The role of adipocytes in the modulation of iron metabolism in obesity

Hepatic and adipocyte cells respond differentially to iron overload, hypoxic and inflammatory challenge

(2012) M. Andrews et al.   BIOMETALS

Overweight impairs efficacy of iron supplementation in iron-deficient South African children: a randomized controlled intervention

(2012) J Baumgartner et al.   INTERNATIONAL JOURNAL OF OBESITY

Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression

(2011) Christine Grigorakaki et al.   BIOCHEMICAL PHARMACOLOGY

Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice

(2011) Maria Pini et al.   CYTOKINE

Intestinal DMT1 Cotransporter Is Down-regulated by Hepcidin via Proteasome Internalization and Degradation

(2011) Carole Brasse–Lagnel et al.   GASTROENTEROLOGY

White adipocytes: More than just fat depots

(2011) Sarah L. Henry et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Diet-induced obesity leads to decreased hepatic iron storage in mice

(2011) Jayong Chung et al.   NUTRITION RESEARCH

Hemojuvelin: A New Link Between Obesity and Iron Homeostasis

(2011) Nathalie Luciani et al.   Obesity

Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release HepcidinIn Vivo

(2011) Lisa Tussing-Humphreys et al.   TheScientificWorldJOURNAL

Adipocyte Hypoxia Increases Hepatocyte Hepcidin Expression

(2010) Korry Joseph Hintze et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

(2010) D. H. Lee et al.   BLOOD

Severe iron deficiency blunts the response of the iron regulatory gene Hamp and pro-inflammatory cytokines to lipopolysaccharide

(2010) D. Darshan et al.   HAEMATOLOGICA

Effect of body mass index reduction on serum hepcidin levels and iron status in obese children

(2010) A Amato et al.   INTERNATIONAL JOURNAL OF OBESITY

Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression

(2010) Julia E. Maxson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

(2010) Ivana De Domenico et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli

(2009) H. Huang et al.   BLOOD

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

(2009) D. R. Ashby et al.   HAEMATOLOGICA

Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children

(2009) I Aeberli et al.   INTERNATIONAL JOURNAL OF OBESITY

Hepcidin in Obese Children as a Potential Mediator of the Association between Obesity and Iron Deficiency

(2009) Emanuele Miraglia del Giudice et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Excess Adiposity, Inflammation, and Iron-Deficiency in Female Adolescents

(2009) Lisa M. Tussing-Humphreys et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Cholestasis downregulate hepcidin expression through inhibiting IL-6-induced phosphorylation of signal transducer and activator of transcription 3 signaling

(2009) Ying-Hsien Huang et al.   LABORATORY INVESTIGATION

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Elevated Systemic Hepcidin and Iron Depletion in Obese Premenopausal Females

(2009) Lisa M. Tussing-Humphreys et al.   Obesity

Molecular mechanisms of normal iron homeostasis

(2009) A.-S. Zhang et al.   Hematology-American Society of Hematology Education Program

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Immunoassay for human serum hepcidin

(2008) T. Ganz et al.   BLOOD

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

(2008) M. A. Melis et al.   HAEMATOLOGICA

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

(2008) M B Zimmermann et al.   INTERNATIONAL JOURNAL OF OBESITY

Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes

(2008) Bohan Wang et al.   JOURNAL OF ENDOCRINOLOGY

Is Obesity Associated With Anemia of Chronic Disease? A Population-based Study

(2008) Karlee J. Ausk et al.   Obesity

Bariatric Surgery Can Correct Iron Depletion in Morbidly Obese Women: A Link with Chronic Inflammation

(2008) Rodolphe Anty et al.   OBESITY SURGERY

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Hepcidin inhibits apical iron uptake in intestinal cells

(2007) Natalia P. Mena et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD

Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site

(2007) Lan Lin et al.   BLOOD CELLS MOLECULES AND DISEASES

Obesity-Related Hypoferremia Is Not Explained by Differences in Reported Intake of Heme and Nonheme Iron or Intake of Dietary Factors that Can Affect Iron Absorption

(2007) Carolyn M. Menzie et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION