Article
Chemistry, Multidisciplinary
Satya Ranjan Sahoo, Debkumar Bera, Sumit Saha, Nirmal Goswami
Summary: Metal-thiolate complexes exhibit unique photophysical properties and reversible catalytic and photoluminescence properties under different pH conditions, showing potential for applications in pH and CO2 sensing. The complexes demonstrate two distinct structural states at different pH levels, highlighting their versatility for various applications.
Article
Chemistry, Multidisciplinary
Kumar Babu Busi, Subhalaxmi Das, Mathangi Palanivel, Krishna Kanta Ghosh, Balazs Gulyas, Parasuraman Padmanabhan, Sabyasachi Chakrabortty
Summary: We have developed a simple and cost-effective method for the synthesis of red-/green-color-emitting protein/amino acid-mediated copper nanoclusters (Cu NCs) in water. These Cu NCs exhibited strong fluorescence, aqueous colloidal stability, and low toxicity, making them suitable for applications in biology and environmental science. The optical properties of the Cu NCs responded linearly to changes in pH, and they showed a robust pH reversible nature between pH 7 and 11, which has potential for rapid and localized pH sensing. Additionally, the Cu NCs were found to be efficient optical probes for fluoride ion detection, with different limits of detection for protein-Cu NCs and amino acid-Cu NCs.
Article
Chemistry, Multidisciplinary
Ruimeng Sun, Ruijuan Lv, Yang Zhang, Ting Du, Yuhan Li, Lixia Chen, Yanfei Qi
Summary: In this study, core-shell Cu/Au nanoparticles were synthesized and shown to possess peroxidase activity for the detection of H2O2 and glucose. The method exhibits a good detection range and detection limit, making it highly promising for various applications.
Article
Chemistry, Analytical
Le Li, Ting Liu, Meifang Wang, Yong'an Ren, Nan Jia, Huaiyu Bu, Gang Xie, Hang Xu, Yongli Wu, Xiangyuan Ouyang
Summary: By synthesizing snowflake-like DNA crystals and copper nanoclusters, a turn-on label-free fluorescence detection method for actin with improved stability and emission intensity was developed. The detection limit was significantly lower than previous methods and the linear range was wider, showing potential for practical applications in biosensors.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Anuj K. Saini, Suban K. Sahoo
Summary: The water-soluble fluorescent organic nanoparticles (PDAPLP NPs) were synthesized and applied for the detection of glutathione (GSH) and pH. The fluorescence intensity of the nanoparticles was quenched in the presence of MnO2 nanospheres, but could be restored upon addition of GSH. This nanoprobing approach offers a fast, simple, and highly selective method for GSH detection.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jinglin Shen, Qianwen Xiao, Panpan Sun, Jin Feng, Xia Xin, You Yu, Wei Qi
Summary: The self-assembly of chiral metal nanoclusters into ordered microstructures with enhanced phosphorescence and optical activities was achieved by manipulating Au nanoclusters modified by L-/D-cysteine. The compact aggregation structures were essential for emission enhancement and chirality amplification, with the microflowers exhibiting pH-responsiveness. Additionally, the pH-responsive photoluminescence ON/OFF switch of the microflowers could be utilized for reliable information encryption and decryption.
Article
Chemistry, Analytical
Xue Hu, Xiaodan Zhang, Haiyan Cao, Yuming Huang
Summary: The study introduces a new strategy for preparing photoluminescent Cu NCs using Cu-MOFs as precursors, which can be applied in a ratiometric fluorescent sensing platform for pH detection. The Cu NCs exhibit unique pH-dependent photoluminescence property, offering potential for applications in bioassays and other fields.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Kumar Babu Busi, Jyothi Kotha, Shamili Bandaru, Jyothi Priyanka Ghantasala, Sheik Haseena, Keerti Bhamidipati, Nagaprasad Puvvada, Mahesh Kumar Ravva, Manjunatha Thondamal, Sabyasachi Chakrabortty
Summary: Metal nanoclusters, especially copper nanoclusters, have attracted significant attention due to their high emission properties, strong colloidal stability, and low toxicity. In this study, researchers successfully improved the photoluminescence intensity and colloidal stability of copper nanoclusters by optimizing reaction parameters. Moreover, the synthesized copper nanoclusters exhibited reduced toxicity in both in vitro and in vivo models.
Article
Chemistry, Analytical
Lian Xiang, Lin-Lei Liu, Ruo Yuan, Ya-Qin Chai
Summary: In this study, Cu nanoclusters (Cu NCs) with strong aggregation-induced electrochemiluminescence (AIECL) were used to develop an ECL biosensor for ultrasensitive detection of miR-141. The ECL intensity of the aggregative Cu NCs was significantly enhanced with the increased content of Cu(I), which could form rod-shaped aggregates and improve the ECL response. By utilizing the cascade strand displacement amplification (SDA) strategy, an outstanding ECL biosensor was developed with a linear range from 10 aM to 1 nM and a detection limit of 1.2 aM for miR-141. This approach provides a new idea for the detection of biomolecules in disease diagnosis using non-noble metal nanomaterials as robust ECL emitters.
ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Ruyan Xie, Nannan Zhang, Yaoyao Qu, Mingyu Tang, Fang Zhang, Fang Chai, Zhongmin Su
Summary: A facile one-pot strategy was developed to synthesize fluorescent Cu nanoclusters with L-histidine as stabilizer and ascorbic acid as reducing agent. The Cu nanoclusters exhibited stable water dispersibility and emitted bright cyan emission. They showed excellent selectivity and sensitivity for detecting 2,4-dinitrophenol (DNP), making them a promising dual-mode detector. The environmental tolerance of the Cu nanoclusters probe was also demonstrated, highlighting their potential in DNP monitoring and water sample analysis.
Article
Biophysics
Jinzhu Ma, Zhangdi Lu, Chenmin Li, Yingjian Luo, Yu-e Shi, Parvej Alam, Jacky W. Y. Lam, Zhenguang Wang, Ben Zhong Tang
Summary: A strategy for selective and sensitive detection of glutathione (GSH) based on UiO-66-NH2 and Cu nanoclusters (NCs) was reported. The fluorescence of UiO-66-NH2 was enhanced after reacting with GSH, and UiO-66-NH2 was further used for synthesizing UiO-66-NH2@Cu NCs. Ratiometric fluorescence response was observed to discriminate GSH over cysteine (Cys).
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Physical
Sourav Biswas, Saikat Das, Yuichi Negishi
Summary: This Minireview provides a comprehensive coverage of the optimal design strategies and controlled synthesis of copper nanoclusters (Cu NCs) as catalysts. It discusses the tuning of active sites at the atomic level, the influence of cluster size, shape, structure, ligands and heteroatom doping on catalytic activity, and various catalytic applications ranging from chemical catalysis to emerging photocatalysis and electrocatalysis.
NANOSCALE HORIZONS
(2023)
Article
Agriculture, Multidisciplinary
Fangfang Du, Zhe Cheng, Guanghui Wang, Minglu Li, Wenjing Lu, Shaomin Shuang, Chuan Dong
Summary: In this work, carbon nanodots (CNDs) were synthesized using a one-pot hydrothermal method, showing excellent photostability, biocompatibility, and water solubility. They were used as a dual-responsive nanosensor for the detection of vitamin B-2 and pH, as well as a turn-off fluorescent sensor for pH monitoring, showing promising applications in food and medicine sample analysis and intracellular pH sensing.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Spectroscopy
Rui-Xian Zhao, An-Yong Liu, Qiu-Lin Wen, Bi-Chao Wu, Jun Wang, Yi-Lin Hu, Zheng-Fen Pu, Jian Ling, Qiue Cao
Summary: A glutathione stabilized Au nanoclusters were synthesized and used for selective detection of cobalt ions, showing linear relationship and high detection limit.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Zhongxiang Zuo, Xinxin Pan, Ge Yang, Yuemin Zhang, Xingwen Liu, Jinrun Zha, Xun Yuan
Summary: This study introduces the design of aggregation-induced emission (AIE)-featured PEG-condensed Cu(i)-p-MBA aggregates (PCuA). The PCuA, with the combined advantages of AIE trait and intrinsic antibacterial property of Cu species, exhibits enhanced photodynamic antibacterial activities against broad-spectrum bacteria, providing a paradigm in the design of novel antibacterial agents.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).