureh Zamanzadeh, Alireza Heidari Bakavoli, Javad Ramezani, Samira Soltanian, Javad Asili, Hossein Hosseinzadeh, Saeid Eslami, Zhila Taherzadeh
Summary: The study evaluated the efficacy, safety, and utility of Nigella sativa seeds oil as a complementary treatment for hypertension, glucose control, and lipid metabolism. Results showed that the use of N. sativa seeds oil as an adjunct to common medications exhibited significant antihypertensive effects and beneficial effects on glucose control and lipid metabolism in hypertensive patients.
PHYTOTHERAPY RESEARCH
(2021)
Article
Environmental Sciences
Xiaona Yang, Jin Jiang, Qing Wang, Jiawei Duan, Na Chen, Di Wu, Yankai Xia
Summary: Microplastics pollution is a growing concern, and this study investigates the effects of exposure to aged microplastics on female mice. The findings suggest that aged microplastics exposure significantly affects fat metabolism and hormone production in the ovaries, indicating potential sex-specific health effects of environmental microplastics pollution.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Jinqiu Yao, Fei Wang, Ying Zhang, Zefang Zhang, Jiao Bi, Jia He, Peiwen Li, Xu Han, Yue Wei, Xiaomin Zhang, Huan Guo, Meian He
Summary: The study found that serum BPA concentration was associated with changes in blood lipid levels and dyslipidemia risk in middle-elderly Chinese adults. Serum BPA levels were positively related to total cholesterol, LDL-c, and Non-HDL-c levels. Increased Ln-BPA was associated with increased Delta TC, Delta Non-HDL-c, Delta TC/HDL-c, and Delta Non-HDL-c/HDL-c. The associations were observed in females but not in males.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Agriculture, Dairy & Animal Science
Hongjian Dai, Zengpeng Lv, Zhenwu Huang, Nanwei Ye, Simeng Li, Jingle Jiang, Ying Cheng, Fangxiong Shi
Summary: The supplementation of dietary HF significantly improved the egg laying rate and hatching rate, reduced serum lipid levels, and improved liver and ovarian function in aged breeder hens. Additionally, it enhanced the activity of antioxidant enzymes and reversed ovarian apoptosis and morphological damage. In conclusion, dietary HF supplementation can enhance reproductive performance by regulating lipid metabolism and improving ovarian function in aged breeder hens.
Article
Pediatrics
Huan Gu, Long Hao, Mingxi Li, Ji Li
Summary: This study aimed to assess the individual effects of overweight/obesity and tobacco exposure, as well as their combined effects on hypertension in children. The study found a significant correlation between overweight/obesity and tobacco exposure with the prevalence of hypertension in children. The combined effect of overweight/obesity and tobacco exposure also increased the odds of hypertension in children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Anastasia Ponasenko, Maxim Sinitsky, Varvara Minina, Anna Vesnina, Maria Khutornaya, Alexander Prosekov, Olga Barbarash
Summary: More than two billion people worldwide are overweight or obese, and even apparently healthy individuals are affected by obesity. This study found that polymorphisms in immune response and lipid metabolism genes may be associated with changes in obesity risk in the Caucasian population.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mihai Lupu, Camelia Alexandra Coada, Diana -Valentina Tudor, Ioana Baldea, Adrian Florea, Vlad -Alexandru Toma, Ana Lupsor, Remus Moldovan, Nicoleta Decea, Gabriela Adriana Filip
Summary: Iron dysmetabolism is common in heart failure patients, especially those with reduced ejection fraction. Chronic hypertension, a common risk factor for heart failure and death, is associated with iron deficiency. Iron deposition in organs can cause oxidative stress and cell death. In a rat model of cardiac hypertrophy induced by pressure overload, iron chelation with deferiprone reduced inflammation, lipid peroxidation, mitochondrial iron levels, and hypertrophy. This suggests that iron redistribution, particularly in mitochondria, may have beneficial effects in the cardiovascular system.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fioralba Pindozzi, Carlo Socci, Massimiliano Bissolati, Monica Marchi, Elisabetta Devecchi, Alessandro Saibene, Caterina Conte
Summary: This study found that nutritional ketosis is associated with greater weight loss and better metabolic status in patients undergoing bariatric metabolic surgery. Patients with better metabolic status have a higher capacity for ketogenesis, leading to more significant weight loss.
WORLD JOURNAL OF DIABETES
(2022)