Article
Nutrition & Dietetics
Nan Li, Haiyan Shi, Qiaofeng Guo, Yanming Gan, Yuhang Zhang, Jiajie Jia, Liang Zhang, Yue Zhou
Summary: This study evaluated the effects of aerobic exercise on obesity-associated inflammation and insulin resistance. The results showed that aerobic exercise can reduce weight gain and glucose intolerance, and improve insulin sensitivity in high-fat diet mice. This was achieved by reducing lipid content, inflammation, and macrophage infiltration in skeletal muscles.
Article
Biochemistry & Molecular Biology
Jun-Won Heo, Mi-Hyun No, Jinkyung Cho, Youngju Choi, Eun-Jeong Cho, Dong-Ho Park, Tae-Woon Kim, Chang-Ju Kim, Dae Yun Seo, Jin Han, Young C. Jang, Su-Jeen Jung, Ju-Hee Kang, Hyo-Bum Kwak
Summary: Moderate aerobic exercise training can improve mitochondrial function and structure in skeletal muscle, reducing obesity and hyperglycemia induced by high-fat diet. Exercise attenuates mitochondrial dysfunction, imbalance of fusion and fission, and dysregulation of mitophagy caused by high-fat diet, ultimately mitigating obesity-induced insulin resistance.
Article
Cell Biology
Carolyn Chee, Chris E. Shannon, Aisling Burns, Anna L. Selby, Daniel Wilkinson, Kenneth Smith, Paul L. Greenhaff, Francis B. Stephens
Summary: Increasing muscle total carnitine content in older men can enhance fat oxidation and intramyocellular lipid utilization during exercise. However, this intervention did not lead to improvements in resting insulin-stimulated whole-body or skeletal muscle glucose disposal. Further research is needed to explore the potential metabolic benefits of carnitine supplementation in older adults with impaired lipid turnover.
Article
Endocrinology & Metabolism
Xiaoyan Hao, Honghai He, Liyuan Tao, Peng Wang
Summary: This study explored the relationship between serum homocysteine levels, body composition, and the likelihood of having nonalcoholic fatty liver disease (NAFLD) in Chinese healthcare workers. The results showed that NAFLD patients had higher body mass index, waistline, neck circumference, abdominal visceral fat area, total cholesterol, triglycerides, high-density lipoprotein cholesterol, glucose, and homocysteinemia compared to controls. Additionally, skeletal-muscle content was associated with a lower risk of NAFLD, while factors such as BMI, waistline, neck circumference, and hyperhomocysteinemia were associated with a higher risk of NAFLD. These findings may offer a novel approach for diagnosing NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Monika Imierska, Piotr Zabielski, Kamila Roszczyc-Owsiejczuk, Emilia Sokolowska, Karolina Pogodzinska, Iwona Kojta, Agnieszka Blachnio-Zabielska
Summary: Skeletal muscles play a crucial role in insulin-stimulated glucose uptake, and a high-fat diet can lead to metabolic changes in muscles, including the development of insulin resistance. Accumulation of biologically active lipids, particularly ceramides, in muscles is shown to be important in the development of insulin resistance. Silencing the gene responsible for ceramide synthesis can reduce ceramide accumulation and improve the insulin signaling pathway.
Article
Biochemistry & Molecular Biology
Venkatesh Gopalan, Jadegoud Yaligar, Navin Michael, Kavita Kaur, Rengaraj Anantharaj, Sanjay Kumar Verma, Suresh Anand Sadananthan, Giang Thi Thu Le, Jorming Goh, S. Sendhil Velan
Summary: Investigations on obese rodent models have shown that 12 weeks of aerobic exercise training can effectively improve metabolic health, fat depots, ectopic fat, and inflammation.
BIOSCIENCE REPORTS
(2021)
Article
Multidisciplinary Sciences
Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima
Summary: This study found that intramuscular adipose tissue is negatively correlated with adiponectin levels in normal-weight older adults, independent of waist circumference. Additionally, the dynamics of adiponectin differ from other circulating biochemical parameters in older men and women.
Article
Multidisciplinary Sciences
Wenliang Zhang, Baiyang You, Dake Qi, Ling Qiu, Jeffrey W. Ripley-Gonzalez, Fan Zheng, Siqian Fu, Cui Li, Yaoshan Dun, Suixin Liu
Summary: Obesity can cause skeletal muscle dysfunction, while Trimetazidine has the potential to improve muscle atrophy, correct metabolic abnormalities, and enhance mitochondrial quality control.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Mojtaba Kaviani, Azimeh Izadi, Javad Heshmati
Summary: Low carbohydrate high fat (LCHF) diets are effective for weight and fat mass loss, but may impair maximal and supramaximal exercise performance. Creatine supplementation can increase muscle power output and reduce fatigue, potentially improving body composition. Combining creatine with LCHF diets may lead to enhanced fat loss and better body composition.
MEDICAL HYPOTHESES
(2021)
Article
Multidisciplinary Sciences
Goh Eun Chung, Sohee Oh, Dong-Won Ahn, Su Hwan Kim, Yong Jin Jung, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Ji Bong Jeong
Summary: This study aimed to evaluate the effects of interactions between various body composition parameters, including obesity, visceral adiposity, and sarcopenia, on the risk of nonalcoholic fatty liver disease (NAFLD). The study found that there were significant interactions between obesity and visceral adiposity, as well as between obesity and sarcopenia, affecting NAFLD.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ao Sun, Xiaoqin Hu, Huijian Chen, Yulan Ma, Xiyue Yan, Dangsheng Peng, Jie Ping, Youe Yan
Summary: Research has shown that ursolic acid acts as an anti-obesity agent by increasing irisin secretion and promoting the beiging of white adipose tissue (WAT).
Article
Nutrition & Dietetics
Masahiro Matsui, Akira Fukuda, Saori Onishi, Kosuke Ushiro, Tomohiro Nishikawa, Akira Asai, Soo Ki Kim, Hiroki Nishikawa
Summary: The relationship between insulin resistance (IR) and body composition was investigated in Japanese health check-up recipients. The study found that IR can control the balance between fat and skeletal muscle in Japanese adults.
Article
Biochemistry & Molecular Biology
Haixia Ma, Valentina Sukonina, Wei Zhang, Fang Meng, Santhilal Subhash, Henrik Palmgren, Ida Alexandersson, Huiming Han, Shuping Zhou, Stefano Bartesaghi, Chandrasekhar Kanduri, Svren Enerback
Summary: In recent years, lactate has been recognized as an important circulating energy substrate and aerobic glycolysis has been identified as a metabolic choice involving increased glucose uptake and lactate production despite normal oxygen levels. This study demonstrates that the transcription factor Foxp1 regulates glucose uptake and lactate production in adipocytes and myocytes. Foxp1 directly interacts with the promoter consensus cis-elements that regulate expression of several enzymes in the glycolytic pathway. Knockdown of Foxp1 suppresses these enzyme levels and impairs glucose uptake and lactate production. This suggests that Foxp1 plays a crucial role in regulating aerobic glycolysis in adipose tissue and muscle.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell Biology
Alex Brown, Aaron C. Q. Thomas, Aidan A. Hatt, Chris McGlory, Stuart M. Phillips, Dinesh Kumbhare, Gianni Parise, Sophie Joanisse
Summary: This study investigated the acute effects of aerobic conditioning on satellite cells (SCs) and ribosomes in skeletal muscle. The results showed that aerobic conditioning increased the abundance of type-I SCs and the acute increase in ribosome content following eccentric contractions.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Lei Xu, Jie Jia, Shudan Miao, Lijing Gong, Jin Wang, Shiyi He, Ying Zhang
Summary: The study aimed to investigate the effects of aerobic exercise on the CHRONO-BMAL1 pathway and glucose metabolism in high-fat diet-fed mice. The results showed that aerobic exercise prevented weight gain, dyslipidemia, and systemic insulin resistance in the high-fat diet-fed mice. It also decreased the amount of CHRONO bound to BMAL1 and increased glucose uptake, oxidation, and glycogenesis in skeletal muscle.
Article
Nutrition & Dietetics
Hideaki Kumahara, Makoto Ayabe, Misato Ichibakase, Akari Tashima, Maiko Chiwata, Tomomi Takashi
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2015)
Article
Sport Sciences
M. Ayabe, H. Kumahara, K. Morimura, H. Tanaka
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2015)
Article
Physiology
Hiroshi Kumagai, Takuro Tobina, Noriko Ichinoseki-Sekine, Ryo Kakigi, Takamasa Tsuzuki, Hirofumi Zempo, Keisuke Shiose, Eiichi Yoshimura, Hideaki Kumahara, Makoto Ayabe, Yasuki Higaki, Ryo Yamada, Hiroyuki Kobayashi, Akira Kiyonaga, Hisashi Naito, Hiroaki Tanaka, Noriyuki Fuku
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Endocrinology & Metabolism
Eiichi Yoshimura, Hideaki Kumahara, Takuro Tobina, Takuro Matsuda, Kiwa Watabe, Sakiko Matono, Makoto Ayabe, Akira Kiyonaga, Keizo Anzai, Yasuki Higaki, Hiroaki Tanaka
Article
Nutrition & Dietetics
Hideaki Kumahara, Makoto Ayabe
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2019)
Article
Anthropology
Makoto Ayabe, Hideaki Kumahara, Ayako Yamaguchi-Watanabe, Hitoshi Chiba, Noriko Kobayashi, Ichiro Sakuma, Kojiro Ishii
ANNALS OF HUMAN BIOLOGY
(2019)
Article
Sport Sciences
Hideaki Kumahara, Chihiro Ohta, Erina Nabeshima, Ai Nakayama, Sayoko Mine, Takako Yamato
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2020)
Article
Neurosciences
Makoto Ayabe, Hideaki Kumahara
Article
Geriatrics & Gerontology
Ryo Miyazaki, Makoto Ayabe, Hideaki Kumahara, Kazuhiro Morimura, Yoshihide Inukai
Summary: The study found that a 3-month light-to-moderate intensity aerobic exercise intervention significantly improved objectively measured sleep quality among community-dwelling older people, regardless of their baseline sleep conditions. These results suggest that exercise can have a positive impact on sleep quality in older individuals.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Makoto Ayabe, Sungjin Park, Roy J. Shephard, Yukitoshi Aoyagi
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2015)
Article
Endocrinology & Metabolism
Eiichi Yoshimura, Hideaki Kumahara, Takuro Tobina, Takuro Matsuda, Makoto Ayabe, Akira Kiyonaga, Keizo Anzai, Yasuki Higaki, Hiroaki Tanaka
JOURNAL OF OBESITY
(2014)