Article
Chemistry, Analytical
Delphine Zanella, Adele Henin, Steven Mascrez, Pierre-Hugues Stefanuto, Flavio Antonio Franchina, Jean-Francois Focant, Giorgia Purcaro
Summary: The potential of exhaled breath for disease diagnosis is significant, but standardized sampling and analysis procedures are necessary for reliable results. This study validates the performance of two different comprehensive two-dimensional gas chromatography coupled to mass spectrometry platforms in different laboratories, using the Peppermint Initiative guidelines. The platforms successfully tracked the peppermint oil metabolites in exhaled breath over a 6.5-hour period.
JOURNAL OF SEPARATION SCIENCE
(2022)
Review
Chemistry, Analytical
Eliise Tammekivi, Christophe Geantet, Chantal Lorentz, Karine Faure
Summary: This review summarizes the studies published since 2010 on the utilization of gas chromatography (GC) or liquid chromatography (LC) as one dimension in two-dimensional (2D) chromatographic analysis for characterizing and monitoring the valorization processes of various biowastes. The article highlights the challenges and prospects of using 2D chromatography for analyzing polar, poorly volatile, and thermally unstable compounds in biowastes. The different 2D setups used for monitoring biowaste conversion processes are also discussed.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Yuta Fujihashi, Akihito Ishizaki
Summary: The study explores spectroscopic measurements using entangled three photons, combining time-resolved entangled photon spectroscopy with monochromatic pumping and frequency-dispersed two-photon counting technique. The method allows for enhanced sensitivity and selectivity in measurements by suppressing undesired accidental photon counts in the detector.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Analytical
Weiyi Wen, Ping Xu, Haiping Xiang, Mengyi Wen, Xuemin Ye, Chu Chu, Shengqiang Tong
Summary: In this study, a comprehensive two-dimensional countercurrent chromatography (CCC) combined with gas chromatography (GC) was used to characterize the chemical constituents of Artemisia argyi essential oil and evaluate the orthogonality of the 2D chromatographic system. A solvent system composed of n-hexane/acetonitrile/methanol (2:2:1, v/v/v) was selected for the first dimensional separation and all CCC fractions were analyzed by GC. A 2D contour plot was created to visualize the chemical compositions. A total of 1392 peaks were obtained through the comprehensive 2D CCC x GC separation and high spatial coverage and low linear correlation coefficient were achieved. Moreover, all compounds were identified by GC-MS. The obtained 2D contour plot could be divided into six zones representing different component groups, which could be used to identify and predict the structure of unknown compounds in Artemisia argyi essential oil for comprehensive characterization.
ANALYTICA CHIMICA ACTA
(2023)
Article
Materials Science, Multidisciplinary
Zhuchi Wang, Shuming Zeng, Yinchang Zhao, Xinming Wang, Jun Ni
Summary: The study focuses on the search for multigap superconductors in two-dimensional boron-based materials doped with metal atoms, resulting in the discovery of stable InB2 and InB4 films with high Tc values of 41.5K and 53K, respectively. Additionally, the superconducting behavior of InB4 films is found to be influenced by biaxial strain, with Tc reaching up to 64K under specific conditions. Other trilayer films like GeB4 and ZnB4 also exhibit high Tc values of 48.5K and 32K, respectively, as two-gap superconductors.
Article
Biochemical Research Methods
Natalia Manousi, Natasa Kalogiouri, Antonio Ferracane, George A. Zachariadis, Victoria F. Samanidou, Peter Q. Tranchida, Luigi Mondello, Erwin Rosenberg
Summary: In this study, a combination of solid-phase microextraction (SPME) Arrow method and comprehensive two-dimensional gas chromatography-mass spectrometry (GC x GC-MS) was developed to analyze the volatile composition of honey samples. The optimized sample preparation protocol ensured high extraction efficiency of the volatile organic compounds (VOCs) associated with the sensory properties and acceptance of honey. SPME Arrow showed higher sensitivity, precision, and capability to extract a larger number of compounds compared to conventional SPME. Overall, SPME Arrow and GC x GC-MS are highly suitable for elucidating the volatile composition of complex food samples, offering enhanced sensitivity and separation efficiency.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Plant Sciences
Patrick J. C. James, Daniel Vuong, Stephen A. Moggach, Ernest Lacey, Matthew J. Piggott
Summary: The lichen natural products pulvinamide, rhizocarpic acid, and epanorin were synthesized and characterized. The syntheses may be biomimetic, considering the occurrence of pulvinic acid dilactone in lichen. The enantiomers and corresponding carboxylic acids were also prepared. The compounds were evaluated for growth inhibitory activity, and rhizocarpic acid showed weak antibacterial and selective antitumor activities.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Engineering, Environmental
Rabia Zafar, Zeshan Arshad, Na Eun Choi, Xiaowei Li, Jin Hur
Summary: This study investigates the preferential adsorption behavior of extracellular polymeric substances (EPS) on two commonly used microplastics (MPs) and explores the effects of UV aging on EPS adsorption. The results show that EPS adsorption is greater on UV-aged MPs than on pristine MPs. Fourier transform infrared (FTIR) spectra reveal that EPS adsorption is governed by hydrogen bonds. Fluorescence spectroscopy shows that protein-like components exhibit higher adsorption affinity than humic-like components. Two-dimensional correlation spectroscopy combined with FTIR (2D-COS-IR) reveals that polysaccharides in EPS are more preferentially adsorbed onto MPs. This study provides new insight into the complex adsorption behavior of EPS on MPs and its implications for the environmental fate of MPs.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Gemma De Grazia, Lorenzo Cucinotta, Danilo Sciarrone, Paola Donato, Emanuela Trovato, Nacera Riad, Mohamed El Hattab, Luigi Mondello, Archimede Rotondo
Summary: In this study, novel compounds were isolated from brown algae using preparative multidimensional gas chromatography. The correct 3D structures were determined by matching the experimental NMR data with density functional theory simulations. This research provides a new approach for structure elucidation of highly asymmetric molecules.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Physical
Thresa A. Wells, Muhire H. Kwizera, Sarah M. Chen, Nihal Jemal, Morgan D. Brown, Peter C. Chen
Summary: High resolution coherent multidimensional spectroscopy can reduce congestion and automatically sort peaks, but the complexity of three-dimensional spectroscopy can be overcome by strategic placement of 2D scans and new pattern recognition methods. Optimum four wave mixing processes and scanning strategies have been identified, with experiments based on nonparametric FWM processes providing significant pattern recognition advantages. Alternative scanning strategies such as synchronous and asynchronous scanning have also been found to create new patterns in 3D space.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Biochemical Research Methods
Danson J. Oliva, Cynthia Cheung, Katelynn A. Perrault
Summary: Comprehensive two-dimensional gas chromatography (GCxGC) is increasingly used for non-targeted characterization of complex volatile mixtures. This study evaluated the success rates of manual Fisher ratio (FR) calculation for feature selection from GCxGC data and its comparison to a critical F-value. Long-term sample storage and spiked interferences were also investigated for their impact on analyzing mixtures using this FR feature selection strategy.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Nino B. L. Milani, Eric van Gilst, Bob W. J. Pirok, Peter J. Schoenmakers
Summary: Although comprehensive 2-D GC is a well-established and widely used analytical method, it is still a highly dynamic field due to numerous innovations. This review discusses recent developments in comprehensive 2-D GC technology, including exciting improvements in modulation methods, detection methods, retention modeling, and data analysis.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Multidisciplinary Sciences
Carolina Parra, Francis C. Niestemski, Alex W. Contryman, Paula Giraldo-Gallo, Theodore H. Geballe, Ian R. Fisher, Hari C. Manoharan
Summary: Spatially resolved scanning tunneling spectroscopy measurements on the 3D superconductor BaPb1-xBixO3 reveal key signatures of emergent electronic granularity, previously only conjectured and observed in 2D thin-film systems. These signatures include emergent superconducting domains, finite energy gap, and enhanced spatial anticorrelation between pairing amplitude and gap magnitude near the superconductor-insulator transition. This suggests the presence of 2D superconducting behavior within a conventional 3D s-wave host, hinting at an unexplained interdimensional phenomenon.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Noor Abdulhussain, Suhas Nawada, Peter Schoenmakers
Summary: This review focuses on the importance of separation and characterization of complex mixtures, particularly in the context of online three-dimensional separation systems. Various combinations are discussed to provide detailed information on complex samples and the need for higher peak capacities. Overall, the review highlights the potential performance, advantages, perspectives, and results obtained from these systems in the past decade.
Review
Materials Science, Multidisciplinary
Peiyan Shen, Yuqi Zhang, Zhongyu Cai, Ruixiang Liu, Xiaoying Xu, Ran Li, Ji-Jiang Wang, De'an Yang
Summary: PCHs, consisting of PCs and stimuli-responsive hydrogels, act as a sensing system for specific analytes by undergoing volume phase transitions upon exposure to external stimuli. The VPT of the hydrogel causes changes in the photonic stopband of the PCs, leading to shifts in Bragg diffraction peak wavelengths. This sensing mechanism allows for the development of various PCH sensors capable of detecting external stimuli.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Monika Wieczerzak, Jacek Namiesnik, Blazej Kudlak
Summary: This study focused on the genotoxicity of pharmaceuticals from different therapeutic groups, both in mixtures and individual solutions, under different environmental conditions. The results showed that the addition of inorganic ions mainly reduced genotoxicity, while changes in the pH of pharmaceutical solutions significantly affected genotoxicity. Synergistic interactions were more commonly observed among mixtures.
DRUG AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Emilia Waraksa, Katarzyna Owczarek, Pawel Kubica, Ewa Klodzinska, Mariusz Ozimek, Robert Wrzesien, Barbara Bobrowska-Korczak, Jacek Namiesnik
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Aleksandra Rutkowska, Aleksandra Olsson, Jacek Namiesnik, Andrzej Milewicz, Jan K. Ludwicki, Pawel Strucinski, Szymon Graczyk
ACTA BIOCHIMICA POLONICA
(2020)
Article
Biochemistry & Molecular Biology
Aleksandra Rutkowska, Aleksandra Olsson, Monika Piotrowska-Szypryt, Jacek Namiesnik
ACTA BIOCHIMICA POLONICA
(2020)
Article
Biochemistry & Molecular Biology
Martyna Lubinska-Szczygel, Zaneta Polkowska, Tomasz Dymerski, Shela Gorinstein
Article
Biochemistry & Molecular Biology
Rocio Salsoso, Alfonso Mate, Fernando Toledo, Carmen M. Vazquez, Luis Sobrevia
Summary: Late-onset preeclampsia is associated with altered endothelial function in the fetoplacental vasculature, causing an imbalance in the L-arginine/NO signaling pathway and reducing umbilical vein dilation to insulin, which requires A(2B)AR activation in HUVECs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Plant Sciences
Anchittha Satjarak, Linda E. Graham, Michael J. Piotrowski, Marie T. Trest, Lee W. Wilcox, Martha E. Cook, Jennifer J. Knack, Patricia Arancibia-Avila
Summary: The study analyzed the epimicrobiota diversity of Nostoc sampled from a wetland in the northern Chilean Altiplano using a combination of different ribosomal RNA gene sequences and microscopy techniques, revealing a wide range of microbial taxa present, with over 60% of them being detected using markers other than 16S rRNA genes.
JOURNAL OF PHYCOLOGY
(2021)
Article
Chemistry, Analytical
Nabil Ali Al-Mekhlafi, Ahmed Mediani, Nor Hadiani Ismail, Faridah Abas, Tomasz Dymerski, Martyna Lubinska-Szczyge, Suchada Vearasilp, Shela Gorinstein
Summary: This study evaluated the metabolic differences among dragon fruit varieties using the H-1NMR technique, showing that methanol and methanol/water extracted similar compounds with higher intensity in methanol. Differences in metabolite profiles were evident among dragon fruit from different origins and varieties, with significant variations shown in Pareto and UV scaling methods for CD3OD extracts.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Applied
Barbara Kusznierewicz, Marika Mroz, Izabela Koss-Mikolajczyk, Jacek Namiesnik
Summary: This study presents methods for assessing the health quality of products containing betalains, comparing data on phytochemical composition of beetroot cultivars using various techniques. Identified that betalain contributes about 50% to the antioxidant activity in red beetroot. Photometric measurements are recommended for simple analysis of betacyanin and betaxanthin content, while liquid chromatography techniques provide more precise information. The combination of liquid chromatography with high-resolution mass spectrometry is recommended for more detailed metabolomics studies, identifying sixty-four phytochemicals in beetroot samples.
Article
Chemistry, Analytical
Dominik Dobrzyniewski, Bartosz Szulczynski, Tomasz Dymerski, Jacek Gebicki
Summary: The article introduces a new method for monitoring and assessing the dry methane reforming process using a gas sensor array and Principal Component Regression calibration method. The results show promising potential for the use of non-selective chemical sensors in conjunction with mathematical models in monitoring industrial processes.
Article
Multidisciplinary Sciences
Monika Baranowska, Zuzanna Koziara, Klaudia Suliborska, Wojciech Chrzanowski, Michael Wormstone, Jacek Namiesnik, Agnieszka Bartoszek
Summary: The study demonstrates the significant impact of interactions between common food flavonoids on their electrochemical properties and bioactivities. Mixtures of flavonoids show enhanced antioxidant properties compared to individual components, with a synergistic effect observed in both chemical and cellular tests. In cellular tests, the mixtures exhibit properties of a new substance rather than those of individual components, stimulating cell growth.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Anchittha Satjarak, Linda E. Graham, Marie T. Trest, Patricia Arancibia-Avila
Summary: In this study, the complete chloroplast genome of the giant species Equisetum xylochaetum was assembled and compared with two other Equisetum species. The analysis revealed conserved traits in chloroplast genome structure and protein-coding regions among Equisetum species. Phylogenetic analysis confirmed the monophyly of Equisetum and provided insights into the relationships among different species. Single-gene phylogenetic estimation and haplotype analysis also shed light on the genetic diversity and mutation rate in Equisetum species.
Article
Mathematics
Veronica Poblete, Fernando Toledo, Octavio Vera
Summary: This study investigates the asymptotic behavior of a waves coupled system with a boundary dissipation of the fractional derivative type. We establish well-posedness and polynomial stability using the semigroup approach, the energy method, and stability results.
PROCEEDINGS OF THE EDINBURGH MATHEMATICAL SOCIETY
(2023)
Article
Microbiology
Cinthia Vasquez-Sandoval, Jose Navarrete, Paula Herrera-Herrera, Patricio Dantagnan, Paola Diaz-Navarrete, Patricia Arancibia-Avila, Claudia Oviedo
Summary: The objective of this study is to isolate and identify native strains from different Chilean coastal environments and evaluate the effect of culture parameters on biomass production and arachidonic acid content. A total of nine strains were identified, and the Lng2 strain was the most prominent one for ARA production. Temperature had an effect on the PUFA profile, while the C/N ratio was identified as a key parameter.
Article
Plant Sciences
Anchittha Satjarak, Michael J. Piotrowski, Linda E. Graham, Marie T. Trest, Lee W. Wilcox, Jennifer J. Knack, Martha E. Cook, Patricia Arancibia-Avila
Summary: This study investigated several lineages of eukaryotic microorganisms associated with the giant Equisetum xylochaetum, revealing protists, epiphytic and endophytic fungi, and cortical nematodes. DNA extraction and sequencing using low-shear methods showed potential benefits of various fungal associations for Equisetum survival.
AMERICAN FERN JOURNAL
(2021)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
