Article
Nutrition & Dietetics
Anja Saalbach, Anna-Theresa Seitz, Johannes Kohlmann, Lena Kalweit, Lisa Vogt, Lars Selig, Kathrin M. Engel, Jan C. Simon
Summary: Obesity and high abdominal fat mass increase the risk of developing psoriasis and worsen its severity. Weight loss has been shown to have a positive effect on psoriasis. The dysregulation of glucose and lipid metabolism, adipose tissue activation, and persistent low-grade inflammation may be the links between obesity and inflammatory diseases. In this study, a dietary intervention focusing on reducing saturated free fatty acids (SFAs) improved psoriatic disease activity independently of weight loss and inhibited the overall pro-inflammatory activation status in psoriasis patients.
Article
Food Science & Technology
Marlou Klein Hazebroek, Annemarie Baars, Mona Mischke, Annemarie Oosting, Evert M. van Schothorst, Lidewij Schipper
Summary: Early-life feeding with an infant formula containing lipid droplets mimicking those in human milk (HM, Nuturis) reduces adiposity and adipocyte size in adulthood, regardless of adult diet. After a western-style diet (WSD) in adulthood, Nuturis programme reduced macrophage-related gene expression and potentially lowers macrophage content, suggesting protective effects against adipose tissue inflammation in later life.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Armando Pena, Micah L. Olson, Stephanie L. Ayers, Dorothy D. Sears, Sonia Vega-Lopez, Abigail T. Colburn, Gabriel Q. Shaibi
Summary: Obesity is linked to chronic inflammation and may increase the risk of type 2 diabetes in youth. This study investigated the relationship between inflammatory biomarkers and insulin sensitivity, beta-cell function, and response to lifestyle intervention in Latino youth with obesity. The findings showed that obesity-related inflammatory mediators were associated with T2D risk factors but were not affected by lifestyle intervention in Latino youth.
Article
Nutrition & Dietetics
Cindy Needham, Claudia Strugnell, Steven Allender, Laura Alston, Liliana Orellana
Summary: This study examines the association and temporal trends between the food environment and BMI of adults. The results show that BMI increases as accessibility to healthy outlets decreases. High access to supermarkets and unhealthy outlets are associated with lower BMI. The research highlights the importance of increasing access to diverse food outlets, particularly healthy ones, for promoting good health.
Review
Endocrinology & Metabolism
Ximena M. Bustamante-Marin, Jenna L. Merlino, Emily Devericks, Meredith S. Carson, Stephen D. Hursting, Delisha A. Stewart
Summary: The global prevalence of obesity and overweight has tripled since 1975, with over 42.5% of adults in the United States being obese. Individuals with obesity often exhibit multiple metabolic disturbances, which are associated with an increased risk of many cancers, including breast cancer. In an obese state, interactions between adipocytes, immune cells, and breast epithelial cells via obesity-associated hormones, angiogenic factors, cytokines, and other mediators can enhance the risk and progression of breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Stephanie D. Burr, Yongbin Chen, Christopher P. Hartley, Xianda Zhao, Jun Liu
Summary: Dietary saturated fatty acids (SFAs) have been linked to atherosclerosis and obesity, while the effects of linoleic acid (LA) intake seem to diverge. This study found that replacing SFAs with LA in a Western diet can reduce the development of atherosclerosis independently of obesity.
SCIENTIFIC REPORTS
(2023)
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Elisabetta Camajani, Ludovica Verde, Ausilia Elce, Evelyn Frias-Toral, Florencia Ceriani, Gabriela Cucalon, Eloisa Garcia-Velasquez, Marwan El Ghoch, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri
Summary: Psoriasis is an immune-mediated inflammatory skin disease associated with multiple comorbidities. Obesity is a risk factor for the onset and severity of psoriasis. The very-low-calorie ketogenic diet (VLCKD) has shown significant effects in reducing inflammatory processes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Lan Wang, Wei Huang, Chuan Zhao, Yuanchao Hu, Shenghui Cui
Summary: Unsustainable diets are a major factor in the nutrition-health-environment trilemma. This study examines the diet-related impacts of different socio-economic groups and finds that inequality in food consumption and its related impacts is present and growing. Reformed responsibility allocation systems are necessary for better environmental management during dietary transitions.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Nutrition & Dietetics
Amos K. Laar, Phyllis Addo, Richmond Aryeetey, Charles Agyemang, Francis Zotor, Gershim Asiki, Krystal K. Rampalli, Gideon S. Amevinya, Akua Tandoh, Silver Nanema, Akosua Pokua Adjei, Matilda E. Laar, Kobby Mensah, Dennis Laryea, Daniel Sellen, Stefanie Vandevijvere, Christopher Turner, Hibbah Osei-Kwasi, Mark Spires, Christine Blake, Dominic Rowland, Suneetha Kadiyala, Isabel Madzorera, Adama Diouf, Namukolo Covic, Isaac M. Dzudzor, Reginald Annan, Peiman Milani, John Nortey, Nicholas Bricas, Sukati Mphumuzi, Kenneth Yongabi Anchang, Ali Jafri, Meenal Dhall, Amanda Lee, Sally Mackay, Samuel O. Oti, Karen Hofman, Edward A. Frongillo, Michelle Holdsworth
Summary: This paper highlights the lack of research and policy action in Africa to improve food environments and reduce the intake of suboptimal diets and its adverse health outcomes. The dietary and nutrition transitions in Africa have led to changes in food environments and dietary behaviors, contributing to the complex burden of malnutrition-obesity and other diet-related noncommunicable diseases. Unhealthy or obesogenic food environments have been linked to suboptimal diets and associated adverse health outcomes. The paper emphasizes the urgent need for contextual evidence to motivate and enable supportive food environments in Africa for better population health.
ADVANCES IN NUTRITION
(2022)
Review
Dentistry, Oral Surgery & Medicine
Ferda Pamuk, Alpdogan Kantarci
Summary: Nutrition is crucial for maintaining homeostatic balance, health, and longevity, and is closely linked to inflammatory diseases and obesity. Obesity has severe implications on various organ systems and disease processes, but its impact on periodontal inflammation and the association between nutritional balance and periodontal inflammation require further exploration.
PERIODONTOLOGY 2000
(2022)
Article
Nutrition & Dietetics
Kathrin Hetz, Nuwan Weerasinghe, Holly Rippin, Kremlin Wickramasinghe, Olga Zhiteneva, Muhammad Arslan Usman, Christos Politis, Gauden Galea
Summary: The rapidly growing field of digital meal delivery platforms has brought both opportunities and challenges for public health. This paper introduces a novel digital platform designed for monitoring the out of home (OOH) food environment and highlights the potential benefits it can bring. Despite the gaps in regulations and lack of publicly available individual data, this platform holds promise for better understanding the digital food environment, supporting healthier food choices, and informing future policy interventions. Mandatory regulations in the digital food sector are advocated to ensure comprehensive and transparent nutrition information and equality in access to nutritious foods.
Article
Biochemistry & Molecular Biology
Moeun Lee, Ye-Rang Yun, Eun Ji Choi, Jung Hee Song, Jin Yong Kang, Daun Kim, Ki Won Lee, Ji Yoon Chang
Summary: This study investigated the effect of fermented vegetable juice (VJ) obtained from a blend of four crops on adipogenesis and identified active compounds. Two lactic acid bacteria were used to ferment the VJ, and their effectiveness was evaluated in cells and mice. The results showed that LAB-fermented VJ and its metabolites have the potential to counter obesity and can be therapeutically effective.
Article
Medicine, General & Internal
Carmen Monthe-Dreze, Izzuddin M. Aris, Sheryl L. Rifas-Shiman, Nitin Shivappa, James R. Hebert, Emily Oken, Sarbattama Sen
Summary: Prenatal psychosocial stress and nutrition may program offspring adiposity, but their combined longitudinal associations in the offspring are poorly understood.
Review
Food Science & Technology
Luigi Barrea, Sara Cacciapuoti, Matteo Megna, Ludovica Verde, Claudio Marasca, Rosa Vono, Elisabetta Camajani, Annamaria Colao, Silvia Savastano, Gabriella Fabbrocini, Giovanna Muscogiuri
Summary: Acne is an inflammatory disease caused by hormonal changes and bacterial infection. The influence of diet on acne is a growing topic, but the research findings have been contradictory. Very low-calorie ketogenic diet (VLCKD), which has been associated with weight loss and reduced inflammation, has the potential to benefit acne treatment. This review aims to provide evidence from scientific literature to support the use of VLCKD in acne treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
L. Godny, L. Reshef, T. Sharar Fischler, S. Elial-Fatal, T. Pfeffer-Gik, B. Raykhel, K. Rabinowitz, A. Levi-Barda, T. T. Perets, R. Barkan, I Goren, J. E. Ollech, H. Yanai, U. Gophna, I Dotan
Summary: The feasibility of a microbiota-targeted Mediterranean diet intervention in healthy subjects was investigated in this pilot study. The results showed that increasing adherence to the Mediterranean diet was associated with a reduction in fecal calprotectin and beneficial microbial alterations. Therefore, microbiota-targeted lifestyle interventions may have important implications for modulating the intestinal ecosystem and microbiome-mediated diseases.
Article
Surgery
Richard Welbourn, Marianne Hollyman, Robin Kinsman, John Dixon, Ricardo Cohen, John Morton, Amir Ghaferi, Kelvin Higa, Johan Ottosson, Francois Pattou, Salman Al-Sabah, Merhan Anvari, Jacques Himpens, Ronald Liem, Villy Vage, Peter Walton, Wendy Brown, Lilian Kow
Summary: International comparative practice of bariatric-metabolic surgeries for T2DM patients is not well understood. Older men with higher rates of BMI <35 kg/m2 have an increased likelihood of having T2DM and undergoing food rerouting operations.
Article
Anesthesiology
Alison Flehr, Jan Coles, John B. Dixon, Stephen J. Gibson, Samuel L. Brilleman, Melissa L. Harris, Deborah Loxton
Summary: The relationship between interpersonal injury and body pain was found to be mediated by biopsychological burden, while the relationship between physical injury and body pain was not. Patients with a history of interpersonal injury and body pain were found to have a greater biopsychological burden.
Article
Medicine, General & Internal
Nicholas L. Syn, David E. Cummings, Louis Z. Wang, Daryl J. Lin, Joseph J. Zhao, Marie Loh, Zong Jie Koh, Claire Alexandra Chew, Ying Ern Loo, Bee Choo Tai, Guowei Kim, Jimmy Bok-Yan So, Lee M. Kaplan, John B. Dixon, Asim Shabbir
Summary: Metabolic-bariatric surgery significantly reduces all-cause mortality and extends life expectancy in obese adults, with a more pronounced effect seen in patients with pre-existing diabetes.
Article
Peripheral Vascular Disease
Nina Eikelis, John B. Dixon, Elisabeth A. Lambert, Geula Hanin, Yonat Tzur, David S. Greenberg, Hermona Soreq, Francine Z. Marques, Michael T. Fahey, Geoffrey A. Head, Markus P. Schlaich, Gavin W. Lambert
Summary: The study revealed an association between miR-132 and markers of cardiovascular and metabolic disease, suggesting that reduction of miR-132 may be a target for regulating liver lipid homeostasis and controlling obesity-related blood pressure.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Gastroenterology & Hepatology
Sanita L. Ley, Meg H. Zeller, Jennifer Reiter-Purtill, David E. Kleiner, John Dixon, Stavra Xanthakos
Summary: This study found that certain unhealthy eating behaviors are associated with the occurrence of pediatric nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), and internalizing psychopathology is also associated with an increased risk of NAFLD.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Endocrinology & Metabolism
Claire E. E. de Vries, Caroline B. Terwee, May Al Nawas, Bart A. van Wagensveld, Ignace M. C. Janssen, Ronald S. L. Liem, Simon W. Nienhuijs, Ricardo Cohen, Elisabeth F. C. van Rossum, Wendy A. Brown, Amir A. Ghaferi, Johan Ottosson, Karen D. Coulman, Tarissa B. Z. Petry, Stephanie Sogg, Lisa West-Smith, Jason C. G. Halford, Ximena Ramos Salas, John B. Dixon, Salman Al-Sabah, Wei-Jei Lee, John Roger Andersen, Stuart W. Flint, Maarten M. Hoogbergen, Brooke Backman, Ellen Govers, Nadya Isack, Caroline Clay, Susie Birney, Maureen Gunn, Paul Masterson, Audrey Roberts, Jacky Nesbitt, Riccardo Meloni, Sarah le Brocq, Sandra de Blaeij, Christina Kraaijveld, Floor van der Steen, Bibian Visser, Petra Hamers, Valerie M. Monpellier
Summary: The lack of standardization in measuring patient-reported outcomes (PROs) and PRO measures (PROMs) has led to the quality of life being underrepresented in obesity treatment research. The S.Q.O.T. initiative aims to standardize the measurement of quality of life in obesity treatment, and the first consensus meeting brought together experts and patients to identify key PROs and preferred PROMs. This meeting provided a first step towards standardizing PROs and PROMs in obesity treatment research.
Editorial Material
Dermatology
Anthony Dixon, Athanassios Kyrgidis, Christopher Zachary, John Dixon, Catalin Popescu, Michael Sladden, Zoe Apalla, Stuart Anderson, Giuseppe Argenziano, Demitrios Ioannides, Alexander Nirenberg, Aimillios Lallas, Samuel Zagarella, Caterina Longo, Harvey Smith, Howard Steinman, Thrasivoulos Tzellos, Lloyd Cleaver, Ken Leahey, Christos C. Zouboulis, J. Meirion Thomas
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Tania P. Markovic, Joseph Proietto, John B. Dixon, Georgia Rigas, Gary Deed, Jeffrey M. Hamdorf, Erica Bessell, Nathalie Kizirian, Sofianos Andrikopoulos, Stephen Colagiuri
Summary: Obesity is a complex chronic disease with various factors, and it is associated with multiple complications. The treatment for non-pregnant adults with obesity should be determined based on their body indices (body mass index (BMI) and waist circumference) and the presence and severity of obesity-related complications. Supervised lifestyle interventions, such as reduced or low energy diet, very low energy diet (VLED), or pharmacotherapy, should be the focus for individuals with BMI 30-40 kg/m2 or abdominal obesity without complications, aiming for a weight loss of 10-15%. For individuals with BMI 30-40 kg/m2 or abdominal obesity and complications, or those with BMI > 40 kg/m2, a weight loss target of 10-15% body weight is recommended, and more intensive interventions like VLED, pharmacotherapy, or bariatric surgery may be required, potentially in combination. Those with BMI > 40 kg/m2 and complications should aim for a weight loss target of > 15% and be referred to specialist care, which may involve VLED with or without pharmacotherapy and bariatric surgery.
OBESITY RESEARCH & CLINICAL PRACTICE
(2022)
Article
Clinical Neurology
Anna L. L. Hatton, Katrina Williams, Mark D. D. Chatfield, Sheree Hurn, Jayishni N. N. Maharaj, Elise M. M. Gane, Thomas Cattagni, John Dixon, Keith Rome, Graham Kerr, Sandra G. G. Brauer
Summary: Innovative shoe insoles designed to enhance sensory information on the plantar surface of the feet could improve walking in people with Multiple Sclerosis. However, a study comparing the effects of textured and smooth insoles found no differences in gait, foot sensation, and patient-reported outcomes. Further investigation is needed to explore optimal insole design.
Article
Psychology, Clinical
Daniel J. van den Hoek, Clint T. Miller, Steve F. Fraser, Steve E. Selig, Toni Rice, Mariee Grima, Carolina Ika Sari, Gavin W. Lambert, John B. Dixon
Summary: This study explored the effects of dietary weight loss intervention, with and without exercise, on health-related quality of life, depressive symptoms, and anxiety in premenopausal women. The results showed that the addition of exercise to energy restriction had a significant positive impact on health-related quality of life, depressive symptoms, and state and trait anxiety scores. Exercise can improve mental health and quality of life in women with severe obesity without further weight loss.
JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Letter
Dermatology
A. J. Dixon, H. K. Steinman, A. Kyrgidis, H. Smith, M. Sladden, C. Zouboulis, G. Argenziano, Z. Apalla, A. Lallas, C. Longo, A. Nirenberg, C. Popescu, J. B. Dixon, T. Tzellos, C. Zachary, L. Cleaver, S. Anderson, S. Zagarella, J. M. Thomas
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Surgery
John B. Dixon, Stuart J. Anderson, Jeffery Hamdorf
Letter
Surgery
John B. Dixon
Article
Surgery
Karen D. D. Coulman, Katy Chalmers, Jane Blazeby, John Dixon, Lilian Kow, Ronald Liem, Dimitri J. J. Pournaras, Johan Ottosson, Richard Welbourn, Wendy Brown, Kerry Avery
Summary: This study developed a Core Registry Set (CRS) - core data to include in bariatric surgery registries globally, which is the first step towards unifying bariatric surgery registries internationally. We recommend the CRS is included as a minimum dataset in all bariatric registries worldwide. Adoption of the CRS will enable meaningful international comparisons of bariatric operations.
Meeting Abstract
Endocrinology & Metabolism
Shelley Ehrlich, Jane Khoury, Anita Courcoulas, John Dixon, Michael Helmrath, Mary Evans, Kate McCracken, Eliza Buyers, Stephanie Sisley, Carroll Harmon, Marc Michalsky, Todd Jenkins, Thomas Inge
